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Material informatics-driven insights into brain cancer nanocarriers: A bibliometric comparison of PLGA vs. liposomes

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OpenNano 2025年 21卷

作者： Makalew, Brilly Andro Abrori, Syauqi Abdurrahman Computer Science Department School of Computer Science Bina Nusantara University Jakarta 11480 Indonesia Automotive & Robotics Program Computer Engineering Department BINUS ASO School of Engineering Bina Nusantara University Jakarta 11480 Indonesia

This study explores a comparative analysis of PLGA nanoparticles and liposomes as potential carriers for brain cancer drug delivery, with a special focus on how material informatics enhances their design, biocompatibility, and drug release profiles to improve treatment efficacy and contribute to sustainable health outcomes. The investigation employed a bibliometric analysis using Scopus and VOSviewer to uncover the role of material informatics in optimizing these nanocarriers. The analysis revealed that material informatics, particularly through the application of machine learning and molecular dynamics simulations, significantly optimizes the performance of both PLGA nanoparticles and liposomes. The results highlighted distinct strengths of each nanocarrier: PLGA nanoparticles excel in biodegradability, while liposomes offer superior drug encapsulation capabilities. However, material informatics techniques bridged these enhancing drug release kinetics, stability, and biocompatibility. These improvements are crucial for effective delivery across the blood-brain barrier, a major challenge in brain cancer treatment. The integration of computational modelling, machine learning, and high-throughput screening enabled by material informatics is shown to be a key factor in advancing the design and optimization of these nanocarriers. By leveraging these tools, researchers can develop more personalized and efficient drug delivery systems tailored to address the specific challenges of glioblastoma therapy, ultimately contributing to sustainable health outcomes © 2024 The Author(s)

关键词： Bibliometric analysis Brain cancer Drug delivery Liposomes Material informatics Nanocarriers PLGA nanoparticles VOSviewer

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Overlapped Error Correction Codes in Two-Dimensional Structures

Overlapped Error Correction Codes in Two-Dimensional Structu...

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IEEE Latin American Symposium on Circuits and Systems (LASCAS)

作者： Andrew Fritsch Wagner Savaris Adahil Muniz Giovanna Borba Rodrigo Girardi Jarbas Silveira César Marcon Graduate Program in Computer Science (PPGCC) Pontifical Catholic University of Rio Grande do Sul (PUCRS) Brazil Graduate Program in Teleinformatics Engineering (PPGETI) Federal University of Ceará (UFC) Brazil

ISBN: (数字)9798331522124

ISBN: (纸本)9798331522131

The continuous advancement of communication systems necessitates the development of algorithms capable of identifying and correcting errors that may arise during data transmission and storage. This pursuit of reliability is particularly crucial in critical systems and sectors that are challenging to access, such as space exploration, passenger transportation, and financial services. In this context, the Error Correction Code (ECC) is a fundamental tool for providing a certain degree of reliability to these systems. This research proposes a novel technique to enhance the error correction capacity of ECCs by leveraging region overlapping. Specifically, we propose correcting data areas protected by more than one ECC, which allows for the inference of logical correlations between ECCs, thereby augmenting their error detection and correction capability. Our focus is bidimensional codeword structures, commonly known as 2D-ECCs, which entail a hierarchical arrangement of ECCs. We evaluated the ECC proposal, comparing its error correction and detection capabilities. Through this evaluation, we aim to demonstrate the technique's efficacy in bolstering the reliability and resilience of communication systems, particularly in critical domains where precision and accuracy are paramount.

