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arXiv 2025年

作者： Luo, Gongning Xu, Mingwang Chen, Hongyu Liang, Xinjie Tao, Xing Ni, Dong Jeong, Hyunsu Kim, Chulhong Stock, Raphael Baumgartner, Michael Kirchhoff, Yannick Rokuss, Maximilian Maier-Hein, Klaus Yang, Zhikai Fan, Tianyu Boutry, Nicolas Tereshchenko, Dmitry Moine, Arthur Charmetant, Maximilien Sauer, Jan Du, Hao Bai, Xiang-Hui Raikar, Vipul Pai Montoya-Del-Angel, Ricardo Martí, Robert Luna, Miguel Lee, Dongmin Qayyum, Abdul Mazher, Moona Guo, Qihui Wang, Changyan Awasthi, Navchetan Zhao, Qiaochu Wang, Wei Wang, Kuanquan Wang, Qiucheng Dong, Suyu School of Computer Science and Technology Harbin Institute of Technology Harbin150001 China Department of Mathematics Faculty of Science National University of Singapore Singapore National-Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering Shenzhen University Medical School Shenzhen University Shenzhen China Laboratory Shenzhen University Shenzhen China School of Biomedical Engineering and Informatics Nanjing Medical University Nanjing China Pohang Korea Republic of Heidelberg Division of Medical Image Computing Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Germany Heidelberg Germany HIDSS4Health - Helmholtz Information and Data Science School for Health Karlsruhe Heidelberg Germany Pattern Analysis and Learning Group Department of Radiation Oncology Heidelberg University Hospital Germany Department of Biomedical Engineering and Health KTH Royal Institute of Technology Stockholm Sweden France FathomX Singapore Saw Swee Hock School of Public Health National University of Singapore Singapore Philips Research University of Girona Spain Department of Robotics and Mechatronics Engineering DGIST Korea Republic of Department of Interdisciplinary Studies of Artificial Intelligence DGIST Korea Republic of National Heart and Lung Institute Faculty of Medicine Imperial College London London United Kingdom Centre for Medical Image Computing Department of Computer Science University College London London United Kingdom Lab School of Communication and Information Engineering Shanghai University Shanghai China Faculty of Science Mathematics and Computer Science Informatics Institute University of Amsterdam Amsterdam1090 GH Netherlands Department of Biomedical Engineering and Physics Amsterdam UMC Amsterdam1081 HV Netherlands Xi’an Jiaotong-Liverpool University China Department of Ultrasound Harbin Medical University Cancer Hospital No. 150 Haping Road Nangang

Breast cancer is one of the most common causes of death among women worldwide. Early detection helps in reducing the number of deaths. Automated 3D Breast Ultrasound (ABUS) is a newer approach for breast screening, which has many advantages over handheld mammography such as safety, speed, and higher detection rate of breast cancer. Tumor detection, segmentation, and classification are key components in the analysis of medical images, especially challenging in the context of 3D ABUS due to the significant variability in tumor size and shape, unclear tumor boundaries, and a low signal-to-noise ratio. The lack of publicly accessible, well-labeled ABUS datasets further hinders the advancement of systems for breast tumor analysis. Addressing this gap, we have organized the inaugural Tumor Detection, Segmentation, and Classification Challenge on Automated 3D Breast Ultrasound 2023 (TDSC-ABUS2023). This initiative aims to spearhead research in this field and create a definitive benchmark for tasks associated with 3D ABUS image analysis. In this paper, we summarize the top-performing algorithms from the challenge and provide critical analysis for ABUS image examination. We offer the TDSC-ABUS challenge as an open-access platform at https://***/ to benchmark and inspire future developments in1algorithmic research. © 2025, CC BY.

关键词： Image segmentation

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Study of Helicopter Optimal Autorotation Landing Procedure in Tail Rotor Drive Failure

Study of Helicopter Optimal Autorotation Landing Procedure i...

