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38th International Cosmic Ray Conference, ICRC 2023

作者： Takeishi, R. Álvarez Crespo, N. Arbet-Engels, A. Baquero Larriva, A. Baxter, J. Biederbeck, N. Caroff, S. Di Marco, G. Fallah Ramazani, V. Green, D. Heckmann, L. Láinez, M. Nickel, L. Nievas Rosillo, M. Pons, E. Priyadarshi, C. Sanchez, D.A. Vázquez Acosta, M. Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Antonelli, L.A. Aramo, C. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Bhattacharjee, P. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heller, M. HerreraLlorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Jimenez Martinez, I. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lamanna, G. Lamastra, A. Institute for Cosmic Ray Research University of Tokyo Chiba Kashiwa277-8582 Japan Grupo de Electronica Universidad Complutense de Madrid Av. Complutense s/n Madrid28040 Spain Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador Department of Physics TU Dortmund University Otto-Hahn-Str. 4 Dortmund44227 Germany Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules - IN2P3 Annecy74000 France Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Tenerife La Laguna Spain Institut für Theoretische Physik Lehrstuhl IV: Plasma-Astroteilchenphysik Ruhr-Universität Bochum Universitätsstraße 150 Bochum44801 Germany The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Department of Physics Tokai University Japan Departament de Física Quàntica i Astrofísica Institut de Ciències delCosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Uni

Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory. It will consist of three different sizes of telescopes, with a collective improvement of about an order of magnitude in sensitivity, compared with the current generation gamma-ray telescopes. LargeSized Telescopes (LSTs) will be the most sensitive at energies from tens of GeV up to a few TeVs, and will be the best suited to observe gamma-ray sources such as Active Galactic Nuclei (AGN). The first Large-Sized Telescope prototype (LST-1), inaugurated in 2018 and currently in commissioning phase, has accumulated more than one thousand hours of data to date. From 2020 to 2022, we have detected various gamma-ray sources, and prominent among them are several well-known AGN, like Mrk 421, Mrk 501, 1ES 1959+650, 1ES 0647+250, PG 1553+113, etc. We report on light curves and energy spectra reconstructed out of these observations down to energies of tens of GeV, which is very close to the energy threshold of LST-1. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Active Galactic Nuclei

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Performance of joint gamma-ray observations with MAGIC and LST-1 telescopes 38

Performance of joint gamma-ray observations with MAGIC and L...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Di Pierro, F. Berti, A. de Menezes, R. Jobst, E. Ohtani, Y. Sitarek, J. Suda, Y. Visentin, E. Abe, H. Abe, K. Abe, S. Abhir, J. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Aniello, T. Ansoldi, S. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Cornelia, A. Artero, M. Asano, K. Aubert, P. Baack, D. Babić, A. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Besenrieder, J. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Biland, A. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bošnjak, Ž. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Busetto, G. Campoy-Ordaz, A. Cardillo, M. Caroff, S. Carosi, A. Carosi, R. Carrasco, M.S. Carretero-Castrillo, M. Cassol, F. Castro-Tirado, A.J. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chilingarian, A. Chytka, L. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Costantini, H. Covino, S. D’Amico, G. Dalchenko, M. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delfino, M. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Del Popolo, A. Depaoli, D. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Fariña, L. Fattorini, A. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Font, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Garczarczyk, M. Gasbarra, C. Gasparrini, D. Gasparyan, S. Gaug, M. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. INFN Torino Via P. Giuria 1 Torino Italy Max-Planck-Institut für Physik Föhringer Ring 6 München Germany Università degli Studi di Torino Dipartimento di Fisica Via P. Giuria 1 Torino Italy University of Tokyo Institute for Cosmic Ray Research 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan University of Lodz Faculty of Physics and Applied Informatics ul. Pomorska 149-153 Lodz Poland Hiroshima University Physics Program Graduate School of Advanced Science and Engineering Hiroshima739-8526 Japan Department of Physics Tokai University Japan ETH Zürich Switzerland Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain Italy INFN Sezione di Trieste Università degli Studi di Udine Italy Italy INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Department of Physics TU Dortmund University Germany Croatia Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Italy Università di Pisa INFN Pisa Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari

