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Measurement of the and tH production rates in the H → decay channel using proton-proton collision data at = 13 TeV

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Journal of High Energy Physics 2025年第2期2025卷 1-75页

作者： Hayrapetyan, A. Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. Chatterjee, S. Damanakis, K. Dragicevic, M. Hussain, P. S. Jeitler, M. Krammer, N. Li, A. Liko, D. Mikulec, I. Schieck, J. Schöfbeck, R. Schwarz, D. Sonawane, M. Templ, S. Waltenberger, W. Wulz, C.-E. Darwish, M. R. Janssen, T. Van Mechelen, P. Breugelmans, N. D’Hondt, J. Dansana, S. De Moor, A. Delcourt, M. Heyen, F. Lowette, S. Makarenko, I. Müller, D. Tavernier, S. Tytgat, M. Van Onsem, G. P. Van Putte, S. Vannerom, D. Bilin, B. Clerbaux, B. Das, A. K. De Lentdecker, G. Evard, H. Favart, L. Gianneios, P. Jaramillo, J. Khalilzadeh, A. Khan, F. A. Lee, K. Mahdavikhorrami, M. Malara, A. Paredes, S. Shahzad, M. A. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. De Coen, M. Dobur, D. Gokbulut, G. Hong, Y. Knolle, J. Lambrecht, L. Marckx, D. Mota Amarilo, K. Samalan, A. Skovpen, K. Van Den Bossche, N. van der Linden, J. Wezenbeek, L. Benecke, A. Bethani, A. Bruno, G. Caputo, C. De Favereau De Jeneret, J. Delaere, C. Donertas, I. S. Giammanco, A. Guzel, A. O. Jain, Sa. Lemaitre, V. Lidrych, J. Mastrapasqua, P. Tran, T. T. Wertz, S. Alves, G. A. Alves Gallo Pereira, M. Coelho, E. Correia Silva, G. Hensel, C. Menezes De Oliveira, T. Moraes, A. Rebello Teles, P. Soeiro, M. Vilela Pereira, A. Aldá Júnior, W. L. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Gomes De Souza, R. Macedo, M. Martins, J. Mora Herrera, C. Mundim, L. Nogima, H. Pinheiro, J. P. Santoro, A. Sznajder, A. Thiel, M. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Maietto Silverio, I. Mercadante, P. G. Novaes, S. F. Orzari, B. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Shumka, E. Keshri, S. Thakur, S. Cheng, T. Javaid, T. Yuan, L. Hu, Z. Liang, Z. Liu, J. Yi, K. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. Jiang, C. H. Yerevan Physics Institute Yerevan Armenia Yerevan State University Yerevan Armenia Institut für Hochenergiephysik Vienna Austria TU Wien Vienna Austria Universiteit Antwerpen Antwerpen Belgium Institute of Basic and Applied Sciences Faculty of Engineering Arab Academy for Science Technology and Maritime Transport Alexandria Egypt Vrije Universiteit Brussel Brussel Belgium Ghent University Ghent Belgium Université Libre de Bruxelles Bruxelles Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual de Campinas Campinas Brazil Federal University of Rio Grande do Sul Porto Alegre Brazil UFMS Nova Andradina Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Nanjing Normal University Nanjing China The University of Iowa Iowa City U.S.A. Institute of High Energy Physics Beijing China University of Chinese Academy of Sciences Beijing China China Center of Advanced Science and Technology Beijing China China Spallation Neutron Source Guangdong China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Guangdong Provincial Key Laboratory of Nuclear Science and Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal University Guangzhou China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Henan Normal University Xinxiang China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) — Fudan University Shanghai China Zhejiang University Hangzhou

An analysis of the production of a Higgs boson (H) in association with a top quark-antiquark pair ( $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ ) or a single top quark (tH) is presented. The Higgs boson decay into a bottom quark-antiquark pair (H → $$ \textrm{b}\overline{\textrm{b}} $$ ) is targeted, and three different final states of the top quark decays are considered, defined by the number of leptons (electrons or muons) in the event. The analysis utilises proton-proton collision data collected at the CERN LHC with the CMS experiment at $$ \sqrt{s} $$ = 13 TeV in 2016–2018, which correspond to an integrated luminosity of 138 fb−1. The observed $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ production rate relative to the standard model expectation is 0.33 ± 0.26 = 0.33 ± 0.17(stat) ± 0.21(syst). Additionally, the $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ production rate is determined in intervals of Higgs boson transverse momentum. An upper limit at 95% confidence level is set on the tH production rate of 14.6 times the standard model prediction, with an expectation of $$ {19.3}_{-6.0}^{+9.2} $$ . Finally, constraints are derived on the strength and structure of the coupling between the Higgs boson and the top quark from simultaneous extraction of the $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ and tH production rates, and the results are combined with those obtained in other Higgs boson decay channels.

