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Middle East and North African Health informatics Association (MENAHIA): Building Sustainable Collaboration

Yearbook of Medical informatics 2018年第1期27卷 286-291页

作者： Najeeb Al-Shorbaji Mowafa Househ Adel Taweel Abdullah Alanizi Bennani Othmani Mohammed Haitham Abaza Hala Bawadi Hamayon Rasuly Khalid Alyafei Luis Fernandez-Luque Mohamed Shouman Osama El-Hassan Rada Hussein Riyad Alshammari Salah Mandil Sarah Shouman Shahrad Taheri Tamer Emara Wasmiya Dalhem Zaid Al-Hamdan Zineb Serhier eHealth and Knowledge Management Consultant Retired Director of Knowledge Ethics and Research Department WHO/HQ Amman Jordan Department of Health Informatics College of Public Health and Health Informatics King Saud Bin Abdulaziz University for Health Sciences Ministry of National Guard-Health Affairs Riyadh Saudi Arabia Department of Computer Science BirZeit University Ramallah Palestine Head of Medical Informatics Unit 20 August Hospital Ibn Rochd University Hospital Casablanca Head of Casablanca Medical Informatics Laboratory Medical Faculty of Casablanca Morocco Department of Biomedical Engineering Misr University for Science & Technology Cairo Egypt Associate Professor College of Nursing University of Jordan Amman Jordan eHealth Program Coordinator Bamyan Provincial Hospital Bamyan City Afghanistan Chief Medical Informatics Officer (CMIO) - SIDRA Assistant Professor Clinical Pediatrics at Weill Cornell Medicine Qatar Qatar Computing Research Institute Hamad Bin Khalifa University Doha Qatar Faculty of Medicine Ain Shams University Cairo Egypt Vice-Chair of Emirates Health Informatics Society Head of eHealth Section at Dubai Health Authority Dubai United Arab Emirates Founder and Former Director of the Biomedical Informatics Center of Excellence (BMICoE) Information Technology Institute (ITI) Ministry of Communications and Information Technology (MCIT) Egypt President of Saudi Association for Health Informatics Riyadh Saudi Arabia Senior Consultant on eStrategies and eHealth to WHO and ITU Geneva Switzerland Department of Medicine Weill Cornell Medical College in Qatar Qatar Foundation Doha Qatar Executive Director of Nursing Informatics Hamad Medical Corporation Qatar Associate Professor of Nursing Management Faculty of Nursing Jordan University of Science and Technology Irbid Jordan Professor at Medical Informatics Laboratory Faculty of Medicine and Pharmacy Hassan II University Casablanca Morocco

There has been a growing interest in Health informatics applications, research, and education within the Middle East and North African Region over the past twenty years. People of this region share similar cultural and religious values, primarily speak the Arabic language, and have similar health care related issues, which are in dire need of being addressed. Health informatics efforts, organizations, and initiatives within the region have been largely under-represented within, but not ignored by, the International Medical informatics Association (IMIA). Attempts to create bonds and collaboration between the different organizations of the region have remained scattered, and often, resulted in failure despite the fact that the need for a united health informatics collaborative within the region has never been more crucial than today. During the 2017 MEDINFO, held in Hangzhou, China, a new organization, the Middle East and North African Health informatics Association (MENAHIA) was conceived as a regional non-governmental organization to promote and facilitate health informatics uptake within the region endorsing health informatics research and educational initiatives of the 22 countries represented within the region. This paper provides an overview of the collaboration and efforts to date in forming MENAHIA and displays the variety of initiatives that are already occurring within the MENAHIA region, which MENAHIA will help, endorse, support, share, and improve within the international forum of health informatics.

关键词： eHealth Middle East and North Africa Health informatics collaboration MENAHIA Universal Health Coverage Bioinformatics International Medical informatics Association

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A new method of reconstructing images of gamma-ray telescopes applied to the LST-1 of CTAO

