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An Insight Into Neurodegeneration: Harnessing Functional MRI Connectivity in the Diagnosis of Mild Cognitive Impairment

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An Insight Into Neurodegeneration: Harnessing Functional MRI...

17th International Joint Conference on Biomedical engineering Systems and Technologies, BIOSTEC 2024

作者： Han, Shuning Sun, Zhe Zhao, Kanhao Duan, Feng Caiafa, Cesar F. Zhang, Yu Solé-Casals, Jordi Data and Signal Processing Research Group University of Vic-Central University of Catalonia Catalonia Vic08500 Spain Image Processing Research Group RIKEN Center for Advanced Photonics Riken Saitama Wako-Shi Japan Faculty of Health Data Science Juntendo University Chiba Urayasu Japan Department of Bioengineering Lehigh University BethlehemPA18015 United States Tianjin Key Laboratory of Brain Science and Intelligent Rehabilitation Nankai University Tianjin China Instituto Argentino de Radioastronomía-CCT La Plata CONICET/ CIC-PBA/ UNLP V. Elisa 1894 Argentina Department of Electrical and Computer Engineering Lehigh University BethlehemPA18015 United States Department of Psychiatry University of Cambridge CambridgeCB20SZ United Kingdom

Alzheimer’s disease is a progressive form of memory loss that worsens over time. Detecting it early, when memory issues are mild, is crucial for effective interventions. Recent advancements in computer technology, specifically Graph Convolutional Networks (GCNs), have proven to be powerful tools for analyzing Magnetic Resonance Imaging (MRI) data comprehensively. In this study, we developed a GCN framework for diagnosing mild cognitive impairment (MCI) by examining the functional connectivity (FC) derived from resting-state functional MRI (rfMRI) data. Our research systematically explored various types and processing methods of FC, evaluating their performance on the OASIS-3 dataset. The experimental results revealed several key findings. On the one hand, the proposed GCN exhibited significantly superior performance over both the baseline GCN and the Support Vector Machine (SVM) models, with statistically significant differences. It attained the highest average accuracy of 80.3% and a peak accuracy of 88.2%. On the other hand, the GCN frame work obtained using individual FCs showed overall slightly better performance than the one using global FCs. However, it is important to note that GCNs using global networks with appropriate connectivity can achieve comparable or even better performance than individual networks in certain cases. Finally, our results also indicate that the connectivity within specific brain regions, such as VIS, DMN, SMN, VAN, and FPC, may play a more significant role in GCN-based MRI classification for MCI diagnosis. These findings significantly contribute to the understanding of neurodegenerative disorders and offer valuable insights into the diverse ap plications of GCNs in brain analysis and disease detection. © 2024 by SCITEPRESS– Science and Technology Publications, Lda.

关键词： Neurodegenerative diseases

LYSTO: The Lymphocyte Assessment Hackathon and Benchmark Dataset

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arXiv 2023年

作者： Jiao, Yiping van der Laak, Jeroen Albarqouni, Shadi Li, Zhang Tan, Tao Bhalerao, Abhir Ma, Jiabo Sun, Jiamei Pocock, Johnathan Pluim, Josien P.W. Koohbanani, Navid Alemi Bashir, Raja Muhammad Saad Raza, Shan E Ahmed Liu, Sibo Graham, Simon Wetstein, Suzanne Khurram, Syed Ali Watson, Thomas Rajpoot, Nasir Veta, Mitko Ciompi, Francesco Department of Pathology Radboud University Medical Center Nijmegen Netherlands School of Artificial Intelligence Nanjing University of Information Science Technology China Center for Medical Image Science and Visualization Linköping University Linköping Sweden Helmholtz AI Helmholtz Zentrum München Nuerherberg 85764 Germany Faculty of Informatics Technical University of Munich Garching85748 Germany College of Aerospace Science and Engineering National University of Defense Technology China Hunan Provincial Key Laboratory of Image Measurement and Vision Navigation China Macao Polytechnic University China Department of Computer Science University of Warwick Coventry United Kingdom Huazhong University of Science and Technology China Singapore Medical Image Analysis Group Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands School of Clinical Dentistry University of Sheffield Sheffield United Kingdom United Kingdom

