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Adaptive pattern recognition by self-organizing neural networks

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Adaptive pattern recognition by self-organizing neural netwo...

Neural and Fuzzy Systems: The Emerging Science of Intelligent Computing 1994

作者： Mitra, Sunanda Kim, Yong Soo Pemmaraju, Surya Computer Vision and Image Analysis Laboratory Department of Electrical Engineering Texas Tech University M.S. 3102 LubbockTX79409-3102 United States

Nonlinear decision boundaries separating similar regions in unlabeled data sets are encountered in many real applications but are extremely difficult to generate by statistical decision models. Supervised multilayered neural networks are capable of generating some nonlinear decision boundaries but require extensive training procedures leading to computational burden as well. Unsupervised self-organizing neural nets are capable of forming crisp clusters from unlabeled data sets. A recent trend has been to integrate the concept of fuzzy sets with adaptive learning inherent to neural nets. Such integration yields not only better clustering of similar data groups, it may also provide a method for generating nonlinear boundaries among clusters in close proximity. The weaknesses and strengths of such integrated self-organizing neuro-fuzzy models for adaptive pattern recognition are described. Successful classification of standard data sets and generation of nonlinear decision boundaries among neighboring clusters from computer generated data are demonstrated with a recently developed integrated adaptive fuzzy clustering (IAFC) model. © 2017 SPIE.

关键词： Classification (of information)

Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 2 — Ex vivo imaging: added value and acquisition

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arXiv 2022年

作者： Schilling, Kurt G. Grussu, Francesco Ianus, Andrada Hansen, Brian Howard, Amy F.D. Barrett, Rachel L.C. Aggarwal, Manisha Michielse, Stijn Nasrallah, Fatima Syeda, Warda Wang, Nian Veraart, Jelle Roebroeck, Alard Bagdasarian, Andrew F. Eichner, Cornelius Sepehrband, Farshid Zimmermann, Jan Soustelle, Lucas Bowman, Christien Tendler, Benjamin C. Hertanu, Andreea Jeurissen, Ben Verhoye, Marleen Frydman, Lucio de Looij, Yohan van Hike, David Dunn, Jeff F. Miller, Karla Landman, Bennett A. Shemesh, Noam Anderson, Adam McKinnon, Emilie Farquharson, Shawna Acqua, Flavio Dell Pierpaoli, Carlo Drobnjak, Ivana Leemans, Alexander Harkins, Kevin D. Descoteaux, Maxime Xu, Duan Huang, Hao Santin, Mathieu D. Grant, Samuel C. Obenaus, Andre Kim, Gene S. Wu, Dan Le Bihan, Denis Blackband, Stephen J. Ciobanu, Luisa Fieremans, Els Bai, Ruiliang Leergaard, Trygve B. Zhang, Jiangyang Dyrby, Tim B. Allan Johnson, G. Cohen-Adad, Julien Budde, Matthew D. Jelescu, Ileana O. Radiology and Radiological Sciences Vanderbilt University Medical Center NashvilleTN United States Vanderbilt University Institute of Imaging Science Vanderbilt University NashvilleTN United States Radiomics Group Vall d’Hebron Institute of Oncology Vall d’Hebron Barcelona Hospital Campus Barcelona Spain Queen Square MS Centre Queen Square Institute of Neurology Faculty of Brain Sciences University College London London United Kingdom Champalimaud Research Champalimaud Foundation Lisbon Portugal Center of Functionally Integrative Neuroscience Aarhus University Aarhus Denmark Department of Bioengineering Imperial College London London United Kingdom FMRIB Centre Wellcome Centre for Integrative Neuroimaging Nuffield Department of Clinical Neurosciences University of Oxford Oxford United Kingdom Department of Neuroimaging Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom NatBrainLab Department of Forensics and Neurodevelopmental Sciences Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine BaltimoreMD United States Maastricht University Medical Center Maastricht Netherlands The Queensland Brain Institute The University of Queensland Queensland Australia Melbourne Neuropsychiatry Centre The University of Melbourne ParkvilleVIC Australia Department of Radiology and Imaging Sciences Indiana University IN United States Stark Neurosciences Research Institute Indiana University School of Medicine IN United States Center for Biomedical Imaging NYU Grossman School of Medicine New YorkNY United States Faculty of psychology and Neuroscience Maastricht University Maastricht Netherlands Department of Chemical & Biomedical Engineering FAMU-FSU College of Engineering Florida State University TallahasseeFL United States Center for Interdisciplinary Magnetic Re

