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Applications of node-based resilience graph theoretic framework to clustering autism spectrum disorders phenotypes

Applied Network science 2018年第1期3卷 38页

作者： Matta, John Zhao, Junya Ercal, Gunes Obafemi-Ajayi, Tayo Department of Computer Science Southern Illinois University Edwardsville EdwardsvilleIL United States Department of Computer Science Missouri State University SpringfieldMO United States Engineering Program Missouri State University SpringfieldMO United States

With the growing ubiquity of data in network form, clustering in the context of a network, represented as a graph, has become increasingly important. Clustering is a very useful data exploratory machine learning tool that allows us to make better sense of heterogeneous data by grouping data with similar attributes based on some criteria. This paper investigates the application of a novel graph theoretic clustering method, Node-Based Resilience clustering (NBR-Clust), to address the heterogeneity of Autism Spectrum Disorder (ASD) and identify meaningful subgroups. The hypothesis is that analysis of these subgroups would reveal relevant biomarkers that would provide a better understanding of ASD phenotypic heterogeneity useful for further ASD studies. We address appropriate graph constructions suited for representing the ASD phenotype data. The sample population is drawn from a very large rigorous dataset: Simons Simplex Collection (SSC). Analysis of the results performed using graph quality measures, internal cluster validation measures, and clinical analysis outcome demonstrate the potential usefulness of resilience measure clustering for biomedical datasets. We also conduct feature extraction analysis to characterize relevant biomarkers that delineate the resulting subgroups. The optimal results obtained favored predominantly a 5-cluster configuration. © 2018, The Author(s).

关键词： Graph theory

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Innovation Leadership Honors program: Addressing engineering education needs through curriculum enhancement

Innovation Leadership Honors Program: Addressing engineering...

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39th Annual Frontiers in Education Conference: Imagining and engineering Future CSET Education, FIE 2009

作者： Stevens, Karl K. VanEpps, Tim Schlossberg, Sharon M. Agarwal, Ankur Hamza-Lup, Georgiana L. College of Engineering and Computer Science Florida Atlantic University United States Innovation Leadership Honors Program College of Engineering and Computer Science Florida Atlantic University United States Department of Computer Science and Engineering Florida Atlantic University United States

ISBN: (纸本)9781424447152

The emerging challenges of the "engineer of 2020" have been clearly identified and extensively discussed. It has become evident that there is a crucial need for change in the practice of engineering and the education of future engineers. Specifically, engineering disciplines need to be broadened and enriched to better prepare graduates for working in a constantly changing global economy. In response to these challenges, the Executive Advisory Council of the College of engineering and computer science undertook the task of advising the College on the strategic changes needed in the engineering curricula. As a result a new program was conceptualized and designated by Florida Atlantic University as the Innovation Leadership Honors program. This program, which we believe to be the first of its kind, was designed as an overlay for our existing curricula in engineering and computer science, and is intended to provide a select group of students an enhanced background and training in innovation, entrepreneurship, leadership, and communication. program content, criteria and procedures for selection of student participants, Advisory Council participation in delivery of the program, and other administrative details are described in the paper. © 2009 IEEE.

关键词： Curricula

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Nature of college advisor in the twenty-first century

Nature of college advisor in the twenty-first century

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2001 ASEE Annual Conference and Exposition: Peppers, Papers, Pueblos and Professors

作者： Gregory, James M. Desrosiers, Raymond Heinze, Lloyd Bagert, Don Rivera, John Texas Tech University College of Engineering Chemical Engineering Department Petroleum Engineering Computer Science Coll. of Engineering BRIDGE Program

Advising is an important task for success of college students, especially students with professional majors, such as engineering. In addition to meeting the breadth of a college education, students in a professional major must also complete depth of study in math and science and the application of this knowledge in professional development. The requirements are strict and the sequencing of courses is critical for both academic success and efficiency in graduating by the desired date. Advisors are more than schedulers of classes. The selection and scheduling of classes should be efficient so both the student and the advisor can focus on issues critical to the academic success of the student. In a global sense, advisors provide the service of career development ranging in process from selection of major to professional development and management of a system of life-long learning. This paper identifies the duties of a modern advisor and discusses the advising process with the aid of web-based tools to increase both the efficiency and quality of advisement. Applications of this technology in the College of engineering at Texas Tech University have been very successful. Students appreciate the quickness of the process and the ability to consider and plan all activities - not just the courses. Advisors are also happy with the shift away from scheduling and toward professional and personal issues that promote long-term academic and professional success.

