Gender imbalance in academia has been confirmed in terms of a variety of indicators, and its magnitude often varies from country to country. Europe and North America, which cover a large fraction of research workforce...
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Human movement analysis is crucial in health and sports biomechanics for understanding physical performance, guiding rehabilitation, and preventing injuries. However, existing tools are often proprietary, expensive, a...
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Antiretroviral therapy (ART) has been proven to be highly effective in reducing the impact of human immunodeficiency virus (HIV) infection. However, as more people receive initial ART treatment, the risk of developing...
Antiretroviral therapy (ART) has been proven to be highly effective in reducing the impact of human immunodeficiency virus (HIV) infection. However, as more people receive initial ART treatment, the risk of developing resistance and eventual treatment failure increases, leading to the need for second-line treatment regimens. Understanding the factors that contribute to virologic failure to second-line ART is crucial in preventing switching to the more expensive and toxic third-line regimens. This study provides information on the prevalence, rate, and predictors of virologic failure (VF) among clients on second-line ART in Tanzania. We followed 4718 clients for 15100 person-years (PY) of observations. Of them, 1402 (29.72%) experienced virologic failure at a rate of 92.85 per 1000 PY of observations (95% CI 88.11, 97.84). Factors that were associated with VF included: having a viral load count of ≥ 1000 copies/mL during first-line ART, with a hazard ratio (HR) 4.65 (95% CI 3.57, 6.07), using lopinavir (LPV/r) as a protease inhibitor during second-line ART (HR 4.20 (95% CI 3.12, 7.10), having a CD4 count < 200 cells/mm3 during second-line ART (HR 1.89 (95% CI 1.46, 2.44), and being on ART for 13–35 months (HR 8.22 (95% CI 2.21, 30.61). Paradoxically, having a CD4 count < 200 cells/mm3 during first-line ART treatment was associated with a reduced risk of virologic failure (HR 0.77 (95% CI 0.60, 0.99). In Tanzania, approximately 30% of adult clients on second-line ART experience VF at a rate of 92.71 per 1000 person-years. This high virologic failure rate underscores the urgent need for targeted interventions, such as enhancing adherence support, optimizing drug regimens, and regular viral load monitoring. These interventions will reduce the need for switching to the more costly and toxic third-line ART therapy and are also crucial for achieving the UNAIDS goal of 95% viral suppression among treated individuals by 2030.
To model the periodicity of beats, state-of-the-art beat tracking systems use "post-processing trackers" (PPTs) that rely on several empirically determined global assumptions for tempo transition, which work...
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Today’s pluralistic and globalized society requires a global perspective in how we think, view ourselves, and relate to others to collaborate successfully with people with different cultural backgrounds. To support t...
Today’s pluralistic and globalized society requires a global perspective in how we think, view ourselves, and relate to others to collaborate successfully with people with different cultural backgrounds. To support the development of a global perspective, universities cultivate international co-operations to enable international mobility for students, faculty, and staff. However, in-person mobility can be inhibited due to various reasons. To support a wider pool of students gaining international experience, modern digital mediated course formats can be used to offer virtual instead of in-person mobility. This contribution evaluates a digital mediated course for mechanical engineering students (Global engineering, GE) held in co-operation between an US and a Portuguese university, where internationally mixed student groups working on design projects in an Hyflex setting. Asides a literature driven discussion about the need for Global Engineers and a detailed description of the GE course, a longitudinal analysis was performed to assess the impact of the GE course on the students’ development of a global perspective. The longitudinal analysis showed strong statistical support that the digitally mediated GE course improved the participating students’ global perspective, assessed with the Global Perspective Inventory (GPI), tremendously. The observed improvements were in three of the six GPI dimensions comparable to an in-person semester abroad. Limitations of the study and future investigations are discussed.
Transitioning the energy sector to zero or net-zero emission of greenhouse gasses (GHG) and substantially reducing other pollutants is a massive, costly, and long-term effort. The typical starting point and centerpiec...
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This study introduces the Quantum-Train Quantum Fast Weight programmer (QT-QFWP) framework, enabling efficient and scalable programming of variational quantum circuits (VQCs) through quantum-driven parameter updates f...
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ISBN:
(数字)9798331531591
ISBN:
(纸本)9798331531607
This study introduces the Quantum-Train Quantum Fast Weight programmer (QT-QFWP) framework, enabling efficient and scalable programming of variational quantum circuits (VQCs) through quantum-driven parameter updates for the classical slow programmer controlling the fast programmer VQC. By optimizing quantum and classical parameter management, QT-QFWP significantly reduces parameters (by 70–90%) compared to Quantum Long Short-Term Memory (QLSTM) and Quantum Fast Weight programmer (QFWP) while maintaining accuracy. Benchmarking on time-series tasks—including Damped Simple Harmonic Motion (SHM), NARMA5, and Simulated Gravitational Waves (GW)—demonstrates superior efficiency and predictive accuracy. QT-QFWP is particularly advantageous for near-term quantum systems, addressing qubit and gate fidelity constraints, enhancing VQC deployment in time-sensitive applications, and expanding quantum computing’s role in machine learning.
a, s Abstract: The recent growth of the Internet of Things’ services and applications has increased data processing and storage requirements. The Edge computing concept aims to leverage the processing capabilities of...
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This paper introduces HAAQI-Net, a non-intrusive deep learning-based music audio quality assessment model for hearing aid users. Unlike traditional methods like the Hearing Aid Audio Quality Index (HAAQI) that require...
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The influence of genetic predisposition on changes in brain morphology during aging remains largely unknown. This study explores the effects of genetic predisposition on three key brain regions: total brain volume (TB...
The influence of genetic predisposition on changes in brain morphology during aging remains largely unknown. This study explores the effects of genetic predisposition on three key brain regions: total brain volume (TBV), lateral ventricular volume (LVV), and total hippocampal volume (THV). The brain age gap estimate (BrainAGE) biomarker is used as an input to a genome-wide association study to determine which single nucleotide polymorphisms (SNPs) and genes are associated with accelerated brain aging. Six independent significant SNPs were found to contribute to accelerated morphological changes: TBV had associations on chromosome 17 linked with brain aging, and the total THV had independent significant associations in the APOC1 and TOMM40 gene regions related to neurodegeneration. Lastly, LVV presented a possible novel discovery in the gene NUAK1, known to play a role in cellular senescence. This study provides a framework to uncover complex associations between brain aging physiology and genetics.
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