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A compositional object-based approach to learning physical dynamics 5

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A compositional object-based approach to learning physical d...

5th International Conference on Learning Representations, ICLR 2017

作者： Chang, Michael B. Ullman, Tomer Torralba, Antonio Tenenbaum, Joshua B. Department of Electrical Engineering and Computer Science MIT Department of Brain and Cognitive Sciences MIT

We present the Neural Physics Engine (NPE), a framework for learning simulators of intuitive physics that naturally generalize across variable object count and different scene configurations. We propose a factorization of a physical scene into composable object-based representations and a neural network architecture whose compositional structure factorizes object dynamics into pairwise interactions. Like a symbolic physics engine, the NPE is endowed with generic notions of objects and their interactions;realized as a neural network, it can be trained via stochastic gradient descent to adapt to specific object properties and dynamics of different worlds. We evaluate the efficacy of our approach on simple rigid body dynamics in two-dimensional worlds. By comparing to less structured architectures, we show that the NPE's compositional representation of the structure in physical interactions improves its ability to predict movement, generalize across variable object count and different scene configurations, and infer latent properties of objects such as mass. © ICLR 2019 - Conference Track Proceedings. All rights reserved.

关键词： Stochastic systems

Artificial Intelligence for Dementia Research Methods Optimization

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arXiv 2023年

作者： Bucholc, Magda James, Charlotte Al Khleifat, Ahmad Badhwar, AmanPreet Clarke, Natasha Dehsarvi, Amir Madan, Christopher R. Marzi, Sarah J. Shand, Cameron Schilder, Brian M. Tamburin, Stefano Tantiangco, Hanz M. Lourida, Ilianna Llewellyn, David J. Ranson, Janice M. Cognitive Analytics Research Lab School of Computing Engineering & Intelligent Systems Ulster University Derry United Kingdom NIHR Bristol Biomedical Research Centre University Hospitals Bristol Weston NHS Foundation Trust University of Bristol Bristol United Kingdom Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology & Neuroscience King's College London London United Kingdom Lab Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal Montréal Canada Institut de Génie Biomédical Université de Montréal Montréal Canada Département de Pharmacologie et Physiologie Université de Montréal Montréal Canada Aberdeen Biomedical Imaging Centre School of Medicine Medical Sciences and Nutrition University of Aberdeen Aberdeen United Kingdom School of Psychology University of Nottingham Nottingham United Kingdom UK Dementia Research Institute Imperial College London London United Kingdom Department of Brain Sciences Imperial College London London United Kingdom Centre for Medical Image Computing Department of Computer Science University College London London United Kingdom Department of Neurosciences Biomedicine and Movement Sciences University of Verona Verona Italy Information School University of Sheffield Sheffield United Kingdom University of Exeter Medical School Exeter United Kingdom The Alan Turing Institute London United Kingdom

Introduction: Machine learning (ML) has been extremely successful in identifying key features from high-dimensional datasets and executing complicated tasks with human expert levels of accuracy or greater. Methods: We summarize and critically evaluate current applications of ML in dementia research and highlight directions for future research. Results: We present an overview of ML algorithms most frequently used in dementia research and highlight future opportunities for the use of ML in clinical practice, experimental medicine, and clinical trials. We discuss issues of reproducibility, replicability and interpretability and how these impact the clinical applicability of dementia research. Finally, we give examples of how state-of-the-art methods, such as transfer learning, multi-task learning, and reinforcement learning, may be applied to overcome these issues and aid the translation of research to clinical practice in the future. Discussion: ML-based models hold great promise to advance our understanding of the underlying causes and pathological mechanisms of dementia. © 2023, CC BY.

关键词： Clinical research

Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 2 — Ex vivo imaging: added value and acquisition