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Measurement of the inclusive cross section in final states with at least one lepton and additional jets with 302 pb−1 of pp collisions at = 5.02 TeV

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Journal of High Energy Physics 2025年第4期2025卷 1-44页

作者： Hayrapetyan, A. Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. Chatterjee, S. Damanakis, K. Dragicevic, M. Hussain, P. S. Jeitler, M. Krammer, N. Li, A. Liko, D. Mikulec, I. Schieck, J. Schöfbeck, R. Schwarz, D. Sonawane, M. Waltenberger, W. Wulz, C.-E. Janssen, T. Van Laer, T. Van Mechelen, P. Breugelmans, N. D’Hondt, J. Dansana, S. De Moor, A. Delcourt, M. Heyen, F. Lowette, S. Makarenko, I. Müller, D. Tavernier, S. Tytgat, M. Van Onsem, G. P. Van Putte, S. Vannerom, D. Bilin, B. Clerbaux, B. Das, A. K. De Lentdecker, G. Evard, H. Favart, L. Gianneios, P. Jaramillo, J. Khalilzadeh, A. Khan, F. A. Lee, K. Mahdavikhorrami, M. Malara, A. Paredes, S. Shahzad, M. A. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. De Coen, M. Dobur, D. Gokbulut, G. Hong, Y. Knolle, J. Lambrecht, L. Marckx, D. Mota Amarilo, K. Skovpen, K. Van Den Bossche, N. van der Linden, J. Wezenbeek, L. Benecke, A. Bethani, A. Bruno, G. Caputo, C. De Favereau De Jeneret, J. Delaere, C. Donertas, I. S. Giammanco, A. Guzel, A. O. Jain, Sa. Lemaitre, V. Lidrych, J. Mastrapasqua, P. Tran, T. T. Wertz, S. Alves, G. A. Alves Gallo Pereira, M. Coelho, E. Correia Silva, G. Hensel, C. Menezes De Oliveira, T. Mora Herrera, C. Moraes, A. Rebello Teles, P. Soeiro, M. Vilela Pereira, A. Aldá Júnior, W. L. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Gomes De Souza, R. Laux Kuhn, T. Macedo, M. Martins, J. Mundim, L. Nogima, H. Pinheiro, J. P. Santoro, A. Sznajder, A. Thiel, M. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Maietto Silverio, I. Mercadante, P. G. Novaes, S. F. Orzari, B. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Shumka, E. Keshri, S. Laroze, D. Thakur, S. Cheng, T. Javaid, T. Yuan, L. Hu, Z. Liang, Z. Liu, J. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. Jiang, C. H. Kapoor Yerevan Physics Institute Yerevan Armenia Yerevan State University Yerevan Armenia Institut für Hochenergiephysik Vienna Austria TU Wien Vienna Austria Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Ghent University Ghent Belgium Université Libre de Bruxelles Bruxelles Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual de Campinas Campinas Brazil Federal University of Rio Grande do Sul Porto Alegre Brazil UFMS Nova Andradina Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China University of Chinese Academy of Sciences Beijing China China Center of Advanced Science and Technology Beijing China China Spallation Neutron Source Guangdong China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Guangdong Provincial Key Laboratory of Nuclear Science and Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal University Guangzhou China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Nanjing Normal University Nanjing China Henan Normal University Xinxiang China The University of Iowa Iowa City USA Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineeri

A measurement of the top quark pair ( $$ \textrm{t}\overline{\textrm{t}} $$ ) production cross section in proton-proton collisions at a centre-of-mass energy of 5.02 TeV is presented. The data were collected at the LHC in autumn 2017, in dedicated runs with low-energy and low-intensity conditions with respect to the default configuration, and correspond to an integrated luminosity of 302 pb−1. The measurement is performed using events with one electron or muon, and multiple jets, at least one of them being identified as originating from a b quark (b tagged). Events are classified based on the number of all reconstructed jets and of b-tagged jets. Multivariate analysis techniques are used to enhance the separation between the signal and backgrounds. The measured cross section is $$ 62.5\pm 1.6{\left(\textrm{stat}\right)}_{-2.5}^{+2.6}\left(\textrm{syst}\right)\pm 1.2\left(\textrm{lumi}\right) $$ pb. A combination with the result in the dilepton channel based on the same data set yields a value of 62.3 ± 1.5 (stat) ± 2.4 (syst) ± 1.2 (lumi) pb, to be compared with the standard model prediction of $$ {69.5}_{-3.7}^{+3.5} $$ pb at next-to-next-to-leading order in perturbative quantum chromodynamics.

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Expanding the active inference landscape: More intrinsic motivations in the perception-action loop

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arXiv 2018年

作者： Biehl, Martin Guckelsberger, Christian Salge, Christoph Smith, Simon C. Polani, Daniel Araya Inc. Tokyo Japan Computational Creativity Group Department of Computing Goldsmiths University of London London United Kingdom Game Innovation Lab Department of Computer Science and Engineering New York University New York CityNY United States Sepia Lab Adaptive Systems Research Group Department of Computer Science University of Hertfordshire Hatfield United Kingdom Institute of Perception Action and Behaviour School of Informatics University of Edinburgh United Kingdom

Active inference is an ambitious theory that treats perception, inference and action selection of autonomous agents under the heading of a single principle. It suggests biologically plausible explana-tions for many cognitive phenomena, including consciousness. In active inference, action selection is driven by an objective function that evaluates possible future actions with respect to current, inferred beliefs about the world. Active inference at its core is independent from extrinsic rewards, resulting in a high level of robustness across e.g. different environments or agent morphologies. In the liter- A ture, paradigms that share this independence have been summarised under the notion of intrinsic motivations. In general and in contrast to active inference, these models of motivation come without a commitment to particular inference and action selection mechanisms. In this article, we study if the inference and action selection machinery of active inference can also be used by alternatives to the originally included intrinsic motivation. The perception-action loop explicitly relates inference and action selection to the environment and agent memory, and is consequently used as foundation for our analysis. We reconstruct the active inference approach, locate the original formulation within, and show how alternative intrinsic motivations can be used while keeping many of the original fea-tures intact. Furthermore, we illustrate the connection to universal reinforcement learning by means of our formalism. Active inference research may profit from comparisons of the dynamics induced by alternative intrinsic motivations. Research on intrinsic motivations may profit from an additional way to implement intrinsically motivated agents that also share the biological plausibility of active inference.62F15, 91B06 Copyright © 2018, The Authors. All rights reserved.

关键词： Profitability

Combination of Measurements of the Top Quark Mass from Data Collected by the ATLAS and CMS Experiments at s=7 and 8 TeV

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Physical Review Letters 2024年第26期132卷 261902-261902页