We introduce LYSTO, the Lymphocyte Assessment Hackathon, which was held in conjunction with the MICCAI 2019 Conference in Shenzen (China). The competition required participants to automatically assess the number of lymphocytes, in particular T-cells, in histopathological images of colon, breast, and prostate cancer stained with CD3 and CD8 immunohistochemistry. Differently from other challenges setup in medical image analysis, LYSTO participants were solely given a few hours to address this problem. In this paper, we describe the goal and the multi-phase organization of the hackathon;we describe the proposed methods and the on-site results. Additionally, we present post-competition results where we show how the presented methods perform on an independent set of lung cancer slides, which was not part of the initial competition, as well as a comparison on lymphocyte assessment between presented methods and a panel of pathologists. We show that some of the participants were capable to achieve pathologist-level performance at lymphocyte assessment. After the hackathon, LYSTO was left as a lightweight plug-and-play benchmark dataset on grand-challenge website, together with an automatic evaluation platform. LYSTO has supported a number of research in lymphocyte assessment in oncology. LYSTO will be a long-lasting educational challenge for deep learning and digital pathology, it is available at https://***/.MSC Codes 68T07 © 2023, CC BY.

关键词： Pathology

Line Drawing Guided Progressive Inpainting of Mural Damage

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arXiv 2022年

作者： Li, Luxi Zou, Qin Zhang, Fan Yu, Hongkai Chen, Long Song, Chengfang Huang, Xianfeng Wang, Xiaoguang Li, Qingquan Department of Computer Science Technology United International College of Beijing Normal University HongKong Baptist University Zhuhai China Machine Vision and Robotics Laboratory School of Computer Science Wuhan University Wuhan China State Key Laboratory of Surveying Mapping and Remote Sensing Information Engineering Wuhan University Wuhan China Department of Electrical Engineering and Computer Science Cleveland State University OH United States Institute of Automation Chinese Academy of Sciences Beijing China Cultural Heritage Intelligent Computing Laboratory Wuhan University Wuhan China Guangming Laboratory Shenzhen University Shenzhen China

Mural image inpainting is far less explored compared to its natural image counterpart and remains largely unsolved. Most existing image-inpainting methods tend to take the target image as the only input and directly repair the damage to generate a visually plausible result. These methods obtain high performance in restoration or completion of some pre-defined objects, e.g., human face, fabric texture, and printed texts, etc., however, are not suitable for repairing murals with varying subjects and large damaged areas. Moreover, due to discrete colors in paints, mural inpainting may suffer from apparent color bias. To this end, in this paper, we propose a line drawing guided progressive mural inpainting method. It divides the inpainting process into two steps: structure reconstruction and color correction, implemented by a structure reconstruction network (SRN) and a color correction network (CCN), respectively. In structure reconstruction, SRN utilizes the line drawing as an assistant to achieve large-scale content authenticity and structural stability. In color correction, CCN operates a local color adjustment for missing pixels which reduces the negative effects of color bias and edge jumping. The proposed approach is evaluated against the current state-of-the-art image inpainting methods. Qualitative and quantitative results demonstrate the superiority of the proposed method in mural image inpainting. The codes and data are available at https://***/qinnzou/mural-image-inpainting . © 2022, CC BY-NC-ND.