The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non-invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructure and brain connectivity. Ex vivo dMRI has several experimental advantages including higher signal-to-noise ratio (SNR) and spatial resolution compared to in vivo studies, and enabling more advanced diffusion contrasts for improved microstructure and connectivity characterization. Another major advantage of ex vivo dMRI is the direct comparison with histological data, as a crucial methodological validation. However, there are a number of considerations that must be made when performing ex vivo experiments. The steps from tissue preparation, image acquisition and processing, and interpretation of results are complex, with many decisions that not only differ dramatically from in vivo imaging of small animals, but ultimately affect what questions can be answered using the data. This work represents "Part 2" of a 3-part series of recommendations and considerations for preclinical dMRI. We describe best practices for dMRI of ex vivo tissue, with a focus on the value that ex vivo imaging adds to the field of dMRI and considerations in ex vivo image acquisition. We first give general considerations and foundational knowledge that must be considered when designing experiments. We briefly describe differences in specimens and models and discuss why some may be more or less appropriate for different studies. We then give guidelines for ex vivo protocols, including tissue fixation, sample preparation, and MR scanning. In each section, we attempt to provide guidelines and recommendations, but also highlight areas for which no guidelines exist (and why), and where future work should lie. An overarching goal herein is to enhance the rigor and reproducibility of ex vivo dMRI acquisitions and analyses, and thereby advance biomedical knowledge. © 2022, CC BY.

关键词： image acquisition

Considerations and Recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 1 — In vivo small-animal imaging

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arXiv 2022年

作者： Jelescu, Ileana O. Grussu, Francesco Ianus, Andrada Hansen, Brian Barrett, Rachel L.C. Aggarwal, Manisha Michielse, Stijn Nasrallah, Fatima Syeda, Warda Wang, Nian Veraart, Jelle Roebroeck, Alard Bagdasarian, Andrew F. Eichner, Cornelius Sepehrband, Farshid Zimmermann, Jan Soustelle, Lucas Bowman, Christien Tendler, Benjamin C. Hertanu, Andreea Jeurissen, Ben Verhoye, Marleen Frydman, Lucio de Looij, Yohan van Hike, David Dunn, Jeff F. Miller, Karla Landman, Bennett A. Shemesh, Noam Anderson, Adam McKinnon, Emilie Farquharson, Shawna Acqua, Flavio Dell Pierpaoli, Carlo Drobnjak, Ivana Leemans, Alexander Harkins, Kevin D. Descoteaux, Maxime Xu, Duan Huang, Hao Santin, Mathieu D. Grant, Samuel C. Obenaus, Andre Kim, Gene S. Wu, Dan Le Bihan, Denis Blackband, Stephen J. Ciobanu, Luisa Fieremans, Els Bai, Ruiliang Leergaard, Trygve B. Zhang, Jiangyang Dyrby, Tim B. Johnson, G. Allan Cohen-Adad, Julien Budde, Matthew D. Schilling, Kurt G. Department of Radiology Lausanne University Hospital University of Lausanne Lausanne Switzerland CIBM Center for Biomedical Imaging Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland Radiomics Group Vall d’Hebron Institute of Oncology Vall d’Hebron Barcelona Hospital Campus Barcelona Spain Queen Square MS Centre Queen Square Institute of Neurology Faculty of Brain Sciences University College London London United Kingdom Champalimaud Research Champalimaud Foundation Lisbon Portugal Center of Functionally Integrative Neuroscience Aarhus University Aarhus Denmark Department of Neuroimaging Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom NatBrainLab Department of Forensics and Neurodevelopmental Sciences Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine BaltimoreMD United States Maastricht University Medical Center Maastricht Netherlands The Queensland Brain Institute The University of Queensland Queensland Australia Melbourne Neuropsychiatry Centre The University of Melbourne ParkvilleVIC Australia Department of Radiology and Imaging Sciences Indiana University IN United States Stark Neurosciences Research Institute Indiana University School of Medicine IN United States Center for Biomedical Imaging NYU Grossman School of Medicine New YorkNY United States Faculty of psychology and Neuroscience Maastricht University Maastricht Netherlands Department of Chemical & Biomedical Engineering FAMU-FSU College of Engineering Florida State University TallahasseeFL United States Center for Interdisciplinary Magnetic Resonance National HIgh Magnetic Field Laboratory TallahasseeFL United States Department of Neuropsychology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany USC Stevens Neuroimaging and Informatics Instit

