Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
Scalability and information personal privacy are vital for training and deploying large-scale deep learning *** learning trains models on exclusive information by aggregating weights from various devices and taking ad...
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Scalability and information personal privacy are vital for training and deploying large-scale deep learning *** learning trains models on exclusive information by aggregating weights from various devices and taking advantage of the device-agnostic environment of web ***,relying on a main central server for internet browser-based federated systems can prohibit scalability and interfere with the training process as a result of growing client ***,information relating to the training dataset can possibly be extracted from the distributed weights,potentially reducing the privacy of the local data used for *** this research paper,we aim to investigate the challenges of scalability and data privacy to increase the efficiency of distributed training *** a result,we propose a web-federated learning exchange(WebFLex)framework,which intends to improve the decentralization of the federated learning *** is additionally developed to secure distributed and scalable federated learning systems that operate in web browsers across heterogeneous ***,WebFLex utilizes peer-to-peer interactions and secure weight exchanges utilizing browser-to-browser web real-time communication(WebRTC),efficiently preventing the need for a main central *** has actually been measured in various setups using the MNIST *** results show WebFLex’s ability to improve the scalability of federated learning systems,allowing a smooth increase in the number of participating devices without central data *** addition,WebFLex can maintain a durable federated learning procedure even when faced with device disconnections and network ***,it improves data privacy by utilizing artificial noise,which accomplishes an appropriate balance between accuracy and privacy preservation.
Recommender systems are effective in mitigating information overload, yet the centralized storage of user data raises significant privacy concerns. Cross-user federated recommendation(CUFR) provides a promising distri...
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Recommender systems are effective in mitigating information overload, yet the centralized storage of user data raises significant privacy concerns. Cross-user federated recommendation(CUFR) provides a promising distributed paradigm to address these concerns by enabling privacy-preserving recommendations directly on user devices. In this survey, we review and categorize current progress in CUFR, focusing on four key aspects: privacy, security, accuracy, and efficiency. Firstly,we conduct an in-depth privacy analysis, discuss various cases of privacy leakage, and then review recent methods for privacy protection. Secondly, we analyze security concerns and review recent methods for untargeted and targeted *** untargeted attack methods, we categorize them into data poisoning attack methods and parameter poisoning attack methods. For targeted attack methods, we categorize them into user-based methods and item-based methods. Thirdly,we provide an overview of the federated variants of some representative methods, and then review the recent methods for improving accuracy from two categories: data heterogeneity and high-order information. Fourthly, we review recent methods for improving training efficiency from two categories: client sampling and model compression. Finally, we conclude this survey and explore some potential future research topics in CUFR.
The disappearance of Indigenous languages results in a decrease in cultural diversity, hence making the preservation of these languages extremely important. Conventional methods of documentation are lengthy, and the p...
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Partial multi-label learning（PML） allows learning from rich-semantic objects with inaccurate annotations, where a set of candidate labels are assigned to each training example but only some of them are valid. Existi...
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Partial multi-label learning（PML） allows learning from rich-semantic objects with inaccurate annotations, where a set of candidate labels are assigned to each training example but only some of them are valid. Existing approaches rely on disambiguation to tackle the PML problem, which aims to correct noisy candidate labels by recovering the ground-truth labeling information ahead of prediction model induction. However, this dominant strategy might be suboptimal as it usually needs extra assumptions that cannot be fully satisfied in real-world scenarios. Instead of label correction, we investigate another strategy to tackle the PML problem, where the potential ambiguity in PML data is eliminated by correcting instance features in a label-specific manner. Accordingly, a simple yet effective approach named PASE, i.e., partial multi-label learning via label-specific feature corrections, is proposed. Under a meta-learning framework, PASElearns to exert label-specific feature corrections so that potential ambiguity specific to each class label can be eliminated and the desired prediction model can be induced on these corrected instance features with the provided candidate labels. Comprehensive experiments on a wide range of synthetic and real-world data sets validate the effectiveness of the proposed approach.
In traditional digital twin communication system testing,we can apply test cases as completely as possible in order to ensure the correctness of the system implementation,and even then,there is no guarantee that the d...
