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arXiv 2021年

作者： Wagner, Martin Müller-Stich, Beat-Peter Kisilenko, Anna Tran, Duc Heger, Patrick Mündermann, Lars Lubotsky, David M. Müller, Benjamin Davitashvili, Tornike Capek, Manuela Reinke, Annika Yu, Tong Vardazaryan, Armine Innocent Nwoye, Chinedu Padoy, Nicolas Liu, Xinyang Lee, Eung-Joo Disch, Constantin Meine, Hans Xia, Tong Jia, Fucang Kondo, Satoshi Reiter, Wolfgang Jin, Yueming Long, Yonghao Jiang, Meirui Dou, Qi Heng, Pheng Ann Twick, Isabell Kirtac, Kadir Hosgor, Enes Bolmgren, Jon Lindström Stenzel, Michael von Siemens, Björn Kenngott, Hannes G. Nickel, Felix von Frankenberg, Moritz Mathis-Ullrich, Franziska Maier-Hein, Lena Speidel, Stefanie Bodenstedt, Sebastian Department for General Visceral and Transplantation Surgery Heidelberg University Hospital Im Neuenheimer Feld 420 Heidelberg69120 Germany Heidelberg Im Neuenheimer Feld 460 Heidelberg69120 Germany Data Assisted Solutions Corporate Research & Technology KARL STORZ SE & Co. KG Dr. Karl-Storz-Str. 34 Tuttlingen78332 Germany Im Neuenheimer Feld 223 Heidelberg69120 Germany Im Neuenheimer Feld 223 Heidelberg69120 Germany Faculty of Mathematics and Computer Science Heidelberg University Im Neuenheimer Feld 205 Heidelberg69120 Germany ICube University of Strasbourg CNRS France 300 bd Sébastien Brant - CS 10413 Illkirch CedexF-67412 France IHU Strasbourg France 1 Place de l'hôpital Strasbourg67000 France Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Hospital 111 Michigan Ave NW WashingtonDC20010 United States University of Maryland College Park 2405 A V Williams Building College ParkMD20742 United States Fraunhofer Institute for Digital Medicine MEVIS Max-von-Laue-Str. 2 Bremen28359 Germany University of Bremen FB3 Medical Image Computing Group ℅ Fraunhofer MEVIS Am Fallturm 1 Bremen28359 Germany Lab for Medical Imaging and Digital Surgery Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen518055 China Konika Minolta Inc. JP TOWER 2-7-2 Marunouchi Chiyoda-ku Tokyo100-7015 Japan Wintegral GmbH Ehrenbreitsteiner Str. 36 München80993 Germany Department of Computer Science and Engineering Ho Sin-Hang Engineering Building The Chinese University of Hong Kong Sha Tin NT Hong Kong Caresyntax GmbH Komturstr. 18A Berlin12099 Germany Department of Surgery Salem Hospital of the Evangelische Stadtmission Heidelberg Zeppelinstrasse 11-33 Heidelberg69121 Germany Health Robotics and Automation Laboratory Institute for Anthropomatics and Robotics Karlsruhe Institute of Technology Geb. 40.28 KIT Campus Süd Engler-Bunte-Ring 8 Karlsruhe76131 Germany Medical Faculty Heidelberg Uni

PURPOSE: Surgical workflow and skill analysis are key technologies for the next generation of cognitive surgical assistance systems. These systems could increase the safety of the operation through context-sensitive warnings and semi-autonomous robotic assistance or improve training of surgeons via data-driven feedback. In surgical workflow analysis up to 91% average precision has been reported for phase recognition on an open data single-center video dataset. In this work we investigated the generalizability of phase recognition algorithms in a multi-center setting including more difficult recognition tasks such as surgical action and surgical skill. METHODS: To achieve this goal, a dataset with 33 laparoscopic cholecystectomy videos from three surgical centers with a total operation time of 22 hours was created. Labels included framewise annotation of seven surgical phases with 250 phase transitions, 5514 occurences of four surgical actions, 6980 occurences of 21 surgical instruments from seven instrument categories and 495 skill classifications in five skill dimensions. The dataset was used in the 2019 international Endoscopic vision challenge, sub-challenge for surgical workflow and skill analysis. Here, 12 research teams trained and submitted their machine learning algorithms for recognition of phase, action, instrument and/or skill assessment. RESULTS: F1-scores were achieved for phase recognition between 23.9% and 67.7% (n=9 teams), for instrument presence detection between 38.5% and 63.8% (n=8 teams), but for action recognition only between 21.8% and 23.3% (n=5 teams). The average absolute error for skill assessment was 0.78 (n=1 team). CONCLUSION: Surgical workflow and skill analysis are promising technologies to support the surgical team, but are not solved yet, as shown by our comparison of machine learning algorithms. This novel HeiChole benchmark can be used for comparable evaluation and validation of future work. In future studies, it is of utmost impo

关键词： Learning algorithms

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Author Correction: Federated learning enables big data for rare cancer boundary detection

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Nature communications 2023年第1期14卷 436页