The prototype Large-Sized Telescope (LST-1) of the Cherenkov Telescope Array Observatory (CTAO) is in commissioning phase at the Observatorio del Roque de Los Muchachos at 2200 m a.s.l. in La Palma (Canary Islands, Spain). LST-1 is a 23-m diameter telescope and is the first of four that will compose the LST part of the CTAO Northern array. The LST subarray is optimized to provide the best sensitivity for gamma rays in the 20 GeV - 200 GeV energy range. The MAGIC telescopes, which are located approximately 100 m from the LST-1, is operating as a two 17-m telescope stereoscopic system for more than 14 years. LST-1 and MAGIC routinely perform joint observations of gamma-ray sources to exploit the potential of the three-telescope system. This contribution describes the analysis pipeline and evaluates the performance of the system using Monte Carlo simulations and data on the Crab Nebula. The sensitivity achieved during joint observations with MAGIC and LST-1 is about 30% higher than that of MAGIC alone. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Stereo image processing

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TOI-3493 b: A planet with a Neptune-like density transiting a bright G0-type star

arXiv

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arXiv 2025年

作者： Chaturvedi, P. Goffo, E. Gandolfi, D. Persson, C.M. Hatzes, A.P. Nowak, G. Bonfanti, A. Bieryla, A. Cochran, W.D. Collins, K.A. Fajardo-Acosta, S.B. Howell, S.B. Jenkins, J.M. Korth, J. Livingston, J. Pallé, E. Quinn, S.N. Schwarz, R.P. Seager, S. Shporer, A. Stassun, K.G. Striegel, S. Van Eylen, V. Watkins, C.N. Winn, J.N. Ziegler, C. Thüringer Landessternwarte Tautenburg Sternwarte 5 Tautenburg07778 Germany Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Mumbai400005 India Dipartimento di Fisica Università degli Studi di Torino via Pietro Giuria 1 TorinoI-10125 Italy Department of Space Earth and Environment Chalmers University of Technology Onsala Space Observatory Onsala43992 Sweden Institute of Astronomy Faculty of Physics Astronomy and Informatics Nicolaus Copernicus University Grudziądzka 5 Toruń87-100 Poland Space Research Institute Austrian Academy of Sciences Schmiedlstrasse 6 GrazA-8042 Austria Center for Astrophysics | Harvard & Smithsonian 60 Garden Street CambridgeMA02138 United States McDonald Observatory The University of Texas AustinTX United States Center for Planetary Systems Habitability The University of Texas AustinTX United States Caltech IPAC Mail Code 100-22 PasadenaCA91125 United States NASA Ames Research Center Moffett Field CA94035 United States Lund Observatory Division of Astrophysics Department of Physics Lund University Box 118 Lund22100 Sweden Astrobiology Center 2-21-1 Osawa Mitaka Tokyo181-8588 Japan National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Astronomical Science Program Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Calle Vía Láctea s/n Tenerife La Laguna38205 Spain Tenerife La Laguna38206 Spain Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States Department of Earth Atmospheric and Planetary Sciences Massachusetts Institute of Technology CambridgeMA02139 United States Department of Aeronautics and Astronautics MIT 77 Massachusetts Avenue CambridgeMA02139 United States Department of Physics and Astronomy Vanderbilt University NashvilleTN37235 United States SETI Institute Mountain ViewCA94043 U

We report the discovery of TOI-3493 b, a sub-Neptune-sized planet on an 8.15-d orbit transiting the bright (V=9.3) G0 star HD 119355 (aka TIC 203377303) initially identified by NASA’s TESS space mission. With the aim of confirming the planetary nature of the transit signal detected by TESS and determining the mass of the planet, we performed an intensive Doppler campaign with the HARPS spectrograph, collecting radial velocity measurements. We found that TOI-3493 b lies in a nearly circular orbit and has a mass of 9.0 ± 1.2 M and a radius of 3.22 ± 0.08 R, implying a bulk density of 1.47+0.23-0.22g cm−3, consistent with a composition comprising a small solid core surrounded by a thick H/He-dominated atmosphere. © 2025, CC BY.