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In traditional digital twin communication system testing,we can apply test cases as completely as possible in order to ensure the correctness of the system implementation,and even then,there is no guarantee that the digital twin communication system implementation is completely *** verification is currently recognized as a method to ensure the correctness of software system for communication in digital twins because it uses rigorous mathematical methods to verify the correctness of systems for communication in digital twins and can effectively help system designers determine whether the system is designed and implemented *** this paper,we use the interactive theorem proving tool Isabelle/HOL to construct the formal model of the X86 architecture,and to model the related assembly *** verification result shows that the system states obtained after the operations of relevant assembly instructions is consistent with the expected states,indicating that the system meets the design expectations.
In the realm of deep learning, Generative Adversarial Networks (GANs) have emerged as a topic of significant interest for their potential to enhance model performance and enable effective data augmentation. This paper...
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Recently, redactable blockchain has been proposed and leveraged in a wide range of real systems for its unique properties of decentralization, traceability, and transparency while ensuring controllable on-chain data r...
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Recently, redactable blockchain has been proposed and leveraged in a wide range of real systems for its unique properties of decentralization, traceability, and transparency while ensuring controllable on-chain data redaction. However, the development of redactable blockchain is now obstructed by three limitations, which are data privacy breaches, high communication overhead, and low searching efficiency, respectively. In this paper, we propose PriChain, the first efficient privacy-preserving fine-grained redactable blockchain in decentralized settings. PriChain provides data owners with rights to control who can read and redact on-chain data while maintaining downward compatibility, ensuring the one who can redact will be able to read. Specifically, inspired by the concept of multi-authority attribute-based encryption, we utilize the isomorphism of the access control tree, realizing fine-grained redaction mechanism, downward compatibility, and collusion resistance. With the newly designed structure, PriChain can realize O（n） communication and storage overhead compared to prior O（n2） schemes. Furthermore, we integrate multiple access trees into a tree-based dictionary, optimizing searching efficiency. Theoretical analysis proves that PriChain is secure against the chosen-plaintext attack and has competitive complexity. The experimental evaluations show that PriChain realizes 10× efficiency improvement of searching and 100× lower communication and storage overhead on average compared with existing schemes.
In the fields of intelligent transportation and multi-task cooperation, many practical problems can be modeled by colored traveling salesman problem(CTSP). When solving large-scale CTSP with a scale of more than 1000d...
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In the fields of intelligent transportation and multi-task cooperation, many practical problems can be modeled by colored traveling salesman problem(CTSP). When solving large-scale CTSP with a scale of more than 1000dimensions, their convergence speed and the quality of their solutions are limited. This paper proposes a new hybrid IT?(HIT?) algorithm, which integrates two new strategies, crossover operator and mutation strategy, into the standard IT?. In the iteration process of HIT?, the feasible solution of CTSP is represented by the double chromosome coding, and the random drift and wave operators are used to explore and develop new unknown regions. In this process, the drift operator is executed by the improved crossover operator, and the wave operator is performed by the optimized mutation strategy. Experiments show that HIT? is superior to the known comparison algorithms in terms of the quality solution.
Sentiment analysis plays an important role in distilling and clarifying content from movie reviews,aiding the audience in understanding universal views towards the ***,the abundance of reviews and the risk of encounte...
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Sentiment analysis plays an important role in distilling and clarifying content from movie reviews,aiding the audience in understanding universal views towards the ***,the abundance of reviews and the risk of encountering spoilers pose challenges for efcient sentiment analysis,particularly in Arabic *** study proposed a Stochastic Gradient Descent(SGD)machine learning(ML)model tailored for sentiment analysis in Arabic and English movie *** allows for fexible model complexity adjustments,which can adapt well to the Involvement of Arabic language *** adaptability ensures that the model can capture the nuances and specifc local patterns of Arabic text,leading to better *** distinct language datasets were utilized,and extensive pre-processing steps were employed to optimize the datasets for *** proposed SGD model,designed to accommodate the nuances of each language,aims to surpass existing models in terms of accuracy and *** SGD model achieves an accuracy of 84.89 on the Arabic dataset and 87.44 on the English dataset,making it the top-performing model in terms of accuracy on both *** indicates that the SGD model consistently demonstrates high accuracy levels across Arabic and English *** study helps deepen the understanding of sentiments across various linguistic *** many studies that focus solely on movie reviews,the Arabic dataset utilized here includes hotel reviews,ofering a broader perspective.
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