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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Stochastic optimal control navigation with the avoidance of unsafe configurations

Stochastic optimal control navigation with the avoidance of ...

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International Conference on Unmanned Aircraft Systems (ICUAS)

作者： Alexey A. Munishkin Dejan Milutinović David W. Casbeer UC Santa Cruz CA Computer Engineering Department UC Santa Cruz CA Control Science Center of Excellence Air Force Research Laboratory Wright-Patterson AFB OH

ISBN: (纸本)9781467393355

Long-time planning horizons are required to safely navigate one vehicle in the presence of another, possibly non-cooperative vehicle. They give rise to computational issues preventing the real-time implementation of safe navigation algorithms. In this paper, we consider two nonholonomic vehicles, of which one (blue) has the goal to enter the “tail” of the other (red). Neither the goal nor the navigation strategy of the red vehicle is known by the blue vehicle. To anticipate this uncertainty, the blue vehicle uses infinite horizon stochastic optimal control. Using the stochastic optimal control and backward Kolmogorov equation, the blue is navigated to avoid unsafe configurations from which the red can enter the “tail” of the blue and gain advantage over it. Our results are illustrated by numerical simulations and the feasibility of the control for the real-time implementation is tested with small-scale robot experiments.

关键词： Vehicles Optimal control Stochastic processes Aircraft navigation Real-time systems Uncertainty

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Approximate Analysis of MIMO based Cooperative Communication in α - μ Channel Distribution

Approximate Analysis of MIMO based Cooperative Communication...

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International Conference on Communication Systems and Networks

作者： Amodh Kant Saxena Shashank Goyal Rakhesh Singh Kshetrimayum Department of Electrical Engineering and Computer Science UC Irvine Open Systems Operations Visa Inc. Department of Electronics and Electrical Engineering IIT Guwahati

ISBN: (纸本)9781467396233

In the present work we have analysed the performance of a dual hop cooperative communication system. Multiple relays are taken for DF (Decode and Forward) relaying of signal from source to the destination over i.i.d. α - μ generalized fading channel distribution. Multiple antennas are realized at all the receive and transmit nodes on the source, relay and destination with Orthogonal Space Time Block Coding (OSTBC) implementation. Theoretical approximation for Symbol Error Rate (SER) performance is evaluated for Binary Phase Shift Keying (BPSK) and 4-Quadrature Amplitude Modulation (4-QAM) schemes as a function of Signal to Noise Ratio (SNR) using the Moment Generating Function (MGF) of the channel distribution. The variation of performance with number of relays used is studied. Monte Carlo simulation is used for verification of the analytical expression obtained.

关键词： approximate analysis Binary phase shift keying cooperative communication relay destination multiple input multiple output systems signal to noise ratios space time block coding

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Measuring Auto Switch Between Wi-Fi and Mobile Data Networks in an Urban Area 2016

Measuring Auto Switch Between Wi-Fi and Mobile Data Networks...

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Proceedings of the 12th Conference on International Conference on Network and Service Management

作者： Jonghwan Hyun Youngjoon Won David Sang-Chul Nahm James Won-Ki Hong Dept. of Computer Science and Engineering POSTECH Pohang Korea Dept. of Information System Hanyang University Seoul Korea Dept. of Computer Science UC Berkeley CA USA

ISBN: (纸本)9783901882852

To preserve consistent throughput, smartphones are equipped with a network switch feature (handover in heterogeneous networks). Frequent switching is often blamed to be a QoE downgrader in populated areas. In this paper, we measured auto switch occurrences between Wi-Fi and mobile data networks. We deployed an Android monitoring application for 89 participants and collected network status information up to 10 days long. We observed that auto switch occurred on average 2.53 times per hour and RTT decreased as the smartphone preferred to stay in Wi-Fi. Also, 68% of all users connected to Wi-Fi longer than the mobile data networks.

关键词： 4G

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Measuring auto switch between Wi-Fi and mobile data networks in an urban area

Measuring auto switch between Wi-Fi and mobile data networks...