作者： A. Hayrapetyan A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee K. Damanakis M. Dragicevic P. S. Hussain M. Jeitler N. Krammer A. Li D. Liko I. Mikulec J. Schieck R. Schöfbeck D. Schwarz M. Sonawane S. Templ W. Waltenberger C.-E. Wulz M. R. Darwish T. Janssen P. Van Mechelen E. S. Bols J. D’Hondt S. Dansana A. De Moor M. Delcourt H. El Faham S. Lowette I. Makarenko D. Müller A. R. Sahasransu S. Tavernier M. Tytgat S. Van Putte D. Vannerom B. Clerbaux G. De Lentdecker L. Favart D. Hohov J. Jaramillo A. Khalilzadeh K. Lee M. Mahdavikhorrami A. Malara S. Paredes L. Pétré N. Postiau L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer M. De Coen D. Dobur Y. Hong J. Knolle L. Lambrecht G. Mestdach C. Rendón A. Samalan K. Skovpen N. Van Den Bossche J. van der Linden L. Wezenbeek A. Benecke G. Bruno C. Caputo C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre J. Lidrych P. Mastrapasqua K. Mondal T. T. Tran S. Wertz G. A. Alves E. Coelho C. Hensel T. Menezes De Oliveira A. Moraes P. Rebello Teles M. Soeiro W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza R. Gomes De Souza J. Martins C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima A. Santoro A. Sznajder M. Thiel A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores P. G. Mercadante S. F. Novaes B. Orzari Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Shopova G. Sultanov A. Dimitrov L. Litov B. Pavlov P. Petkov A. Petrov E. Shumka S. Keshri S. Thakur T. Cheng Q. Guo T. Javaid L. Yuan Z. Hu J. Liu K. Yi G. M. Chen H. S. Chen M. Chen F. Iemmi C. H. Jiang A. Kapoor H. Liao Z.-A. Liu R. Sharma J. N. Song J. Tao C. Wang J. Wang Z. Wang H. Zhang A. Agapitos Y. Ban A. Levin C. Li Q. Li Y. Mao S. J. Qian X. Sun D. Wang H. Yang L. Zhang C. Zhou Z. You N. Lu G. Bauer X. Gao D. Leggat H. Okawa Y. Zhang Z. Lin C. Lu M. Xiao C. Avila D. A. Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Indian Institute of Technology Madras Madras India APC Université Paris Cité CNRS/IN2P3 Paris France Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria IJCLab Université Paris-Saclay CNRS/IN2P3 91405 Orsay France Instituto De Alta Investigación Universidad de Tarapacá Casilla 7 D Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Department of Physics Oxford University Oxford United Kingdom School of Physics and Astronomy Shanghai Jiao Tong University Key Laboratory for Particle Astrophysics and Cosmology (MOE) SKLPPC Shanghai China Department of Physics Chinese University of Hong Kong Shatin N.T. Hong Kong China Department of Physics University of Michigan Ann Arbor Michigan USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Department of Modern Physics and State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei China Department of Physics Nanjing University Nanjing China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Nanjing Normal University Nanjing China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Zhe

A combination of fifteen top quark mass measurements performed by the ATLAS and CMS experiments at the LHC is presented. The datasets used correspond to an integrated luminosity of up to 5 and 20 fb−1 of proton-proton collisions at center-of-mass energies of 7 and 8 TeV, respectively. The combination includes measurements in top quark pair events that exploit both the semileptonic and hadronic decays of the top quark, and a measurement using events enriched in single top quark production via the electroweak t channel. The combination accounts for the correlations between measurements and achieves an improvement in the total uncertainty of 31% relative to the most precise input measurement. The result is mt=172.52±0.14(stat)±0.30(syst) GeV, with a total uncertainty of 0.33 GeV.

关键词： Top quark Hadron colliders

AGlobal benchmark of algorithms for segmentinglate gadolinium-enhanced cardiac magnetic resonance imaging

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arXiv 2020年

作者： Xiong, Zhaohan Xia, Qing Hu, Zhiqiang Huang, Ning Bian, Cheng Zheng, Yefeng Vesal, Sulaiman Ravikumar, Nishant Maier, Andreas Yang, Xin Heng, Pheng-Ann Ni, Dong Li, Caizi Tong, Qianqian Si, Weixin Puybareau, Elodie Khoudli, Younes Géraud, Thierry Chen, Chen Bai, Wenjia Rueckert, Daniel Xu, Lingchao Zhuang, Xiahai Luo, Xinzhe Jia, Shuman Sermesant, Maxime Liu, Yashu Wang, Kuanquan Borra, Davide Masci, Alessandro Corsi, Cristiana De Vente, Coen Veta, Mitko Karim, Rashed Preetha, Chandrakanth Jayachandran Engelhardt, Sandy Qiao, Menyun Wang, Yuanyuan Tao, Qian Nuñez-Garcia, Marta Camara, Oscar Savioli, Nicolo Lamata, Pablo Zhao, Jichao Auckland Bioengineering Institute University of Auckland Auckland New Zealand State Key Lab of Virtual Reality Technology and Systems Beihang University Beijing China School of Electronics Engineering and Computer Science Peking University Beijing China SenseTime Inc Shenzhen China Tencent Jarvis Laboratory Shenzhen China Pattern Recognition Lab Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Germany Department of Computer Science and Engineering Chinese University of Hong Kong Hong Kong National-Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering Shenzhen University Shenzhen China School of Computer Science Wuhan University Wuhan China Shenzhen Key Laboratory of Virtual Reality and Human Interaction Technology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen China Epita Research and Development Laboratory Paris France Department of Computing Imperial College London London United Kingdom School of Naval Architecture Shanghai Jiao Tong University Ocean & Civil Engineering Shanghai China School of Data Science Fudan University Shanghai China Epione Research Group Universite Cote d'Azur Inria Sophia Antipolis France Harbin Institute of Technology School of Computer Science and Technology Harbin China Department of Electric University of Bologna Electronic and Information Engineering Cesena Italy Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands School of Biomedical Engineering and Imaging Sciences Kings College London London United Kingdom Faculty of Electrical Engineering and Information Technology University of Magdeburg Magdeburg Germany Heidelberg University Hospital Germany Biomedical Engineering Center Fudan University Shanghai China Department of Radiology Leiden University Medical Center Leiden Netherlands Department of Information and Communication Technologies Universitat Pompeu Fabra Barcelona Spain D