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arXiv 2022年

作者： Schilling, Kurt G. Grussu, Francesco Ianus, Andrada Hansen, Brian Howard, Amy F.D. Barrett, Rachel L.C. Aggarwal, Manisha Michielse, Stijn Nasrallah, Fatima Syeda, Warda Wang, Nian Veraart, Jelle Roebroeck, Alard Bagdasarian, Andrew F. Eichner, Cornelius Sepehrband, Farshid Zimmermann, Jan Soustelle, Lucas Bowman, Christien Tendler, Benjamin C. Hertanu, Andreea Jeurissen, Ben Verhoye, Marleen Frydman, Lucio de Looij, Yohan van Hike, David Dunn, Jeff F. Miller, Karla Landman, Bennett A. Shemesh, Noam Anderson, Adam McKinnon, Emilie Farquharson, Shawna Acqua, Flavio Dell Pierpaoli, Carlo Drobnjak, Ivana Leemans, Alexander Harkins, Kevin D. Descoteaux, Maxime Xu, Duan Huang, Hao Santin, Mathieu D. Grant, Samuel C. Obenaus, Andre Kim, Gene S. Wu, Dan Le Bihan, Denis Blackband, Stephen J. Ciobanu, Luisa Fieremans, Els Bai, Ruiliang Leergaard, Trygve B. Zhang, Jiangyang Dyrby, Tim B. Allan Johnson, G. Cohen-Adad, Julien Budde, Matthew D. Jelescu, Ileana O. Radiology and Radiological Sciences Vanderbilt University Medical Center NashvilleTN United States Vanderbilt University Institute of Imaging Science Vanderbilt University NashvilleTN United States Radiomics Group Vall d’Hebron Institute of Oncology Vall d’Hebron Barcelona Hospital Campus Barcelona Spain Queen Square MS Centre Queen Square Institute of Neurology Faculty of Brain Sciences University College London London United Kingdom Champalimaud Research Champalimaud Foundation Lisbon Portugal Center of Functionally Integrative Neuroscience Aarhus University Aarhus Denmark Department of Bioengineering Imperial College London London United Kingdom FMRIB Centre Wellcome Centre for Integrative Neuroimaging Nuffield Department of Clinical Neurosciences University of Oxford Oxford United Kingdom Department of Neuroimaging Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom NatBrainLab Department of Forensics and Neurodevelopmental Sciences Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine BaltimoreMD United States Maastricht University Medical Center Maastricht Netherlands The Queensland Brain Institute The University of Queensland Queensland Australia Melbourne Neuropsychiatry Centre The University of Melbourne ParkvilleVIC Australia Department of Radiology and Imaging Sciences Indiana University IN United States Stark Neurosciences Research Institute Indiana University School of Medicine IN United States Center for Biomedical Imaging NYU Grossman School of Medicine New YorkNY United States Faculty of psychology and Neuroscience Maastricht University Maastricht Netherlands Department of Chemical & Biomedical Engineering FAMU-FSU College of Engineering Florida State University TallahasseeFL United States Center for Interdisciplinary Magnetic Re

The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non-invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructure and brain connectivity. Ex vivo dMRI has several experimental advantages including higher signal-to-noise ratio (SNR) and spatial resolution compared to in vivo studies, and enabling more advanced diffusion contrasts for improved microstructure and connectivity characterization. Another major advantage of ex vivo dMRI is the direct comparison with histological data, as a crucial methodological validation. However, there are a number of considerations that must be made when performing ex vivo experiments. The steps from tissue preparation, image acquisition and processing, and interpretation of results are complex, with many decisions that not only differ dramatically from in vivo imaging of small animals, but ultimately affect what questions can be answered using the data. This work represents "Part 2" of a 3-part series of recommendations and considerations for preclinical dMRI. We describe best practices for dMRI of ex vivo tissue, with a focus on the value that ex vivo imaging adds to the field of dMRI and considerations in ex vivo image acquisition. We first give general considerations and foundational knowledge that must be considered when designing experiments. We briefly describe differences in specimens and models and discuss why some may be more or less appropriate for different studies. We then give guidelines for ex vivo protocols, including tissue fixation, sample preparation, and MR scanning. In each section, we attempt to provide guidelines and recommendations, but also highlight areas for which no guidelines exist (and why), and where future work should lie. An overarching goal herein is to enhance the rigor and reproducibility of ex vivo dMRI acquisitions and analyses, and thereby advance biomedical knowledge. © 2022, CC BY.

关键词： Image acquisition

Considerations and Recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 1 — In vivo small-animal imaging