Small-animal diffusion MRI (dMRI) has been used for methodological development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. The steps from animal setup and monitoring, to acquisition, analysis, and interpretation are complex, with many decisions that may ultimately affect what questions can be answered using the resultant data. This work aims to present selected recommendations and guidelines from the diffusion community, on best practices for preclinical dMRI of in vivo animals. We describe the general considerations and foundational knowledge that must be considered when designing experiments. We briefly describe differences in animal species and disease models and discuss why some may be more or less appropriate for different studies. We then give guidelines for in vivo acquisition protocols, including decisions on hardware, animal preparation, and imaging sequences, followed by advice for data processing including pre-processing, model-fitting, and tractography. Finally, we provide an online resource which lists publicly available preclinical dMRI datasets and software packages, to promote responsible and reproducible research. In each section, we attempt to provide guides and recommendations, but also highlight areas for which no guidelines exist (and why), and where future work should focus. While we mainly cover the central nervous system (on which most preclinical dMRI studies are focused), we also provide, where possible and applicable, recommendations for other organs of interest. An overarching goal herein is to enhance the rigor and reproducibility of small animal dMRI acquisitions and analyses, and thereby advance biomedical knowledge. © 2022, CC BY-NC-ND.

关键词： Invertebrates

QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation - analysis of Ranking Scores and Benchmarking Results

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arXiv 2021年

作者： Mehta, Raghav Filos, Angelos Baid, Ujjwal Sako, Chiharu McKinley, Richard Rebsamen, Michael Dätwyler, Katrin Meier, Raphael Radojewski, Piotr Murugesan, Gowtham Krishnan Nalawade, Sahil Ganesh, Chandan Wagner, Ben Yu, Fang F. Fei, Baowei Madhuranthakam, Ananth J. Maldjian, Joseph A. Daza, Laura Gómez, Catalina Arbeláez, Pablo Dai, Chengliang Wang, Shuo Reynaud, Hadrien Mo, Yuanhan Angelini, Elsa Guo, Yike Bai, Wenjia Banerjee, Subhashis Pei, Linmin Murat, A.K. Rosas-González, Sarahi Zemmoura, Ilyess Tauber, Clovis Vu, Minh H. Nyholm, Tufve Löfstedt, Tommy Ballestar, Laura Mora Vilaplana, Veronica McHugh, Hugh Talou, Gonzalo Maso Wang, Alan Patel, Jay Chang, Ken Hoebel, Katharina Gidwani, Mishka Arun, Nishanth Gupta, Sharut Aggarwal, Mehak Singh, Praveer Gerstner, Elizabeth R. Kalpathy-Cramer, Jayashree Boutry, Nicolas Huard, Alexis Vidyaratne, Lasitha Rahman, Md Monibor Iftekharuddin, Khan M. Chazalon, Joseph Puybareau, Elodie Tochon, Guillaume Ma, Jun Cabezas, Mariano Llado, Xavier Oliver, Arnau Valencia, Liliana Valverde, Sergi Amian, Mehdi Soltaninejad, Mohammadreza Myronenko, Andriy Hatamizadeh, Ali Feng, Xue Dou, Quan Tustison, Nicholas Meyer, Craig Shah, Nisarg A. Talbar, Sanjay Weber, Marc-André Mahajan, Abhishek Jakab, Andras Wiest, Roland Fathallah-Shaykh, Hassan M. Nazeri, Arash Milchenko, Mikhail Marcus, Daniel Kotrotsou, Aikaterini Colen, Rivka Freymann, John Kirby, Justin Davatzikos, Christos Menze, Bjoern Bakas, Spyridon Gal, Yarin Arbel, Tal McGill University MontrealQC Canada Group University of Oxford Oxford United Kingdom University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine The University of Pennsylvania PhiladelphiaPA United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States University Institute of Diagnostic and Interventional Neuroradiology University of Bern Inselspital Bern University Hospital Bern Switzerland Department of Radiology University of Texas Southwestern Medical Center DallasTX United States Department of Bioengineering University of Texas DallasTX United States Advanced Imaging Research Center University of Texas Southwestern Medical Center DallasTX United States Universidad de los Andes Bogotá Colombia Data Science Institute Imperial College London London United Kingdom NIHR Imperial BRC ITMAT Data Science Group Imperial College London London United Kingdom Department of Brain Sciences Imperial College London London United Kingdom Machine Intelligence Unit Indian Statistical Institute Kolkata India Department of CSE University of Calcutta Kolkata India Department of Information Technology Uppsala University Uppsala Sweden Department of Diagnostic Radiology The University of Pittsburgh Medical Center PittsburghPA United States UMR U1253 iBrain Université de Tours Inserm Tours France Department of Radiation Sciences Umeå University Umeå Sweden Department of Computing Science Umeå University Umeå Sweden Signal Theory and Communications Department Universitat Politècnica de Catalunya Barcelona Tech Barcelona Spain Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand Radiology Department Auckland City Hospital Auckland New Zealand Auckland Bioengineering Institute University of Auckland New Zealand Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology

Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment segmentation (e.g., tumor and lesion sub-regions) is particularly challenging, and potential errors hinder translating DL models into clinical workflows. Quantifying the reliability of DL model predictions in the form of uncertainties could enable clinical review of the most uncertain regions, thereby building trust and paving the way toward clinical translation. Several uncertainty estimation methods have recently been introduced for DL medical image segmentation tasks. Developing scores to evaluate and compare the performance of uncertainty measures will assist the end-user in making more informed decisions. In this study, we explore and evaluate a score developed during the BraTS 2019 and BraTS 2020 task on uncertainty quantification (QU-BraTS) and designed to assess and rank uncertainty estimates for brain tumor multi-compartment segmentation. This score (1) rewards uncertainty estimates that produce high confidence in correct assertions and those that assign low confidence levels at incorrect assertions, and (2) penalizes uncertainty measures that lead to a higher percentage of under-confident correct assertions. We further benchmark the segmentation uncertainties generated by 14 independent participating teams of QU-BraTS 2020, all of which also participated in the main BraTS segmentation task. Overall, our findings confirm the importance and complementary value that uncertainty estimates provide to segmentation algorithms, highlighting the need for uncertainty quantification in medical image analyses. Finally, in favor of transparency and reproducibility, our evaluation code is made publicly available at https://***/RagMeh11/QU-BraTS. © 2021, CC BY.

关键词： Benchmarking

Comparison of brain connectomes using geodesic distance on manifold: A twins study

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arXiv 2019年

作者： Yamin, A. Dayan, M. Squarcina, L. Brambilla, P. Murino, V. Diwadkar, V. Sona, D. Pattern Analysis and Computer Vision Istituto Italiano di Tecnologia Genova Italy Department of Electrical Electronics and Telecommunication Engineering and Naval Architecture Università degli Studi di Genova Italy Scientific Institute IRCCS "E. Medea" Bosisio Parini Italy Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Università di Milano Italy Department of Computer Science Università di Verona Italy Department of Psychiatry & Behavioral Neuroscience Wayne State University DetroitMI United States Neuroinformatics Laboratory Fondazione Bruno Kessler Trento Italy

fMRI is a unique non-invasive approach for understanding the functional organization of the human brain, and task-based fMRI promotes identification of functionally relevant brain regions associated with a given task. Here, we use fMRI (using the Poffenberger Paradigm) data collected in mono- and dizygotic twin pairs to propose a novel approach for assessing similarity in functional networks. In particular, we compared network similarity between pairs of twins in task-relevant and task-orthogonal networks. The proposed method measures the similarity between functional networks using a geodesic distance between graph Laplacians. With method we show that networks are more similar in monozygotic twins compared to dizygotic twins. Furthermore, the similarity in monozygotic twins is higher for task-relevant, than task-orthogonal networks. Copyright © 2019, The Authors. All rights reserved.