关键词： Fault tolerance Fault tolerant systems Transportation Error correction codes Error correction Space exploration Proposals Integrated circuit reliability Financial services Resilience

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Reward invigorates isometric gripping actions

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Journal of Neurophysiology 2025年第4期133卷 1282-1294页

作者： Marbaker, Rachel M. Schmad, Ryan C. Al-Ghamdi, Razan A. Sukumar, Shruthi Ahmed, Alaa A. Department of Mechanical Engineering University of Colorado Boulder Boulder CO United States Department of Electrical Engineering University of Colorado Boulder Boulder CO United States Department of Computer Science University of Colorado Boulder Boulder CO United States Biomedical Engineering Program University of Colorado Boulder Boulder CO United States

Individuals exhibit a propensity to move faster toward more rewarding stimuli. Although this phenomenon has been observed in movements, the effect of reward on implicit control of isometric actions, such as gripping or grasping, is relatively unknown. How reward-related invigoration generalizes to other effortful actions is an important question. Reward invigorates reaching movements and saccades, supporting the idea that reward pays the additional effort cost of moving faster. Effort in isometric force generation is less understood, so here we ask whether and how reward-related invigoration generalizes to isometric force gripping. And if so, what implicit characteristics of gripping change when there is a prospect of reward? Participants (n = 19) gripped a force transducer and the force applied was mapped to radial position of an onscreen cursor. Each trial, a target appeared in one of four locations;increasing grip force moved the cursor toward the target. The gripping action was interchangeable for all target positions. In each block of 100 trials, one target was consistently rewarded, whereas the other targets were not. When gripping to acquire the rewarded target, participants reacted faster, generated force more rapidly and to a greater extent, without increasing variance and without increasing the rising force-time integral. These findings support the generalization of reward-related invigoration in isometric force tasks, and that the brain exquisitely trades-off reward and effort costs to obtain reward more rapidly without increasing variance and without more effort costs than necessary. NEW & NOTEWORTHY Gripping actions are important for day-to-day tasks, for medical diagnostics like strength and force control, and for choice selection in decision-making experiments. Comparing isometric gripping responses to reward and nonreward cues, we observed reward-based invigoration mediated by selective increases in effort. These findings can be leveraged to provide

关键词： decision making effort grasping movement vigor speed-accuracy tradeoff

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Unlocking the potential of RNN and CNN models for accurate rehabilitation exercise classification on multi-datasets

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Multimedia Tools and Applications 2025年第3期84卷 1261-1301页

作者： Zaher, Moamen Ghoneim, Amr S. Abdelhamid, Laila Atia, Ayman Software Engineering Program Faculty of Computers & Artificial Intelligence—Helwan University Cairo Ain Helwan11795 Egypt Computer Science Department Faculty of Computers & Artificial Intelligence—Helwan University Cairo Ain Helwan11795 Egypt Information System Department Faculty of Computers & Artificial Intelligence—Helwan University Cairo Ain Helwan11795 Egypt Cairo Ain Helwan11795 Egypt Giza October12451 Egypt

Physical rehabilitation is crucial in healthcare, facilitating recovery from injuries or illnesses and improving overall health. However, a notable global challenge stems from the shortage of professional physiotherapists, particularly acute in some developing countries, where the ratio can be as low as one physiotherapist per 100,000 individuals. To address these challenges and elevate patient care, the field of physical rehabilitation is progressively integrating computer Vision and Human Activity Recognition (HAR) techniques. Numerous research efforts aim to explore methodologies that assist in rehabilitation exercises and evaluate patient movements, which is crucial as incorrect exercises can potentially worsen conditions. This study investigates applying various deep-learning models for classifying exercises using the benchmark KIMORE and UI-PRMD datasets. Employing Bi-LSTM, LSTM, CNN, and CNN-LSTM, alongside a Random Search for architectural design and Hyper-parameter tuning, our investigation reveals the (CNN) model as the top performer. After applying cross-validation, the technique achieves remarkable mean testing accuracy rates of 93.08% on the KIMORE dataset and 99.7% on the UI-PRMD dataset. This marks a slight improvement of 0.75% and 0.1%, respectively, compared to previous techniques. In addition, expanding beyond exercise classification, this study explores the KIMORE dataset’s utility for disease identification, where the (CNN) model consistently demonstrates an outstanding accuracy of 89.87%, indicating its promising role in both exercises and disease identification within the context of physical rehabilitation. © The Author(s) 2024.

关键词： Classification (of information)

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A Multi-UAV Charging Station Enabling Free Landing by Grid Pattern Transmitter

A Multi-UAV Charging Station Enabling Free Landing by Grid P...