Segmentation of cardiac images, particularly late gadolinium-enhanced magnetic resonance imaging (LGE-MRI)widely used for visualizing diseased cardiacstructures, is a crucial first step for clinical diagnosis and treatment. However, direct segmentation ofLGE-MRIsischallenging due to *** most clinical studies have relied on manual and labor-intensive approaches, automatic methods are of high interest, particularly optimized machine learning *** address this, we organized the "2018 Left Atrium Segmentation Challenge" using 154 3D LGE-MRIs, currently the world's largest cardiac LGE-MRI dataset, and associated labels of the left atriumsegmented by three medical experts,ultimately attractingthe participation of27 international teams. In this paper, extensive analysis of the submitted algorithms using technical and biological metrics was performed by undergoing subgroup analysis and conducting hyper-parameter analysis,offeringan overall picture ofthe major design choices of convolutional neural networks(CNNs) and practical considerations for achieving state-of-the-art left atrium segmentation. Results show the top methodachieved a dice score of 93.2%and a mean surface to a surface distance of 0.7mm, significantly outperforming prior state-of-the-art. Particularly, our analysisdemonstrated that double, sequentially usedCNNs, in which a first CNN is used for automatic region-of-interestlocalization and a subsequent CNN is used for refinedregional segmentation, achieved far superiorresults than traditional methods and pipelinescontaining *** findings from this study can potentially be extended to other imaging datasets and modalities, having an impact on the wider medical imaging *** large-scale benchmarking study makes a significant step towards much-improved segmentation methods for cardiac LGE-MRIs, and will serveas animportant benchmark for evaluating and comparing the future works in the field. Copyright © 2020, Th

关键词： Magnetic resonance imaging

A universal language for finding mass spectrometry data patterns

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Nature Methods 2025年 1-8页

作者： Damiani, Tito Jarmusch, Alan K. Aron, Allegra T. Petras, Daniel Phelan, Vanessa V. Zhao, Haoqi Nina Bittremieux, Wout Acharya, Deepa D. Ahmed, Mohammed M. A. Bauermeister, Anelize Bertin, Matthew J. Boudreau, Paul D. Borges, Ricardo M. Bowen, Benjamin P. Brown, Christopher J. Chagas, Fernanda O. Clevenger, Kenneth D. Correia, Mario S. P. Crandall, William J. Crüsemann, Max Fahy, Eoin Fiehn, Oliver Garg, Neha Gerwick, William H. Gilbert, Jeffrey R. Globisch, Daniel Gomes, Paulo Wender P. Heuckeroth, Steffen James, C. Andrew Jarmusch, Scott A. Kakhkhorov, Sarvar A. Kang, Kyo Bin Kessler, Nikolas Kersten, Roland D. Kim, Hyunwoo Kirk, Riley D. Kohlbacher, Oliver Kontou, Eftychia E. Liu, Ken Lizama-Chamu, Itzel Luu, Gordon T. Luzzatto Knaan, Tal Mannochio-Russo, Helena Marty, Michael T. Matsuzawa, Yuki McAvoy, Andrew C. McCall, Laura-Isobel Mohamed, Osama G. Nahor, Omri Neuweger, Heiko Niedermeyer, Timo H. J. Nishida, Kozo Northen, Trent R. Overdahl, Kirsten E. Rainer, Johannes Reher, Raphael Rodriguez, Elys Sachsenberg, Timo T. Sanchez, Laura M. Schmid, Robin Stevens, Cole Subramaniam, Shankar Tian, Zhenyu Tripathi, Ashootosh Tsugawa, Hiroshi van der Hooft, Justin J. J. Vicini, Andrea Walter, Axel Weber, Tilmann Xiong, Quanbo Xu, Tao Pluskal, Tomáš Dorrestein, Pieter C. Wang, Mingxun Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Prague Czech Republic Metabolomics Core Facility Immunity Inflammation and Disease Laboratory Division of Intramural Research National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park NC United States Department of Chemistry and Biochemistry University of Denver Denver CO United States Functional Metabolomics Lab CMFI Cluster of Excellence University of Tuebingen Tuebingen Germany Department of Biochemistry University of California Riverside Riverside CA United States Department of Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz Medical Campus Aurora CO United States Collaborative Mass Spectrometry Innovation Center Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA United States Biologicals and Natural Products Discovery Crop Protection R & D Corteva Agrisciences Indianapolis IN United States BioMolecular Sciences School of Pharmacy University of Mississippi Oxford MS United States Pharmacognosy Faculty of Pharmacy Al-Azhar University Nasr City Egypt Department of Fundamental Chemistry Institute of Chemistry University of São Paulo São Paulo Brazil Department of Chemistry Case Western Reserve University Cleveland OH United States Walter Mors Institute of Research on Natural Products Federal University of Rio de Janeiro Rio de Janeiro Brazil Environmental Genomics and Systems Biology Division Lawrence Berkeley National Lab Berkeley CA United States The Joint Genome Institute Lawrence Berkeley National Lab Berkeley CA United States Mass Spectrometry Center of Expertise Regulatory and Stewardship Corteva Agrisciences Indianapolis IN United States Biologicals and Natural Products Crop Protection R & D Corteva Agrisciences Indianapolis IN United States Department of Chemistry – BMC Science for Life Laborat

