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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Shun-Cheng Chang Hsin-Pei Yu Yi-Hsien Hsieh Pochuang Wang Weichung Wang Tung-Hung Su Jia-Horng Kao Che Lin Graduate Institute of Communication Engineering National Taiwan University (NTU) Taipei Taiwan Department of Computer Science and Information Engineering NTU Taipei Taiwan Institute of Applied Mathematical Sciences NTU Taipei Taiwan Department of Internal Medicine Division of Gastroenterology and Hepatology National Taiwan University Hospital Taipei Taiwan Department of Electrical Engineering NTU Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine NTU Taipei Taiwan Smart Medicine and Health Informatics Program NTU Taipei Taiwan

ISBN: (数字)9798350351552

ISBN: (纸本)9798350351569

Deep learning has revolutionized medical imaging, offering advanced methods for accurate diagnosis and treatment planning. The BCLC staging system is crucial for staging Hepatocellular Carcinoma (HCC), a high-mortality cancer. An automated BCLC staging system could significantly enhance diagnosis and treatment planning efficiency. However, we found that BCLC staging, which is directly related to the size and number of liver tumors, aligns well with the principles of the Multiple Instance Learning (MIL) framework. To effectively achieve this, we proposed a new preprocessing technique called Masked Cropping and Padding(MCP), which addresses the variability in liver volumes and ensures consistent input sizes. This technique preserves the structural integrity of the liver, facilitating more effective learning. Furthermore, we introduced Re ViT, a novel hybrid model that integrates the local feature extraction capabilities of Convolutional Neural Networks (CNNs) with the global context modeling of Vision Transformers (ViTs). Re ViT leverages the strengths of both architectures within the MIL framework, enabling a robust and accurate approach for BCLC staging. We will further explore the trade-off between performance and interpretability by employing TopK Pooling strategies, as our model focuses on the most informative instances within each bag.

关键词： Visualization Accuracy Three-dimensional displays Liver Transformers Planning Convolutional neural networks Context modeling Biomedical imaging Tumors

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A BCLC Staging System for Hepatocellular Carcinoma using Swin Transformer and CT Imaging

A BCLC Staging System for Hepatocellular Carcinoma using Swi...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Shun-Cheng Chang Pochuang Wang Weichung Wang Tung-Hung Su Jia-Horng Kao Che Lin Graduate Institute of Communication Engineering National Taiwan University (NTU) Taipei Taiwan Department of Computer Science and Information Engineering NTU Taipei Taiwan NTU Institute of Applied Mathematical Sciences Taipei Taiwan Department of Internal Medicine Division of Gastroenterology and Hepatology National Taiwan University Hospital Taipei Taiwan Department of Electrical Engineering NTU Taipei Taiwan NTU Center for Advanced Computing and Imaging in Biomedicine Taipei Taiwan NTU Smart Medicine and Health Informatics Program Taipei Taiwan

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

The Barcelona Clinic Liver Cancer (BCLC) staging system plays a crucial role in clinical planning, offering valuable insights for effectively managing hepatocellular carcinoma. Accurate prediction of BCLC stages can significantly ease the workload on radiologists. However, few datasets are explicitly designed for discerning BCLC stages. Despite the common practice of appending BCLC labels to clinical data within datasets, the inherent imbalance in BCLC distribution is further amplified by the diverse purposes for which datasets are curated. In this study, we aim to develop a BCLC staging system using the advanced Swin Transformer model. Additionally, we explore the integration of two datasets, each originally intended for separate objectives, highlighting the critical challenge of preserving class distribution in practical study designs. This exploration is pivotal for ensuring the applicability of our developed staging system in the designed clinical settings. Our resulting BCLC staging system demonstrates an accuracy of 55.81% (±7.8%), contributing to advancing medical image-based research for predicting BCLC stages.

关键词： Liver cancer Accuracy Computed tomography Biological system modeling Transformers Planning Biomedical imaging

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Preliminary Design for Reference tracking feedback for Medical Cyber-Physical Pharmacokinetic Systems

Preliminary Design for Reference tracking feedback for Medic...

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IEEE International Conference on Automatica (ICA-ACCA)

作者： Pedro M. Oliveira Daniel Bustos Rodolfo Lobo Márcio J. Lacerda Jonathan M. Palma Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil Dept. of Translational Medicine Universidad Católica del Maule Talca Chile Ingenieria en Telecomunicaciones e Informática Universidad Diego Portales Santiago Chile Centre for Communications Technology School of Computing and Digital Media London Metropolitan University London UK Faculty of Engineering Universidad de Talca Curicó Chile

ISBN: (数字)9798350378115

ISBN: (纸本)9798350378122

This paper addresses the reference tracking control problem for Medical Cyber-Physical Systems (MCPS). The control theory is employed to guarantee the suitable concentration of drugs in the body of patients to guarantee a safe treatment. The MCPS is modeled as a switched system, and the modes consider the different scenarios for the problem. A discrete-time model is utilized for the pharmacokinetic process, and the zero input control strategy is employed to design state-feedback controllers with a guaranteed exponential convergence rate. A numerical experiment is presented to illustrate the validity and effectiveness of our method.