arXiv

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arXiv 2024年

作者： Abe, K. Abe, S. Abhishek, A. Acero, F. Aguasca-Cabot, A. Agudo, I. Alispach, C. Alvarez Crespo, N. Ambrosino, D. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Asano, K. Aubert, P. Baktash, A. Balbo, M. Bamba, A. Baquero Larriva, A. Barres de Almeida, U. Barrio, J.A. Barrios Jiménez, L. Batkovic, I. Baxter, J. Becerra González, J. Bernardini, E. Bernete Medrano, J. Berti, A. Bezshyiko, I. Bhattacharjee, P. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Borkowski, G. Brunelli, G. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Castrejón, N. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chon, G. Chytka, L. Cicciari, G.M. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Da Vela, P. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. de Menezes, R. Del Burgo, R. Del Peral, L. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukazawa, Y. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, D. Green, J. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Inoue, S. Ioka, K. Iori, M. Iuliano, A. Jimenez Martinez, I. Jimenez Quiles, J. Jurysek, J. Kagaya, M. Kalashev, O. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Lemoigne, L. Linhoff, M. Department of Physics Tokai University 4-1-1 Kita-Kaname Kanagawa Hiratsuka259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Sezione di Fisica Via Roma 56 Siena53100 Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM Gif-sur-YvetteF-91191 Cedex France FSLAC IRL 2009 CNRS/IAC Tenerife La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 Barcelona08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Department of Astronomy University of Geneva Chemin d’Ecogia 16 VersoixCH-1290 Switzerland IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid Plaza de Ciencias 1. Ciudad Universitaria Madrid28040 Spain INFN Sezione di Napoli Via Cintia ed. G Napoli80126 Italy INAF Osservatorio Astronomico di Roma Via di Frascati 33 Monteporzio Catone00040 Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany INFN Sezione di Padova Università degli Studi di Padova Via Marzolo 8 Padova35131 Italy Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules IN2P3 Annecy74000 France Universität Hamburg Institut für Experimentalphysik Luruper Chaussee 149 Hamburg22761 Germany Graduate School of Science University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador Centro Brasileiro de Pesquisas Físicas Rua Xavier Sigaud 150 RJ Rio de Janeiro22290-180 Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna C. Vía Láctea s/n Santa Cruz de Tenerife La Laguna38205 Spain CIEMAT Avda. Complutense 40 Madrid28040 Spain University of Geneva Département de Physique Nucléaire et Corpusculaire 24 Quai Ernest Ansernet

Context. Imaging atmospheric Cherenkov telescopes (IACTs) are used to observe very high-energy photons from the ground. Gamma rays are indirectly detected through the Cherenkov light emitted by the air showers they induce. The new generation of experiments, in particular the Cherenkov Telescope Array Observatory (CTAO), sets ambitious goals for discoveries of new gamma-ray sources and precise measurements of the already discovered ones. To achieve these goals, both hardware and data analysis must employ cutting-edge techniques. This also applies to the LST-1, the first IACT built for the CTAO, which is currently taking data on the Canary island of La Palma. Aims. This paper introduces a new event reconstruction technique for IACT data, aiming to improve the image reconstruction quality and the discrimination between the signal and the background from misidentified hadrons and electrons. Methods. The technique models the development of the extensive air shower signal, recorded as a waveform per pixel, seen by CTAO telescopes’ cameras. Model parameters are subsequently passed to random forest regressors and classifiers to extract information on the primary particle. Results. The new reconstruction was applied to simulated data and to data from observations of the Crab Nebula performed by the LST-1. The event reconstruction method presented here shows promising performance improvements. The angular and energy resolution, and the sensitivity, are improved by 10 to 20% over most of the energy range. At low energy, improvements reach up to 22%, 47%, and 50%, respectively. A future extension of the method to stereoscopic analysis for telescope arrays will be the next important step. Copyright © 2024, The Authors. All rights reserved.

关键词： Stereo image processing

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Follow-up observations of GW170817 with the MAGIC telescopes 37

Follow-up observations of GW170817 with the MAGIC telescopes

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37th International Cosmic Ray Conference, ICRC 2021