关键词： Earth atmosphere

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Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma

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Biomedicine and Pharmacotherapy 2023年第1期166卷 115429-115429页

作者： Hsieh, Chiao-Hui Huang, Chen-Tsung Cheng, Yi-Sheng Hsu, Chun-Hua Hsu, Wen-Ming Chung, Yun-Hsien Liu, Yen-Lin Yang, Tsai-Shan Chien, Chia-Yu Lee, Yu-Hsuan Huang, Hsuan-Cheng Juan, Hsueh-Fen Department of Life Science National Taiwan University Taipei Taiwan Center for Computational and Systems Biology National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Institute of Plant Biology National Taiwan University Taipei Taiwan Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica Taipei Taiwan Department of Agricultural Chemistry National Taiwan University Taipei Taiwan Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine Taipei Taiwan

Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness. Recent investigations have uncovered that phosphoglycerate dehydrogenase (PHGDH), an essential enzyme for de novo serine synthesis, serves as a non-oncogene dependency in high-risk neuroblastoma. In this study, we show that homoharringtonine (HHT) acts as a PHGDH inhibitor, inducing intricate alterations in cellular metabolism, and thus providing an efficient treatment for neuroblastoma. We have experimentally verified the reliance of neuroblastoma on PHGDH and employed molecular docking, thermodynamic evaluations, and X-ray crystallography techniques to determine the bond interactions between HHT and PHGDH. Administering HHT to treat neuroblastoma resulted in effective cell elimination in vitro and tumor reduction in vivo. Metabolite and functional assessments additionally disclosed that HHT treatment suppressed de novo serine synthesis, initiating intricate metabolic reconfiguration and oxidative stress in neuroblastoma. Collectively, these discoveries highlight the potential of targeting PHGDH using HHT as a potent approach for managing high-risk neuroblastoma. © 2023 The Authors

关键词： Computational molecular docking Drug discovery High-risk neuroblastoma Metabolic reprogramming Molecular target therapy Phosphoglycerate dehydrogenase

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Exploring disparities of teleconsultation readiness: A comparative analysis of healthcare facilities in Indonesia

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DIGITAL HEALTH 2024年 10卷

作者： Daniel Chriswinanto Adityo Nugroho Katherina Adisaputro Mitra Andini Sigilipoe Ida Ayu Triastuti Suryani Hutomo Ardhinta Bellano Septarda Aryososepti Yuwono Caraka Randi Yusuf Dedik Sulistiawan Balqis Gusbela Jason C Hsu Emily Chia-Yu Su Faculty of Medicine Universitas Kristen Duta Wacana Yogyakarta IndonesiaGraduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Faculty of Medicine Universitas Kristen Duta Wacana Yogyakarta Indonesia Faculty of Public Health Universitas Ahmad Dahlan Yogyakarta IndonesiaSchool of Public Health Taipei Medical University Taipei International PhD Program in Biotech and Healthcare Management College of Management Taipei Medical University Taipei International PhD Program in Biotech and Healthcare Management College of Management Taipei Medical University TaipeiClinical Data Center Office of Data Science Taipei Medical University TaipeiClinical Big Data Research Center Taipei Medical University Hospital TaipeiResearch Center of Health Care Industry Data Science College of Management Taipei Medical University Taipei Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University TaipeiClinical Big Data Research Center Taipei Medical University Hospital TaipeiInstitute of Biomedical Informatics College of Medicine National Yang Ming Chiao Tung University Taipei

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Very-high-energy gamma-ray detection and long-term multi-wavelength view of the flaring blazar B2 1811+31

