Nanoscale porous silicon waveguides, both on silicon substrates and free-standing membranes, are explored for biosensing applications. Measured detection limits in the nanomolar range are reported for DNA sensing.
Nanoscale porous silicon waveguides, both on silicon substrates and free-standing membranes, are explored for biosensing applications. Measured detection limits in the nanomolar range are reported for DNA sensing.
Ubiquitin ligases play a central role in determining the specificity of the ubiquitination system by selecting a myriad of appropriate candidate proteins for modification. The U-box is a recently identified, ubiquitin...
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Ubiquitin ligases play a central role in determining the specificity of the ubiquitination system by selecting a myriad of appropriate candidate proteins for modification. The U-box is a recently identified, ubiquitin ligase activityrelated protein domain that shows greater presence in plants than in other organisms. In this study, we identified 77 putative U-box proteins from the rice genome using a battery of whole genome analysis algorithms. Most of the U-box protein genes are expressed, as supported by the identification of their corresponding expressed sequence tags （ESTs）, full-length cDNAs, or massively parallel signature sequencing （MPSS） tags. Using the same algorithms, we identified 61 U-box proteins from the Arabidopsis genome. The rice and Arabidopsis U-box proteins were classified into nine major classes based on their domain compositions. Comparison between rice and Arabidopsis U-box proteins indicates that the majority of rice and Arabidopsis U-box proteins have the same domain organizations. The inferred phylogeny established the homology between rice and Arabidopsis U-box/ARM proteins. Cell death assay using the rice protoplast system suggests that one rice U-box gene, OsPUB51, might act as a negative regulator of cell death signaling. In addition, the selected U-box proteins were found to be functional E3 ubiquitin ligases. The identification and analysis of rice U-box proteins hereby at the genomic level will help functionally characterize this class of E3 ubiquitin ligase in the future.
The malicious botnets are evaluated as the serious threat of the Internet society in future. As the botnets are more clever and artful, the detection of botnets is not easy. Recently malicious botnets evolve into HTTP...
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The malicious botnets are evaluated as the serious threat of the Internet society in future. As the botnets are more clever and artful, the detection of botnets is not easy. Recently malicious botnets evolve into HTTP botnets out of typical IRC botnets and it is difficult to response effectively with existing methods which are using DNS traffic. In this paper, we show the relations of HTTP clients to HTTP servers, and propose the method to search malicious HTTP botnets by using degree of periodic repeatability.
Biophotonic imaging can be used to characterize tumor growth in animal models. Estimation of the numbers and location of target cells is dependent on accurate segmentation of a target region from the background lumine...
Biophotonic imaging can be used to characterize tumor growth in animal models. Estimation of the numbers and location of target cells is dependent on accurate segmentation of a target region from the background luminescence of the animal body. Existing software systems extract general regions of interest in complex images but can fail to detect details or faint regions of interest in the presence of higher luminescent activity. Limited work has been published in the analysis of these images. We explore the use of popular medical image segmentation techniques in segmentation of bioluminescence images. The ability of each algorithm in detecting regions of interest is tested using established performance measures. Based on the characteristics of bioluminescence images of animal tumor models, and the performance of the algorithms, we formulate a framework for segmentation techniques best suited for this application.
Single-suture craniosynostosis is a condition of the sutures of the infant's skull that causes major craniofacial deformities and is associated with an increased risk of cognitive deficits and learning/language di...
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Single-suture craniosynostosis is a condition of the sutures of the infant's skull that causes major craniofacial deformities and is associated with an increased risk of cognitive deficits and learning/language disabilities. In this paper we adapt to classification of synostostic head shapes a Bayesian methodology that overcomes the limitations of our previously published shape representation and classification techniques. We evaluate our approach in a series of large-scale experiments and show performance superior to those of standard approaches such as Fourier descriptors, cranial spectrum, and Euclidian-distance-based analyses.
The ever changing engineering curriculum mandates an emphasis on interdisciplinary projects. Through interdisciplinary projects, students will be exposed to a curriculum that allows them to work in teams of multi-disc...
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