Accurate prediction of peptide spectra is crucial for improving the efficiency and reliability of proteomic analysis,as well as for gaining insight into various biological *** this study,we introduce Deep MS Simulator...
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Accurate prediction of peptide spectra is crucial for improving the efficiency and reliability of proteomic analysis,as well as for gaining insight into various biological *** this study,we introduce Deep MS Simulator(DMSS),a novel attention-based model tailored for forecasting theoretical spectra in mass *** has undergone rigorous validation through a series of experiments,consistently demonstrating superior performance compared to current methods in forecasting theoretical *** superior ability of DMSS to distinguish extremely similar peptides highlights the potential application of incorporating our predicted intensity information into mass spectrometry search engines to enhance the accuracy of protein *** findings contribute to the advancement of proteomics analysis and highlight the potential of the DMSS as a valuable tool in the field.
Association in-between features has been demonstrated to improve the representation ability of data. However, the original association data reconstruction method may face two issues: the dimension of reconstructed dat...
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Association in-between features has been demonstrated to improve the representation ability of data. However, the original association data reconstruction method may face two issues: the dimension of reconstructed data is undoubtedly higher than that of original data, and adopted association measure method does not well balance effectiveness and efficiency. To address above two issues, this paper proposes a novel association-based representation improvement method, named as AssoRep. AssoRep first obtains the association between features via distance correlation method that has some advantages than Pearson’s correlation coefficient. Then an improved matrix is formed via stacking the association value of any two features. Next, an improved feature representation is obtained by aggregating the original feature with the enhancement matrix. Finally, the improved feature representation is mapped to a low-dimensional space via principal component analysis. The effectiveness of AssoRep is validated on 120 datasets and the fruits further prefect our previous work on the association data reconstruction.
Gridlet allocation in a computational grid environment is a major research issue to obtain not only the efficient gridlet allocation technique but also the time needed to obtain the efficient allocation technique. Gri...
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In this fast-paced Digital Age, Natural Language Processing (NLP) can prove beneficial in consuming quality information efficiently. With the ever-growing number of learning resources, it is becoming onerous for stude...
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The integration of machine learning and electrocatalysis presents nota ble advancements in designing and predicting the performance of chiral materials for hydrogen evolution reactions(HER).This study utilizes theoret...
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The integration of machine learning and electrocatalysis presents nota ble advancements in designing and predicting the performance of chiral materials for hydrogen evolution reactions(HER).This study utilizes theoretical calculations and machine learning techniques to assess the HER performance of both chiral and achiral M-N-SWCNTs(M=In,Bi,and Sb)single-atom catalysts(SACs).The stability preferences of metal atoms are dependent on chirality when interacting with chiral *** HER activity of the right-handed In-N-SWCNT is 5.71 times greater than its achiral counterpart,whereas the left-handed In-N-SWCNT exhibits a 5.12-fold *** calculated hydrogen adsorption free energy for the right-handed In-N-SWCNT reaches as low as-0.02 *** enhancement is attributed to the symmetry breaking in spin density distribution,transitioning from C_(2V)in achiral SACs to C_(2)in chiral SACs,which facilitates active site transfer and enhances local spin ***-handed M-N-SWCNTs exhibit superiorα-electron separation and transport efficiency relative to left-handed variants,owing to the chiral induced spin selectivity(CISS)effect,with spin-upα-electron density reaching 3.43×10^(-3)e/Bohr^(3)at active *** learning provides deeper insights,revealing that the interplay of weak spatial electronic effects and appropriate curvature-chirality effects significantly enhances HER performance.A weaker spatial electronic effect correlates with higher HER activity,larger exchange current density,and higher turnover *** curvature-chirality effect undersco res the influence of intrinsic structures on HER *** findings offer critical insights into the role of chirality in electrocatalysis and propose innovative approaches for optimizing HER through chirality.
According to WHO reports, cancer is the leading cause of death worldwide. The second most prevalent cause of cancer-related death in both men and women is colorectal cancer (CRC). One potential approach for reducing t...
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Software-defined networking (SDN) offers enhanced control over network infrastructure through a central controller, but it remains vulnerable to security threats like DDoS attacks. This paper proposes an automatic att...
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Inspired by basic circuit connection methods,memristors can also be utilized in the construction of complex discrete chaotic *** investigate the dynamical effects of hybrid memristors,we propose two hybrid tri-memrist...
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Inspired by basic circuit connection methods,memristors can also be utilized in the construction of complex discrete chaotic *** investigate the dynamical effects of hybrid memristors,we propose two hybrid tri-memristor hyperchaotic(HTMH)mapping structures based on the hybrid parallel/cascade and cascade/parallel operations,*** the HTMH mapping structure with hybrid parallel/cascade operation as an example,this map possesses a spatial invariant set whose stability is closely related to the initial states of the *** distributions and bifurcation behaviours dependent on the control parameters are explored with numerical ***,the memristor initial offset-boosting mechanism is theoretically demonstrated,and memristor initial offset-boosting behaviours are numerically *** results clarify that the HTMH map can exhibit hyperchaotic behaviours and extreme multistability with homogeneous coexisting infinite *** addition,an FPGA hardware platform is fabricated to implement the HTMH map and generate pseudorandom numbers(PRNs)with high ***,the generated PRNs can be applied in Wasserstein generative adversarial nets(WGANs)to enhance training stability and generation capability.
The paper presents advancements in healthcare data capture through the application of image-based extraction techniques, which include sophisticated image processing techniques such as resizing and adaptive thresholdi...
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The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have be...
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The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-KDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.
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