作者： Sarthak Pati Ujjwal Baid Brandon Edwards Micah Sheller Shih-Han Wang G Anthony Reina Patrick Foley Alexey Gruzdev Deepthi Karkada Christos Davatzikos Chiharu Sako Satyam Ghodasara Michel Bilello Suyash Mohan Philipp Vollmuth Gianluca Brugnara Chandrakanth J Preetha Felix Sahm Klaus Maier-Hein Maximilian Zenk Martin Bendszus Wolfgang Wick Evan Calabrese Jeffrey Rudie Javier Villanueva-Meyer Soonmee Cha Madhura Ingalhalikar Manali Jadhav Umang Pandey Jitender Saini John Garrett Matthew Larson Robert Jeraj Stuart Currie Russell Frood Kavi Fatania Raymond Y Huang Ken Chang Carmen Balaña Jaume Capellades Josep Puig Johannes Trenkler Josef Pichler Georg Necker Andreas Haunschmidt Stephan Meckel Gaurav Shukla Spencer Liem Gregory S Alexander Joseph Lombardo Joshua D Palmer Adam E Flanders Adam P Dicker Haris I Sair Craig K Jones Archana Venkataraman Meirui Jiang Tiffany Y So Cheng Chen Pheng Ann Heng Qi Dou Michal Kozubek Filip Lux Jan Michálek Petr Matula Miloš Keřkovský Tereza Kopřivová Marek Dostál Václav Vybíhal Michael A Vogelbaum J Ross Mitchell Joaquim Farinhas Joseph A Maldjian Chandan Ganesh Bangalore Yogananda Marco C Pinho Divya Reddy James Holcomb Benjamin C Wagner Benjamin M Ellingson Timothy F Cloughesy Catalina Raymond Talia Oughourlian Akifumi Hagiwara Chencai Wang Minh-Son To Sargam Bhardwaj Chee Chong Marc Agzarian Alexandre Xavier Falcão Samuel B Martins Bernardo C A Teixeira Flávia Sprenger David Menotti Diego R Lucio Pamela LaMontagne Daniel Marcus Benedikt Wiestler Florian Kofler Ivan Ezhov Marie Metz Rajan Jain Matthew Lee Yvonne W Lui Richard McKinley Johannes Slotboom Piotr Radojewski Raphael Meier Roland Wiest Derrick Murcia Eric Fu Rourke Haas John Thompson David Ryan Ormond Chaitra Badve Andrew E Sloan Vachan Vadmal Kristin Waite Rivka R Colen Linmin Pei Murat Ak Ashok Srinivasan J Rajiv Bapuraj Arvind Rao Nicholas Wang Ota Yoshiaki Toshio Moritani Sevcan Turk Joonsang Lee Snehal Prabhudesai Fanny Morón Jacob Mandel Konstantinos Kamnitsas Ben Glocker Luke V M Dixon Matthew Williams Peter Zamp Center for Biomedical Image Computing and Analytics (CBICA) University of Pennsylvania Philadelphia PA USA. Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Informatics Technical University of Munich Munich Bavaria Germany. Intel Corporation Santa Clara CA USA. Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany. Clinical Cooperation Unit Neuropathology German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ) Heidelberg Germany. Department of Neuropathology Heidelberg University Hospital Heidelberg Germany. Division of Medical Image Computing German Cancer Research Center Heidelberg Germany. Pattern Analysis and Learning Group Department of Radiation Oncology Heidelberg University Hospital Heidelberg Germany. Neurology Clinic Heidelberg University Hospital Heidelberg Germany. Department of Radiology & Biomedical Imaging University of California San Francisco San Francisco CA USA. Symbiosis Center for Medical Image Analysis Symbiosis International University Pune Maharashtra India. Department of Neuroimaging and Interventional Radiology National Institute of Mental Health and Neurosciences Bangalore Karnataka India. Department of Radiology School of Medicine and Public Health University of Wisconsin Madison WI USA. Department of Medical Physics School of Medicine and Public Health University of Wisconsin Madison WI USA. Leeds Teaching Hospitals Trust Department of Radiology Leeds UK. Department of Radiology Brigham and Women's Hospital Harvard Medical School Boston MA USA. Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown MA USA. Catalan Institute of Oncology Badalona Spain. Consorci MAR Parc de Salut de Barcelona Catalonia Spain. Department of Radiology (IDI

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Standardized Assessment of Automatic Segmentation of White Matter Hyperintensities and Results of the WMH Segmentation Challenge