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International Conference on Network and Service Management

ISBN: (纸本)9781509032365

关键词： IEEE 802.11 Standard Switches Mobile communication Mobile computing Smart phones Manuals Monitoring

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Meeting Soft Deadlines in Single- and Multi-server Systems

Meeting Soft Deadlines in Single- and Multi-server Systems

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International Teletraffic Congress, ITC 21

作者： Esa Hyytiä Rhonda Righter Jorma Virtamo Department of Computer Science University of Iceland Department of Industrial Engineering and Operations Research UC Berkeley Department of Communications and Networking Aalto University

ISBN: (纸本)9781509013043

We consider single-and multi-server systems, where jobs have a maximum waiting time (deadline) defined, e.g., by a service level agreement. A fixed cost is associated with deadline violations and the task is to minimize the long-run cumulative costs. Job sizes (service durations) are observed upon arrival, and current queue backlogs are known. For a single FCFS server, the optimization task is to find the optimal admission policy that may reject a job upon arrival if admitting it would cause in future one or more deadlines to be violated (in expectation). For parallel FCFS servers, the policy must (i) either accept or reject a job upon arrival, and if accepted, (ii) assign it to one of the servers. We derive efficient deadline-aware policies in the MDP framework. For a single server, we obtain the optimal admission policy. For dispatching to parallel servers, we develop efficient heuristic admission and dispatching policies, whose performances are evaluated by means of numerical examples. Additionally, we give some exact closed-form results for heavy-traffic limits.

关键词： Servers Dispatching Queueing analysis Steady-state Context Delays Admission control

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The Atacama Cosmology Telescope: Detection of the pairwise kinematic Sunyaev-Zel’dovich effect with SDSS DR15 galaxies

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Physical Review D 2021年第4期104卷 043502-043502页

作者： V. Calafut P. A. Gallardo E. M. Vavagiakis S. Amodeo S. Aiola J. E. Austermann N. Battaglia E. S. Battistelli J. A. Beall R. Bean J. R. Bond E. Calabrese S. K. Choi N. F. Cothard M. J. Devlin C. J. Duell S. M. Duff A. J. Duivenvoorden J. Dunkley R. Dunner S. Ferraro Y. Guan J. C. Hill G. C. Hilton M. Hilton R. Hložek Z. B. Huber J. Hubmayr K. M. Huffenberger J. P. Hughes B. J. Koopman A. Kosowsky Y. Li M. Lokken M. Madhavacheril J. McMahon K. Moodley S. Naess F. Nati L. B. Newburgh M. D. Niemack L. A. Page B. Partridge E. Schaan A. Schillaci C. Sifón D. N. Spergel S. T. Staggs J. N. Ullom L. R. Vale A. Van Engelen J. Van Lanen E. J. Wollack Z. Xu Department of Astronomy Cornell University Ithaca New York 14853 USA Department of Physics Cornell University Ithaca New York 14853 USA Center for Computational Astrophysics Flatiron Institute New York New York 10010 USA NIST Quantum Devices Group 325 Broadway Mailcode 817.03 Boulder Colorado 80305 USA Physics Department Sapienza University of Rome Piazzale Aldo Moro 5 I-00185 Rome Italy Canadian Institute for Theoretical Astrophysics University of Toronto Toronto Ontario M5S 3H8 Canada School of Physics and Astronomy Cardiff University The Parade Cardiff CF24 3AA United Kingdom Department of Applied and Engineering Physics Cornell University Ithaca New York USA 14853 Department of Physics and Astronomy University of Pennsylvania 209 South 33rd Street Philadelphia Pennsylvania 19104 USA Joseph Henry Laboratories of Physics Jadwin Hall Princeton University Princeton New Jersey 08544 USA Department of Astrophysical Sciences Peyton Hall Princeton University Princeton New Jersey 08544 USA Instituto de Astrofísica and Centro de Astro-Ingeniería Facultad de Física Pontificia Universidad Católica de Chile Avenue Vicuña Mackenna 4860 7820436 Macul Santiago Chile Lawrence Berkeley National Laboratory One Cyclotron Road Berkeley California 94720 USA Berkeley Center for Cosmological Physics UC Berkeley Berkley California 94720 USA Department of Physics and Astronomy University of Pittsburgh Pittsburgh Pennsylvania 15260 USA Department of Physics Columbia University New York New York 10027 USA Astrophysics Research Centre University of KwaZulu-Natal Westville Campus Durban 4041 South Africa David A. Dunlap Department of Astronomy and Astrophysics University of Toronto 50 St. George Street Toronto Ontario M5S 3H4 Canada Dunlap Institute for Astronomy and Astrophysics University of Toronto 50 St. George Street Toronto Ontario M5S 3H4 Canada Department of Physics Florida State University Tallahassee Florida 32306 USA Department of Physics and