关键词： Restoration

Analyzing Diversity in Healthcare LLM Research: A Scientometric Perspective

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arXiv 2024年

作者： Restrepo, David Wu, Chenwei Vásquez-Venegas, Constanza Matos, João Gallifant, Jack Celi, Leo Anthony Bitterman, Danielle S. Nakayama, Luis Filipe Laboratory for Computational Physiology Massachusetts Institute of Technology CambridgeMA United States Departamento de Telematica Universidad del Cauca Cauca Popayán Colombia Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI United States Scientific Image Analysis Lab Faculty of Medicine Universidad de Chile RM Santiago Chile Department of Computer Science Faculty of Engineering Universidad de Concepción Biobio Concepción Chile Department of Biostatistics Harvard TH Chan School of Public Health BostonMA United States Department of Medicine Beth Israel Deaconess Medical Center BostonMA United States Artificial Intelligence in Medicine Program Mass General Brigham Harvard Medical School BostonMA United States Department of Ophthalmology São Paulo Federal University São Paulo São Paulo Brazil

The deployment of large language models (LLMs) in healthcare has demonstrated substantial potential for enhancing clinical decision-making, administrative efficiency, and patient outcomes. However, the underrepresentation of diverse groups in the development and application of these models can perpetuate biases, leading to inequitable healthcare delivery. This paper presents a comprehensive scientometric analysis of LLM research for healthcare, including data from January 1, 2021, to July 1, 2024. By analyzing metadata from PubMed and Dimensions, including author affiliations, countries, and funding sources, we assess the diversity of contributors to LLM research. Our findings highlight significant gender and geographic disparities, with a predominance of male authors and contributions primarily from high-income countries (HICs). We introduce a novel journal diversity index based on Gini diversity to measure the inclusiveness of scientific publications. Our results underscore the necessity for greater representation in order to ensure the equitable application of LLMs in healthcare. We propose actionable strategies to enhance diversity and inclusivity in artificial intelligence research, with the ultimate goal of fostering a more inclusive and equitable future in healthcare innovation. © 2024, CC BY.

关键词： Decision making

Deep cellular recurrent network for efficient analysis of time-series data with spatial information

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arXiv 2021年

作者： Vidyaratne, Lasitha Alam, Mahbubul Glandon, Alexander Shabalina, Anna Tennant, Christopher Iftekharuddin, Khan M. The Vision Lab in Department of Electrical and Computer Engineering Old Dominion University NorfolkVA23529 United States The Jefferson Laboratory Newport NewsVA23606 United States

Efficient processing of large-scale time series data is an intricate problem in machine learning. Conventional sensor signal processing pipelines with hand engineered feature extraction often involve huge computational cost with high dimensional data. Deep recurrent neural networks have shown promise in automated feature learning for improved time-series processing. However, generic deep recurrent models grow in scale and depth with increased complexity of the data. This is particularly challenging in presence of high dimensional data with temporal and spatial characteristics. Consequently, this work proposes a novel deep cellular recurrent neural network (DCRNN) architecture to efficiently process complex multi-dimensional time series data with spatial information. The cellular recurrent architecture in the proposed model allows for location-aware synchronous processing of time series data from spatially distributed sensor signal sources. Extensive trainable parameter sharing due to cellularity in the proposed architecture ensures efficiency in the use of recurrent processing units with high-dimensional inputs. This study also investigates the versatility of the proposed DCRNN model for classification of multi-class time series data from different application domains. Consequently, the proposed DCRNN architecture is evaluated using two time-series datasets: a multichannel scalp EEG dataset for seizure detection, and a machine fault detection dataset obtained in-house. The results suggest that the proposed architecture achieves state-of-the-art performance while utilizing substantially less trainable parameters when compared to comparable methods in the literature. © 2021, CC BY-NC-SA.