关键词： Students

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Multifunctional metaoptics based on bilayer metasurfaces

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Light(science & Applications) 2019年第1期8卷 466-474页

作者： You Zhou Ivan I.Kravchenko Hao Wang Hanyu Zheng Gong Gu Jason Valentine Interdisciplinary Materials Science Program Vanderbilt UniversityNashvilleTN 37212USA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Min H.Kao Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996USA Department of Electric Engineering and Computer Science Vanderbilt UniversityNashvilleTN 37212USA Department of Mechanical Engineering Vanderbilt UniversityNashvilleTN 37212USA

Optical metasurfaces have become versatile platforms for manipulating the phase,amplitude,and polarization of light.A platform for achieving independent control over each of these properties,however,remains elusive due to the limited engineering space available when using a single-layer *** instance,multiwavelength metasurfaces suffer from performance limitations due to space filling constraints,while control over phase and amplitude can be achieved,but only for a single ***,we explore bilayer dielectric metasurfaces to expand the design space for *** ability to independently control the geometry and function of each layer enables the development of multifunctional metaoptics in which two or more optical properties are independently *** a proof of concept,we demonstrate multiwavelength holograms,multiwavelength waveplates,and polarization-insensitive 3D holograms based on phase and amplitude *** proposed architecture opens a new avenue for designing complex flat optics with a wide variety of functionalities.

关键词： surface. optics independently

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AI-driven 3D Spatial Transcriptomics

arXiv

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arXiv 2025年

作者： Almagro-Pérez, Cristina Song, Andrew H. Weishaupt, Luca Kim, Ahrong Jaume, Guillaume Williamson, Drew F.K. Hemker, Konstantin Lu, Ming Y. Singh, Kritika Chen, Bowen Le, Long Phi Baras, Alexander S. Jiang, Sizun Bashashati, Ali Liu, Jonathan T.C. Mahmood, Faisal Department of Pathology Mass General Brigham Harvard Medical School BostonMA United States Cancer Program Broad Institute of Harvard and MIT CambridgeMA United States Data Science Program Dana-Farber Cancer Institute BostonMA United States Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology CambridgeMA United States Department of Pathology Pusan National University Busan Korea Republic of Department of Pathology and Laboratory Medicine Emory University School of Medicine AtlantaGA United States Department of Computer Science & Technology University of Cambridge Cambridge United Kingdom Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States Rutgers Robert Wood Johnson Medical School New BrunswickNJ United States Department of Pathology Johns Hopkins Hospital BaltimoreMD United States Department of Biomedical Engineering Johns Hopkins Hospital BaltimoreMD United States Broad Institute of Harvard and MIT CambridgeMA United States Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School BostonMA United States Department of Pathology Dana Farber Cancer Institute BostonMA United States Department of Pathology and Laboratory Medicine University of British Columbia VancouverBC Canada School of Biomedical Engineering University of British Columbia VancouverBC Canada Department of Mechanical Engineering Bioengineering Laboratory Medicine & Pathology University of Washington SeattleWA United States Harvard Data Science Initiative Harvard University CambridgeMA United States