关键词： Brain

Deep learning methods for lung cancer segmentation in whole-slide histopathology images - The ACDC@lungHP challenge 2019

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arXiv 2020年

作者： Li, Zhang Zhang, Jiehua Tan, Tao Teng, Xichao Sun, Xiaoliang Li, Yang Liu, Lihong Xiao, Yang Lee, Byungjae Li, Yilong Zhang, Qianni Sun, Shujiao Zheng, Yushan Yan, Junyu Li, Ni Hong, Yiyu Ko, Junsu Jung, Hyun Liu, Yanling Chen, Yu-Cheng Wang, Ching-Wei Yurovskiy, Vladimir Maevskikh, Pavel Khanagha, Vahid Jiang, Yi Feng, Xiangjun Liu, Zhihong Li, Daiqiang Schüffler, Peter J. Yu, Qifeng Chen, Hui Tang, Yuling Litjens, Geert College of Aerospace Science and Engineering National University of Defense Technology Changsha410073 China Department of Mathematics and Computer Science Eindhoven University of Technology Netherlands and ScreenPoint Medical Eindhoven Nijmegen5600 MB Netherlands Pingan Technology Shenzhen China Lunit Inc. Seoul Korea Republic of School of Electrical Engineering and Computer Science Queen Mary University of London London United Kingdom Image Processing Center School of Astronautics Beihang University Beijing102206 China Beijing Advanced Innovation Center for Biomedical Engineering Beijing100191 China Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Image Processing Center School of Astronautics Beihang University Beijing102206 China AstLab School of Automatationm Beihang University Beijing China Department of R&D Center Arontier Co. Ltd. Seoul Korea Republic of Frederick National Laboratory United States Center of Computer Vision and Medical Imaging Graduate Institute of Biomedical Engineering Graduate institute of Applied Science and Technology National Taiwan University of Science and Technology AI Explore Taipei Taiwan Research Department Sky-chain Global Yekaterinburg Russia Audio Solutions Team Motorola Solutions Inc. PlantationFL United States Second Xiangya Hospital Central South University Changsha China Hunan Biotechnology Ltd. Changsha China Hunan Cancer Hospital Central South University Changsha China Memorial Sloan Kettering Cancer Center United States First Hospital of Changsha City Changsha China Radboud University Medical Center Nijmegen Netherlands

Accurate segmentation of lung cancer in pathology slides is a critical step in improving patient care. We proposed the ACDC@LungHP (Automatic Cancer Detection and Classification in Whole-slide Lung Histopathology) challenge for evaluating different computer-aided diagnosis (CADs) methods on the automatic diagnosis of lung cancer. The ACDC@LungHP 2019 focused on segmentation (pixel-wise detection) of cancer tissue in whole slide imaging (WSI), using an annotated dataset of 150 training images and 50 test images from 200 patients. This paper reviews this challenge and summarizes the top 10 submitted methods for lung cancer segmentation. All methods were evaluated using the false positive rate, false negative rate, and DICE coefficient (DC). The DC ranged from 0.7354±0.1149 to 0.8372±0.0858. The DC of the best method was close to the inter-observer agreement (0.8398±0.0890). All methods were based on deep learning and categorized into two groups: multi-model method and single model method. In general, multi-model methods were significantly better (p Copyright © 2020, The Authors. All rights reserved.