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Annual IEEE Conference on Applied Power Electronics Conference and Exposition (APEC)

作者： Jungho Kim Hyunkyeong Jo Seoktae Seo Bonyoung Lee Hyungki Min Franklin Bien School of Electrical and Computer Engineering Ulsan National Institute of Science and Technology Ulsan Korea Program in Information & Communication Technology Convergence Ulsan National Institute of Science and Technology Ulsan Korea

ISBN: (数字)9798331516116

ISBN: (纸本)9798331516123

This paper proposed a novel landing platform with wireless power transfer (WPT) to charge multiple unmanned aerial vehicles (UAVs) without restrictions on landing locations or alignment. A transmitter is designed using wires to charge a wide area. To overcome the disadvantages of system made by wires, a grid pattern transmitter and double power line are proposed. These structures provide multiple charging with free positioning of receivers and excite the transmitter lines in wide area properly. The optimized system is composed of 0.15m square cells, providing a 0.9 m by 0.9 m charging area. By experiment, it can efficiently charge four 0.1 m square receivers located anywhere in transmitter. The overall efficiency of four receivers is 37.5%. Also, the experimental results verify that it is unnecessary to align the receiver within the cell, as it has a 2.62% error due to rotation and a 2.94 % error due to position within the cell.

关键词： Coils Magnetic flux leakage Transmitters Wires Windings Receivers Wireless power transfer Autonomous aerial vehicles Current distribution Power electronics

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The Robustness of Structural Features in Species Interaction Networks

arXiv

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arXiv 2025年

作者： Fard, Sanaz Hasanzadeh Dolson, Emily Department of Computer Science and Engineering Michigan State University United States Program in Ecology Evolution and Behavior Michigan State University United States

Species interaction networks are a powerful tool for describing ecological communities;they typically contain nodes representing species, and edges representing interactions between those species. For the purposes of drawing abstract inferences about groups of similar networks, ecologists often use graph topology metrics to summarize structural features. However, gathering the data that underlies these networks is challenging, which can lead to some interactions being missed. Thus, it is important to understand how much different structural metrics are affected by missing data. To address this question, we analyzed a database of 148 real-world bipartite networks representing four different types of species interactions (pollination, host-parasite, plant-ant, and seed-dispersal). For each network, we measured six different topological properties: number of connected components, variance in node betweenness, variance in node PageRank, largest Eigenvalue, the number of non-zero Eigenvalues, and community detection as determined by four different algorithms. We then tested how these properties change as additional edges – representing data that may have been missed – are added to the networks. We found substantial variation in how robust different properties were to the missing data. For example, the Clauset-Newman-Moore and Louvain community detection algorithms showed much more gradual change as edges were added than the label propagation and Girvan-Newman algorithms did, suggesting that the former are more robust. Robustness also varied for some metrics based on interaction type. These results provide a foundation for selecting network properties to use when analyzing messy ecological network data. © 2025, CC BY.

关键词： Anthropogenic

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Fiber optic SERS sensors for rapid detection and identification of Salmonella in turkey products 25

Fiber optic SERS sensors for rapid detection and identificat...

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Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV 2025

作者： Abuhelwa, Mai Chenggeer, Fnu Bandara, Adheesha Liu, Jiayu Willoughby, Paige Carlson, Anna Trout, Kate E. Morey, Amit Kinzel, Ed Mustapha, Azlin Almasri, Mahmoud Department of Electrical Engineering and Computer Science University of Missouri ColumbiaMO65211 United States Food Science Program University of Missouri ColumbiaMO65211 United States Cargill Inc WichitaKS67202 United States College of Health Sciences University of Missouri ColumbiaMO65211 United States Department of Poultry Science Auburn University AuburnAL36849 United States University of Notre Dame IN46556 United States

ISBN: (纸本)9781510683686

This study validates a fiber optics-based Surface Enhanced Raman Spectroscopy (SERS) sensor for detecting Salmonella in raw turkey samples. The sensor uses nanoantenna arrays on a side-polished optical fiber core with a fixed periodicity of 0.77 μm to maximize the SERS signal intensity. A 3D-printed chamber and microstructure optimize light reflection, improving sensitivity. The sensor detects Salmonella at 0.4-0.5 CFU/ml in 10 minutes, offering cost-effective, portable pathogen detection. © 2025 SPIE.