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IEEE International Conference on robotics and Biomimetics

作者： Xufei Yan Renliang Chen Shiqiang Zhu Anhuan Xie Jason Gu Research Center for Intelligent Robotics Zhejiang Lab Hangzhou China Zhejiang Engineering Research Center for Intelligent Robotics Hangzhou China National Key Laboratory of Science and Technology on Rotorcraft Aeromechanics College of Aeronautics Nanjing University of Aeronautics and Astronautics Nanjing Jiangsu China Intelligent Robot Research Center Zhejiang Lab Hangzhou Zhejiang China Department of Electrical and Computer Engineering Dalhousie University Halifax NS Canada

ISBN: (纸本)9781665481106

This paper investigates the optimal landing trajectory and control procedure when a helicopter undergoes autorotation due to tail rotor drive failure (TRDF), in which an optimal control methodology is proposed. First, a helicopter flight dynamics model with TRDF was developed. Then, the autorotation in TRDF was converted to be a nonlinear optimal control problem, solved by direct node collocation method and sequential quadratic programming algorithm. Finally, a model helicopter (Z11) with single main rotor and tail rotor was used to demonstrate the proposed approach. An optimal autorotation landing procedure in TRDF was determined accordingly. Results indicate that the airframe will immediately respond to the excess torque generated by the main rotor via yawing, sideslip and rolling when TRDF occurs. The pilot is recommended to shut down the engine and perform a series of critical operations to stabilize the violent yaw and roll movements. In addition, flight test data were used to validate the numerical simulations of autorotation landing. The proposed optimal control approach provides a useful tool to investigate helicopter TRDF autorotation landing procedure.

关键词： Torque Biological system modeling Helicopters Rotors Optimal control Tail Numerical simulation

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Few-shot learning based histopathological image classification of colorectal cancer

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Intelligent Medicine 2024年第4期4卷 256-267页

作者： Rui Li Xiaoyan Li Hongzan Sun Jinzhu Yang Md Rahaman Marcin Grzegozek Tao Jiang Xinyu Huang Chen Li Key Laboratory of Intelligent Computing in Medical Image Ministry of EducationNortheastern UniversityShenyangLiaoning 110167China Cancer Hospital China Medical UniversityShenyangLiaoning 110122China Shengjing Hospital China Medical UniversityShenyang.Liaoning 110000China Institute for Medical Informatics University of LuebeckGermany Department of Knowledge Engineering University of Economics in KatowicePoland School of Intelligent Medicine Chengdu University of Traditional Chinese MedicineChengduSichuan 610075China International Joint Institute of Robotics and Intelligent Systems Chengdu University of Information TechnologyChengduSichuan 610225China School of Computer Science and Engineering University of New South WalesSydneyNSW 2052Australia

Background Colorectal cancer is a prevalent and deadly disease worldwide,posing significant diagnostic *** histopathologic image classification is often inefficient and *** some histopathologists use computer-aided diagnosis to improve efficiency,these methods depend heavily on exten-sive data and specific annotations,limiting their *** address these challenges,this paper proposes a method based on few-shot *** This study introduced a few-shot learning approach that combines transfer learning and contrastive learning to classify colorectal cancer histopathology images into benign and malignant *** model comprises modules for feature extraction,dimensionality reduction,and classification,trained using a combi-nation of contrast loss and cross-entropy *** this paper,we detailed the setup of hyperparameters:n-way,κ-shot,β,and the creation of support,query,and test *** Our method achieved over 98% accuracy on a query dataset with 35 samples per category using only 10 training samples per *** documented the model’s loss,accuracy,and the confusion matrix of the ***,we employed the t-SNE algorithm to analyze and assess the model’s classification *** The proposed model may demonstrate significant advantages in accuracy and minimal data depen-dency,performing robustly across all tested n-way,κ-shot *** consistently achieved over 93% accuracy on comprehensive test datasets,including 1916 samples,confirming its high classification accuracy and strong generalization *** research could advance the use of few-shot learning in medical diagnostics and also lays the groundwork for extending it to deal with rare,difficult-to-diagnose cases.