作者： Stamerra, A. Salafia, O.S. Berti, A. Covino, S. D'Elia, V. Miceli, D. Nava, L. Patricelli, B. Righi, C. Inoue, S. Antonelli, L.A. Ansoldi, S. De Lotto, B. Longo, F. Tavecchio, F. Acciari, V.A. Arbet Engels, A. Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. Barres de Almeida, U. Barrio, J.A. Batković, I. Becerra González, J. Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bökenkamp, H. Bonnoli, G. Bošnjak, Ž. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colak, S.M. Colombo, E. Contreras, J.L. Cortina, J. D'Amico, G. Da Vela, P. Dazzi, F. De Angelis, A. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Pierro, F. Di Venere, L. Do Souto Espiñeira, E. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Fallah Ramazani, V. Fattorini, A. Fonseca, M.V. Font, L. Fruck, C. Fukami, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Green, J.G. Green, D. Hadasch, D. Hahn, A. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hütten, M. Inada, T. Ishio, K. Iwamura, Y. Jiménez Martínez, I. Jormanainen, J. Jouvin, L. Karjalainen, M. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Machado de Oliveira Fraga, B. Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Maraschi, L. Mariotti, M. Martínez, M. Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miener, T. Miranda, J.M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Nakamori, T. Neustroev, V. Nigro, C. Nilsson, K. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J.M. INAF - Osservatorio Astronomico di Roma Rome Italy INAF - Osservatorio Astronomico di Brera Merate Italy Rome Italy Max-Planck-Institut für Physik München Germany Space Science Data Center - Agenzia Spaziale Italiana Rome Italy European Gravitational Observatory Pisa Italy RIKEN Saitama Wako Japan Università di Udine INFN Trieste Udine Italy Dipartimento di Fisica Università di Trieste Trieste Italy Scuola Normale Superiore Pisa Italy Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain Università di Udine INFN Trieste UdineI-33100 Italy RomeI-00136 Italy ETH Zürich ZürichCH-8093 Switzerland E-08193 Spain The University of Tokyo Chiba Kashiwa277-8582 Japan Technische Universität Dortmund DortmundD-44221 Germany Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil Università di Padova INFN PadovaI-35131 Italy University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Università di Siena INFN Pisa SienaI-53100 Italy ZeuthenD-15738 Germany Max-Planck-Institut für Physik MünchenD-80805 Germany Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Università di Pisa INFN Pisa PisaI-56126 Italy Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Armenian MAGIC Group A. Alikhanyan National Science Laboratory Yerevan0036 Armenia Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica Università e del Politecnico di Bari BariI-70125 Italy Croatian MAGIC Group University of Rijeka Department of Physics Rijeka51000 Croatia Universität Würzburg WürzburgD-

The discovery of the electromagnetic counterpart AT2017gfo and the GRB 170817A, associated to the binary neutron star merger GW170817, was one of the major advances in the study of gamma-ray bursts (GRBs) and the hallmark of the multi-messenger astronomy with gravitational waves. Another breakthrough in GRB physics is represented by the discovery of the highly energetic, teraelectronvolt (TeV) component in the GRB 190114C, possibly an universal component in all GRBs. This conclusion is also suggested by the hint of TeV emission in the short GRB 160821B and a few more events reported in the literature. The missing observational piece is the joint detection of TeV emission and gravitational waves from a short GRB and its progenitor. MAGIC observed the counterpart AT2017gfo as soon as the visibility conditions allowed it, namely from January to June 2018. These observations correspond to the maximum flux level observed in the radio and X-ray bands. The upper limits derived from TeV observations are compared with the modelling of the late non-thermal emission using the multi-frequency SED. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0)

关键词： Gravity waves

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GLOBAL CLIMATE

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Bulletin of the American Meteorological Society 2024年第8期105卷 S12-S155页

作者： Dunn, R.J.H. Blannin, J. Gobron, N. Miller, J.B. Willett, K.M. Met Office Hadley Centre Exeter United Kingdom European Commission Joint Research Centre Ispra Italy NOAA Global Monitoring Laboratory Boulder Colorado European Centre for Medium-Range Weather Forecasts Reading United Kingdom University of Maryland College Park Maryland European Centre for Medium-Range Weather Forecasts Bonn Germany Department of Meteorology and National Centre for Earth Observation University of Reading Reading United Kingdom Hampton University Hampton Virginia National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Agriculture Osaka Metropolitan University Sakai Japan NOAA/NESDIS National Centers for Environmental Information Asheville North Carolina Science Faculty Universidad Nacional de Colombia Bogotá Colombia University of Bremen Bremen Germany Centro de Investigaciones sobre Desertificación – Spanish National Research Council (CSIC-UV-GVA) Valencia Spain Hydro-Climate Extremes Lab (H-CEL) Ghent University Ghent Belgium Laboratoire des Sciences du Climat et de l’Environnement (LSCE) LSCE/IPSL CEA-CNRS-UVSQ Gif-sur-Yvette France Instituto de Geografía Pontificia Universidad Católica de Valparaíso Valparaíso Chile Physical Science and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia University of Reading Reading United Kingdom Institute Pierre Simon Laplace (IPSL) Guyancourt France School of Engineering Newcastle University Newcastle-upon-Tyne United Kingdom Université Paris Cité Institut de physique du globe de Paris CNRS IGN F-75005 Paris France Univ Gustave Eiffel ENSG IGN F-77455 Marne-la-Vallée France Laboratoire EDYTEM CNRS/Université Savoie Mont-Blanc Le Bourget-du-Lac France Global Modeling and Assimilation Office NASA Goddard Space Flight Center Greenbelt Maryland Universität Hamburg Hamburg Germany Climate Dynamics Lab University of St Andrews St Andrews United Kingdom Ea

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GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

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Nature genetics 2023年第9期55卷 1471-1482页

