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Material informatics-driven insights into brain cancer nanocarriers: A bibliometric comparison of PLGA vs. liposomes

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OpenNano 2025年 21卷

作者： Makalew, Brilly Andro Abrori, Syauqi Abdurrahman Computer Science Department School of Computer Science Bina Nusantara University Jakarta 11480 Indonesia Automotive & Robotics Program Computer Engineering Department BINUS ASO School of Engineering Bina Nusantara University Jakarta 11480 Indonesia

This study explores a comparative analysis of PLGA nanoparticles and liposomes as potential carriers for brain cancer drug delivery, with a special focus on how material informatics enhances their design, biocompatibility, and drug release profiles to improve treatment efficacy and contribute to sustainable health outcomes. The investigation employed a bibliometric analysis using Scopus and VOSviewer to uncover the role of material informatics in optimizing these nanocarriers. The analysis revealed that material informatics, particularly through the application of machine learning and molecular dynamics simulations, significantly optimizes the performance of both PLGA nanoparticles and liposomes. The results highlighted distinct strengths of each nanocarrier: PLGA nanoparticles excel in biodegradability, while liposomes offer superior drug encapsulation capabilities. However, material informatics techniques bridged these enhancing drug release kinetics, stability, and biocompatibility. These improvements are crucial for effective delivery across the blood-brain barrier, a major challenge in brain cancer treatment. The integration of computational modelling, machine learning, and high-throughput screening enabled by material informatics is shown to be a key factor in advancing the design and optimization of these nanocarriers. By leveraging these tools, researchers can develop more personalized and efficient drug delivery systems tailored to address the specific challenges of glioblastoma therapy, ultimately contributing to sustainable health outcomes © 2024 The Author(s)

关键词： Bibliometric analysis Brain cancer Drug delivery Liposomes Material informatics Nanocarriers PLGA nanoparticles VOSviewer

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2.3-μm deep UV micro-LEDs fabricated by self-aligned selective thermal oxidation process

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Optics Letters 2025年第11期50卷 3628-3631页

作者： Zhiyuan Liu Haicheng Cao Tingang Liu Patsy A. Mira Cortez Zixian Jiang Kexin Ren Na Xiao Yi Lu Xiao Tang Zuojian Pan Xiaohang Li Advanced Semiconductor Laboratory Electrical and Computer Engineering Program CEMSE Division King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia

Recently, techniques for fabricating micro-sized deep ultraviolet light-emitting diodes (DUV LEDs) have been gaining attention. In this work, we propose a selective thermal oxidation (STO) process to fabricate ultra-small DUV micro-LEDs. Annealed in the air at 900°C for 2 h, the p-layers without SiO 2 protection are oxidized into insulating oxides, and oxygen penetrates into parts of the quantum wells. In contrast, the patterned SiO 2 protects the LED structure in the pixel regions. Therefore, micro-LED pixels are formed by the patterned SiO 2 and thermal oxidation process rather than the conventional reactive ion etching. The formed oxide in the unprotected region can function as the insulation layer between p–n electrodes. Meanwhile, the boundary between the pixel and the surrounding oxide is naturally formed during thermal oxidation, which is a “self-aligned” process. Dielectric deposition, precise lithography alignment, and aperture etching in the conventional process are no longer required in STO-based micro-LED fabrication, which reduces production complexity and cost. Based on the STO process, we have achieved 2.3-µm DUV micro-LED standalone pixels and arrays with a 270-nm emission wavelength. The standalone DUV micro-LED is possibly the smallest reported in the literature to date, which has a low-operation voltage of 4.9 and 6.75 V at 10 and 1000 A/cm 2 . Meanwhile, the fabricated DUV micro-LED arrays show leakage current density 4 × 10 −7 A/cm 2 at −5 V and a peak EQE of 0.77% under unpackaged conditions. We hope this work provides a new insight into micro-LED fabrication and further promotes future performance growth of DUV LEDs.