arXiv

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arXiv 2019年

作者： Kuijf, Hugo J. Biesbroek, J. Matthijs Bresser, Jeroen de Heinen, Rutger Andermatt, Simon Bento, Mariana Berseth, Matt Belyaev, Mikhail Cardoso, M. Jorge Casamitjana, Adrià Collins, D. Louis Dadar, Mahsa Georgiou, Achilleas Ghafoorian, Mohsen Jin, Dakai Khademi, April Knight, Jesse Li, Hongwei Lladó, Xavier Luna, Miguel Mahmood, Qaiser McKinley, Richard Mehrtash, Alireza Ourselin, Sébastien Park, Bo-yong Park, Hyunjin Park, Sang Hyun Pezold, Simon Puybareau, Elodie Rittner, Leticia Sudre, Carole H. Valverde, Sergi Vilaplana, Verónica Wiest, Roland Xu, Yongchao Xu, Ziyue Zeng, Guodong Zhang, Jianguo Zheng, Guoyan Chen, Christopher Flier, Wiesje van der Barkhof, Frederik Viergever, Max A. Biessels, Geert Jan Image Sciences Institute UMC Utrecht Utrecht University Netherlands Brain Center Rudolf Magnus UMC Utrecht Utrecht University Netherlands Department of Radiology UMC Utrecht Department of Radiology LUMC Leiden Netherlands Department of Biomedical Engineering University of Basel Allschwil Switzerland Radiology and Clinical Neuroscience Hotchkiss Brain Institute University of Calgary AB Canada NLP Logix Skolkovo Institute of Science and Technology School of Biomedical Engineering and Imaging Sciences King’s College London Centre for Medical Image Computing University College London Signal Theory and Communications Department Universitat Politècnica de Catalunya BarcelonaTech Barcelona Spain McGill University Canada Computational Statistics and Machine Learning MSc University College London TomTom Amsterdam Netherlands Department of Radiology and Imaging Science National Institutes of Health United States Ryerson University Canada University of Guelph Canada Sun Yat-sen University University of Dundee Technical University of Munich Research institute of Computer Vision and Robotics University of Girona Spain Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology Daegu Korea Republic of Pakistan Institute of Nuclear Science and Technology Support Center for Advanced Neuroimaging Institute for Diagnostic and Interventional Neuroradiology Inselspital University of Bern Switzerland Electrical and Computer Engineering Department University of British Columbia Vancouver Department of Radiology Brigham and Women’s Hospital Harvard Medical School Boston School of Biomedical Engineering and Imaging Sciences King’s College London Suwon Korea Republic of School of Electronic and Electrical Engineering Sungkyunkwan University Suwon Korea Republic of France School of Electrical and Computer Engineering University of Campinas SP Brazil School of Biomedical Engineering and Imaging Sciences King’s College London Centre for Medical I

Quantification of cerebral white matter hyperintensities (WMH) of presumed vascular origin is of key importance in many neurological research studies. Currently, measurements are often still obtained from manual segmentations on brain MR images, which is a laborious procedure. Automatic WMH segmentation methods exist, but a standardized comparison of the performance of such methods is lacking. We organized a scientific challenge, in which developers could evaluate their method on a standardized multi-center/-scanner image dataset, giving an objective comparison: the WMH Segmentation Challenge (https://***/).Sixty T1+FLAIR images from three MR scanners were released with manual WMH segmentations for training. A test set of 110 images from five MR scanners was used for evaluation. Segmentation methods had to be containerized and submitted to the challenge organizers. Five evaluation metrics were used to rank the methods: (1) Dice similarity coefficient, (2) modified Hausdorff distance (95th percentile), (3) absolute log-transformed volume difference, (4) sensitivity for detecting individual lesions, and (5) F1-score for individual lesions. Additionally, methods were ranked on their inter-scanner *** participants submitted their method for evaluation. This paper provides a detailed analysis of the results. In brief, there is a cluster of four methods that rank significantly better than the other methods, with one clear winner. The inter-scanner robustness ranking shows that not all methods generalize to unseen *** challenge remains open for future submissions and provides a public platform for method evaluation. Copyright © 2019, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

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Augmented Cognition via Brainwave Entrainment in Virtual Reality: An Open, Integrated Brain Augmentation in a Neuroscience System Approach

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Augmented Human research 2017年第1期2卷 1-14页

作者： Emanuele Argento George Papagiannakis Eva Baka Michail Maniadakis Panos Trahanias Michael Sfakianakis Ioannis Nestoros Computational Vision and Robotics Laboratory Institute of Computer Science Foundation for Research and Technology Heraklion Greece Department of Computer Science University of Crete Heraklion Greece Department of Medicine University of Greece Heraklion Greece Department of Business Administration University of Piraeus Piraeus Greece Synchronal Amphiaraia University of Crete Snip-off Company Athens Greece

Building on augmented cognition theory and technology, our novel contribution in this work enables accelerated, certain brain functions related to task performance as well as their enhancement. We integrated in an open-source framework, latest immersive virtual reality (VR) head-mounted displays, with the Emotiv EPOC EEG headset in an open neuro- and biofeedback system for cognitive state detection and augmentation. Our novel methodology allows to significantly accelerate content presentation in immersive VR, while lowering brain frequency at alpha level—without losing content retention by the user. In our pilot experiments, we tested our innovative VR platform by presenting to N = 25 subjects a complex 3D maze test and different learning procedures for them on how to exit it. The subjects exposed to our VR-induced entrainment learning technology performed significantly better than those exposed to other “classical” learning procedures. In particular, cognitive task performance augmentation was measured for: learning time, complex navigational skills and decision-making abilities, orientation ability.

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Development of a swarm UAV simulator integrating realistic motion control models for disaster operations

arXiv

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arXiv 2017年

作者： Siddiqui, Kazi Tanvir Ahmed Feil-Seifer, David Jiang, Tianyi Jose, Sonu Liu, Siming Louis, Sushil Robotics Research Laboratory Computer Science and Engineering Department University of Nevada Reno Reno Nevada89557 United States Evolutionary Computing Systems Lab Computer Science and Engineering Department University of Nevada Reno Reno Nevada89557 United States

Simulation environments for Unmanned Aerial Vehicles (UAVs) can be very useful for prototyping user interfaces and training personnel that will operate UAVs in the real world. The realistic operation of such simulations will only enhance the value of such training. In this paper, we present the integration of a model-based waypoint navigation controller into the Reno Rescue Simulator for the purposes of providing a more realistic user interface in simulated environments. We also present potential uses for such simulations, even for real-world operation of UAVs. Copyright © 2017, The Authors. All rights reserved.