作者： Remi Stevelink Dorothee Kasteleijn-Nolst Trenite Bobby P. C. Koeleman Dick Lindhout Anja C. M. Sonsma Ciarán Campbell Gianpiero L. Cavalleri Norman Delanty Hany El-Naggar Austin Lacey Peter Widdess-Walsh Colin P. Doherty Siwei Chen Claire Churchhouse Mark J. Daly Yen-Chen A. Feng Daniel P. Howrigan Mitja I. Kurki Benjamin M. Neale Aarno Palotie Wei Zhou Namrata Gupta Henrike O. Heyne Bassel Abou-Khalil Kevin F. Haas R. S. Taneja Oluyomi M. Adesoji Michael Nothnagel Peter Nürnberg Thomas Sander Zaid Afawi Ilan Blatt Amos D. Korczyn Elisabetta Amadori Ganna Balagura Antonella Riva Marcello Scala Paolo Scudieri Pasquale Striano Federico Zara Michele Iacomino Francesca Madia Alison Anderson Patrick Kwan Terence J. O’Brien Slavé Petrovski K. Meng Tan Marian Todaro Joseph Anderson Danielle M. Andrade Quratulain Zulfiqar Ali Grazia Annesi Pauls Auce Andreja Avbersek Simona Balestrini Vera Braatz Claudia B. Catarino Krishna Chinthapalli Jennifer Jamnadas-Khoda Dalia Kasperavičiūte Costin Leu Josemir W. Sander Sanjay M. Sisodiya Sara Zagaglia Melanie Bahlo Karen L. Oliver Mark D. Baker Beata Fonferko-Shadrach William O. Pickrell Carmen Barba Claudia Bianchini Viola Doccini Renzo Guerrini Davide Mei Martino Montomoli Elena Parrini Annalisa Vetro Karen Barboza Fabrice Bartolomei Thomas Bast Bernhard J. Steinhoff Larry Baum Stacey S. Cherny Pak Sham Tobias Baumgartner Christian E. Elger Kerstin Hallmann Wolfram S. Kunz Rainer Surges Randi von Wrede Gábor Zsurka Betül Baykan Nerses Bebek Yeşim Kesim Albert J. Becker Susanne Schoch Felicitas Becker Caitlin A. Bennett Samuel F. Berkovic Stephanie L. Leech Brigid M. Regan Ingrid E. Scheffer Bianca Berghuis Ahmad Beydoun Wassim Nasreddine Francesca Bisulli Lidia Di Vito Lorenzo Ferri Tania Giangregorio Laura Licchetta Raffaella Minardi Barbara Mostacci Carlotta Stipa Paolo Tinuper Lorenzo Muccioli Federica Pondrelli Dheeraj R. Bobbili Emadeldin Hassanin Roland Krause Zied Landoulsi Patrick May Ingo Borggraefe Christian Bosselmann Christian Hengsbach Josua Kegele Stephen Lauxmann Department of Genetics University Medical Center Utrecht Utrecht The Netherlands Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands School of Pharmacy and Biomolecular Sciences The Royal College of Surgeons in Ireland Dublin Ireland The FutureNeuro Research Centre Dublin Ireland Department of Neurology Beaumont Hospital Dublin Ireland Department of Neurology St. James’s Hospital Dublin Ireland Analytic and Translational Genetics Unit Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of Harvard and M.I.T Cambridge MA USA Institute for Molecular Medicine Finland (FIMM) University of Helsinki Helsinki Finland Psychiatric & Neurodevelopmental Genetics Unit Department of Psychiatry Massachusetts General Hospital and Harvard Medical School Boston MA USA Division of Biostatistics Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan Hasso Plattner Institute Digital Health Center University of Potsdam Potsdam Germany Hasso Plattner Institute Mount Sinai School of Medicine New York City NY USA Department of Neurology Vanderbilt University Medical Center Nashville TN USA Cologne Center for Genomics (CCG) University of Cologne Faculty of Medicine and University Hospital Cologne Cologne Germany University Hospital Cologne Cologne Germany Department of Neurology Charité Universitaetsmedizin Berlin Campus Virchow-Clinic Berlin Germany Tel-Aviv University Sackler Faculty of Medicine Ramat Aviv Israel Department of Neurology Sheba Medical Center Ramat Gan Israel Department of Neurosciences Rehabilitation Ophthalmology Genetics Maternal and Child Health University of Genova Genova Italy IRCCS Istituto Giannina Gaslini Genova Italy Department of Medicine University of Melbour

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes of epilepsy, and 52,538 controls. We identify 26 genome-wide significant loci, 19 of which are specific to genetic generalized epilepsy (GGE). We implicate 29 likely causal genes underlying these 26 loci. SNP-based heritability analyses show that common variants explain between 39.6% and 90% of genetic risk for GGE and its subtypes. Subtype analysis revealed markedly different genetic architectures between focal and generalized epilepsies. Gene-set analyses of GGE signals implicate synaptic processes in both excitatory and inhibitory neurons in the brain. Prioritized candidate genes overlap with monogenic epilepsy genes and with targets of current antiseizure medications. Finally, we leverage our results to identify alternate drugs with predicted efficacy if repurposed for epilepsy treatment.