关键词： Light emitting diodes Light extraction Lithography Multiple quantum wells Quantum wells Ultraviolet light emitting diodes

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A Multi-UAV Charging Station Enabling Free Landing by Grid Pattern Transmitter

A Multi-UAV Charging Station Enabling Free Landing by Grid P...

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Annual IEEE Conference on Applied Power Electronics Conference and Exposition (APEC)

作者： Jungho Kim Hyunkyeong Jo Seoktae Seo Bonyoung Lee Hyungki Min Franklin Bien School of Electrical and Computer Engineering Ulsan National Institute of Science and Technology Ulsan Korea Program in Information & Communication Technology Convergence Ulsan National Institute of Science and Technology Ulsan Korea

ISBN: (数字)9798331516116

ISBN: (纸本)9798331516123

This paper proposed a novel landing platform with wireless power transfer (WPT) to charge multiple unmanned aerial vehicles (UAVs) without restrictions on landing locations or alignment. A transmitter is designed using wires to charge a wide area. To overcome the disadvantages of system made by wires, a grid pattern transmitter and double power line are proposed. These structures provide multiple charging with free positioning of receivers and excite the transmitter lines in wide area properly. The optimized system is composed of 0.15m square cells, providing a 0.9 m by 0.9 m charging area. By experiment, it can efficiently charge four 0.1 m square receivers located anywhere in transmitter. The overall efficiency of four receivers is 37.5%. Also, the experimental results verify that it is unnecessary to align the receiver within the cell, as it has a 2.62% error due to rotation and a 2.94 % error due to position within the cell.

关键词： Coils Magnetic flux leakage Transmitters Wires Windings Receivers Wireless power transfer Autonomous aerial vehicles Current distribution Power electronics

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Chiral exceptional point enhanced active tuning and non reciprocity in micro-resonators

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光：科学与应用（英文版） 2025年第2期14卷 401-410页

作者： Hwaseob Lee Lorry Chang Ali Kecebas Dun Mao Yahui Xiao Tiantian Li Andrea Alù Sahin K.Özdemir Tingyi Gu Department of Electrical and Computer Engineering University of DelawareNewarkDelaware 19716USA Department of Engineering Science and Mechanics Pennsylvania State UniversityUniversity ParkPA 16802USA Photonics Initiative Advanced Science Research CenterCity University of New YorkNew YorkNY 10031USA Physics Program Graduate CenterCity University of New YorkNew YorkNY 10016USA Department of Engineering Science and Mechanics Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Electrical and Computer Engineering Saint Louis UniversitySaint LouisMO 63103USA

Exceptional points(EPs)have been extensively explored in mechanical,acoustic,plasmonic,and photonic ***,little is known about the role of EPs in tailoring the dynamic tunability of optical devices.A specific type of EPs known as chiral EPs has recently attracted much attention for controlling the flow of light and for building sensors with better responsivity.A recently demonstrated route to chiral EPs via lithographically defined symmetric Mie scatterers on the rim of resonators has not only provided the much-needed mechanical stability for studying chiral EPs,but also helped reduce losses originating from nanofabrication imperfections,facilitating the in-situ study of chiral EPs and their contribution to the dynamics and tunability of ***,we use asymmetric Mie scatterers to break the rotational symmetry of a microresonator,to demonstrate deterministic thermal tuning across a chiral EP,and to demonstrate EP-mediated chiral optical nonlinear response and efficient electro-optic *** results indicate asymmetric electro-optic modulation with up to 17 dB contrast at GHz and CMOS-compatible voltage *** wafer-scale nano-manufacturing of chiral electro-optic modulators and the chiral EP-tailored tunning may facilitate new micro-resonator functionalities in quantum information processing,electromagnetic wave control,and optical interconnects.