关键词： Biological organs

Aggregation Signature for Small Object Tracking

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arXiv 2019年

作者： Liu, Chunlei Ding, Wenrui Yang, Jinyu Murino, Vittorio Zhang, Baochang Han, Jungong Guo, Guodong School of Electrical and Information Engineering Beihang University Beijing China Unmanned System Research Institute Beihang University Beijing China School of Computer Science University of Birmingham British United Kingdom University of Verona Verona Italy Pattern Analysis and Computer Vision department Istituto Italiano di Tecnologia Genoa Italy School of Automation Science and Electrical Engineering Beihang University Beijing China Shenzhen Academy of Aerospace Technology Shenzhen China WMG Data Science Group University of Warwick CoventryCV4 7AL United Kingdom Institute of Deep Learning Baidu Research and National Engineering Laboratory for Deep Learning Technology and Application

—Small object tracking becomes an increasingly important task, which however has been largely unexplored in computer vision. The great challenges stem from the facts that: 1) small objects show extreme vague and variable appearances, and 2) they tend to be lost easier as compared to normal-sized ones due to the shaking of lens. In this paper, we propose a novel aggregation signature suitable for small object tracking, especially aiming for the challenge of sudden and large drift. We make three-fold contributions in this work. First, technically, we propose a new descriptor, named aggregation signature, based on saliency, able to represent highly distinctive features for small objects. Second, theoretically, we prove that the proposed signature matches the foreground object more accurately with a high probability. Third, experimentally, the aggregation signature achieves a high performance on multiple datasets, outperforming the state-of-the-art methods by large margins. Moreover, we contribute with two newly collected benchmark datasets, i.e., small90 and small112, for visually small object tracking. The datasets will be available in https://***/bczhangbczhang/. Copyright © 2019, The Authors. All rights reserved.

关键词： Large dataset

Morphologically Decoupled Structured Sparsity for Rotation-Invariant Hyperspectral image analysis

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Morphologically Decoupled Structured Sparsity for Rotation-I...

作者： Prasad, Saurabh Labate, Demetrio Cui, Minshan Zhang, Yuhang Hyperspectral Image Analysis Laboratory Department of Electrical and Computer Engineering University of Houston HoustonTX77004 United States Department of Mathematics University of Houston HoustonTX77004 United States

Hyperspectral imagery has emerged as a popular sensing modality for a variety of applications, and sparsity-based methods were shown to be very effective to deal with challenges coming from high dimensionality in most hyperspectral classification problems. In this paper, we challenge the conventional approach to hyperspectral classification that typically builds sparsity-based classifiers directly on spectral reflectance features or features derived directly from the data. We assert that hyperspectral image (HSI) processing can benefit very significantly by decoupling data into geometrically distinct components since the resulting decoupled components are much more suitable for sparse representation-based classifiers. Specifically, we apply morphological separation to decouple data into texture and cartoon-like components, which are sparsely represented using local discrete cosine bases and multiscale shearlets, respectively. In addition to providing a structured sparse representation, this approach allows us to build classifiers with invariance properties specific to each geometrically distinct component of the data. The experimental results using real-world HSI data sets demonstrate the efficacy of the proposed framework for classifying multichannel imagery under a variety of adverse conditions - in particular, small training sample size, additive noise, and rotational variabilities between training and test samples. © 2017 IEEE.

