Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
Breast cancer poses a threat to women’s health and contributes to an increase in mortality rates. Mammography has proven to be an effective tool for the early detection of breast cancer. However, it faces many challe...
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Breast cancer poses a threat to women’s health and contributes to an increase in mortality rates. Mammography has proven to be an effective tool for the early detection of breast cancer. However, it faces many challenges in early breast cancer detection due to poor image quality, traditional segmentation, and feature extraction. Therefore, this work addresses these issues and proposes an attention-based backpropagation convolutional neural network (ABB-CNN) to detect breast cancer from mammogram images more accurately. The proposed work includes image enhancement, reinforcement learning-based semantic segmentation (RLSS), and multiview feature extraction and classification. The image enhancement is performed by removing noise and artefacts through a hybrid filter (HF), image scaling through a pixel-based bilinear interpolation (PBI), and contrast enhancement through an election-based optimization (EO) algorithm. In addition, the RLSS introduces intelligent segmentation by utilizing a deep Q network (DQN) to segment the region of interest (ROI) strategically. Moreover, the proposed ABB-CNN facilitates multiview feature extraction from the segmented region to classify the mammograms into normal, malignant, and benign classes. The proposed framework is evaluated on the collected and the digital database for screening mammography (DDSM) datasets. The proposed framework provides better outcomes in terms of accuracy, sensitivity, specificity, precision, f-measure, false-negative rate (FNR) and area under the curve (AUC). This work achieved (99.20%, 99.35%), (99.56%, 99.66%), (98.96%, 98.99%), (99.05%, 99.12%), (0.44%, 0.34%), (99.31%, 99.39%) and (99.27%, 99.32%) of accuracy, sensitivity, specificity, precision, FNR, f-measure and AUC on (collected, DDSM datasets), respectively. This research addresses the prevalent challenges in breast cancer identification and offers a robust and highly accurate solution by integrating advanced deep-learning techniques. The evaluated re
Animation is a widespread artistic expression that holds a special place in people's hearts. Traditionally, animation creation has relied heavily on manual techniques, demanding skilled drawing abilities and a sig...
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In the past decade, studies on illegal fishing have neglected to consider illegal underwater fishing. Traditionally, supervisor-based methods have been used to manually interpret underwater behavior;however, existing ...
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Heart disease increases the strain on the heart by reducing its ability to pump blood throughout the body, which can lead to heart attacks and strokes. Heart disease is becoming a global threat to the world due to peo...
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Plaintext-checkable encryption (PCE) can support searches over ciphertext by directly using plaintext. The functionality of a search is modeled by a specific check algorithm that takes a pair of target plaintext and c...
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From a medical perspective,the 12 leads of the heart in an electrocardiogram(ECG)signal have functional dependencies with each ***,all these leads report different aspects of an *** differences lie in the level of hig...
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From a medical perspective,the 12 leads of the heart in an electrocardiogram(ECG)signal have functional dependencies with each ***,all these leads report different aspects of an *** differences lie in the level of highlighting and displaying information about that *** example,although all leads show traces of atrial excitation,this function is more evident in lead II than in any other *** this article,a new model was proposed using ECG functional and structural dependencies between heart *** the prescreening stage,the ECG signals are segmented from the QRS point so that further analyzes can be performed on these segments in a more detailed *** mutual information indices were used to assess the relationship between *** order to calculate mutual information,the correlation between the 12 ECG leads has been *** output of this step is a matrix containing all mutual ***,to calculate the structural information of ECG signals,a capsule neural network was implemented to aid physicians in the automatic classification of cardiac *** architecture of this capsule neural network has been modified to perform the classification *** the experimental results section,the proposed model was used to classify arrhythmias in ECG signals from the Chapman *** evaluations showed that this model has a precision of 97.02%,recall of 96.13%,F1-score of 96.57%and accuracy of 97.38%,indicating acceptable performance compared to other state-of-the-art *** proposed method shows an average accuracy of 2%superiority over similar works.
The multi-modal object detection technology based on visible-thermal vision sensors has drawn significant attention as it is capable of achieving reliable object detection in complex scenes with challenging lighting c...
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Iris biometrics allow contactless authentication, which makes it widely deployed human recognition mechanisms since the couple of years. Susceptibility of iris identification systems remains a challenging task due to ...
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For differentiating and customizing different classes of traffic and virtualizing physical resources of networks and machines, B5G/5G specifies several novel mechanisms, including VNF, SDN, Service Function Chaining, ...
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