Despite being information rich, the vast majority of untargeted mass spectrometry data are underutilized;most analytes are not used for downstream interpretation or reanalysis after publication. The inability to dive into these rich raw mass spectrometry datasets is due to the limited flexibility and scalability of existing software tools. Here we introduce a new language, the Mass Spectrometry Query Language (MassQL), and an accompanying software ecosystem that addresses these issues by enabling the community to directly query mass spectrometry data with an expressive set of user-defined mass spectrometry patterns. Illustrated by real-world examples, MassQL provides a data-driven definition of chemical diversity by enabling the reanalysis of all public untargeted metabolomics data, empowering scientists across many disciplines to make new discoveries. MassQL has been widely implemented in multiple open-source and commercial mass spectrometry analysis tools, which enhances the ability, interoperability and reproducibility of mining of mass spectrometry data for the research community. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2025.

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Considering discrepancy when calibrating a mechanistic electrophysiology model

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arXiv 2020年

作者： Lei, Chon Lok Ghosh, Sanmitra Whittaker, Dominic G. Aboelkassem, Yasser Beattie, Kylie A. Cantwell, Chris D. Delhaas, Tammo Houston, Charles Novaes, Gustavo Montes Panfilov, Alexander V. Pathmanathan, Pras Riabiz, Marina Weber dos Santos, Rodrigo Worden, Keith Mirams, Gary R. Wilkinson, Richard D. Computational Biology & Health Informatics Dept. of Computer Science University of Oxford United Kingdom MRC Biostatistics Unit University of Cambridge United Kingdom Centre for Mathematical Medicine & Biology School of Mathematical Sciences University of Nottingham United Kingdom Department of Bioengineering University of California San Diego United States Systems Modeling and Translational Biology GlaxoSmithKline R&D Stevenage United Kingdom ElectroCardioMaths Programme Centre for Cardiac Engineering Imperial College London United Kingdom CARIM School for Cardiovascular Diseases Maastricht University Netherlands Graduate Program in Computational Modeling Universidade Federal de Juiz de Fora Brazil Department of Physics and Astronomy Ghent University Belgium Laboratory of Computational Biology and Medicine Ural Federal University Ekaterinburg Russia U.S. Food and Drug Administration Center for Devices and Radiological Health Office of Science and Engineering Laboratories United States Department of Biomedical Engineering King’s College London Alan Turing Institute United Kingdom Dynamics Research Group Department of Mechanical Engineering University of Sheffield United Kingdom School of Mathematics and Statistics University of Sheffield United Kingdom

Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions. The field of cardiac simulation has begun to explore and adopt UQ methods to characterise uncertainty in model inputs and how that propagates through to outputs or predictions. In this perspective piece we draw attention to an important and under-addressed source of uncertainty in our predictions — that of uncertainty in the model structure or the equations themselves. The difference between imperfect models and reality is termed model discrepancy, and we are often uncertain as to the size and consequences of this discrepancy. Here we provide two examples of the consequences of discrepancy when calibrating models at the ion channel and action potential scales. Furthermore, we attempt to account for this discrepancy when calibrating and validating an ion channel model using different methods, based on modelling the discrepancy using Gaussian processes (GPs) and autoregressive-moving-average (ARMA) models, then highlight the advantages and shortcomings of each approach. Finally, suggestions and lines of enquiry for future work are provided. Copyright © 2020, The Authors. All rights reserved.

关键词： Uncertainty analysis

BioViz: An Interactive Visualization Engine for the Design of Digital Microfluidic Biochips

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BioViz: An Interactive Visualization Engine for the Design o...

2017 IEEE computer Society Annual Symposium on VLSI, ISVLSI 2017

作者： Stoppe, Jannis Keszöcze, Oliver Luenert, Maximilian Wille, Robert Drechsler, Rolf Cyber-Physical Systems DFKI GmbH Bibliothekstr. 5 Bremen28359 Germany Group of Computer Architecture University of Bremen Bibliothekstr. 5 Bremen28359 Germany Institute for Integrated Circuits Johannes Kepler University Linz Altenbergerstraße 69 Linz4040 Austria

ISBN: (纸本)9781509067626

In order to shorten the required time for the analysis of medical substances, Digital Microfluidic Biochips (DMFBs) have been suggested. They allow for handling small amounts of samples and reagents on a circuit board and, thus, automatically execute medical experiments that are usually conducted manually in laboratories. However, there are various challenges in the design of DMFBs. Issues such as routing and layouting are complex and currently being investigated by various researchers and engineers. Although first automatic solutions assist them, the obtained results are usually provided in a complex and \mbox{non-intuitive} fashion. This makes the utilization and evaluation of existing approaches for DMFB design a tedious task. In this paper, we present a solution for this problem by proposing a visualization scheme for DMFBs that explicitly addresses these problems. To this end, a grammar is proposed which allows the description of resulting designs and their properties. The contributions of this work allow for a design methodology which is easy to use and provides a hassle-free environment for the involved researchers and engineers. © 2017 IEEE.