关键词： active point micro chiral enhanced exceptional reciprocity resonators tuning

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PHORTEX: Physically-Informed Operational Robotic Trajectories for Scientific Expeditions

Field Robotics

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Field Robotics 2025年 4卷 138-181页

作者： Victoria L. Preston Genevieve E. Flaspohler John W. Fisher Anna P. M. Michel Nicholas Roy Applied Ocean Physics and Engineering Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program Cambridge MA 02139 Electrical Engineering and Computer Science Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program Cambridge MA 02139 Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge MA 02139 Applied Ocean Physics and Engineering Woods Hole Oceanographic Institution Woods Hole MA 02543

Mobile robots are increasingly used to collect valuable in situ samples during scientific expeditions. However, many phenomena of scientific interest—deep-sea hydrothermal plumes, algal blooms, warm-core eddies, and lava flows—are spatiotemporal distributions that evolve on spatial and temporal scales that complicate sample collection. Here, we consider the problem of charting the space-time dynamics of deep-sea hydrothermal plumes with the state-of-the-art autonomous underwater vehicle (AUV) Sentry. In the hydrothermal plume charting problem, the plume state is driven by complicated and unobserved dynamics in the deep sea. To effectively sample the moving plume, an autonomy system must infer plume dynamics from sparse, point observations, while respecting operational constraints of AUV Sentry that restrict the set of possible trajectories to nonadaptive, uniform-coverage patterns. We frame the plume charting problem as a sequential decision-making problem and formulate a mission planner PHORTEX (PHysically-informed Operational Robotic Trajectories for Expeditions) that strategically designs full mission trajectories for Sentry, where each mission plan is informed by the observations of the last. PHORTEX is composed of a trajectory optimizer, which maximizes expected samples collected within a moving plume, and PHUMES (PHysically-informed Uncertainty Models for Environment Spatiotemporality), a modeling framework that leverages an embedded simulator of idealized plume physics as an inductive bias to enable dynamics learning from extreme partial observations and a few Sentry deployments. In both simulation and in field trials at a hydrothermal site in the Gulf of California, we demonstrate that Sentry using PHORTEX learns to track a moving hydrothermal plume and gather samples that significantly improve upon baseline spatial and temporal diversity for use in downstream science tasks.

关键词： Trajectory Sensors Oceans Vehicle dynamics Robot sensing systems Adaptation models Spatiotemporal phenomena Decision making Marine robots Environmental monitoring Mobile robots

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A Two-stage Reconfiguration in Network Function Virtualization: Toward Service Function Chain Optimization

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IEEE Transactions on Network and Service Management 2025年

作者： Assis, Karcius D. R. Almeida, Raul C. Baghban, Hojjat Santos, Alex F. Boutaba, Raouf Electrical and Computer Engineering Department Salvador Brazil University of Waterloo David R. Cheriton School of Computer Science Canada Department of Electronics and Systems Recife Brazil Chang Gung University Department of Artificial Intelligence Taiwan Chang Gung University College of Intelligent Computing Taiwan Center of Science and Technology in Energy and Sustainability Brazil Postgraduate Program in Computer Science Bahia Brazil

Network Function Virtualization (NFV), as a promising paradigm, speeds up the service deployment by separating network functions from proprietary devices and deploying them on common servers in the form of software. Any service in NFV-enabled networks is achieved as a Service Function Chain (SFC) which consists of a series of ordered Virtual Network Functions (VNFs). However, migration of VNFs for more flexible services within a dynamic NFV-enabled network is a key challenge to be addressed. Current VNF migration studies mainly focus on single VNF migration decisions without considering the sharing and concurrent migration of VNF instances. In this paper, we assume that each deployed VNF is used by multiple SFCs and deal with the optimal placement for the contemporaneous migration of VNFs based on the actual network situation. We formalize the VNF migration and SFC reconfiguration problem as a mathematical model, which aims to minimize the VNF migration between nodes or the total number of core changes per node. The approach is a two-stage MILP based on optimal order to solve the reconfiguration. Extensive evaluation shows that the proposed approach can reduce the change in terms of location or number of cores per node in a 6-node and 14-node networks while ensuring network latency compared with the model without reconfiguration. © 2004-2012 IEEE.