arXiv

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arXiv 2025年

作者： Abe, K. Abe, S. Abhir, J. Abhishek, A. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Engels, A. Arbet Arcaro, C. Asano, K. Babić, A. de Almeida, U. Barres Barrio, J.A. Barrios-Jiménez, L. Batković, I. Baxter, J. González, J. Becerra Bednarek, W. Bernardini, E. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Bronzini, E. Burelli, I. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Cerasole, D. Ceribella, G. Chilingarian, A. Cifuentes, A. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Ammando, F. D’Amico, G. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. de Menezes, R. Delfino, M. Delgado, J. Mendez, C. Delgado Di Pierro, F. Di Tria, R. Di Venere, L. Dinesh, A. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsaesser, D. Escudero, J. Fariña, L. Foffano, L. Font, L. Fröse, S. Fukazawa, Y. López, R.J. García Garczarczyk, M. Gasparyan, S. Gaug, M. Paiva, J.G. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Gradetzke, T. Grau, R. Green, D. Green, J.G. Günther, P. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Llorente, J. Herrera Hrupec, D. Imazawa, R. Israyelyan, D. Itokawa, T. Martínez, I. Jiménez Quiles, J. Jiménez Jormanainen, J. Kankkunen, S. Kayanoki, T. Kerszberg, D. Khachatryan, M. Kluge, G.W. Kobayashi, Y. Konrad, J. Kouch, P.M. Kubo, H. Kushida, J. Láinez, M. Lamastra, A. Lindfors, E. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lulić, L. Lyard, E. Majumdar, P. Makariev, M. Maneva, G. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Maruševec, P. Mas-Aguilar, A. Mazin, D. Menchiari, S. Mender, S. Miceli, D. Miranda, J.M. Mirzoyan, R. González, M. Molero Molina, E. Mondal, H.A. Moralejo, A. Nakamori, T. Nanci, C. Neustroev, V. Nickel, L. Rosillo, M. Nievas Nigro, C. Nikolić, L. Nilsson, K. Nishijima, K. Ekoume, T. Njoh Noda, K. Japanese MAGIC Group Department of Physics Tokai University Kanagawa Hiratsuka259-1292 Japan The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Università di Siena INFN Pisa SienaI-53100 Italy Bellaterra BarcelonaE-08193 Spain Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik GarchingD-85748 Germany Università di Padova INFN PadovaI-35131 Italy Zagreb10000 Croatia URCA RJ Rio de Janeiro22290-180 Brazil IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Instituto de Astrofísica de Canarias and Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa INFN Pisa PisaI-56126 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari BariI-70125 Italy Armenian MAGIC Group A. Alikhanyan National Science Laboratory Yerevan0036 Armenia Department for Physics and Technology University of Bergen Norway INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy Croatian MAGIC Group University of Rijeka Faculty of Physics Rijeka51000 Croatia Universität Würzburg WürzburgD-97074 Germany Technische Universität Dortmund DortmundD-44221 Germany Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan ZeuthenD-15738 Germany Armenian MAGIC Gro

Context. Among the blazars whose emission has been detected up to very-high-energy (VHE;100 GeV 14 δD cm to the size of the emission region responsible for the γ-ray flare, δD being the relativistic Doppler factor of the region. During the 2020 high state, the average spectrum became harder in the HE γ-ray band compared to the low states. A similar behaviour has been observed in X rays. Conversely, during different activity periods, we find harder-when-brighter trends in X rays and a hint of softer-when-brighter trends at HE γ rays. Long-term HE γ-ray and optical correlation indicates the same emission regions dominate the radiative output in both ranges, whereas the evolution at 15 GHz shows no correlation with the fluxes at higher frequencies. We test one-zone and two-zone synchrotron-self-Compton models for describing the broad-band spectral energy distribution during the 2020 flaring state and investigate the self-consistency of the proposed scenario. Copyright © 2025, The Authors. All rights reserved.

关键词： Synchrotron radiation

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Time-dependent modelling of short-term variability in the TeV-blazar VER J0521+211 during the major flare in 2020

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Astronomy and Astrophysics 2025年 694卷