关键词： Visualization

A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067

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arXiv 2023年

作者： Luque, R. Osborn, H.P. Leleu, A. Pallé, E. Bonfanti, A. Barragán, O. Wilson, T.G. Broeg, C. Cameron, A. Collier Lendl, M. Maxted, P.F.L. Alibert, Y. Gandolfi, D. Delisle, J.-B. Hooton, M.J. Egger, J.A. Nowak, G. Lafarga, M. Rapetti, D. Twicken, J.D. Morales, J.C. Carleo, I. Orell-Miquel, J. Adibekyan, V. Alonso, R. Alqasim, A. Amado, P.J. Anderson, D.R. Anglada-Escudé, G. Bandy, T. Bárczy, T. Navascues, D. Barrado Barros, S.C.C. Baumjohann, W. Bayliss, D. Bean, J.L. Beck, M. Beck, T. Benz, W. Billot, N. Bonfils, X. Borsato, L. Boyle, A.W. Brandeker, A. Bryant, E.M. Cabrera, J. Gaxiola, S. Carrazco Charbonneau, D. Charnoz, S. Ciardi, D.R. Cochran, W.D. Collins, K.A. Crossfield, I.J.M. Csizmadia, Sz. Cubillos, P.E. Dai, F. Davies, M.B. Deeg, H.J. Deleuil, M. Deline, A. Delrez, L. Demangeon, O.D.S. Demory, B.-O. Ehrenreich, D. Erikson, A. Esparza-Borges, E. Falk, B. Fortier, A. Fossati, L. Fridlund, M. Fukui, A. Garcia-Mejia, J. Gill, S. Gillon, M. Goffo, E. Chew, Y. Gomez Maqueo Güdel, M. Guenther, E.W. Günther, M.N. Hatzes, A.P. Helling, Ch. Hesse, K.M. Howell, S.B. Hoyer, S. Ikuta, K. Isaak, K.G. Jenkins, J.M. Kagetani, T. Kiss, L.L. Kodama, T. Korth, J. Lam, K.W.F. Laskar, J. Latham, D.W. des Etangs, A. Lecavelier Leon, J.P.D. Livingston, J.H. Magrin, D. Matson, R.A. Matthews, E.C. Mordasini, C. Mori, M. Moyano, M. Munari, M. Murgas, F. Narita, N. Nascimbeni, V. Olofsson, G. Osborne, H.L.M. Ottensamer, R. Pagano, I. Parviainen, H. Peter, G. Piotto, G. Pollacco, D. Queloz, D. Quinn, S.N. Quirrenbach, A. Ragazzoni, R. Rando, N. Ratti, F. Rauer, H. Redfield, S. Ribas, I. Ricker, G.R. Rudat, A. Sabin, L. Salmon, S. Santos, N.C. Scandariato, G. Schanche, N. Schlieder, J.E. Seager, S. Ségransan, D. Shporer, A. Simon, A.E. Smith, A.M.S. Sousa, S.G. Stalport, M. Szabó, Gy.M. Thomas, N. Tuson, A. Udry, S. Vanderburg, A.M. Van Eylen, V. Van Grootel, V. Venturini, J. Walter, I. Walton, N.A. Watanabe, N. Winn, J.N. Zingales, T. Department of Astronomy & Astrophysics University of Chicago ChicagoIL60637 United States Space Research and Planetary Sciences Physics Institute University of Bern Gesellschaftsstrasse 6 Bern3012 Switzerland Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States Observatoire Astronomique de l’Université de Genève Chemin Pegasi 51 Versoix1290 Switzerland Instituto de Astrofisica de Canarias Via Lactea s/n Tenerife La Laguna38200 Spain Departamento de Astrofisica Universidad de La Laguna Astrofísico Francisco Sanchez s/n Tenerife La Laguna38206 Spain Space Research Institute Austrian Academy of Sciences Schmiedlstrasse 6 GrazA-8042 Austria Sub-department of Astrophysics Department of Physics University of Oxford OxfordOX1 3RH United Kingdom Centre for Exoplanet Science SUPA School of Physics and Astronomy University of St Andrews North Haugh St AndrewsKY16 9SS United Kingdom Department of Physics University of Warwick Gibbet Hill Road CoventryCV4 7AL United Kingdom Centre for Exoplanets and Habitability University of Warwick CoventryCV4 7AL United Kingdom Center for Space and Habitability University of Bern Gesellschaftsstrasse 6 Bern3012 Switzerland Astrophysics Group Lennard Jones Building Keele University StaffordshireST5 5BG United Kingdom Dipartimento di Fisica Universita degli Studi di Torino via Pietro Giuria 1 TorinoI-10125 Italy Cavendish Laboratory JJ Thomson Avenue CambridgeCB3 0HE United Kingdom Institute of Astronomy Faculty of Physics Astronomy and Informatics Nicolaus Copernicus University Grudzicadzka 5 Torun87-100 Poland NASA Ames Research Center Moffett FieldCA94035 United States Research Institute for Advanced Computer Science Universities Space Research Association WashingtonDC20024 United States SETI Institute Mountain ViewCA94043 United States Campus UAB Can Magrans s/n Bellaterra08193 Spain Gran Capità

Planets with radii between that of the Earth and Neptune (hereafter referred to as "sub-Neptunes") are found in close-in orbits around more than half of all Sun-like stars [1, 2]. Yet, their composition, formation, and evolution remain poorly understood [3]. The study of multi-planetary systems offers an opportunity to investigate the outcomes of planet formation and evolution while controlling for initial conditions and environment. Those in resonance (with their orbital periods related by a ratio of small integers) are particularly valuable because they imply a system architecture practically unchanged since its birth. Here, we present the observations of six transiting planets around the bright nearby star HD 110067. We find that the planets follow a chain of resonant orbits. A dynamical study of the innermost planet triplet allowed the prediction and later confirmation of the orbits of the rest of the planets in the system. The six planets are found to be sub-Neptunes with radii ranging from 1.94 to 2.85 R☉. Three of the planets have measured masses, yielding low bulk densities that suggest the presence of large hydrogen-dominated atmospheres. © 2023, CC BY.

关键词： Planets