关键词： Unmanned aerial vehicles (UAV)

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The ultra-high-energy event KM3-230213A within the global neutrino landscape

arXiv

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arXiv 2025年

作者： Adriani, O. Aiello, S. Albert, A. Alhebsi, A.R. Alshamsi, M. Garre, S. Alves Ambrosone, A. Ameli, F. Andre, M. Aphecetche, L. Ardid, M. Ardid, S. Argüelles, C. Aublin, J. Badaracco, F. Bailly-Salins, L. Bardačová, Z. Baret, B. Bariego-Quintana, A. Becherini, Y. Bendahman, M. Gualandi, F. Benfenati Benhassi, M. Bennani, M. Benoit, D.M. Berbee, E. Berti, E. Bertin, V. Betti, P. Biagi, S. Boettcher, M. Bonanno, D. Bottai, S. Bouasla, A.B. Boumaaza, J. Bouta, M. Bouwhuis, M. Bozza, C. Bozza, R.M. Brânzaş, H. Bretaudeau, F. Breuhaus, M. Bruijn, R. Brunner, J. Bruno, R. Buis, E. Buompane, R. Busto, J. Caiffi, B. Calvo, D. Capone, A. Carenini, F. Carretero, V. Cartraud, T. Castaldi, P. Cecchini, V. Celli, S. Cerisy, L. Chabab, M. Chen, A. Cherubini, S. Chiarusi, T. Circella, M. Clark, R. Cocimano, R. Coelho, J.A.B. Coleiro, A. Condorelli, A. Coniglione, R. Coyle, P. Creusot, A. Cuttone, G. Dallier, R. De Benedittis, A. De Wasseige, G. Decoene, V. Deguire, P. Del Rosso, I. Di Mauro, L.S. Di Palma, I. Díaz, A.F. Diego-Tortosa, D. Distefano, C. Domi, A. Donzaud, C. Dornic, D. Drakopoulou, E. Drouhin, D. Ducoin, J.-G. Duverne, P. Dvornický, R. Eberl, T. Eckerová, E. Eddymaoui, A. van Eeden, T. Eff, M. van Eijk, D. El Bojaddaini, I. El Hedri, S. El Mentawi, S. Ellajosyula, V. Enzenhöfer, A. Ferrara, G. Filipović, M.D. Filippini, F. Franciotti, D. Fusco, L.A. Gal, T. Méndez, J. García Soto, A. Garcia Oliver, C. Gatius Geißelbrecht, N. Genton, E. Ghaddari, H. Gialanella, L. Gibson, B.K. Giorgio, E. Goos, I. Goswami, P. Gozzini, S.R. Gracia, R. Guidi, C. Guillon, B. Gutiérrez, M. Haack, C. van Haren, H. Heijboer, A. Hennig, L. Hernández-Rey, J.J. Idrissi, A. Ibnsalih, W. Idrissi Illuminati, G. Janik, O. Joly, D. de Jong, M. de Jong, P. Jung, B.J. Kalaczyński, P. Kamp, N. Keegans, J. Kikvadze, V. Kistauri, G. Kopper, C. Kouchner, A. Kovalev, Y.Y. Krupa, L. Kueviakoe, V. Kulikovskiy, V. Kvatadze, R. Labalme, M. Lahmann, R. INFN Sezione di Firenze via Sansone 1 Sesto Fiorentino50019 Italy Università di Firenze Dipartimento di Fisica e Astronomia via Sansone 1 Sesto Fiorentino50019 Italy Via Santa Sofia 64 Catania95123 Italy Université de Strasbourg CNRS IPHC UMR 7178 StrasbourgF-67000 France Université de Haute Alsace rue des Frères Lumière Mulhouse68093 Cedex France Khalifa University of Science and Technology Department of Physics PO Box 127788 Abu Dhabi United Arab Emirates Aix Marseille Univ CNRS IN2P3 CPPM Marseille France c/Catedrático José Beltrán 2 Valencia Paterna46980 Spain Università di Napoli "Federico II" Dip. Scienze Fisiche "E. Pancini" Complesso Universitario di Monte S. Angelo Via Cintia ed. G Napoli80126 Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo Via Cintia ed. G Napoli80126 Italy INFN Sezione di Roma Piazzale Aldo Moro 2 Roma00185 Italy Universitat Politècnica de Catalunya Laboratori d’Aplicacions Bioacústiques Centre Tecnològic de Vilanova i la Geltrú Avda. Rambla Exposició s/n Vilanova i la Geltrú08800 Spain Subatech IMT Atlantique IN2P3-CNRS Nantes Université 4 rue Alfred Kastler - La Chantrerie BP Nantes20722 44307 France Universitat Politècnica de València Instituto de Investigación para la Gestión Integrada de las Zonas Costeras C/ Paranimf 1 Gandia46730 Spain Harvard University Department of Physics Laboratory for Particle Physics and Cosmology Lyman Laboratory 17 Oxford St. CambridgeMA02138 United States Université Paris Cité CNRS Astroparticule et Cosmologie ParisF-75013 France INFN Sezione di Genova Via Dodecaneso 33 Genova16146 Italy Università di Genova Via Dodecaneso 33 Genova16146 Italy LPC CAEN Normandie Univ ENSICAEN UNICAEN CNRS IN2P3 6 boulevard Maréchal Juin Caen14050 France Comenius University in Bratislava Department of Nuclear Physics and Biophysics Mlynska dolina F1 Bratislava842 48 Slovakia Czech Technical University in Prague Institute of Experimen