关键词： Clustering algorithms

Survey on Deep Face Restoration: From Non-blind to Blind and Beyond

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arXiv 2023年

作者： Li, Wenjie Wang, Mei Zhang, Kai Li, Juncheng Li, Xiaoming Zhang, Yuhang Gao, Guangwei Deng, Weihong Lin, Chia-Wen The Pattern Recognition and Intelligent System Laboratory School of Artificial Intelligence Beijing University of Posts and Telecommunications Beijing China The Computer Vision Lab ETH Zürich Zürich Switzerland The School of Communication and Information Engineering Shanghai University Shanghai China The Nanyang Technological University Singapore The Intelligent Visual Information Perception Laboratory Institute of Advanced Technology Nanjing University of Posts and Telecommunications Nanjing China The Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan

Face restoration (FR) is a specialized field within image restoration that aims to recover low-quality (LQ) face images into high-quality (HQ) face images. Recent advances in deep learning technology have led to significant progress in FR methods. In this paper, we begin by examining the prevalent factors responsible for real-world LQ images and introduce degradation techniques used to synthesize LQ images. We also discuss notable benchmarks commonly utilized in the field. Next, we categorize FR methods based on different tasks and explain their evolution over time. Furthermore, we explore the various facial priors commonly utilized in the restoration process and discuss strategies to enhance their effectiveness. In the experimental section, we thoroughly evaluate the performance of state-of-the-art FR methods across various tasks using a unified benchmark. We analyze their performance from different perspectives. Finally, we discuss the challenges faced in the field of FR and propose potential directions for future advancements. The open-source repository corresponding to this work can be found at https://***/24wenjie-li/Awesome-Face-Restoration. Copyright © 2023, The Authors. All rights reserved.

关键词： Restoration

DF-DM: A foundational process model for multimodal data fusion in the artificial intelligence era

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arXiv 2024年

作者： Restrepo, David Wu, Chenwei Vásquez-Venegas, Constanza Nakayama, Luis Filipe Celi, Leo Anthony López, Diego M. Laboratory for Computational Physiology Massachusetts Institute of Technology CambridgeMA United States Departamento de Telemática Universidad del Cauca Cauca Popayán Colombia Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI United States Scientific Image Analysis Lab Universidad de Chile Santiago Santiago Chile Department of Ophthalmology São Paulo Federal University São Paulo São Paulo Brazil Department of Biostatistics Harvard TH Chan School of Public Health BostonMA United States Department of Medicine Beth Israel Deaconess Medical Center BostonMA United States

In the big data era, integrating diverse data modalities poses significant challenges, particularly in complex fields like healthcare. This paper introduces a new process model for multimodal Data Fusion for Data Mining, integrating embeddings and the Cross-Industry Standard Process for Data Mining with the existing Data Fusion Information Group model. Our model aims to decrease computational costs, complexity, and bias while improving efficiency and reliability. We also propose"disentangled dense fusion," a novel embedding fusion method designed to optimize mutual information and facilitate dense inter-modality feature interaction, thereby minimizing redundant information. We demonstrate the model’s efficacy through three use cases: predicting diabetic retinopathy using retinal images and patient metadata, domestic violence prediction employing satellite imagery, internet, and census data, and identifying clinical and demographic features from radiography images and clinical notes. The model achieved a Macro F1 score of 0.92 in diabetic retinopathy prediction, an R-squared of 0.854 and sMAPE of 24.868 in domestic violence prediction, and a macro AUC of 0.92 and 0.99 for disease prediction and sex classification, respectively, in radiological analysis. These results underscore the Data Fusion for Data Mining model’s potential to significantly impact multimodal data processing, promoting its adoption in diverse, resource-constrained *** Codes 68T30 © 2024, CC BY.

关键词： Forecasting

NTIRE 2023 Challenge on Efficient Super-Resolution: Methods and Results

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NTIRE 2023 Challenge on Efficient Super-Resolution: Methods ...