We present a 5.4σ detection of the pairwise kinematic Sunyaev-Zeldovich (kSZ) effect using Atacama Cosmology Telescope (ACT) and Planck CMB observations in combination with Luminous Red Galaxy samples from the Sloan Digital Sky Survey (SDSS) DR15 catalog. Results are obtained using three ACT CMB maps: co-added 150 and 98 GHz maps, combining observations from 2008–2018 (ACT DR5), which overlap with SDSS DR15 over 3,700 sq. deg., and a component-separated map using night-time only observations from 2014–2015 (ACT DR4), overlapping with SDSS DR15 over 2,089 sq. deg. Comparisons of the results from these three maps provide consistency checks in relation to potential frequency-dependent foreground contamination. A total of 343,647 galaxies are used as tracers to identify and locate galaxy groups and clusters from which the kSZ signal is extracted using aperture photometry. We consider the impact of various aperture photometry assumptions and covariance estimation methods on the signal extraction. Theoretical predictions of the pairwise velocities are used to obtain best-fit, mass-averaged, optical depth estimates for each of five luminosity-selected tracer samples. A comparison of the kSZ-derived optical depth measurements obtained here to those derived from the thermal SZ effect for the same sample is presented in a companion paper.

关键词： Cosmic microwave background Cosmological parameters Large scale structure of the Universe

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The Atacama Cosmology Telescope: Probing the baryon content of SDSS DR15 galaxies with the thermal and kinematic Sunyaev-Zel’dovich effects

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Physical Review D 2021年第4期104卷 043503-043503页

作者： E. M. Vavagiakis P. A. Gallardo V. Calafut S. Amodeo S. Aiola J. E. Austermann N. Battaglia E. S. Battistelli J. A. Beall R. Bean J. R. Bond E. Calabrese S. K. Choi N. F. Cothard M. J. Devlin C. J. Duell S. M. Duff A. J. Duivenvoorden J. Dunkley R. Dunner S. Ferraro Y. Guan J. C. Hill G. C. Hilton M. Hilton R. Hložek Z. B. Huber J. Hubmayr K. M. Huffenberger J. P. Hughes B. J. Koopman A. Kosowsky Y. Li M. Lokken M. Madhavacheril J. McMahon K. Moodley S. Naess F. Nati L. B. Newburgh M. D. Niemack L. A. Page B. Partridge E. Schaan A. Schillaci C. Sifón D. N. Spergel S. T. Staggs J. N. Ullom L. R. Vale A. Van Engelen J. Van Lanen E. J. Wollack Z. Xu Department of Physics Cornell University Ithaca New York 14853 USA Department of Astronomy Cornell University Ithaca New York 14853 USA Center for Computational Astrophysics Flatiron Institute New York New York 10010 USA NIST Quantum Sensors Group 325 Broadway Boulder Colorado 80305 USA Physics Department Sapienza University of Rome Piazzale Aldo Moro 5 I-00185 Rome Italy Canadian Institute for Theoretical Astrophysics University of Toronto Toronto Ontario M5S 3H8 Canada School of Physics and Astronomy Cardiff University The Parade Cardiff CF24 3AA United Kingdom Department of Applied and Engineering Physics Cornell University Ithaca New York 14853 USA Department of Physics and Astronomy University of Pennsylvania 209 South 33rd Street Philadelphia Pennsylvania 19104 USA Joseph Henry Laboratories of Physics Jadwin Hall Princeton University Princeton New Jersey 08544 USA Department of Astrophysical Sciences Peyton Hall Princeton University Princeton New Jersey 08544 USA Instituto de Astrofísica and Centro de Astro-Ingeniería Facultad de Física Pontificia Universidad Católica de Chile Avenida Vicuña Mackenna 4860 7820436 Macul Santiago Chile Lawrence Berkeley National Laboratory One Cyclotron Road Berkeley California 94720 USA Berkeley Center for Cosmological Physics UC Berkeley California 94720 USA Department of Physics and Astronomy University of Pittsburgh Pittsburgh Pennsylvania 15260 USA Department of Physics Columbia University New York New York 10027 USA Astrophysics Research Centre University of KwaZulu-Natal Westville Campus Durban 4041 South Africa David A. Dunlap Department of Astronomy and Astrophysics University of Toronto 50 St. George Street Toronto Ontario M5S 3H4 Canada Dunlap Institute for Astronomy and Astrophysics University of Toronto 50 St. George Street Toronto Ontario M5S 3H4 Canada Department of Physics Florida State University Tallahassee Florida 32306 USA Department of Physics and Astronomy Rutgers Th