On February 13th, 2023, the KM3NeT/ARCA telescope detected a neutrino candidate with an estimated energy in the hundreds of PeVs. In this article, the observation of this ultra-high-energy neutrino is discussed in light of null observations above tens of PeV from the IceCube and Pierre Auger observatories. Performing a joint fit of all experiments under the assumption of an isotropic E−2 flux, the best-fit single-flavour flux normalisation is E2Φ1fν+ν¯ = 7.5 × 10−10 GeVcm−2s−1sr−1 in the 90% energy range of the KM3NeT event. Furthermore, the ultra-high-energy data are then fit together with the IceCube measurements at lower energies, either with a single power law or with a broken power law, allowing for the presence of a new component in the spectrum. The joint fit including non-observations by other experiments in the ultra-high-energy region shows a slight preference for a break in the PeV regime if the "High-Energy Starting Events" sample is included, and no such preference for the other two IceCube samples investigated. A stronger preference for a break appears if only the KM3NeT data is considered in the ultra-high-energy region, though the flux resulting from such a fit would be inconsistent with null observations from IceCube and Pierre Auger. In all cases, the observed tension between KM3NeT and other datasets is of the order of 2.5σ − 3σ, and increased statistics are required to resolve this apparent tension and better characterise the neutrino landscape at ultra-high energies. Copyright © 2025, The Authors. All rights reserved.

关键词： Neutrons

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The Liver Tumor Segmentation Benchmark (LiTS)

arXiv

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arXiv 2019年

作者： Bilic, Patrick Christ, Patrick Li, Hongwei Bran Vorontsov, Eugene Ben-Cohen, Avi Kaissis, Georgios Szeskin, Adi Jacobs, Colin Mamani, Gabriel Efrain Humpire Chartrand, Gabriel Lohöfer, Fabian Holch, Julian Walter Sommer, Wieland Hofmann, Felix Hostettler, Alexandre Lev-Cohain, Naama Drozdzal, Michal Amitai, Michal Marianne Vivanti, Refael Sosna, Jacob Ezhov, Ivan Sekuboyina, Anjany Navarro, Fernando Kofler, Florian Paetzold, Johannes C. Shit, Suprosanna Hu, Xiaobin Lipková, Jana Rempfler, Markus Piraud, Marie Kirschke, Jan Wiestler, Benedikt Zhang, Zhiheng Hülsemeyer, Christian Beetz, Marcel Ettlinger, Florian Antonelli, Michela Bae, Woong Bellver, Míriam Bi, Lei Chen, Hao Chlebus, Grzegorz Dam, Erik B. Dou, Qi Fu, Chi-Wing Georgescu, Bogdan Giró-I-Nieto, Xavier Gruen, Felix Han, Xu Heng, Pheng-Ann Hesser, Jürgen Moltz, Jan Hendrik Igel, Christian Isensee, Fabian Jäger, Paul Jia, Fucang Kaluva, Krishna Chaitanya Khened, Mahendra Kim, Ildoo Kim, Jae-Hun Kim, Sungwoong Kohl, Simon Konopczynski, Tomasz Kori, Avinash Krishnamurthi, Ganapathy Li, Fan Li, Hongchao Li, Junbo Li, Xiaomeng Lowengrub, John Ma, Jun Maier-Hein, Klaus Maninis, Kevis-Kokitsi Meine, Hans Merhof, Dorit Pai, Akshay Perslev, Mathias Petersen, Jens Pont-Tuset, Jordi Qi, Jin Qi, Xiaojuan Rippel, Oliver Roth, Karsten Sarasua, Ignacio Schenk, Andrea Shen, Zengming Torres, Jordi Wachinger, Christian Wang, Chunliang Weninger, Leon Wu, Jianrong Xu, Daguang Yang, Xiaoping Yu, Simon Chun-Ho Yuan, Yading Yue, Miao Zhang, Liping Cardoso, Jorge Bakas, Spyridon Braren, Rickmer Heinemann, Volker Pal, Christopher Tang, An Kadoury, Samuel Soler, Luc van Ginneken, Bram Greenspan, Hayit Joskowicz, Leo Menze, Bjoern Department of Informatics Technical University of Munich Germany Department of Quantitative Biomedicine University of Zurich Switzerland Ecole Polytechnique de Montréal Canada Department of Medical Imaging Radboud University Medical Center Nijmegen Netherlands Department of Biomedical Engineering Tel-Aviv University Israel Germany Pattern Analysis and Learning Group Department of Radiation Oncology Heidelberg University Hospital Heidelberg Germany Philips Research China Philips China Innovation Campus Shanghai China School of Biomedical Engineering & Imaging Sciences King0s College London London United Kingdom Institute for AI in Medicine Technical University of Munich Germany Department of Computer Science Guangdong University of Foreign Studies China Institute for diagnostic and interventional radiology Klinikum rechts der Isar Technical University of Munich Germany Institute for Diagnostic and Interventional Neuroradiology Klinikum Rechts der Isar Technical University of Munich Germany Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital Nanjing University Medical School China Department of Computing Imperial College London London United Kingdom Institute for Tissue Engineering and Regenerative Medicine Helmholtz Zentrum München Neuherberg Germany Brigham and Women's Hospital Harvard Medical School United States School of Computer Science and Engineering The Hebrew University of Jerusalem Israel University of Pennsylvania PA United States Pte. Ltd. Singapore Medical Imaging and Reconstruction Lab Department of Engineering Design Indian Institute of Technology Madras India Sensetime Shanghai China Department of Radiology Perelman School of Medicine University of Pennsylvania United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PA United States Co. Ltd China MontréalQC Canada Department of Radiology Radiation Oncology and Nuclear Medicine University of Montréal