2023 IEEE/CVF Conference on computer vision and Pattern Recognition Workshops, CVPRW 2023

作者： Li, Yawei Zhang, Yulun Timofte, Radu Van Gool, Luc Yu, Lei Li, Youwei Li, Xinpeng Jiang, Ting Wu, Qi Han, Mingyan Lin, Wenjie Jiang, Chengzhi Luo, Jinting Fan, Haoqiang Liu, Shuaicheng Wang, Yucong Cai, Minjie Li, Mingxi Zhang, Yuhang Fan, Xian-Jun Sheng, Yankai Mao, Yanyu Zhang, Nihao Wang, Qian Zheng, Mingjun Sun, Long Pan, Jinshan Dong, Jiangxin Tang, Jinhui Yang, Zhongbao Wang, Yan Pan, Erlin Cai, Qixuan Dai, Xinan Zhussip, Magauiya Kalyazin, Nikolay Vyal, Dmitry Zou, Xueyi Yan, Youliang Chung, Heaseo Zhang, Jin Yu, Gaocheng Zhang, Feng Wang, Hongbin Liao, Bohao Du, Zhibo Wu, Yu-Liang Shi, Gege Peng, Long Wang, Yang Cao, Yang Zha, Zhengjun Huang, Zhi-Kai Chen, Yi-Chung Chiang, Yuan-Chun Yang, Hao-Hsiang Chen, Wei-Ting Chang, Hua-En Chen, I-Hsiang Hsieh, Chia-Hsuan Kuo, Sy-Yen Liu, Xin Pan, Jiahao Yu, Hongyuan Yu, Weichen Ge, Lin Dong, Jiahua Zou, Yajun Wu, Zhuoyuan Han, Binnan Zhang, Xiaolin Zhang, Heng Yin, Xuanwu Zuo, Kunlong Deng, Weijian Yuan, Hongjie Lu, Zengtong Ouyang, Mingyu Ma, Wenzhuo Liu, Nian Zheng, Hanyou Zhang, Yuantong Zhang, Junxi Chen, Zhenzhong Gendy, Garas Sabor, Nabil Hou, Jingchao He, Guanghui Zhu, Yurui Wang, Xi Fu, Xueyang Zha, Zheng-Jun Yin, Daheng Liu, Mengyang Chen, Baijun Li, Ao Luo, Lei Jin, Kangjun Zhu, Ce Zhang, Xiaoming Xie, Chengxing Li, Linze Meng, Haiteng Zhang, Tianlin Li, Tianrui Zhao, Xiaole Zhang, Zhao Li, Baiang Zheng, Huan Zhao, Suiyi Gao, Yangcheng Ren, Jiahuan Hu, Kang Shi, Jingpeng Wu, Zhijian Huang, Dingjiang Zhu, Jinchen Li, Hui Xv, Qianru Liu, Tianle Weng, Shizhuang Wu, Gang Jiang, Junpeng Liu, Xianming Jiang, Junjun Zhang, Mingjian Hu, Jing Wu, Chengxu Fan, Qinrui Feng, Chengming Luo, Ziwei Hu, Shu Lyu, Siwei Wu, Xi Wang, Xin Computer Vision Lab ETH Zurich Switzerland Computer Vision Lab University of Würzburg Germany Megvii Technology China MicroBT China College of Computer Science and Electronic Engineering Hunan University China Attrsense Xian University of Posts and Telecommunications Xi'an China National Engineering Laboratory for Cyber Event Warning and Control Technologies China Nanjing University of Science and Technology China Nankai University China University of Electronic Science and Technology of China China Tianjin University China Noah's Ark Lab Huawei Technologies McMaster University Canada Espresomedia Korea Republic of AntGroup China University of Science and Technology of China China Department of Electrical Engineering National Taiwan University Taiwan Graduate Institute of Communication Engineering National Taiwan University Taiwan Graduate Institute of Electronics Engineering National Taiwan University Taiwan ServiceNow United States China Mobile Research Institute China Chongqing University of Technology China Multimedia Department Xiaomi Inc. China Institute of Automation Chinese Academy of Sciences China Shenyang Institute of Automation Chinese Academy of Sciences China School of Information and Communication Engineering Communication University of China China Smart Classroom Division Ruijie Networks Co. Ltd. China School of Remote Sensing and Information Engineering Wuhan University China Micro-Nano Electronics Department Shanghai Jiao Tong University Shanghai200240 China Electrical Engineering Department Faculty of Engineering Assiut University Assiut71516 Egypt Southeast University China University of Electronic Science and Technology of China Chengdu China Chongqing University of Posts and Telecommunications Chongqing China Information Technology Co. Ltd Hangzhou China Southwest Jiaotong University China National Space Science Center Chinese Academy of Science China Hefei University of Technology Hefei China Anhui University China Fried Ric