关键词： Network function virtualization

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The Wilhelm Tell Dataset of Affordance Demonstrations 20

The Wilhelm Tell Dataset of Affordance Demonstrations

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20th Annual ACM/IEEE International Conference on Human-Robot Interaction, HRI 2025

作者： Ringe, Rachel Pomarlan, Mihai Tsiogkas, Nikolaos De Giorgis, Stefano Hedblom, Maria Malaka, Rainer University of Bremen Digital Media Lab Bremen Germany University of Bremen Bremen Germany Ku Leuven Department of Computer Science Leuven Belgium Institute of Cognitive Sciences and Technologies National Research Council Catania Italy Jönköping School of Engineering Department of Computing Jönköping Sweden

ISBN: (纸本)9798350378931

Affordances - i.e. possibilities for action that an environment or objects in it provide - are important for robots operating in human environments to perceive. Existing approaches train such capabilities on annotated static images or shapes. This work presents a novel dataset for affordance learning of common household tasks. Unlike previous approaches, our dataset consists of video sequences demonstrating the tasks from first- and third-person perspectives, along with metadata about the affordances that are manifested in the task, and is aimed towards training perception systems to recognize affordance manifestations. The demonstrations were collected from several participants and in total record about seven hours of human activity. The variety of task performances also allows studying preparatory maneuvers that people may perform for a task, such as how they arrange their task space, which is also relevant for collaborative service robots. © 2025 IEEE.

关键词： Industrial robots

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Unlocking the potential of RNN and CNN models for accurate rehabilitation exercise classification on multi-datasets

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Multimedia Tools and Applications 2025年第3期84卷 1261-1301页

作者： Zaher, Moamen Ghoneim, Amr S. Abdelhamid, Laila Atia, Ayman Software Engineering Program Faculty of Computers & Artificial Intelligence—Helwan University Cairo Ain Helwan11795 Egypt Computer Science Department Faculty of Computers & Artificial Intelligence—Helwan University Cairo Ain Helwan11795 Egypt Information System Department Faculty of Computers & Artificial Intelligence—Helwan University Cairo Ain Helwan11795 Egypt Cairo Ain Helwan11795 Egypt Giza October12451 Egypt

Physical rehabilitation is crucial in healthcare, facilitating recovery from injuries or illnesses and improving overall health. However, a notable global challenge stems from the shortage of professional physiotherapists, particularly acute in some developing countries, where the ratio can be as low as one physiotherapist per 100,000 individuals. To address these challenges and elevate patient care, the field of physical rehabilitation is progressively integrating computer Vision and Human Activity Recognition (HAR) techniques. Numerous research efforts aim to explore methodologies that assist in rehabilitation exercises and evaluate patient movements, which is crucial as incorrect exercises can potentially worsen conditions. This study investigates applying various deep-learning models for classifying exercises using the benchmark KIMORE and UI-PRMD datasets. Employing Bi-LSTM, LSTM, CNN, and CNN-LSTM, alongside a Random Search for architectural design and Hyper-parameter tuning, our investigation reveals the (CNN) model as the top performer. After applying cross-validation, the technique achieves remarkable mean testing accuracy rates of 93.08% on the KIMORE dataset and 99.7% on the UI-PRMD dataset. This marks a slight improvement of 0.75% and 0.1%, respectively, compared to previous techniques. In addition, expanding beyond exercise classification, this study explores the KIMORE dataset’s utility for disease identification, where the (CNN) model consistently demonstrates an outstanding accuracy of 89.87%, indicating its promising role in both exercises and disease identification within the context of physical rehabilitation. © The Author(s) 2024.