作者： MAGIC Collaboration Abe, S. Abhir, J. Abhishek, A. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Arbet Engels, A. Arcaro, C. Artero, M. Asano, K. Baack, D. Babić, A. Barres De Almeida, U. Barrio, J.A. Batković, I. Bautista, A. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Bronzini, E. Burelli, I. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Cerasole, D. Ceribella, G. Chai, Y. Cifuentes, A. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D'Amico, G. D'Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. De Menezes, R. Delfino, M. Delgado, J. Delgado Mendez, C. Di Pierro, F. Di Tria, R. Di Venere, L. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsaesser, D. Escudero, J. Fariña, L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukami, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giesbrecht Paiva, J.G. Giglietto, N. Giordano, F. Gliwny, P. Gradetzke, T. Grau, R. Green, D. Green, J.G. Günther, P. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera Llorente, J. Hrupec, D. Imazawa, R. Ishio, K. Jiménez Martínez, I. Jormanainen, J. Kankkunen, S. Kayanoki, T. Kerszberg, D. Kluge, G.W. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Láinez, M. Lamastra, A. Leone, F. Lindfors, E. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. Machado De Oliveira Fraga, B. Majumdar, P. Makariev, M. Maneva, G. Manganaro, M. ETH Zürich ZürichCH-8093 Switzerland Università di Siena and INFN Pisa SienaI-53100 Italy BarcelonaE-08193 Spain Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine and INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik GarchingD-85748 Germany Università di Padova and INFN PadovaI-35131 Italy Technische Universität Dortmund DortmundD-44221 Germany Zagreb10000 Croatia Rio de Janeiro22290-180 URCA Brazil IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna La LagunaE-38200 Spain University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa and INFN Pisa PisaI-56126 Italy INFN MAGIC Group: INFN Sezione di Bari Dipartimento Interateneo di Fisica dell'Università e del Politecnico di Bari BariI-70125 Italy Department for Physics and Technology University of Bergen Bergen Norway INFN MAGIC Group: INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy Croatian MAGIC Group: University of Rijeka Faculty of Physics Rijeka51000 Croatia Universität Würzburg WürzburgD-97074 Germany Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan ZeuthenD-15738 Germany Armenian MAGIC Group: ICRANet-Armenia Yerevan0019 Armenia Croatian MAGIC Group: Josip Juraj Strossmayer University of Osijek Department of Physics Osijek31000 Croatia Finnish MAGIC Group: Finnish Centre for Astronomy with ESO Department of Physics and Astronomy U

Self-repairing graphite protective layer has been discovered as a suitable protective layer in blast furnace (BF) hearth in recent years. In the current study, actual samples of self-repairing graphite protective layer taken from a commercial BF were analyzed in detail. The results revealed that the hot face of graphite protective layer exhibits a distinct white graphite luster, with large areas of graphite adhering to the surface. Along the direction of its formation, the sample displays a striped pattern with alternating layers. The graphite is strip-shaped, it is relatively coarse and unevenly distributed. The coarse graphite runs in the same direction, unlike graphite in molten iron which has no fixed direction in a chaotic state. The formation process of selfrepairing graphite protective layer can be concluded, graphite precipitates at the interface through heterogeneous nucleation. Crystal nuclei often preferentially adhere to the surface of these impurities to form, owing to the fact that the nucleation energy of heterogeneous nucleation is lower than that of homogeneous nucleation. Titanium is discovered during the observation of microscopic morphology of graphite protective layer, graphite protective layer is more robust due to the strengthening effect of titanium. Titanium strengthening mechanism of self-repairing graphite protective layer is summarized, the strengthening mechanism can be divided into four steps. TiC particles are dispersed around graphite, which reduces the difficulty of the orientation of flake graphite growth. The presence of TiC increases the growth rate of crystals. The four steps are cyclically performed, so the self-repairing graphite protective layer can precipitate layer by layer through titanium strengthening mechanism, which serves to protect the carbon brick in BF hearth. © EDP sciences, 2025.

关键词： Blast furnaces

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Low energy performance boost through a hardware stereoscopic trigger between CTA LST-1 and MAGIC 38

Low energy performance boost through a hardware stereoscopic...