关键词： Colorectal cancer Few-shot learning Transfer learning Contrastive learning Histopathological images Benign and malignant categories

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A universal bioluminescence tomography system for pre-clinical image-guided radiotherapy research

arXiv

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arXiv 2024年

作者： Tong, Zhishen Deng, Zijian Xu, Xiangkun Newman, Ciara Jia, Xun Zhong, Yuncheng Reinhart, Merle Tsouchlos, Paul Devling, Tim Dehghani, Hamid Iordachita, Iulian Saha, Debabrata Wong, John W. Wang, Ken Kang-Hsin Department of Radiation Oncology University of Texas Southwestern Medical Center DallasTX United States Department of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University BaltimoreMD United States Xstrahl Inc. SuwaneeGA United States School of Computer Science University of Birmingham BirminghamB15 2TT United Kingdom Laboratory for Computational Sensing and Robotics Johns Hopkins University BaltimoreMD United States Department of Radiation Oncology University of Texas Southwestern Medical Center DallasTX United States

CBCT-guided small animal irradiators encounter challenges in localizing soft-tissue targets due to low imaging contrast. Bioluminescence tomography (BLT) offers a promising solution, but they have largely remained in laboratorial development, limiting accessibility for researchers. In this work, we develop a universal, commercial-graded BLT-guided system (MuriGlo) designed to seamlessly integrate with commercial irradiators and empower researchers for translational studies. We demonstrate its capabilities in supporting in vitro and in vivo studies. The MuriGlo comprises detachable mouse bed, thermostatic control, mirrors, filters, and CCD, enabling multi-projection and multi-spectral imaging. We evaluate that the thermostatic control effectively sustains animal temperature at 37°C throughout imaging, and quantify that the system can detect as few as 61 GL261-AkaLuc cells in vitro. To illustrate how the MuriGlo can be utilized for in vivo image-guided research, we present 3 strategies, BLT-guided 5-arc, 2-field box, and BLI-guided single-beam, ranging from complicated high-conformal to simplest high-throughput plans. The high conformal BLT-guided 5-arc plan fully covers the gross tumor volume (GTV) at prescribed dose with minimal normal tissue exposure (3.9%), while the simplified, high-throughput BLT-guided 2-field box achieves 100% GTV coverage but results in higher normal tissue exposure (13.1%). Moreover, we demonstrate that the localization accuracy of MuriGlo for both widely-used SARRP and SmART irradiators is within1 mm, and the tumor coverage reaches over 97% with 0.75mm margin. The universal BLT-guided system offers seamless integration with commercial irradiators, achieving comparable localization accuracy, expected to supporting high-precision radiation research. Copyright © 2024, The Authors. All rights reserved.

关键词： Animals

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Multi-stage image denoising with the wavelet transform

arXiv

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arXiv 2022年

作者： Tian, Chunwei Zheng, Menghua Zuo, Wangmeng Zhang, Bob Zhang, Yanning Zhang, David School of Software Northwestern Polytechnical University Shaanxi Xi’an710129 China National Engineering Laboratory for Integrated Aero-Space-Ground-Ocean Big Data Application Technology Shaanxi Xi’an710129 China School of Computer Science and Technology Harbin Institute of Technology Heilongjiang Harbin150001 China Peng Cheng Laboratory Guangdong Shenzhen518055 China Department of Computer and Information Science University of Macau 999078 China School of Computer Science Northwestern Polytechnical University Shaanxi Xi’an710129 China Guangdong Shenzhen518172 China Shenzhen Institute of Artificial Intelligence and Robotics for Society Shenzhen China

Deep convolutional neural networks (CNNs) are used for image denoising via automatically mining accurate structure information. However, most of existing CNNs depend on enlarging depth of designed networks to obtain better denoising performance, which may cause training difficulty. In this paper, we propose a multi-stage image denoising CNN with the wavelet transform (MWDCNN) via three stages, i.e., a dynamic convolutional block (DCB), two cascaded wavelet transform and enhancement blocks (WEBs) and a residual block (RB). DCB uses a dynamic convolution to dynamically adjust parameters of several convolutions for making a tradeoff between denoising performance and computational costs. WEB uses a combination of signal processing technique (i.e., wavelet transformation) and discriminative learning to suppress noise for recovering more detailed information in image denoising. To further remove redundant features, RB is used to refine obtained features for improving denoising effects and reconstruct clean images via improved residual dense architectures. Experimental results show that the proposed MWDCNN outperforms some popular denoising methods in terms of quantitative and qualitative analysis. Codes are available at https://***/hellloxiaotian/MWDCNN. © 2022, CC BY-NC-ND.