In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image computing and computer-Assisted Intervention (MICCAI) 2017 and 2018. The image dataset is diverse and contains primary and secondary tumors with varied sizes and appearances with various lesion-to-background levels (hyper-/hypo-dense), created in collaboration with seven hospitals and research institutions. Seventy-five submitted liver and liver tumor segmentation algorithms were trained on a set of 131 computed tomography (CT) volumes and were tested on 70 unseen test images acquired from different patients. We found that not a single algorithm performed best for both liver and liver tumors in the three events. The best liver segmentation algorithm achieved a Dice score of 0.963, whereas, for tumor segmentation, the best algorithms achieved Dices scores of 0.674 (ISBI 2017), 0.702 (MICCAI 2017), and 0.739 (MICCAI 2018). Retrospectively, we performed additional analysis on liver tumor detection and revealed that not all top-performing segmentation algorithms worked well for tumor detection. The best liver tumor detection method achieved a lesion-wise recall of 0.458 (ISBI 2017), 0.515 (MICCAI 2017), and 0.554 (MICCAI 2018), indicating the need for further research. LiTS remains an active benchmark and resource for research, e.g., contributing the liver-related segmentation tasks in http://***/. In addition, both data and online evaluation are accessible via ***. © 2019, CC BY-NC-ND.

关键词： Deep learning

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Author Correction: Observation of an ultra-high-energy cosmic neutrino with KM3NeT

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Nature 2025年第8057期640卷 E3页

作者： S. Aiello R. Bruno G. Ferrara E. Leonora F. Longhitano N. Randazzo A. Sinopoulou I. Tosta e Melo A. Albert D. Drouhin T. Pradier A. R. Alhebsi S. Thoudam A. van Vliet M. Alshamsi V. Bertin M. Breuhaus J. Brunner J. Busto L. Cerisy P. Coyle B. De Martino D. Dornic J.-G. Ducoin A. Enzenhöfer S. Henry D. Joly S. Lancelin S. Le Stum N. Lumb F. Magnani C. Paries M. Perrin-Terrin G. Vannoye S. Alves Garre A. Bariego-Quintana D. Calvo V. Cecchini A. Garcia Soto S. R. Gozzini J. J. Hernández-Rey A. Lazo N. Lessing J. Palacios González E. J. Pastor Gomez J. Prado D. Real A. Šaina F. Salesa Greus A. Sánchez Losa J. D. Zornoza J. Zúñiga A. Ambrosone M. Bendahman M. Benhassi C. Bozza R. M. Bozza R. Buompane A. Condorelli A. De Benedittis L. A. Fusco L. Gialanella W. Idrissi Ibnsalih A. Manfreda A. Marinelli F. Marzaioli S. Mastroianni G. Miele P. Migliozzi M. L. Mitsou C. M. Mollo L. Morales-Gallegos M. R. Musone V. Oliviero C. Poirè I. C. Rea A. Simonelli B. Spisso D. Vivolo F. Ameli A. Capone S. Celli I. Di Palma S. Gagliardini M. Mastrodicasa C. A. Nicolau A. Tudorache A. Veutro A. Zegarelli M. Andre M. Anghinolfi F. Badaracco B. Caiffi V. Ellajosyula C. Guidi V. Kulikovskiy L. Malerba M. Marconi B. Ó Fearraigh V. Parisi A. Romanov M. Sanguineti M. Taiuti S. Zavatarelli L. Aphecetche F. Bretaudeau R. Dallier V. Decoene L. Martin M. Ardid S. Ardid J. García Méndez C. A. Quiroz-Rangel C. Argüelles N. Kamp A. Y. Wen H. Atmani J. Boumaaza A. Eddymaoui Y. Tayalati J. Aublin B. Baret Y. Becherini T. Cartraud J. A. B. Coelho A. Coleiro S. Colonges A. Creusot C. Donzaud M. Eff S. El Hedri I. Goos P. Goswami A. Ilioni A. Kouchner M. Lindsey Clark E. Oukacha S. Peña Martínez R. Pestes A. Sharma B. Trocmé V. Van Elewyck C. Verilhac I. Lhenry-Yvon L. Bailly-Salins M. Bennani B. Guillon M. Labalme C. Lastoria G. Lehaut I. Mozun Mateo V. Pestel A. Vacheret Z. Bardačová E. Eckerová F. Mamedov Y. Shitov I. Štekl R. Dvornický F. Šimkovic F. Benfenati Gualandi F. Carenini P. Castaldi T. Chiarusi I. Del Rosso G. Levi A. Margiotta R. Muller INFN Sezione di Catania (INFN-CT) Catania Italy INFN Laboratori Nazionali del Sud (LNS) Catania Italy Dipartimento di Fisica e Astronomia “Ettore Majorana” Università di Catania (INFN-CT) Catania Italy Université de Strasbourg CNRS IPHC UMR 7178 Strasbourg France Université de Haute Alsace Mulhouse France Department of Physics Khalifa University Abu Dhabi United Arab Emirates Aix Marseille Université CNRS/IN2P3 CPPM Marseille France IFIC - Instituto de Física Corpuscular (CSIC - Universitat de València) Paterna Spain INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo Napoli Italy Università di Napoli “Federico II” Dip. Scienze Fisiche “E. Pancini” Complesso Universitario di Monte S. Angelo Napoli Italy Dipartimento di Matematica e Fisica Università degli Studi della Campania “Luigi Vanvitelli” Caserta Italy Dipartimento di Fisica Università di Salerno e INFN Gruppo Collegato di Salerno Fisciano Italy INFN Sezione di Roma Roma Italy Dipartimento di Fisica Università La Sapienza Roma Italy Laboratori d’Aplicacions Bioacústiques Centre Tecnològic de Vilanova i la Geltrú Universitat Politècnica de Catalunya Vilanova i la Geltrú Spain INFN Sezione di Genova Genova Italy Università di Genova Genova Italy LPC CAEN Normandie Université ENSICAEN UNICAEN CNRS/IN2P3 Caen France Subatech IMT Atlantique IN2P3-CNRS Nantes Université Nantes France Instituto de Investigación para la Gestión Integrada de las Zonas Costeras Universitat Politècnica de València Gandia Spain Department of Physics Harvard University Cambridge MA USA Laboratory for Particle Physics and Cosmology Lyman Laboratory Harvard University Cambridge MA USA Faculty of Sciences University Mohammed V in Rabat Rabat Morocco Institute of Applied Physics Mohammed VI Polytechnic University Ben Guerir Morocco Astroparticule et Cosmologie Université Paris Cité CNRS Paris France Institut Universitaire de France Paris France Institute of Experimental and Applied Physics