We present measurements of the average thermal Sunyaev Zel’dovich (tSZ) effect from optically selected galaxy groups and clusters at high signal-to-noise (up to 12σ) and estimate their baryon content within a 2.1′ radius aperture. Sources from the Sloan Digital Sky Survey Baryon Oscillation Spectroscopic Survey DR15 catalog overlap with 3,700 sq deg of sky observed by the Atacama Cosmology Telescope (ACT) from 2008 to 2018 at 150 and 98 GHz (ACT DR5), and 2,089 sq deg of internal linear combination component-separated maps combining ACT and Planck data (ACT DR4). The corresponding optical depths τ¯, which depend on the baryon content of the halos, are estimated using results from cosmological hydrodynamic simulations assuming an active galactic nuclei feedback radiative cooling model. We estimate the mean mass of the halos in multiple luminosity bins, and compare the tSZ-based τ¯ estimates to theoretical predictions of the baryon content for a Navarro-Frenk-White profile. We do the same for τ¯ estimates extracted from fits to pairwise baryon momentum measurements of the kinematic Sunyaev-Zel’dovich effect (kSZ) for the same dataset obtained in a companion paper. We find that the τ¯ estimates from the tSZ measurements in this work and the kSZ measurements in the companion paper agree within 1σ for two out of the three disjoint luminosity bins studied, while they differ by 2–3σ in the highest luminosity bin. The optical depth estimates account for one-third to all of the theoretically predicted baryon content in the halos across luminosity bins. Potential systematic uncertainties are discussed. The tSZ and kSZ measurements provide a step toward empirical Compton-y¯−τ¯ relationships to provide new tests of cluster formation and evolution models.

关键词： Cosmic microwave background Cosmological parameters Cosmology Large scale structure of the Universe

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Representational similarity of actions in the human brain

Representational similarity of actions in the human brain

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International Workshop on Pattern Recognition in NeuroImaging (PRNI)

作者： Burcu A. Urgen Selen Pehlivan Ayse P. Saygin Department of Cognitive Science UC San Diego La Jolla CA Department of Neuroscience University of Parma ITALY Department of Computer Engineering TED University Ankara TURKEY

ISBN: (纸本)9781467365314

Visual processing of actions is supported by a network of brain regions in occipito-temporal, parietal, and premotor cortex in the primate brain, known as the Action Observation Network (AON). What remain unclear are the representational properties of each node of this network. In this study, we investigated the representational content of brain areas in AON using fMRI, representational similarity analysis (RSA), and modeling. Subjects were shown video clips of three agents performing eight different actions during fMRI scanning. We then computed the representational dissimilarity matrices (RDMs) for each brain region, and compared them with that of two sets of model representations that were constructed based on computer vision and semantic attributes. Our findings reveal that different nodes of the AON have different representational properties. PSTS as the visual area of the AON represents high level visual features such as movement kinematics. As one goes higher in the AON hierarchy, representations become more abstract and semantic as our results revealed that parietal cortex represents several aspects of actions such as action category, intention of the action, and target of the action. These results suggest that during visual processing of actions, pSTS pools information from visual cortex to compute movement kinematics, and passes that information to higher levels of AON coding semantics of actions such as action category, intention of action, and target of action, consistent with computational models of visual action recognition.

关键词： Computational modeling Visualization Brain modeling Semantics Humanoid robots Trajectory

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Simple mechanisms for a subadditive buyer and applications to revenue monotonicity 15

Simple mechanisms for a subadditive buyer and applications t...

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16th ACM Conference on Economics and Computation, EC 2015

作者： Rubinstein, Aviad Weinberg, S. Matthew Department of Electrical Engineering and Computer Science UC Berkeley United States Department of Computer Science Princeton University United States

ISBN: (纸本)9781450334105

We study the revenue maximization problem of a seller with n heterogeneous items for sale to a single buyer whose valuation function for sets of items is unknown and drawn from some distribution D. We show that if D is a distribution over subadditive valuations with independent items, then the better of pricing each item separately or pricing only the grand bundle achieves a constant-factor approximation to the revenue of the optimal mechanism. This includes buyers who are k-demand, additive up to a matroid constraint, or additive up to constraints of any downwards-closed set system (and whose values for the individual items are sampled independently), as well as buyers who are fractionally subadditive with item multipliers drawn independently. Our proof makes use of the core-tail decomposition framework developed in prior work showing similar results for the significantly simpler class of additive buyers [Li and Yao 2013;Babaioff et al. 2014]. In the second part of the paper, we develop a connection between approximately optimal simple mechanisms and approximate revenue monotonicity with respect to buyers' valuations. Revenue non-monotonicity is the phenomenon that sometimes strictly increasing buyers' values for every set can strictly decrease the revenue of the optimal mechanism [Hart and Reny 2012]. Using our main result, we derive a bound on how bad this degradation can be (and dub such a bound a proof of approximate revenue monotonicity);we further show that better bounds on approximate monotonicity imply a better analysis of our simple mechanisms.

关键词： combinatorial valuations simple auctions revenue monotonicity revenue optimization

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