关键词： Wavelet transforms

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A Lightweight Flexible Semi-Cylindrical Valve for Seamless Integration in Soft Robots Based on the Giant Electrorheological Fluid

SSRN

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SSRN 2022年

作者： Huang, Tiantian Xu, Denan Zhang, Hang Bai, Ou Aravelli, Aparna Zhou, Xiaoxiao Han, Bin School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan430070 China Human Cyber-Physical Systems Laboratory The Department of Electrical and Computer Engineering Florida International University Florida33174 United States Applied Research Center Florida International University Florida33174 United States Guangdong Intelligent Robotics Institute Dongguan523808 China

Complete compliance of soft robots is a trending research topic. One significant aspect is the control element. In the current work, a flexible electro-rheological (ER) valve development is chosen due to the advantage of its dynamic power density, convenient electronic control mode and no mechanical moving parts. These properties enable the ER valve to be miniaturized and easily integrated into a fluid-driven soft robot. However, the integration effect of the existing flexible ER valve configuration in soft robots is not ideal. In this study, a novel concentric semi-cylindrical flexible giant ER (GER) valve with a dual flowing direction is proposed for a soft robot to enable a larger deformation bending motion with multiple motion modes. The resulting valve has an overall volume of 50 mm 3 , a mass of 0.88 g, and a maximum controlling pressure of 84 kPa with a pressure change rate of 13.9, which is suitable for most soft robot applications. The pressure difference calculation method for the concentric semi-cylindrical GER valve is discussed. The effects of size, voltages, and flow rates on the valve’s static and dynamic performances, as well as the characteristics of the two pressure regulation modes, are investigated through simulations and experiments. The seamless integration and flexibility of the proposed valve are demonstrated by controlling a typical network actuator with six motion modes. Finally, a soft robot composed of two actuators is fabricated and realized the grasping of multiple everyday objects using different motion modes. © 2022, The Authors. All rights reserved.

关键词： Nanofluidics

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Opportunities and challenges for monitoring terrestrial biodiversity in the robotics age

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Nature Ecology and Evolution 2025年第6期9卷 1031-1042页