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Validation of MRI-VLFF for the non-invasive measurement of steatosis in children

GastroHep

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GastroHep 2020年第4期2卷

作者： Miriam B. Vos Eduardo Castillo-Leon Jack Knight-Scott Rebecca Cleeton Alvin Jay Freeman Jennifer K. Frediani Albert Hernandez Stephen F. Simoneaux Jun Kong Alton Brad Farris Michael J House Tim St. Pierre Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Emory University Atlanta GA USA Children's Healthcare of Atlanta Atlanta GA USA Nutrition and Health Sciences Program Laney Graduate School Emory University Atlanta GA USA Department of Radiology Children's Healthcare of Atlanta Atlanta GA USA Department of Computer Science and Biomedical Informatics Emory University Atlanta GA USA Department of Mathematics and Statistics and Computer Science Georgia State University Atlanta GA USA Department of Pathology and Laboratory Medicine Emory University Atlanta GA USA School of Physics Mathematics and Computing The University of Western Australia Crawley WA Australia Resonance Health Ltd Claremont WA Australia

Background & Aims Magnetic resonance-based steatosis measurement of the liver has become the non-invasive gold standard; however very few diagnostic thresholds have been independently validated and none in children. This study was designed to validate diagnostic thresholds, assess repeatability and the relationship to histology of a proprietary MRI volumetric liver fat fraction (VLFF) method (HepaFat-Scan ® ) and magnetic resonance spectroscopy (MRS) proton density fat fraction (PDFF) method. Methods This cross-sectional study assesses the diagnostic accuracy of MRI-VLFF and MRS-PDFF of 50 children who had a clinically indicated liver biopsy. Twenty-five children were randomly selected for intra-examination repeatability. The positive pixel count (PPC) algorithm was used to quantify the area of fat vesicles in the histology. The area under the receiver operating characteristic curve (AUROC) was used to assess the diagnostic accuracy. Bland-Altman plots were used to compare the methods and examine the repeatability. Results The MRI-VLFF ranged from 0.3% to 35.4% and the MRS-PDFF ranged from 0.5% to 36.9%. Based on histopathological analysis, the diagnostic accuracy of MRI-VLFF for steatosis detection (grade 0 vs 1-3) showed an AUROC of 0.95 (95% confidence interval [CI]: 0.89-1.00), whereas MRI-PDFF classified grade 0 vs 1-3 showed an AUROC of 0.96 (95% CI: 0.91-1.00). The repeatability coefficients were 1.8 (±0.5) % for MRI-VLFF and 2.1 (±0.6) % for MRS-PDFF. There was no bias between MRI-VLFF and PPC steatosis. To allow direct comparison, MRS-PDFF was converted to MRS-VLFF. Small, but significant biases were measured between PPC steatosis and MRS-VLFF (−1.38%) and between MRI-VLFF and MRS-VLFF (−1.39%). Conclusions Both MRI-VLFF and MRS-PDFF accurately estimated hepatic steatosis in children with excellent agreement with the histological assessment.

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Constraints on VHE gamma-ray emission of Flat Spectrum Radio Quasars with the MAGIC telescopes