A comprehensive three-dimensional (3D) map of tissue architecture and gene expression is crucial for illuminating the complexity and heterogeneity of tissues across diverse biomedical applications1. However, most spatial transcriptomics (ST) approaches remain limited to two-dimensional (2D) sections of tissue2–4. Although current 3D ST methods hold promise, they typically require extensive tissue sectioning, are complex, are not compatible with non-destructive 3D tissue imaging technologies, and often lack scalability5–8. Here, we present VOlumetrically Resolved Transcriptomics EXpression (VORTEX), an AI framework that leverages 3D tissue morphology and minimal 2D ST to predict volumetric 3D ST. By pretraining on diverse 3D morphology–transcriptomic pairs from heterogeneous tissue samples and then fine-tuning on minimal 2D ST data from a specific volume of interest, VORTEX learns both generic tissue-related and sample-specific morphological correlates of gene expression. This approach enables dense, high-throughput, and fast 3D ST, scaling seamlessly to large tissue volumes far beyond the reach of existing 3D ST techniques. By offering a cost-effective and minimally destructive route to obtaining volumetric molecular insights, we anticipate that VORTEX will accelerate biomarker discovery and our understanding of morphomolecular associations and cell states in complex tissues. Interactive 3D ST volumes can be viewed at https://***/. © 2025, CC BY-NC-ND.

关键词： Vortex flow

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Toward CAM-oriented CAD 19

Toward CAM-oriented CAD

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19th Design Automation Conference, DAC 1982

作者： Arbab, Farhad Lichten, Larry Melkanoff, Michel A. Computer Science Department Manufacturing Engineering Program University of California Los Angeles United States

A new solid modeling scheme is proposed and developed as the core of an integrated approach to the computer aided design and manufacture of mechanical parts. The benefits of this methodology, which considers the manuf... 详细信息

关键词： computer aided design

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Towards the conception of scientific workflows for in silico experiments in software engineering 10

Towards the conception of scientific workflows for in silico...

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Proceedings of the 2010 ACM-IEEE International Symposium on Empirical Software engineering and Measurement

作者： Pereira, Wallace M. Travassos, Guilherme H. Federal University of Rio de Janeiro/COPPE Systems Engineering and Computer Science Program Brazil

ISBN: (纸本)9781450300391

The evolution of science has been supported by complex computerized infrastructures with growing interest in simulation based experiments. This trend can also be observed in Software engineering. Our capacity of acquiring evidences to describe phenomena of interest in the field allowed the building of in silico models that can virtually replicate feasible software behaviors and improve our capacity of observation. In silico experiments demand additional concerns for its planning. One of them is regarding the scientific workflow conception. This task is not easy and to apply ad-hoc approaches can risky the experiment execution, validity and future replications. Regarding this topic, this paper presents some initial results from our research towards an approach to support the conception of scientific workflows for in silico experiments in Software engineering are presented. © 2010 ACM.

关键词： computer software

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3D Printed Biomimetic Composite for Treatment of Osteochondral Defects: A Preliminary Study in Porcine

SSRN

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SSRN 2025年

作者： Eckstein, Kevin N. Liu, Boyuan Schoonraad, Sarah A. Guastaldi, Fernando Pozzi Semeghini Uzcategui, Camila Muralidharan, Archish McLeod, Robert R. Randolph, Mark A. Bryant, Stephanie J. Ferguson, Viginia L. Paul M. Rady Department of Mechanical Engineering University of Colorado at Boulder BoulderCO80309 United States Materials Science and Engineering Program University of Colorado at Boulder BoulderCO80309 United States Division of Oral and Maxillofacial Surgery Department of Surgery Massachusetts General Hospital Harvard School of Dental Medicine Harvard Medical School BostonMA02114 United States Division of Plastic and Reconstructive Surgery Department of Surgery Massachusetts General Hospital Harvard Medical School BostonMA02114 United States Department of Electrical Computer and Energy Engineering University of Colorado at Boulder BoulderCO80309 United States Department of Chemical and Biological Engineering University of Colorado at Boulder BoulderCO80309 United States BioFrontiers Institute University of Colorado at Boulder BoulderCO80309 United States