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Identifying the best machine learning algorithms for brain tumor segmentation, progression assessment, and overall survival prediction in the BRATS challenge

arXiv

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arXiv 2018年

作者： Bakas, Spyridon Reyes, Mauricio Jakab, Andras Bauer, Stefan Rempfler, Markus Crimi, Alessandro Shinohara, Russell Takeshi Berger, Christoph Ha, Sung Min Rozycki, Martin Prastawa, Marcel Alberts, Esther Lipkova, Jana Freymann, John Kirby, Justin Bilello, Michel Fathallah-Shaykh, Hassan M. Wiest, Roland Kirschke, Jan Wiestler, Benedikt Colen, Rivka Kotrotsou, Aikaterini Lamontagne, Pamela Marcus, Daniel Milchenko, Mikhail Nazeri, Arash Weber, Marc-Andr Mahajan, Abhishek Baid, Ujjwal Gerstner, Elizabeth Kwon, Dongjin Acharya, Gagan Agarwal, Manu Alam, Mahbubul Albiol, Alberto Albiol, Antonio Albiol, Francisco J. Alex, Varghese Allinson, Nigel Amorim, Pedro H.A. Amrutkar, Abhijit Anand, Ganesh Andermatt, Simon Arbel, Tal Arbelaez, Pablo Avery, Aaron Azmat, Muneeza Pranjal, B. Bai, Wenjia Banerjee, Subhashis Barth, Bill Batchelder, Thomas Batmanghelich, Kayhan Battistella, Enzo Beers, Andrew Belyaev, Mikhail Bendszus, Martin Benson, Eze Bernal, Jose Bharath, Halandur Nagaraja Biros, George Bisdas, Sotirios Brown, James Cabezas, Mariano Cao, Shilei Cardoso, Jorge M. Carver, Eric N. Casamitjana, Adri Castillo, Laura Silvana Cat, Marcel Cattin, Philippe Cérigues, Albert Chagas, Vinicius S. Chandra, Siddhartha Chang, Yi-Ju Chang, Shiyu Chang, Ken Chazalon, Joseph Chen, Shengcong Chen, Wei Chen, Jefferson W. Chen, Zhaolin Cheng, Kun Choudhury, Ahana Roy Chylla, Roger Clrigues, Albert Colleman, Steven Colmeiro, Ramiro German Rodriguez Combalia, Marc Costa, Anthony Cui, Xiaomeng Dai, Zhenzhen Dai, Lutao Daza, Laura Alexandra Deutsch, Eric Ding, Changxing Dong, Chao Dong, Shidu Dudzik, Wojciech Eaton-Rosen, Zach Egan, Gary Escudero, Guilherme Estienne, Tho Everson, Richard Fabrizio, Jonathan Fan, Yong Fang, Longwei Feng, Xue Ferrante, Enzo Fidon, Lucas Fischer, Martin French, Andrew P. Fridman, Naomi Fu, Huan Fuentes, David Gao, Yaozong Gates, Evan Gering, David Gholami, Amir Gierke, Willi Glocker, Ben Gong, Mingming Gonzlez-Vill, Sandra Grosges, T. Guan, Yuanfang Guo, Sheng Gupta, Sudeep Han, Woo-Sup Han, Il Song Harmuth, Ko Center for Biomedical Image Computing and Analytics University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Institute for Surgical Technology and Biomechanics University of Bern Bern Switzerland Center for MR-Research University Children's Hospital Zurich Zurich Switzerland Support Centre for Advanced Neuroimaging Inselspital Institute for Diagnostic and Interventional Neuroradiology Bern University Hospital Bern Switzerland University Hospital of Zurich Zurich Switzerland Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Philadelphia United States Image-Based Biomedical Modeling Group Technical University of Munich Munich Germany Icahn School of Medicine Mount Sinai Health System New YorkNY United States Leidos Biomedical Research Inc. Frederick National Laboratory for Cancer Research FrederickMD21701 United States Cancer Imaging Program National Cancer Institute National Institutes of Health BethesdaMD20814 United States Department of Neurology University of Alabama at Birmingham BirminghamAL United States Department of Diagnostic Radiology University of Texas MD Anderson Cancer Center HoustonTX United States Department of Psychology Washington University St. LouisMO United States Neuroimaging Informatics and Analysis Center Washington University St. LouisMO United States Department of Radiology Washington University St. LouisMO United States Institute of Diagnostic and Interventional Radiology Pediatric Radiology and Neuroradiology University Medical Center Rostock Ernst-Heydemann-Str. 6 Rostock18057 Germany Tata Memorial Centre Homi Bhabha National Institute Mumbai India Shri Guru Gobind Singhji Institute of Engineering and Technology Nanded India NVIDIA Santa Clara