作者： Pringle, Stephen Dallimer, Martin Goddard, Mark A. Le Goff, Léni K. Hart, Emma Langdale, Simon J. Fisher, Jessica C. Abad, Sara-Adela Ancrenaz, Marc Angeoletto, Fabio Auat Cheein, Fernando Austen, Gail E. Bailey, Joseph J. Baldock, Katherine C. R. Banin, Lindsay F. Banks-Leite, Cristina Barau, Aliyu S. Bashyal, Reshu Bates, Adam J. Bicknell, Jake E. Bielby, Jon Bosilj, Petra Bush, Emma R. Butler, Simon J. Carpenter, Dan Clements, Christopher F. Cully, Antoine Davies, Kendi F. Deere, Nicolas J. Dodd, Michael Drinkwater, Rosie Driscoll, Don A. Dutilleux, Guillaume Dyrmann, Mads Edwards, David P. Farhadinia, Mohammad S. Faruk, Aisyah Field, Richard Fletcher, Robert J. Foster, Chris W. Fox, Richard Francksen, Richard M. Franco, Aldina M. A. Gainsbury, Alison M. Gardner, Charlie J. Giorgi, Ioanna Griffiths, Richard A. Hamaza, Salua Hanheide, Marc Hayward, Matt W. Hedblom, Marcus Helgason, Thorunn Heon, Sui P. Hughes, Kevin A. Hunt, Edmund R. Ingram, Daniel J. Jackson-Mills, George Jowett, Kelly Keitt, Timothy H. Kloepper, Laura N. Kramer-Schadt, Stephanie Labisko, Jim Labrosse, Frédéric Lawson, Jenna Lecomte, Nicolas de Lima, Ricardo F. Littlewood, Nick A. Marshall, Harry H. Masala, Giovanni L. Maskell, Lindsay C. Matechou, Eleni Mazzolai, Barbara McConnell, Alistair Melbourne, Brett A. Miriyev, Aslan Nana, Eric Djomo Ossola, Alessandro Papworth, Sarah Parr, Catherine L. Payo-Payo, Ana Perry, Gad Pettorelli, Nathalie Pillay, Rajeev Potts, Simon G. Prendergast-Miller, Miranda T. Qie, Lan Rolley-Parnell, Persie Rossiter, Stephen J. Rowcliffe, Marcus Rumble, Heather Sadler, Jon P. Sandom, Christopher J. Sanyal, Asiem Schrodt, Franziska Sethi, Sarab S. Shabrani, Adi Siddall, Robert Smith, Simón C. Snep, Robbert P. H. Soulsbury, Carl D. Stanley, Margaret C. Stephens, Philip A. Stephenson, P.J. Struebig, Matthew J. Studley, Matthew Svátek, Martin Tang, Gilbert Taylor, Nicholas K. Umbers, Kate D. L. Ward, Robert J. White, Patrick J. C. Whittingham, Mark J. Wich, Serge Williams, Christopher D. Yakubu, Ibrahim B. Yoh, Natalie Durrell Institute of Conservation and Ecology (DICE) School of Natural Sciences University of Kent Canterbury United Kingdom Centre for Environmental Policy Imperial College London London United Kingdom Department of Geography and Environmental Sciences Northumbria University Newcastle upon Tyne United Kingdom School of Computing Engineering and the Built Environment Edinburgh Napier University Edinburgh United Kingdom Synthotech Ltd Milner Court Hornbeam Square Harrogate United Kingdom Mechanical Engineering Department University College London London United Kingdom HUTAN SWD Kota Kinabalu Malaysia Programa de Pós-Graduação em Gestão e Tecnologia Ambiental da Universidade Federal de Rondonópolis Rondonópolis Brazil Department of Engineering Harper Adams University Newport United Kingdom Applied Ecology Research Group School of Life Sciences Anglia Ruskin University Cambridge United Kingdom Centre for Ecology and Hydrology Penicuik United Kingdom Department of Life Sciences Imperial College London Silwood Park Campus Ascot United Kingdom Department of Urban and Regional Planning Faculty of Earth and Environmental Sciences Bayero University Kano Nigeria Greenhood Nepal Kathmandu Nepal Animal Rural & Environmental Sciences Nottingham Trent University Nottinghamshire United Kingdom School of Biological and Environmental Sciences Liverpool John Moores University Liverpool United Kingdom Lincoln Centre for Autonomous Systems University of Lincoln Lincoln United Kingdom Royal Botanic Garden Edinburgh Edinburgh United Kingdom School of Biological Sciences University of East Anglia Norwich Research Park Norwich United Kingdom Digital Ecology Limited Bristol United Kingdom School of Biological Sciences University of Bristol Bristol United Kingdom Department of Computing Imperial College London London United Kingdom Department of Ecology and Evolutionary Biology University of Colorado Boulder CO United States Faculty of Science Technology Engineering

With biodiversity loss escalating globally, a step change is needed in our capacity to accurately monitor species populations across ecosystems. Robotic and autonomous systems (RAS) offer technological solutions that may substantially advance terrestrial biodiversity monitoring, but this potential is yet to be considered systematically. We used a modified Delphi technique to synthesize knowledge from 98 biodiversity experts and 31 RAS experts, who identified the major methodological barriers that currently hinder monitoring, and explored the opportunities and challenges that RAS offer in overcoming these barriers. Biodiversity experts identified four barrier categories: site access, species and individual identification, data handling and storage, and power and network availability. robotics experts highlighted technologies that could overcome these barriers and identified the developments needed to facilitate RAS-based autonomous biodiversity monitoring. Some existing RAS could be optimized relatively easily to survey species but would require development to be suitable for monitoring of more ‘difficult’ taxa and robust enough to work under uncontrolled conditions within ecosystems. Other nascent technologies (for instance, new sensors and biodegradable robots) need accelerated research. Overall, it was felt that RAS could lead to major progress in monitoring of terrestrial biodiversity by supplementing rather than supplanting existing methods. Transdisciplinarity needs to be fostered between biodiversity and RAS experts so that future ideas and technologies can be codeveloped effectively. © The Author(s) 2025.