关键词： image analysis

Mineral Detection of Neutrinos and Dark Matter. A Whitepaper

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arXiv 2023年

作者： Baum, Sebastian Stengel, Patrick Abe, Natsue Acevedo, Javier F. Araujo, Gabriela R. Asahara, Yoshihiro Avignone, Frank Balogh, Levente Baudis, Laura Boukhtouchen, Yilda Bramante, Joseph Breur, Pieter Alexander Caccianiga, Lorenzo Capozzi, Francesco Collar, Juan I. Ebadi, Reza Edwards, Thomas Eitel, Klaus Elykov, Alexey Ewing, Rodney C. Freese, Katherine Fung, Audrey Galelli, Claudio Glasmacher, Ulrich A. Gleason, Arianna Hasebe, Noriko Hirose, Shigenobu Horiuchi, Shunsaku Hoshino, Yasushi Huber, Patrick Ido, Yuki Igami, Yohei Ishikawa, Norito Itow, Yoshitaka Kamiyama, Takashi Kato, Takenori Kavanagh, Bradley J. Kawamura, Yoji Kazama, Shingo Kenney, Christopher J. Kilminster, Ben Kouketsu, Yui Kozaka, Yukiko Kurinsky, Noah A. Leybourne, Matthew Lucas, Thalles McDonough, William F. Marshall, Mason C. Mateos, Jose Maria Mathur, Anubhav Michibayashi, Katsuyoshi Mkhonto, Sharlotte Murase, Kohta Naka, Tatsuhiro Oguni, Kenji Rajendran, Surjeet Sakane, Hitoshi Sala, Paola Scholberg, Kate Semenec, Ingrida Shiraishi, Takuya Spitz, Joshua Sun, Kai Suzuki, Katsuhiko Tanin, Erwin H. Vincent, Aaron Vladimirov, Nikita Walsworth, Ronald L. Watanabe, Hiroko Stanford Institute for Theoretical Physics Department of Physics Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Ferrara via Giuseppe Saragat 1 FerraraI-44122 Italy Kanagawa Yokohama236-0001 Japan SLAC National Accelerator Laboratory Stanford University 2575 Sand Hill Road Menlo ParkCA94025 United States Department of Physics University of Zurich Winterthurerstrasse 190 ZurichCH-8057 Switzerland Department of Earth and Environmental Sciences Graduate School of Environmental Studies Nagoya University Furo-cho Chikusa-ku Nagoya464-8601 Japan Department of Physics and Astronomy University of South Carolina ColumbiaSC29208 United States Mechanical and Materials Engineering Queen’s University 130 Stuart Street KingstonONK7L 2V9 Canada Department of Physics Engineering Physics and Astronomy Queen’s University 64 Bader Lane KingstonONK7L 2S8 Canada Perimeter Institute for Theoretical Physics WaterlooONN2J 2W9 Canada Istituto Nazionale di Fisica Nucleare Sezione di Milano Via Celoria 16 Milan Italy Dipartimento di Scienze Fisiche e Chimiche Università degli Studi dell’Aquila L’Aquila67100 Italy Department of Physics University of Chicago ChicagoIL60637 United States Department of Physics University of Maryland College ParkMD20742 United States Quantum Technology Center University of Maryland College ParkMD20742 United States The William H. Miller III Department of Physics and Astronomy The Johns Hopkins University BaltimoreMD21218 United States Institute for Astroparticle Physics Karlsruhe Institute of Technology Karlsruhe76021 Germany Earth and Planetary Sciences Stanford University StanfordCA94305-2115 United States Texas Center for Cosmology and Astroparticle Physics Weinberg Institute for Theoretical Physics Department of Physics The University of Texas at Austin AustinTX78712 United States The Oskar Klein Centre Department of Physics Stockholm University AlbaNova

Minerals are solid state nuclear track detectors – nuclear recoils in a mineral leave latent damage to the crystal structure. Depending on the mineral and its temperature, the damage features are retained in the material from minutes (in low-melting point materials such as salts at a few hundred ◦C) to timescales much larger than the 4.5 Gyr-age of the Solar System (in refractory materials at room temperature). The damage features from the O(50) MeV fission fragments left by spontaneous fission of 238U and other heavy unstable isotopes have long been used for fission track dating of geological samples. laboratory studies have demonstrated the readout of defects caused by nuclear recoils with energies as small as O(1) keV. This whitepaper discusses a wide range of possible applications of minerals as detectors for ER O(1) keV nuclear recoils: Using natural minerals, one could use the damage features accumulated over O(10) Myr–O(1) Gyr to measure astrophysical neutrino fluxes (from the Sun, supernovae, or cosmic rays interacting with the atmosphere) as well as search for Dark Matter. Using signals accumulated over months to few-years timescales in laboratory-manufactured minerals, one could measure reactor neutrinos or use them as Dark Matter detectors, potentially with directional sensitivity. Research groups in Europe, Asia, and America have started developing microscopy techniques to read out the O(1)–O(100) nm damage features in crystals left by O(0.1)–O(100) keV nuclear recoils. We report on the status and plans of these programs. The research program towards the realization of such detectors is highly interdisciplinary, combining geoscience, material science, applied and fundamental physics with techniques from quantum information and Artificial Intelligence. Copyright © 2023, The Authors. All rights reserved.

关键词： Minerals