ISBN: (纸本)9798350302493

This paper reviews the NTIRE 2023 challenge on efficient single-image super-resolution with a focus on the proposed solutions and results. The aim of this challenge is to devise a network that reduces one or several aspects such as runtime, parameters, FLOPs, activations, memory footprint, and depth of RFDN while at least maintaining the PSNR of 29.00dB on DIV2K validation datasets. The challenge had 272 registered participants, and 35 teams made valid submissions. They gauge the state-of-the-art for efficient single-image super-resolution. © 2023 IEEE.

关键词： Optical resolving power

A Comprehensive Survey for Hyperspectral image Classification: The Evolution from Conventional to Transformers and Mamba Models

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arXiv 2024年

作者： Ahmad, Muhammad Distefano, Salvatore Khan, Adil Mehmood Mazzara, Manuel Li, Chenyu Li, Hao Aryal, Jagannath Ding, Yao Vivone, Gemine Hong, Danfeng Department of Computer Science National University of Computer and Emerging Sciences Islamabad Pakistan Dipartimento di Matematica e Informatica-MIFT University of Messina Messina98121 Italy School of Computer Science University of Hull HullHU6 7RX United Kingdom Institute of Software Development and Engineering Innopolis University Innopolis420500 Russia Aerospace Information Research Institute Chinese Academy of Sciences Beijing100094 China Big Geospatial Data Management Technical University of Munich Munich85521 Germany Department of Infrastructure Engineering University of Melbourne ParkvilleVIC Australia Intelligent Control Laboratory PLA Rocket Force University of Engineering Xi’an710025 China Institute of Methodologies for Environmental Analysis National Research Council Tito85050 Italy School of Electronic Electrical and Communication Engineering University of Chinese Academy of Sciences Beijing100049 China

Hyperspectral image Classification (HSC) presents significant challenges owing to the high dimensionality and intricate nature of Hyperspectral (HS) data. While traditional Machine Learning (TML) approaches have demonstrated effectiveness, they often encounter substantial obstacles in real-world applications, including the variability of optimal feature sets, subjectivity in human-driven design, inherent biases, and methodological limitations. Specifically, TML suffers from the curse of dimensionality, difficulties in feature selection and extraction, insufficient consideration of spatial information, limited robustness against noise, scalability issues, and inadequate adaptability to complex data distributions. In recent years, Deep Learning (DL) techniques have emerged as robust solutions to address these challenges. This survey offers a comprehensive overview of current trends and future prospects in HSC, emphasizing advancements from DL models to the increasing adoption of Transformer and Mamba Model architectures. We systematically review key concepts, methodologies, and state-of-the-art approaches in DL for HSC. Furthermore, we investigate the potential of Transformer-based models and the Mamba Model in HSC, detailing their advantages and challenges. Emerging trends in HSC are explored, including in-depth discussions on Explainable AI and Interoperability concepts, alongside Diffusion Models for image denoising, feature extraction, and image fusion. To substantiate the efficacy of various conventional DL models, Transformers, and the Mamba Model, comprehensive experimental results were conducted on three HS datasets, yielding notable accuracies: 99.94% on Pavia University, 99.41% on Indian Pines, and 99.97% on the University of Houston dataset. Additionally, we identify several open challenges and pertinent research questions in the field of HSC. Finally, we outline future research directions and potential applications aimed at enhancing the accuracy and effic

关键词： Convolutional neural networks