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Unsupervised Multilayer Fuzzy Neural Networks for Image Clustering

SSRN

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SSRN 2022年

作者： Wang, Yifan Ishibuchi, Hisao Er, Meng Joo Zhu, Jihua School of Software Engineering Xi’an Jiaotong University Xi’an710049 China Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen518055 China Guangdong Provincial Key Laboratory of Brain-inspired Intelligent Computation China College of Marine Electrical Engineering Dalian Maritime University Dalian116026 China Institute of Artificial Intelligence Marine Robotics China

Nowadays, labeling a huge number of images is still a very challenging task. To tackle the problem of unlabeled data, unsupervised learning has been proposed. Among many unsupervised learning algorithms, K-means is the most popular algorithm. However, in a low-dimensional space, fuzzy c-means, which is more robust and less sensitive to initialization, has several advantages over K-means clustering. On the other hand, stacked convolutional pooling structures and manifold representation play pivotal roles in image clustering. In this paper, we proposed an unsupervised multilayer fuzzy neural network for image clustering, which unifies fuzzy systems, multilayer convolutional structures and manifold representation. The main contributions of this work are: First, we extend fuzzy systems to unsupervised tasks by introducing the manifold representation. Next, we proposed the idea of using only a small number of attributes with the largest variances to compute firing strengths. This is to prevent the firing strengths from falling to zero in clustering high-dimensional data. Then, randomly generated convolutional weights are used to extract features, which is a good choice for data without labels. It is demonstrated on a wide range of image datasets that the proposed approach is superior to existing fuzzy and non-fuzzy clustering algorithms. © 2022, The Authors. All rights reserved.

关键词： Fuzzy neural networks

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Improving Referring Expression Comprehension by Suppressing Expression-unrelated Proposals

Improving Referring Expression Comprehension by Suppressing ...

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Electronic Information Engineering and computer Technology (EIECT), International Conference on

作者： Qun Wang Feng Zhu Xiang Li Ruida Ye Key Laboratory of Opto-Electronic Information Processing Chinese Academy of Sciences Shenyang China Shenyang Institute of Automation Chinese Academy of Sciences Shenyang China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang China University of Chinese Academy of Sciences Beijing China Faculty of Computer Science and Engineering Northeastern University Shenyang China Department of Aerospace Engineering and Technology Space Engineering University Beijing China

The prevailing referring expression comprehension (REC) method is based on two stages: 1) detecting multiple candidate proposals using an object detector and 2) aligning proposals with text descriptions. Existing two-stage models have achieved significant improvements with excellent alignment modules. However, their alignment modules treat each proposal equally without filtering expression-unrelated proposals. These expression-unrelated proposals may interfere with the alignment modules’ ability to accurately reason about the target proposal. These proposals also increase the difficulty of training alignment modules. To solve this problem, we propose a new framework, that can suppress expression-unrelated proposals for alignment modules. Specifically, we first design a suppression module, which calculates the relevance scores between the proposals and the expression by using the semantics in the expression. Then, these scores are integrated into three basic alignment modules, including subject, location, and relationship modules, to guide each module to focus on the expression-related proposals. We conduct extensive experiments on three benchmark datasets, and the results show the effectiveness of our suppression module and performance improvement.

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Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

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npj Flexible Electronics 2023年第1期7卷 119-130页

作者： Kiho Kim In Sik Min Tae Hee Kim Do Hyeon Kim Seungwon Hwang Kyowon Kang Kyubeen Kim Sangun Park Jongmin Lee Young Uk Cho Jung Woo Lee Woon-Hong Yeo Young Min Song Youngmee Jung Ki Jun Yu Functional Bio-integrated Electronics and Energy Management Lab School of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and Collaboration Biomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and Computer Science(EECS) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1 Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D Center DNA Lab PharmaresearchSeongnam 13486Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 136-705Republic of Korea School of Materials Science and Engineering Energy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

关键词： optoelectronic enable battery

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