arXiv

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arXiv 2024年

作者： Abe, S. Abhir, J. Abhishek, A. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Engels, A. Arbet Arcaro, C. Artero, M. Asano, K. Babić, A. Baquero, A. de Almeida, U. Barres Barrio, J.A. Batković, I. Bautista, A. Baxter, J. González, J. Becerra Bednarek, W. Bernardini, E. Bernete, J. Berti, A. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Bronzini, E. Burelli, I. Busetto, G. Buson, S. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Cerasole, D. Ceribella, G. Chai, Y. Cifuentes, A. Ciprini, S. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Ammando, F. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. de Menezes, R. Del Popolo, A. Delfino, M. Delgado, J. Mendez, C. Delgado Di Pierro, F. Di Tria, R. Di Venere, L. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Escudero, J. Fariña, L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukami, S. Fukazawa, Y. López, R.J. García Garczarczyk, M. Gasparyan, S. Gaug, M. Paiva, J.G. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Gradetzke, T. Grau, R. Green, D. Green, J.G. Günther, P. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hrupec, D. Hütten, M. Imazawa, R. Ishio, K. Martínez, I. Jiménez Jormanainen, J. Kayanoki, T. Kerszberg, D. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Láinez, M. Lamastra, A. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. de Oliveira Fraga, B. Machado Majumdar, P. Makariev, M. Maneva, G. Mang, N. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Martínez-Chicharro, M. Mas-Aguilar, A. Mazin, D. Menchiari, S. Mender, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. González, M. Molero Molina, E. Mondal, H.A. Moralejo, A. Morcuende, D. Nakamori, T. Nanci, C. Neustroev, V. Nickel, L. Rosillo, M. Nievas Nigro, C. Nikolić, L. Nilsson, K. Nishijima, K. The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Università di Siena INFN Pisa SienaI-53100 Italy Bellaterra BarcelonaE-08193 Spain Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik GarchingD-85748 Germany Università di Padova INFN PadovaI-35131 Italy Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa INFN Pisa PisaI-56126 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari BariI-70125 Italy Department for Physics and Technology University of Bergen Norway INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy Universität Würzburg WürzburgD-97074 Germany Technische Universität Dortmund DortmundD-44221 Germany Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan ZeuthenD-15738 Germany Armenian MAGIC Group: ICRANet-Armenia Yerevan0019 Armenia Croatian MAGIC Group Josip Juraj Strossmayer University of Osijek Department of Physics Osijek31000 Croatia Finnish MAGIC Group Finnish Centre for Astronomy with ESO Department of Physics and Astronomy University of Turku T

Flat spectrum radio quasars (FSRQs) constitute a class of jetted active galaxies characterized by a very luminous accretion disk, prominent and rapidly moving line-emitting cloud structures (Broad Line Region, BLR), and a surrounding dense dust structure known as dusty torus. The intense radiation field of the accretion disk strongly determines the observational properties of FSRQs. While hundreds of such sources have been detected at GeV energies, only a handful of them exhibit emission in the very-high-energy (VHE, E 100 GeV) range. This study presents the results and interpretation derived from a cumulative observation period of 174 hours dedicated to nine FSRQs conducted with the MAGIC telescopes from 2008 to 2020. Our findings indicate no statistically significant (≥ 5 σ) signal for any of the studied sources, resulting in upper limits on the emission within the VHE energy range. In two of the sources, we derived quite stringent constraints on the γ-ray emission in the form of upper limits. Our analysis focuses on modeling the VHE emission of these two sources in search for hints of absorption signatures within the broad line region (BLR) radiation field. For these particular sources, constraints on the distance between the emission region and the central black hole are derived using a phenomenological model. Subsequently, these constraints are tested using a framework based on a leptonic model. Copyright © 2024, The Authors. All rights reserved.

关键词： Germanium alloys

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Performance of the joint LST-1 and MAGIC observations evaluated with Crab Nebula data

arXiv

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arXiv 2023年

作者： Abe, H. Abe, K. Abe, S. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Crespo, N. Alvarez Aniello, T. Ansoldi, S. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baack, D. Babić, A. Baktash, A. Bamba, A. Larriva, A. Baquero Baroncelli, L. de Almeida, U. Barres Barrio, J.A. Batković, I. Baxter, J. González, J. Becerra Bednarek, W. Bernardini, E. Bernardos, M.I. Medrano, J. Bernete Berti, A. Besenrieder, J. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Biland, A. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bošnjak, Ž. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Busetto, G. Ordaz, A. Campoy Cardillo, M. Caroff, S. Carosi, A. Carosi, R. Carrasco, M.S. Carretero-Castrillo, M. Cassol, F. Castro-Tirado, A.J. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cornelia, A. Cortina, J. Costantini, H. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. DelPopolo, A. Deleglise, G. Delfino, M. Mendez, C. Delgado Mengual, J. Delgado Volpe, D. della Dellaiera, M. Depaoli, D. De Angelis, A. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Dominik, R.M. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Díaz, C. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ramazani, V. Fallah Fariña, L. Fattorini, A. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Font, L. Coromina, L. Freixas Fröse, S. Fukami, S. Fukazawa, Y. López, R.J. Garcia Garcia, E. Garczarczyk, M. López, R.J. García Gasbarra, C. Gasparrini, D. Gasparyan, S. Gaug, M. Geyer, D. Paiva, J.G. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Grau, R. Green, D. Green, J.G. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Llorente, J. Herrera Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Department of Physics Tokai University 4-1-1 Kita-Kaname Kanagawa Hiratsuka259-1292 Japan Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Tenerife La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 Barcelona08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Grupo de Electronica Universidad Complutense de Madrid Av. Complutense s/n Madrid28040 Spain RomeI-00136 Italy INFN Sezione di Trieste Università degli studi di Udine via delle scienze 206 Udine33100 Italy Rome Italy INAF - Osservatorio Astronomico di Roma Via di Frascati 33 Monteporzio Catone00040 Italy INFN Sezione di Napoli Via Cintia ed. G Napoli80126 Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Università di Padova INFN PadovaI-35131 Italy The Barcelona Institute of Science and Technology Campus UAB Bellaterra08193 Spain Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules - IN2P3 Annecy74000 France Department of Physics TU Dortmund University Otto-Hahn-Str. 4 Dortmund44227 Germany Zagreb10000 Croatia Universität Hamburg Institut für Experimentalphysik Luruper Chaussee 149 Hamburg22761 Germany Graduate School of Science University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Via Piero Gobetti 93/3 Bologna40129 Italy Centro Brasileiro de Pesquisas Físicas Rua Xavier Sigaud 150 RJ Rio de Janeiro22290-180 Brazil INFN Sezione di Padova