Osteochondral defects in diarthrodial joints can occur as a result of trauma. When left untreated, the surrounding tissues experience abnormal mechanical loads that can cause further degeneration. Thus, treatment of osteochondral defects requires the ability to support physiological loads and prevent further degeneration of surrounding tissues. Additive manufacturing techniques, such as bio-ink printing, have been explored to structurally reinforce soft scaffolds;however, these methods struggle to accurately print complex designs with small feature sizes (e.g., on the order of ~100 micrometers). In this study, we present a composite osteochondral scaffold with regional stiffness gradients, optimized to mimic the mechanical properties of articular cartilage and limit high strains in the subchondral bone. This scaffold incorporates a load-bearing structure, with ≥ 180 μm diameter truss elements, that is 3D printed via projection micro-stereolithography with a biomimetic soft hydrogel. We hypothesized that incorporating a reinforcing structure with cartilage and bone regions possessing tissue-specific stiffnesses, compared to a soft gel alone, would reduce degradation of native cartilage tissue adjacent to osteochondral defects and promote multi-tissue integration in porcine knees after six weeks. Histological analysis and microcomputed tomography revealed site-specific changes in the surrounding tissue, notably in the adjacent cartilage. Mechanical evaluation of adjacent native tissue showed that scaffolds with the 3D printed composite structure resulted in 33% less surrounding cartilage degradation compared to gel-only treatments. Within the defect, the soft gel alone limited mineralization, while the composite supported mineralization but only in its stiffer region. These findings suggest that incorporating a 3D printed reinforcing osteochondral mimetic structure protects the adjacent cartilage, enhances tissue integration, and spatially supports mineralization. © 2

关键词： Bone

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Procedural Low-Poly Buildings using L-System for Turn-based Tactic Game ***

Procedural Low-Poly Buildings using L-System for Turn-based ...

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2024 International of Seminar on Application for Technology of Information and Communication, iSemantic 2024

作者： Benedict, Augusta Steven Rosyidah, Umi Harisa, Ardiawan Bagus Haryanto, Hanny Universitas Dian Nuswantoro Study Program in Information Engineering Faculty of Computer Science Semarang Indonesia

ISBN: (纸本)9798350366648

One of the critical visual components in video game creation is 3D asset prototypes, which also require significant effort. A procedural model using the L-system method for making low-poly buildings can address this issue. This model produces low-poly buildings based on simple parameters input by the user. The model receives input in the form of axioms, which are then processed according to predetermined L-system rules. After the building is formed, it is saved as a prefab in Unity so that it can be reused and modified by the user. The proposed method is implemented to our turn-based tactic *** and provided as a Unity package (add-on). Experimental results show that the buildings generated by the model have a minimalistic yet functional benefits. © 2024 IEEE.

关键词： Game design

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Static Taint Analysis Traversal with Object Oriented Component for Web File Injection Vulnerability Pattern Detection 3

Static Taint Analysis Traversal with Object Oriented Compone...

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3rd International Conference on computer science and Computational Intelligence, ICCSCI 2018

作者： Kurniawan, Aditya Abbas, Bahtiar Saleh Trisetyarso, Agung Isa, Sani Muhammad Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program - Doctor of Computer Science Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta11480 Indonesia Industrial Engineering Department Faculty of Engineering Bina Nusantara University Jakarta11480 Indonesia

We introduce a composition of object-oriented component PHP grammar for taint analysis. Our novel method successfully restructured the PHP parser and reduced grammar artifact objects that must be visited in a taint analysis process by up to 52% grammar variation. Taint analysis is an analysis that detects any injection vulnerability pattern in source code. The analysis identifies the information flow of untrustworthy input that affects the sensitive sink or part of the system. The static taint analysis was run on an abstract syntax tree and traversed all nodes. A static taint analysis uses a parser to traverse abstract syntax trees of the source code. A web PHP parser has 140 grammar combinations in an abstract syntax tree, which has to be traversed to recognize the tainted flow pattern. Additionally, there are many variations of syntax and coding styles for tainted flow patterns. Therefore, the amount of combinations will consume many computation resources. © 2018 The Authors. Published by Elsevier Ltd.

关键词： Syntactics

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