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arXiv 2022年

作者： Jelescu, Ileana O. Grussu, Francesco Ianus, Andrada Hansen, Brian Barrett, Rachel L.C. Aggarwal, Manisha Michielse, Stijn Nasrallah, Fatima Syeda, Warda Wang, Nian Veraart, Jelle Roebroeck, Alard Bagdasarian, Andrew F. Eichner, Cornelius Sepehrband, Farshid Zimmermann, Jan Soustelle, Lucas Bowman, Christien Tendler, Benjamin C. Hertanu, Andreea Jeurissen, Ben Verhoye, Marleen Frydman, Lucio de Looij, Yohan van Hike, David Dunn, Jeff F. Miller, Karla Landman, Bennett A. Shemesh, Noam Anderson, Adam McKinnon, Emilie Farquharson, Shawna Acqua, Flavio Dell Pierpaoli, Carlo Drobnjak, Ivana Leemans, Alexander Harkins, Kevin D. Descoteaux, Maxime Xu, Duan Huang, Hao Santin, Mathieu D. Grant, Samuel C. Obenaus, Andre Kim, Gene S. Wu, Dan Le Bihan, Denis Blackband, Stephen J. Ciobanu, Luisa Fieremans, Els Bai, Ruiliang Leergaard, Trygve B. Zhang, Jiangyang Dyrby, Tim B. Johnson, G. Allan Cohen-Adad, Julien Budde, Matthew D. Schilling, Kurt G. Department of Radiology Lausanne University Hospital University of Lausanne Lausanne Switzerland CIBM Center for Biomedical Imaging Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland Radiomics Group Vall d’Hebron Institute of Oncology Vall d’Hebron Barcelona Hospital Campus Barcelona Spain Queen Square MS Centre Queen Square Institute of Neurology Faculty of Brain Sciences University College London London United Kingdom Champalimaud Research Champalimaud Foundation Lisbon Portugal Center of Functionally Integrative Neuroscience Aarhus University Aarhus Denmark Department of Neuroimaging Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom NatBrainLab Department of Forensics and Neurodevelopmental Sciences Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine BaltimoreMD United States Maastricht University Medical Center Maastricht Netherlands The Queensland Brain Institute The University of Queensland Queensland Australia Melbourne Neuropsychiatry Centre The University of Melbourne ParkvilleVIC Australia Department of Radiology and Imaging Sciences Indiana University IN United States Stark Neurosciences Research Institute Indiana University School of Medicine IN United States Center for Biomedical Imaging NYU Grossman School of Medicine New YorkNY United States Faculty of psychology and Neuroscience Maastricht University Maastricht Netherlands Department of Chemical & Biomedical Engineering FAMU-FSU College of Engineering Florida State University TallahasseeFL United States Center for Interdisciplinary Magnetic Resonance National HIgh Magnetic Field Laboratory TallahasseeFL United States Department of Neuropsychology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany USC Stevens Neuroimaging and Informatics Instit

Small-animal diffusion MRI (dMRI) has been used for methodological development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. The steps from animal setup and monitoring, to acquisition, analysis, and interpretation are complex, with many decisions that may ultimately affect what questions can be answered using the resultant data. This work aims to present selected recommendations and guidelines from the diffusion community, on best practices for preclinical dMRI of in vivo animals. We describe the general considerations and foundational knowledge that must be considered when designing experiments. We briefly describe differences in animal species and disease models and discuss why some may be more or less appropriate for different studies. We then give guidelines for in vivo acquisition protocols, including decisions on hardware, animal preparation, and imaging sequences, followed by advice for data processing including pre-processing, model-fitting, and tractography. Finally, we provide an online resource which lists publicly available preclinical dMRI datasets and software packages, to promote responsible and reproducible research. In each section, we attempt to provide guides and recommendations, but also highlight areas for which no guidelines exist (and why), and where future work should focus. While we mainly cover the central nervous system (on which most preclinical dMRI studies are focused), we also provide, where possible and applicable, recommendations for other organs of interest. An overarching goal herein is to enhance the rigor and reproducibility of small animal dMRI acquisitions and analyses, and thereby advance biomedical knowledge. © 2022, CC BY-NC-ND.

关键词： Invertebrates

Small P values may not yield robust findings:an example using REST-meta-PD

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science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

Population-guided large margin classifier for high-dimension low -sample-size problems

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arXiv 2019年

作者： Yin, Qingbo Adeli, Ehsan Shen, Liran Shen, Dinggang College of Information Science and Technology Dalian Maritime University Dalian116023 China Department of Radiology and BRIC University of North Carolina Chapel HillNC27599 United States Departments of Psychiatry & Behavioral Sciences and Computer Science Stanford University StanfordCA94305-5723 United States College of Marine Electrical Engineering Dalian Maritime University Dalian116023 China Department of Brain and Cognitive Engineering Korea University Seoul02841 Korea Republic of

Various applications in different fields, such as gene expression analysis or computer vision, suffer from data sets with high-dimensional low-sample-size (HDLSS), which has posed significant challenges for standard statistical and modern machine learning methods. In this paper, we propose a novel linear binary classifier, denoted by population-guided large margin classifier (PGLMC), which is applicable to any sorts of data, including HDLSS. PGLMC is conceived with a projecting direction w given by the comprehensive consideration of local structural information of the hyperplane and the statistics of the training samples. Our proposed model has several advantages compared to those widely used approaches. First, it is not sensitive to the intercept term b. Second, it operates well with imbalanced data. Third, it is relatively simple to be implemented based on Quadratic Programming. Fourth, it is robust to the model specification for various real applications. The theoretical properties of PGLMC are proven. We conduct a series of evaluations on two simulated and six real-world benchmark data sets, including DNA classification, digit recognition, medical image analysis, and face recognition. PGLMC outperforms the state-of-the-art classification methods in most cases, or at least obtains comparable results. Copyright © 2019, The Authors. All rights reserved.