引用

38th International Cosmic Ray Conference, ICRC 2023

作者： Baxter, J. Barrio, J.A. Bitossi, M. Donini, A. Mazin, D. Paoletti, R. Pérez Aguilera, A. Tejedor Álvarez, L.Á. Abe, H. Abe, K. Abe, S. Abhir, J. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Aniello, T. Ansoldi, S. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Cornelia, A. Artero, M. Asano, K. Aubert, P. Baack, D. Babić, A. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Besenrieder, J. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Biland, A. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bošnjak, Ž. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Busetto, G. Campoy-Ordaz, A. Cardillo, M. Caroff, S. Carosi, A. Carosi, R. Carrasco, M.S. Carretero-Castrillo, M. Cassol, F. Castro-Tirado, A.J. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chilingarian, A. Chytka, L. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Costantini, H. Covino, S. D’Amico, G. Dalchenko, M. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delfino, M. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Del Popolo, A. Depaoli, D. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Fariña, L. Fattorini, A. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Font, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Garczarczyk, M. Gasbarra, C. Gasparrini, D. Gasparyan, S. Gaug, M. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Institute for Cosmic Ray Research University of Tokyo Chiba Kashiwa277-8582 Japan IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid Spain Sezione di Pisa Pisa56127 Italy Osservatorio Astronomico di Roma Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Università degli Studi di Siena via Roma 56 Siena53100 Italy Department of Physics Tokai University Japan ETH Zürich Switzerland Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain Italy INFN Sezione di Trieste Università degli Studi di Udine Italy Italy INAF Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Department of Physics TU Dortmund University Germany Croatia Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Faculty of Physics and Applied Informatics University of Lodz Poland CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF Osservatorio Astronomico di Brera Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Italy Università di Pisa INFN Pisa Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy ICRANet-Armenia at

The next generation facility for gamma-ray ground-based observations is the Cherenkov Telescope Array (CTA) observatory, which comprises three types of imaging atmospheric Cherenkov telescopes (IACTs). The Large-Sized Telescopes (LSTs) of CTA are the largest telescope type with a mirror dish of 23 m diameter. They cover the low energy end of the accessible gamma-ray energies for IACTs, starting from about 20 GeV up to a few TeV. The first LST prototype, known as LST-1, was officially inaugurated at the Observatorio del Roque de Los Muchachos in La Palma (Canary Islands, Spain) in 2018 and has since performed calibration observations of various known gamma-ray sources. Additionally, the site houses the MAGIC telescopes, two 17 m IACTs situated approximately 100 m away from LST-1, which have been performing stereo observations since 2009. Currently, joint observations between LST-1 and MAGIC are being carried on, and the data taken independently by the two IACT systems is analyzed by combining events via software. However, this method increases the energy threshold, as it discards all but the relatively high-energy events triggered by all three telescopes. To address this issue, we have developed a novel hardware stereo trigger system between LST-1 and MAGIC, which is capable of handling events triggered by any-two out of the three telescopes. In this contribution, we will report on the performance estimation of joint LST-1 and MAGIC observations using the hardware trigger. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Cosmology

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Seeds of Stereotypes: A Large-Scale Textual Analysis of Race and Gender Associations with Diseases in Online Sources

arXiv

引用

arXiv 2024年

作者： Hansen, Lasse Hyldig Andersen, Nikolaj Gallifant, Jack McCoy, Liam G. Stone, James K. Izath, Nura Aguirre-Jerez, Marcela Bitterman, Danielle S. Gichoya, Judy Celi, Leo Anthony Cognitive Science Aarhus University Jens Chr. Skou 2 Aarhus8000 Denmark Laboratory for Computational Physiology Massachusetts Institute of Technology CambridgeMA United States Department of Critical Care Guy’s & St Thomas’ NHS Trust London United Kingdom Division of Neurology University of Alberta AB Canada University of Manitoba Max Rady College of Medicine WinnipegMB Canada Faculty of Computing Mbarara University of Science and Technology Mbarara Uganda Digital Health Department Fundacion Arturo Lopez Perez Santiago Chile Program Mass General Brigham Harvard Medical School BostonMA United States Department of Radiation Oncology Brigham and Women’s Hospital Dana-Farber Cancer Institute BostonMA United States Computational Health Informatics Program Boston Children’s Hospital Harvard Medical School BostonMA United States Department of Radiology Emory University School of Medicine GA United States Division of Pulmonary Critical Care and Sleep Medicine Beth Israel Deaconess Medical Center BostonMA United States Department of Biostatistics Harvard T.H. Chan School of Public Health BostonMA United States