Aims. LST-1, the prototype of the Large-Sized Telescope for the upcoming Cherenkov Telescope Array Observatory, is concluding its commissioning in Observatorio del Roque de los Muchachos on the island of La Palma. The proximity of LST-1 (Large-Sized Telescope 1) to the two MAGIC (Major Atmospheric Gamma Imaging Cherenkov) telescopes permits observations of the same gamma-ray events with both systems. Methods. We describe the joint LST-1+MAGIC analysis pipeline and use simultaneous Crab Nebula observations and Monte Carlo simulations to assess the performance of the three-telescope system. The addition of the LST-1 telescope allows the recovery of events in which one of the MAGIC images is too dim to survive analysis quality cuts. Results. Thanks to the resulting increase in the collection area and stronger background rejection, we find a significant improvement in sensitivity, allowing the detection of 30% weaker fluxes in the energy range between 200 GeV and 3 TeV. The spectrum of the Crab Nebula, reconstructed in the energy range ∼60 GeV to ∼10 TeV, is in agreement with previous measurements. Copyright © 2023, The Authors. All rights reserved.

关键词： Telescopes

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Retracted: Design of Decision Support System Determination of Inventory Inventory Using Single Exponential Smoothing Forecasting Method

Retracted: Design of Decision Support System Determination o...

引用

2018 Workshop on Multidisciplinary and Its Applications: Applied Mathematics, Computer science, Information Systems, and Information Technology, WMA-Mathcomtech 2018

作者： Iqbal, Muhammad Abdullah, Dahlan Hartono, H. Erliana, Cut Ita Sriadhi, S. Nurmawati, N. Prasnowo, M Adhi Hasibuan, Abdurrozzaq Iskandar, Akbar Saddhono, Kundharu Abdussakir, A. Musa, Hastuti Setiawan, Muhammad Ikhsan Sagala, Youmeni Siahaan, Rumiris Sinaga, Eka Mayastika Syahputri, Anggraini Milanie, Feby Aspan, Henry Khaddafi, Muammar Department of Computer System Universitas Pembangunan Panca Budi Medan Indonesia Department of Informatics Universitas Malikussaleh Aceh Indonesia Department of Computer Science STMIK IBBI Medan Indonesia Department of Industrial Engineering Universitas Malikussaleh Aceh Indonesia Department of Electrical Engineering Universitas Negeri Medan Indonesia Faculty of Industry Technique University of 45 Surabaya Indonesia Department of Industrial Engineering Universitas Maarif Hasyim Latif Sidoarjo Indonesia Faculty of Engineering Universitas Islam Sumatera UtaraMedan Indonesia Indonesia Informatics Engineering STMIK AKBA Makassar Indonesia Graduate Program Universitas Sebelas Maret Surakarta Indonesia Department of Mathematics Education State Islamic University of Malang Malang Indonesia Department of Mathematics Universitas Muhammadiyah Parepare Indonesia Department of Civil Engineering Narotama University Surabaya Indonesia STIE Bina Karya Tebing Tinggi Indonesia Universitas Pembangunan Panca Budi Medan Indonesia Department of Accounting Universitas Malikussaleh Aceh Indonesia

The development of information and communication technology at this time has touched all sides of life. Almost no side of human life is not touched by this information technology, which is more synonymous with the world of computerization. No exception also with the computerization that is popular in the corporate environment and government agencies. If in ancient times everything was still done manually. However, at this time all leaders and management have realized the importance of this information technology products that can facilitate them in carrying out the day-to-day corporate functions. Decision Making System of goods purchasing is one of the determinants of the accumulation of goods. If the decision is taken right then stockpiling of goods can be avoided. In this thesis the authors designed a web-based system that helps Management in making the decision of the purchase amount of goods. the system was developed by using Microsoft Visual Studio 2010 and using SQL Server database processing applications. The end result of system design is expected to help minimize the accumulation of goods. © Published under licence by IOP Publishing Ltd.