关键词： Classification (of information)

Multimodal emotion recognition using deep canonical correlation analysis

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arXiv 2019年

作者： Liu, Wei Qiu, Jie-Lin Zheng, Wei-Long Lu, Bao-Liang Center for Brain-Like Computing and Machine Intelligence Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai200240 China Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering Shanghai Jiao Tong University Shanghai200240 China Brain Science and Technology Research Center Shanghai Jiao Tong University Shanghai200240 China Department of Electronic Engineering Shanghai Jiao Tong University Shanghai200240 China Department of Neurology Massachusetts General Hospital Harvard Medical School BostonMA02114 United States

Multimodal signals are more powerful than unimodal data for emotion recognition since they can represent emotions more comprehensively. In this paper, we introduce deep canonical correlation analysis (DCCA) to multimodal emotion recognition. The basic idea behind DCCA is to transform each modality separately and coordinate different modalities into a hyperspace by using specified canonical correlation analysis constraints. We evaluate the performance of DCCA on five multimodal datasets: the SEED, SEED-IV, SEED-V, DEAP, and DREAMER datasets. Our experimental results demonstrate that DCCA achieves state-of-the-art recognition accuracy rates on all five datasets: 94.58% on the SEED dataset, 87.45% on the SEED-IV dataset, 84.33% and 85.62% for two binary classification tasks and 88.51% for a four-category classification task on the DEAP dataset, 83.08% on the SEED-V dataset, and 88.99%, 90.57%, and 90.67% for three binary classification tasks on the DREAMER dataset. We also compare the noise robustness of DCCA with that of existing methods when adding various amounts of noise to the SEED-V dataset. The experimental results indicate that DCCA has greater robustness. By visualizing feature distributions with t-SNE and calculating the mutual information between different modalities before and after using DCCA, we find that the features transformed by DCCA from different modalities are more homogeneous and discriminative across emotions. Copyright © 2019, The Authors. All rights reserved.

关键词： Eye movements

Neural information processing in hierarchical prototypical networks 25th

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Neural information processing in hierarchical prototypical n...

25th International Conference on Neural Information Processing, ICONIP 2018

作者： Ji, Zilong Zou, Xiaolong Liu, Xiao Huang, Tiejun Mi, Yuanyuan Wu, Si State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing100875 China School of Electronics Engineering and Computer Science IDG/McGovern Institute for Brain Research Peking University Beijing100871 China Institute for Neurointelligence School of Medicine Chongqing University Chongqing China

ISBN: (纸本)9783030041816

Prototypical networks (PTNs), which classify unseen data points according to their distances to the prototypes of classes, are a promising model to solve the few-shot learning problem. Mimicking the characteristics of neural systems, the present study extends PTNs in two aspects. Firstly, we develop hierarchical prototypical networks (HPTNs), which construct prototypes at all layers and minimize the weighted classification errors of all layers. Applied to two benchmark datasets, we show that a HPTN has comparable, or slightly better, performances than a PTN. We also find that after training, the HPTN generates good prototype representations in the intermediate layers of the network. Secondly, we demonstrate that the classification operation via distance computation in a PTN can be replaced approximately by the attracting dynamics of the Hopfield model, indicating the potential realization of metric-learning in neural systems. We hope this study establishes a link between PTNs and neural information processing. © Springer Nature Switzerland AG 2018.

关键词： Learning systems

FOCAL KL-DIVERGENCE BASED DILATED CONVOLUTIONAL NEURAL NETWORKS FOR CO-CHANNEL SPEAKER IDENTIFICATION

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FOCAL KL-DIVERGENCE BASED DILATED CONVOLUTIONAL NEURAL NETWO...

IEEE International Conference on Acoustics, Speech and Signal Processing

作者： Shuai Wang Yanmin Qian Kai Yu Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering SpeechLab Department of Computer Science and Engineering Brain Science and Technology Research Center Shanghai Jiao Tong University Shanghai China

ISBN: (纸本)9781538646595

Recognizing the identities of multiple talkers via their overlapped speech is a challenging task, it is also one main difficulty for the "cocktail party problem". In this paper, a novel dilated convolutional neural network with a focal KL-divergence loss function is proposed to tackle this problem. During training, relative loss for the well-classified samples is automatically reduced and consequently more attention is paid to the hard samples. The use of the focal KL-divergence loss function leads to more stable training and improved testing performance. Furthermore, a post processing of assigning different frames with different weights is also adopted and leads to further improvement. The proposed framework can be easily extended from 2-talker to 3-talker speaker identification scenario. Experiments on the artificially generated RSR2015 multi-talker mixed corpus show that the proposed approach can improve multi-talker speaker identification significantly.

关键词： co-channel speaker identification convolutional neural networks focal loss dilated convolution Loudspeakers Neural network speaker recognition personal identity