Background Advancements in Large Language Models (LLMs) hold transformative potential in healthcare, however, recent work has raised concern about the tendency of these models to produce outputs that display racial or gender biases. Although training data is a likely source of such biases, exploration of disease and demographic associations in text data at scale has been limited. Methods We conducted a large-scale textual analysis using a dataset comprising diverse web sources, including Arxiv, Wikipedia, and Common Crawl. The study analyzed the context in which various diseases are discussed alongside markers of race and gender. Given that LLMs are pre-trained on similar datasets, this approach allowed us to examine the potential biases that LLMs may learn and internalize. We compared these findings with actual demographic disease prevalence as well as GPT-4 outputs in order to evaluate the extent of bias representation. Results Our findings indicate that demographic terms are disproportionately associated with specific disease concepts in online texts. gender terms are prominently associated with disease concepts, while racial terms are much less frequently associated. We find widespread disparities in the associations of specific racial and gender terms with the 18 diseases analyzed. Most prominently, we see an overall significant overrepresentation of Black race mentions in comparison to population proportions. Conclusions Our results highlight the need for critical examination and transparent reporting of biases in LLM pretraining datasets. Our study suggests the need to develop mitigation strategies to counteract the influence of biased training data in LLMs, particularly in sensitive domains such as healthcare. © 2024, CC BY.

关键词： Large datasets

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Quantifying quantumness of channels without entanglement

arXiv

引用

arXiv 2021年

作者： Ku, Huan-Yu Kadlec, Josef Černoch, Antonín Quintino, Marco Túlio Zhou, Wenbin Lemr, Karel Lambert, Neill Miranowicz, Adam Chen, Shin-Liang Nori, Franco Chen, Yueh-Nan National Cheng Kung University Tainan701 Taiwan Theoretical Quantum Physics Laboratory RIKEN Cluster for Pioneering Research Saitama Wako-shi351-0198 Japan Palacký University in Olomouc Faculty of Science Joint Laboratory of Optics Palacký University Institute of Physics AS CR 17. listopadu 12 Olomouc771 46 Czech Republic Institute of Physics The Czech Academy of Sciences Joint Laboratory of Optics of PU and IP AS CR 17. listopadu 50A Olomouc772 07 Czech Republic Faculty of Physics University of Vienna Boltzmanngasse 5 Vienna1090 Austria Austrian Academy of Sciences Boltzmanngasse 3 ViennaA-1090 Austria Graduate School of Informatics Nagoya University Chikusa-ku Nagoya464-8601 Japan Institute of Spintronics and Quantum Information Faculty of Physics Adam Mickiewicz University Poznan61-614 Poland Department of Physics National Chung Hsing University Taichung40227 Taiwan Dahlem Center for Complex Quantum Systems Freie Universität Berlin Berlin14195 Germany RIKEN Center for Quantum Computing Saitama Wako351-0198 Japan Department of Physics The University of Michigan Ann ArborMI48109-1040 United States

Quantum channels breaking entanglement, incompatibility, or nonlocality are defined as such because they are not useful for entanglement-based, one-sided device-independent, or device-independent quantum information processing, respectively. Here, we show that such breaking channels are related to complementary tests of macrorealism i.e., temporal separability, channel unsteerability, temporal unsteerability, and the temporal Bell inequality. To demonstrate this we first define a steerability-breaking channel, which is conceptually similar to entanglement and nonlocality-breaking channels and prove that it is identical to an incompatibility-breaking channel. A hierarchy of quantum non-breaking channels is derived, akin to the existing hierarchy relations for temporal and spatial quantum correlations. We then introduce the concept of channels that break temporal correlations, explain how they are related to the standard breaking channels, and prove the following results: (1) A robustness-based measure for non-entanglement-breaking channels can be probed by temporal nonseparability. (2) A non-steerability-breaking channel can be quantified by channel steering. (3) Temporal steerability and non-macrorealism can be used for, respectively, distinguishing unital steerability-breaking channels and nonlocality-breaking channels for a maximally entangled state. Finally, a two-dimensional depolarizing channel is experimentally implemented as a proof-of-principle example to demonstrate the hierarchy relation of non-breaking channels using temporal quantum correlations. Copyright © 2021, The Authors. All rights reserved.

关键词： Quantum entanglement

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