关键词： Drugs Switched systems Design methodology Process control Medical services Cyber-physical systems Numerical models Control theory Pharmacokinetics Convergence

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Predicting Neurological Outcomes of Comatose Cardiac Arrest Patients Using Transformer Neural Networks with EEG Data

Predicting Neurological Outcomes of Comatose Cardiac Arrest ...

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Computers in Cardiology (CinC)

作者： Jefferson Dionisio Che Lin Lian-Yu Lin Wen-Chau Wu Smart Medicine and Health Informatics Program National Taiwan University (NTU) Taipei Taiwan Department of Electrical Engineering NTU Graduate Institute of Communication Engineering NTU School of Medicine NTU Center for Advanced Computing and Imaging in Biomedicine NTU Center for Biotechnology NTU Department of Internal Medicine NTU Hospital Taipei Taiwan Institute of Medical Device and Imaging NTU Department of Radiology College of Medicine NTU Graduate Institute of Clinical Medicine NTU

As part of the 2023 PhysioNet Challenge, our team FINDING_MEMO utilized Transformer to predict outcomes using patient EEG data since it excels at dealing with sequential data like EEG. We mainly used the Transformer encoder block's multi-head self-attention to generate representations from the input and leverage several hidden layers to form the final prediction. Using the latest EEG from every patient, our team achieved the challenge score of 0.42 with the hidden validation set (ranked 36th out of 73 invited teams) and obtained a result of 0.37 (ranked 29th out of 36 qualified teams). Our results show a consistent performance across varying EEG recording durations in both the validation and test set. Our team also had the second-best score when evaluated, with only 12 hours of available recordings in the test set. Such promising results showcase the models' generalizability and clinical potential in predicting outcomes for comatose patients, especially for limited available EEG recordings.

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Dynamic programming Algorithm using Furniture Industry 0/1 Knapsack Problem

Dynamic Programming Algorithm using Furniture Industry 0/1 K...

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International Conference on Cybernetics and Intelligent System (ICORIS)

作者： Mietha Anditta Natashya Amartya Laurens Spits Warnars Harco Leslie Hendric Spits Warnars Arief Ramadhan Teddy Siswanto Teddy Mantoro Nurulhuda Noordin Computer Science Departement School of Computer Science Bina Nusantara University Jakarta Indonesia Information Systems Departement School of Information Systems Bina Nusantara University Jakarta Indonesia Computer Science Departement BINUS Graduate Program - Computer Science Bina Nusantara University Jakarta Indonesia PJJ Informatika Telkom University Bandung Indonesia Information Systems Department Trisakti University Jakarta Indonesia Faculty of Engineering and Technology Sampoerna University Jakarta Indonesia School of Computing Sciences College of Computing Informatics and Mathematics Universiti Teknologi MARA Selangor Malaysia

Dynamic programming is a fundamental algorithm that can be found in our daily lives easily. One of the dynamic programming algorithm implementations consists of solving the 0/1 knapsack problem. A 0/1 knapsack problem can be seen from industrial production cost. It is prevalent that a production cost has to be as efficient as possible, but the expectation is to get the proceeds of the products higher. Thus, the dynamic programming algorithm can be implemented to solve the diverse knapsack problem, one of which is the 0/1 knapsack problem, which would be the main focus of this paper. The implementation was implemented using C language. This paper was created as an early implementation algorithm using a Dynamic program algorithm applied to an Automatic Identification System (AIS) dataset.

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Is Attention All You Need for EEG to Predict Neurological Outcomes in Cardiac Arrest?