关键词： Decision support systems

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Multi-messenger characterization of Mrk501 during historically low X-ray and gamma-ray activity 37

Multi-messenger characterization of Mrk501 during historical...

引用

37th International Cosmic Ray Conference, ICRC 2021

作者： Heckmann, L. Paneque, D. Gasparyan, S. Cerruti, M. Sahakyan, N. Arbet-Engels, A. Acciari, V.A. Ansoldi, S. Antonelli, L.A. Arbet Engels, A. Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. Barres de Almeida, U. Barrio, J.A. Batković, I. Becerra González, J. Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bökenkamp, H. Bonnoli, G. Bošnjak, Ž. Busetto, G. Carosi, R. Ceribella, G. Chai, Y. Chilingarian, A. Cikota, S. Colak, S.M. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Pierro, F. Di Venere, L. Do Souto Espiñeira, E. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Fallah Ramazani, V. Fattorini, A. Fonseca, M.V. Font, L. Fruck, C. Fukami, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Green, J.G. Green, D. Hadasch, D. Hahn, A. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hütten, M. Inada, T. Ishio, K. Iwamura, Y. Jiménez Martínez, I. Jormanainen, J. Jouvin, L. Karjalainen, M. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Machado de Oliveira Fraga, B. Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Maraschi, L. Mariotti, M. Martínez, M. Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Nakamori, T. Nava, L. Neustroev, V. Nigro, C. Nilsson, K. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J.M. Pavletić, L. Peñil, P. Persic, M. Pihet, M. Max-Planck-Institut für Physik MünchenD-80805 Germany ICRANet-Armenia Marshall Baghramian Avenue 24a Yerevan0019 Armenia Martí i Franquès 1 BarcelonaE08028 Spain ETH Zürich ZürichCH-8093 Switzerland Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna La Laguna TenerifeE-38200 Spain Università di Udine INFN Trieste UdineI-33100 Italy RomeI-00136 Italy Bellaterra BarcelonaE-08193 Spain The University of Tokyo Kashiwa Chiba277-8582 Japan Technische Universität Dortmund DortmundD-44221 Germany Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil Università di Padova INFN PadovaI-35131 Italy University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Università di Siena INFN Pisa SienaI-53100 Italy ZeuthenD-15738 Germany INAF Trieste Dept. of Physics and Astronomy University of Bologna Bologna Italy Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Università di Pisa INFN Pisa PisaI-56126 Italy Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Armenian MAGIC Group A. Alikhanyan National Science Laboratory Yerevan0036 Armenia Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica Università e del Politecnico di Bari BariI-70125 Italy Croatian MAGIC Group University of Rijeka Department of Physics Rijeka51000 Croatia Universität Würzburg WürzburgD-97074 Germany Finnish MAGIC Group Finnish Centre for Astronomy with ESO University of Turku TurkuFI-20014 Finland Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Japanese MAGIC Group:

Blazars, together with other active galactic nuclei, are the most luminous persistent sources in our universe;and therefore a prime candidate for very-high-energy (>0.2 TeV, VHE) gamma-ray observations. For the two MAGIC telescopes, the Mrk501 galaxy is among the brightest observed blazars due to its proximity. We report a multi-wavelength and multi-messenger study of Mrk501 with data from 2017 to 2020, when Mrk501 showed a VHE flux typically below 10% that of the Crab Nebula. During this time, we performed three long observations with NuSTAR, which characterized the hard X-ray emission during three different low-activity flux levels. This Mrk501 dataset provided the unprecedented opportunity to study multi-wavelength variability and correlations with sensitive instruments during historically low X-ray and VHE gamma-ray emission (below 5% of the Crab Nebula flux in the VHE range), which could be considered as the baseline emission of Mrk501. We complemented the broadband spectral energy distributions (SED) of the identified historically low X-ray and VHE gamma-ray flux with data published by IceCube, in order to evaluate the potential existence of a hadronic component that is stable (or slowly variable), and less visible than the leptonic component that may dominate the emission during typical and flaring activity. In this contribution, we will also describe the evolution of the broadband SED comparing different theoretical scenarios. © Copyright owned by the author(s).

关键词： Gamma rays

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