Image registration is a fundamental medical image analysis task, and a wide variety of approaches have been proposed. However, only a few studies have comprehensively compared medical image registration approaches on ...
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Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology ...
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Previous research has demonstrated that various properties of infectious diseases can be inferred from online search behaviour. In this work we use time series of online search query frequencies to gain insights about...
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The serotonin 2A receptor (5-HTR) modulates various neurotransmitter systems and is implicated in psychiatric disorders, including depression and schizophrenia. Despite progress, the detailed mechanisms of signaling a...
The serotonin 2A receptor (5-HTR) modulates various neurotransmitter systems and is implicated in psychiatric disorders, including depression and schizophrenia. Despite progress, the detailed mechanisms of signaling at the 5-HTR and its therapeutic implications remain unclear, warranting further exploration. Overcoming the limitations of conventional pharmacology, photopharmacology addresses issues such as spatial selectivity and spatiotemporal resolution by incorporating light as an additional external control element. To study the roles of G protein- and β-arrestin2-dependent signaling pathways independently, we designed a photoswitchable, pathway-selective 5-HTR ligand. In radioligand binding studies, the -photoisomer has a greater affinity than the isomer at the 5-HTR and binds at nanomolar concentrations. In two highly analogous functional assays, the photoswitchable ligand showed a preference for β-arrestin2 recruitment over mini-Gα recruitment relative to LSD, providing a compelling tool for investigating the role of β-arrestin2 recruitment in 5-HTR signaling and elucidating its potential role in psychedelic effects.
Applications such as simulating complicated quantum systems or solving large-scale linear algebra problems are very challenging for classical computers due to the extremely high computational cost. Quantum computers p...
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Due to the impressive learning power, deep learning has achieved a remarkable performance in supervised hash function learning. In this paper, we propose a novel asymmetric supervised deep hashing method to preserve t...
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Results are presented of searches for continuous gravitational waves from 20 accreting millisecond x-ray pulsars with accurately measured spin frequencies and orbital parameters, using data from the third observing ru...
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Results are presented of searches for continuous gravitational waves from 20 accreting millisecond x-ray pulsars with accurately measured spin frequencies and orbital parameters, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. The search algorithm uses a hidden Markov model, where the transition probabilities allow the frequency to wander according to an unbiased random walk, while the J-statistic maximum-likelihood matched filter tracks the binary orbital phase. Three narrow subbands are searched for each target, centered on harmonics of the measured spin frequency. The search yields 16 candidates, consistent with a false alarm probability of 30% per subband and target searched. These candidates, along with one candidate from an additional target-of-opportunity search done for SAX J1808.4−3658, which was in outburst during one month of the observing run, cannot be confidently associated with a known noise source. Additional follow-up does not provide convincing evidence that any are a true astrophysical signal. When all candidates are assumed nonastrophysical, upper limits are set on the maximum wave strain detectable at 95% confidence, h095%. The strictest constraint is h095%=4.7×10−26 from IGR J17062−6143. Constraints on the detectable wave strain from each target lead to constraints on neutron star ellipticity and r-mode amplitude, the strictest of which are ε95%=3.1×10−7 and α95%=1.8×10−5 respectively. This analysis is the most comprehensive and sensitive search of continuous gravitational waves from accreting millisecond x-ray pulsars to date.
Learners participating in Massive Open Online Courses(MOOC) have a wide range of backgrounds and *** MOOC learners sign up the courses to take a brief look;only a few go through the entire content,and even fewer are a...
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ISBN:
(纸本)9781509036202
Learners participating in Massive Open Online Courses(MOOC) have a wide range of backgrounds and *** MOOC learners sign up the courses to take a brief look;only a few go through the entire content,and even fewer are able to eventually obtain a *** discovered this phenomenon after having examined 76 courses on the xuetang X *** specifically,we found that in many courses the learning coverage—one of the metrics used to estimate the learners' active engagement with the online courses—observes a Zipf *** apply the maximum likelihood estimation method to fit the Zipf's law and test our hypothesis using a chi-square *** result from our study is expected to bring insight to the unique learning behavior on MOOC and thus help improve the effectiveness of MOOC learning platforms and the design of courses.
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