Gene regulation is controlled by transcription factor proteins which themselves are encoded as genes. This gives a network of interacting genes which control the functioning of a cell. With the advent of genome wide e...
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Gene regulation is controlled by transcription factor proteins which themselves are encoded as genes. This gives a network of interacting genes which control the functioning of a cell. With the advent of genome wide expression measurements the targets of given transcription factor have been sought through techniques such as clustering. In this paper we consider the harder problem of finding a gene's regulator instead of its targets. We use a model-based differential equation approach combined with a Gaussian process prior distribution for unobserved continuous-time regulator expression profile. Candidate regulators can then be ranked according to model likelihood. This idea, that we refer to as ranked regulator prediction (RRP), is then applied to finding the regulators of Gata3, an important developmental transcription factor, in the development of ear hair cells.
This paper presents a decision support tool for the effectiveness of a Quality Management System (QMS) in a company. To develop this tool, a new approach PAHP based on the combination of the Pareto Optimality Concept ...
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Asynchronous system design in recent years has reemerged as an important vehicle in the field of high performance, low power and secure computing. On the other hand Binary Decision Diagrams (BDDs) have found significa...
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ISBN:
(纸本)9781424473212
Asynchronous system design in recent years has reemerged as an important vehicle in the field of high performance, low power and secure computing. On the other hand Binary Decision Diagrams (BDDs) have found significant applications for many years in the design, synthesis, verification, and testing of VLSI circuits. In this paper we have presented the design of a hybrid Domino PTL-CMOS based 2-bit asynchronous adder, the PTL part of which is designed using the principles of BDD. The designed asynchronous adder has been implemented for 32-bit and the simulation results indicate a reduction of 16% in number of transistors, 8% in power and 21% in power-delay-area-product over earlier reported results without any compromise in the delay. The implementation has been done using UMC 180nm, 1.5V technology.
This article presents a technique for online fault detection under single missing-gate fault (SMGF) model in the reversible circuits. It is shown that in an (n × n) reversible circuit implemented with k-CNOT gate...
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Automatic identification of an individual based on his/her handwriting characteristics is an important forensic tool. In a computational forensic scenario, presence of huge amount of text/information in a questioned d...
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ISBN:
(纸本)9781424475421
Automatic identification of an individual based on his/her handwriting characteristics is an important forensic tool. In a computational forensic scenario, presence of huge amount of text/information in a questioned document cannot be always ensured. Also, compromising in terms of systems reliability under such situation is not desirable. We here propose a system to encounter such adverse situation in the context of Bengali script. Experiments with discrete directional feature and gradient feature are reported here, along with Support Vector Machine (SVM) as classifier. We got promising results of 95.19% writer identification accuracy at first top choice and 99.03% when considering first three top choices.
All Han-based scripts (Chinese, Japanese, and Korean) possess similar visual characteristics. Hence system development for identification of Chinese, Japanese and Korean scripts from a single document page is quite ch...
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All Han-based scripts (Chinese, Japanese, and Korean) possess similar visual characteristics. Hence system development for identification of Chinese, Japanese and Korean scripts from a single document page is quite challenging. It is noted that a Han-based document page might also have Roman script in them. A multi-script OCR system dealing with Chinese, Japanese, Korean, and Roman scripts, demands identification of scripts before execution of respective OCR modules. We propose a system to address this problem using directional features along with a Gaussian Kernel-based Support Vector Machine. We got promising results of 98.39% script identification accuracy at character level and 99.85% at block level, when no rejection was considered.
M-FISH (Multiplex Fluorescent In Situ Hybridization) is a multichannel chromosome imaging technique that allows the color discrimination of human chromosomes. Although M-FISH facilitates the visual detection of chromo...
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M-FISH (Multiplex Fluorescent In Situ Hybridization) is a multichannel chromosome imaging technique that allows the color discrimination of human chromosomes. Although M-FISH facilitates the visual detection of chromosome rearrangements, the success of this technique largely depends on the accuracy of the pixel-by-pixel classification. In this study, we present a semi unsupervised method for M-FISH chromosome image classification. First, we segment the chromosome pixels using an automated thresholding procedure. Five features for each pixel are extracted, describing the intensity of the five channels. These features are then normalized. Second, we employed the K-means algorithm in order to cluster the chromosome pixels into the 24 chromosome classes. We have used the emission information for each chromosome class in order to initialize the cluster centers. Our method has been tested on the ADIR M-FISH database and an overall accuracy of 72.48% is achieved. This methods that use training set to build the classifiers, while our method does not use a training set.
For creating virtual enterprise (VE), which is in general the collaborative partnership between business partners in value chains, the business processes (services) of the resulting organization need to be composed of...
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ISBN:
(纸本)1891706268
For creating virtual enterprise (VE), which is in general the collaborative partnership between business partners in value chains, the business processes (services) of the resulting organization need to be composed of the individual business processes of the participating organizations. This can be realized by means of Service Oriented Architecture (SOA). In our paper we propose a SOA Framework based on Knowledge Bases.
To control particles flying inside the limited search space and deal with the problem of slow search speed and premature convergence, this paper applies the theory of topology, and proposes a novel quotient space-base...
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To control particles flying inside the limited search space and deal with the problem of slow search speed and premature convergence, this paper applies the theory of topology, and proposes a novel quotient space-based boundary condition by using the properties of quotient space and homeomorphism. In this new method, named QsaBC, Search space-zoomed factor and Attractor are introduced to enhance the performance of PSO according to analyzing the dynamic behavior and stability of particles. QsaBC proposed in this paper not only reduces the subjective interference and enforces the capability of global search, but also enhance the power of local search and escaping from an inferior local optimum. Four CEC'2008 benchmark functions are selected to evaluate the performance of QsaBC. Comparative experiments show that QsaBC is more effective to do with the boundary condition, furthermore, can get the satisfactory solution with fast convergence speed, easy calculation and good robustness than other experienced methods.
Service-Oriented Architecture (SOA) provides a flexible architecture for service composition. Service composition can be integrated by atomic Web services developed independently by their providers. With increasing nu...
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Service-Oriented Architecture (SOA) provides a flexible architecture for service composition. Service composition can be integrated by atomic Web services developed independently by their providers. With increasing number of alternative services that implement similar functionality but provide different non-functional (QoS) characteristics, service composition becomes a service selection problem. This paper proposes an efficient service selection approach to facilitate the selection of QoS-based services. The objective of this approach is to obtain a feasible solution with less time. Moreover our approach supports different aggregation structures. The results of experimental evaluation show that our approach can achieve a near-optimal solution very efficiently.
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