关键词： Classification (of information)

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Autolysosomal Dysfunction in Obesity-induced Metabolic Inflammation and Related Disorders

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Current Obesity Reports 2025年第1期14卷 1-16页

作者： Cheong, Lenny Yi Tong Saipuljumri, Eka Norfaishanty Loi, Gavin Wen Zhao Zeng, Jialiu Lo, Chih Hung Lee Kong Chian School of Medicine Nanyang Technological University Singapore 308232 Singapore Program in Neuroscience & Cognitive Science University of Arizona Tucson 85721 AZ United States School of Biomedical Sciences The University of Queensland St Lucia 4072 QLD Australia Department of Biomedical and Chemical Engineering Syracuse University Syracuse 13244 NY United States Interdisciplinary Neuroscience Program Syracuse University Syracuse 13244 NY United States Department of Biology Syracuse University Syracuse 13244 NY United States

Purpose of Review: Obesity is a global health crisis affecting individuals across all age groups, significantly increasing the risk of metabolic disorders such as type 2 diabetes (T2D), metabolic dysfunction-associated fatty liver disease (MAFLD), and cardiovascular diseases. The World Health Organization reported in 2022 that 2.5 billion adults were overweight, with 890 million classified as obese, emphasizing the urgent need for effective interventions. A critical aspect of obesity’s pathophysiology is meta-inflammation—a chronic, systemic low-grade inflammatory state driven by excess adipose tissue, which disrupts metabolic homeostasis. This review examines the role of autolysosomal dysfunction in obesity-related metabolic disorders, exploring its impact across multiple metabolic organs and evaluating potential therapeutic strategies that target autophagy and lysosomal function. Recent Findings: Emerging research highlights the importance of autophagy in maintaining cellular homeostasis and metabolic balance. Obesity-induced lysosomal dysfunction impairs the autophagic degradation process, contributing to the accumulation of damaged organelles and toxic aggregates, exacerbating insulin resistance, lipotoxicity, and chronic inflammation. Studies have identified autophagic defects in key metabolic tissues, including adipose tissue, skeletal muscle, liver, pancreas, kidney, heart, and brain, linking autophagy dysregulation to the progression of metabolic diseases. Preclinical investigations suggest that pharmacological and nutritional interventions—such as AMPK activation, caloric restriction mimetics, and lysosomal-targeting compounds—can restore autophagic function and improve metabolic outcomes in obesity models. Summary: Autolysosomal dysfunction is a pivotal contributor to obesity-associated metabolic disorders, influencing systemic inflammation and metabolic dysfunction. Restoring autophagy and lysosomal function holds promise as a therapeutic strategy to miti

关键词： Autophagy function Lysosomal acidification Metabolic inflammation Neurodegeneration Neuroinflammation Therapeutic strategies

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A portable,low-cost lactate measurement system

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Journal of Measurement science and Instrumentation 2025年第1期16卷 37-46页

作者： WANG Qingqing PAN Yu YU Chuanxin WANG Yanyan ZHANG Kaikai LIU Sheng School of Computer Science and Technology Huaibei Normal UniversityHuaibei 235000China Anhui Provincial Engineering Research Center of Cognitive Behavioral Intelligent Computing and Application Huaibei 235000China

Lactate,as a metabolite,plays a significant role in a number of fields,including medical diagnostics,exercise physiology and food *** methods for lactate measurement often involve expensive and cumbersome *** study developed a portable and low-cost lactate measurement system,including independently detectable hardware circuits and user-friendly embedded software,computer,and smartphone *** experiment verified that the relative error of the detection current in the device circuit was less than 1%.The electrochemical performance was measured by comparing the[Fe(CN)_(6)]^(3−)/[Fe(CN)_(6)]^(4−)solution with the desktop electrochemical workstation CHI660E,and a nearly consistent chronoamperometry(CA)curve was *** modified lactate sensors were used for CA testing of *** the concentration range of 0.1 mmol·L^(−1)to 20 mmol·L^(−1),there was a good linear relationship between lactate concentration and steady-state current,with a correlation coefficient(R2)greater than 0.99 and good repeatability,demonstrating the reliability of the developed *** lactate measurement system developed in this study not only provides excellent detection performance and reliability,but also achieves portability and low cost,providing a new solution for lactate measurement.

关键词： lactate measurement portable device embedded development lactate sensor electrochemical analysis

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