关键词： Multimode fibers

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Light extraction improvement via ITO p-electrodes for InGaN red micro-LEDs emitting at 640 nm

Optics Continuum

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Optics Continuum 2025年第5期4卷 1040-1050页

作者： Cesur Altinkaya Mohammed A Najmi Daisuke Iida Kazuhiro Ohkawa Material Science and Engineering Program Physical Sciences and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia cesur.altinkaya@kaust.edu.sa Electrical and Computer Engineering Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia daisuke.iida@kaust.edu.sa kazuhiro.ohkawa@kaust.edu.sa

We present light extraction efficiency (LEE) improvement for InGaN red micro-light emitting diodes (micro-LEDs) of various sizes operating at low current densities. We compared the characteristics of micro-LEDs with indium tin oxide (ITO) transparent p-electrodes with conventional opaque metal p-electrodes. 50 µm × 50 µm micro-LEDs with ITO p-electrodes achieved a peak on-wafer external quantum efficiency (EQE) of 2.54% with an emission wavelength of 640 nm at a current density as low as 0.4 A/cm 2 . This represents a 1.18-fold improvement in peak EQE compared to devices with metal p-electrodes. Light ray tracing simulation confirmed that the ITO p-electrodes exhibit 1.18 times higher light escape than metal-based micro-LEDs, validating the role of enhanced light extraction. These findings provide valuable insights for advancing high-definition display and VR applications.

关键词： Atomic layer deposition Indium tin oxide Light extraction Opacity Quantum efficiency Ray tracing

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Ontologies in Design: How Imagining a Tree Reveals Possibilities and Assumptions in Large Language Models 25

Ontologies in Design: How Imagining a Tree Reveals Possibili...

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Proceedings of the 2025 CHI Conference on Human Factors in Computing Systems

作者： Nava Haghighi Sunny Yu James A. Landay Daniela Rosner Computer Science Stanford University Stanford California USA Symbolic Systems Program Stanford University Stanford California USA Computer Science Department Stanford University Stanford California USA Human Centered Design & Engineering University of Washington Seattle Washington USA

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Development of Charge Integrator Circuits with a Microcontroller for Cylindrical Capacitive Sensors in Paddy Moisture Balance Detectors

Development of Charge Integrator Circuits with a Microcontro...

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International Electrical Engineering Congress (iEECON)

作者： Sudarat Tokampang Nattapong Apirattanon Noppadon Sisuk Anucha Kaewpoonsuk Deparment of Physics Faculty of Science Naresuan University Phitsanulok Thailand Program of Computer Engineering Faculty of Industrial Technology Phibunsongkhram Rajabhat University Phitsanulok Thailand

ISBN: (数字)9798331543952

ISBN: (纸本)9798331543969

This article presents a method for indirectly measuring the moisture content of paddy using a cylindrical capacitive sensor combined with Charge Integrator Circuits. The moisture measurement device operates based on the principle of the dielectric constant of paddy, which changes according to the moisture content within them. The system consists of a moisture detection section utilizing a cylindrical capacitor, a signal generator operating at a frequency of 500 Hz with a microcontroller, a signal conditioning circuit converting the signal to voltage, and a processing unit. Testing was conducted with paddy at five different moisture levels, demonstrating the ability to accurately determine the moisture content of the rice. When compared to the commercially available PM-450TH moisture meter, the results showed a linear response across the measurement range, with an R 2 value of 0.9824 and an average error of 2.6%. This technology has the potential for further development and application to other types of seeds in the future.

关键词： Accuracy Moisture measurement Microcontrollers Circuits Measurement uncertainty Moisture Dielectric measurement Capacitive sensors Standards Charge measurement

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