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-phenotype, as their sub-regions are depicted by varying intensity profiles disseminated across multi-parametric magnetic resonance imaging (mpMRI) scans, reflecting varying biological properties. Their heterogeneous shape, extent, and location are some of the factors that make these tumors difficult to resect, and in some cases inoperable. The amount of resected tumor is a factor also considered in longitudinal scans, when evaluating the apparent tumor for potential diagnosis of progression. Furthermore, there is mounting evidence that accurate segmentation of the various tumor sub-regions can offer the basis for quantitative image analysis towards prediction of patient overall survival. This study assesses the state-of-the-art machine learning (ML) methods used for brain tumor image analysis in mpMRI scans, during the last seven instances of the International Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we focus on i) evaluating segmentations of the various glioma sub-regions in pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO criteria, and iii) predicting the overall survival from pre-operative mpMRI scans of patients that underwent gross total resection. Finally, we investigate the challenge of identifying the best ML algorithms for each of these tasks, considering that apart from being diverse on each instance of the challenge, the multi-institutional mpMRI BraTS dataset has also been a continuously evolving/growing dataset. Copyright © 2018, The Authors. All rights reserved.

关键词： Tumors

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Author Correction: Why rankings of biomedical image analysis competitions should be interpreted with care

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Nature communications 2019年第1期10卷 588页

作者： Lena Maier-Hein Matthias Eisenmann Annika Reinke Sinan Onogur Marko Stankovic Patrick Scholz Tal Arbel Hrvoje Bogunovic Andrew P Bradley Aaron Carass Carolin Feldmann Alejandro F Frangi Peter M Full Bram van Ginneken Allan Hanbury Katrin Honauer Michal Kozubek Bennett A Landman Keno März Oskar Maier Klaus Maier-Hein Bjoern H Menze Henning Müller Peter F Neher Wiro Niessen Nasir Rajpoot Gregory C Sharp Korsuk Sirinukunwattana Stefanie Speidel Christian Stock Danail Stoyanov Abdel Aziz Taha Fons van der Sommen Ching-Wei Wang Marc-André Weber Guoyan Zheng Pierre Jannin Annette Kopp-Schneider Division of Computer Assisted Medical Interventions (CAMI) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. l.maier-hein@dkfz.de. Division of Computer Assisted Medical Interventions (CAMI) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Centre for Intelligent Machines McGill University Montreal QC H3A0G4 Canada. Christian Doppler Laboratory for Ophthalmic Image Analysis Department of Ophthalmology Medical University Vienna 1090 Vienna Austria. Science and Engineering Faculty Queensland University of Technology Brisbane QLD 4001 Australia. Department of Electrical and Computer Engineering Department of Computer Science Johns Hopkins University Baltimore MD 21218 USA. CISTIB - Center for Computational Imaging & Simulation Technologies in Biomedicine The University of Leeds Leeds Yorkshire LS2 9JT UK. Department of Radiology and Nuclear Medicine Medical Image Analysis Radboud University Center 6525 GA Nijmegen The Netherlands. Institute of Information Systems Engineering TU Wien 1040 Vienna Austria. Complexity Science Hub Vienna 1080 Vienna Austria. Heidelberg Collaboratory for Image Processing (HCI Heidelberg University 69120 Heidelberg Germany. Centre for Biomedical Image Analysis Masaryk University 60200 Brno Czech Republic. Electrical Engineering Vanderbilt University Nashville TN 37235-1679 USA. Institute of Medical Informatics Universität zu Lübeck 23562 Lübeck Germany. Division of Medical Image Computing (MIC) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Institute for Advanced Studies Department of Informatics Technical University of Munich 80333 Munich Germany. Information System Institute HES-SO Sierre 3960 Switzerland. Departments of Radiology Nuclear Medicine and Medical Informatics Erasmus MC 3015 GD Rotterdam The Netherlands. Department of Computer Science University of Warwick Coventry CV4 7AL UK. Department of Radiation Oncology Massachusetts General Hospital Boston MA

In the original version of this Article the values in the rightmost column of Table 1 were inadvertently shifted relative to the other columns. This has now been corrected in the PDF and HTML versions of the Article.

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