Is Attention All You Need for EEG to Predict Neurological Ou...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Jefferson Dionisio Muhammad Rizwan Hidetaka Suzuki Kazi Mahmudul Hassan Ingon Chanpornpakdi Lian-Yu Lin Toshihisa Tanaka Che Lin Department of Smart Medicine and Health Informatics National Taiwan University Taipei Taiwan Artificial Intelligence of Things Taiwan International Graduate Program Academia Sinica Taipei Taiwan Tokyo University of Agriculture and Technology Tokyo Japan Department of Emergency and Critical Care Japanese Red Cross Musashino Hospital Tokyo Japan Department of Internal Medicine Division of Cardiology National Taiwan University College of Medicine and Hospital Taipei Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Graduate Institute of Communication Engineering National Taiwan University Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine National Taiwan University Taipei Taiwan

ISBN: (数字)9798350351552

ISBN: (纸本)9798350351569

Sudden cardiac arrest (SCA) poses a significant health challenge, necessitating accurate predictions of neurological outcomes in comatose patients, where good outcomes are defined as the recovery of most cognitive functions. Electroencephalogram (EEG) serves as a valuable biomarker for monitoring neurological states due to its rich, time-dependent information. This study aims to predict neurological outcomes using early EEG data by employing the Transformer model, which leverages multi-headed attention to identify patterns in lengthy sequences such as hour-long EEG recordings. Unlike traditional methods that use subsampled EEG epochs, we utilize the entire EEG sequences, subdivided into time steps, allowing our model to capture detailed temporal patterns via the attention mechanism. Moreover, we trained our proposed model using each EEG recording as an individual data sample but evaluated our model through aggregated patient-wise predictions. This approach allows us to boost the data sample size. Our results demonstrate promising predictive performance, achieving an AUROC of 0.82 and AUPRC of 0.90 on the holdout test set and an AUROC of 0.73 and AUPRC of 0.93 on an external test set with patient-wise predictions. This study highlights the potential of utilizing attention mechanisms to capture important time series progressions across EEG sequences for improving SCA prognosis.

关键词： Attention mechanisms Biological system modeling Time series analysis Cardiac arrest Predictive models Brain modeling Transformers Electroencephalography Data models Recording

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Android Based Heart-rate Monitoring System using ECG Sensor

Android Based Heart-rate Monitoring System using ECG Sensor

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International Conference on Sustainable engineering and Creative computing (ICSECC)

作者： Rosalina Grace Selina Rila Mandala Faculty of Computing Information Technology Study Program President University Bekasi Indonesia School of Electrical Engineering and Informatics Bandung Institute of Technology Bandung Indonesia

ISBN: (纸本)9781728175898

This research aims to help the user monitor their heart’s condition and notify other people in case of an emergency due to an abnormal heartbeat (normal heartbeat around 60-100 beats per minute). From the heart rate graph, the user could do a consultation with an expert in the nearest hospital using a map feature that will show the nearest hospital with a 1 KM radius from the user’s current location. The heart is undeniably an essential part of the human body system. The heart's missions are to pump blood to the lungs to expel the waste carbon dioxide that resulted from the respiration and pump blood that will deliver oxygen throughout the human body's circulation system. While the blood that carries oxygen being pumped throughout the human body, the heart will provide the oxygen to all cells. Body cells need to use oxygen to get the energy from food through a process called cellular respiration. Monitoring our heartbeat and pulse rate can increase people’s awareness about their heart’s health, motivating, and encouraging people to maintain a healthy eating plan and exercise. This research will be implemented ECG Sensor. The sensor will then send the data to the android application via HC-06 Bluetooth module. Monitoring the heart rate and analyzing the user’s heartbeat will be done in the android with a microcontroller device's help.

关键词： Bluetooth Heart beat Hospitals Microcontrollers Lung Electrocardiography Biomedical monitoring

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Development of a virtual reality environment for rehabilitation of tetraplegics 13

Development of a virtual reality environment for rehabilitat...

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13th International Conference on Biomedical Electronics and Devices, BIODEVICES 2020 - Part of 13th International Joint Conference on Biomedical engineering Systems and Technologies, BIOSTEC 2020

作者： Ginja, Gabriel Augusto Varoto, Renato Cliquet, Alberto Bioengineering Post Graduate Program University of São Paulo Av. Trabalhador São Carlense 400 São CarlosCEP 13566-590 Brazil Electrical and Computing Engineering Department University of São Paulo São Carlos SP Brazil Orthopedics and Traumatology Department Faculty of Medical Sciences University of Campinas Campinas SP Brazil

ISBN: (纸本)9789897583988

Treatments based on Virtual Reality have been successfully used in motor rehabilitation of issues such as Spinal Cord Injury and Stroke. Highly immersive Virtual environments combined with biofeedback can be utilized to train functional activities on patients with these motor disabilities. This work details the development of a portable Virtual Reality environment to train upper limbs activities on Spinal Cord Injury subjects. The Virtual Reality environment depicts a personalized physiotherapy room where the user trains elbow and shoulder by reaching 5 spots on table. Also the user have a biofeedback of both hands’ position. Finally this system will be integrated a pilot biomechanical analysis using The Motion Monitor system to compare a group of patients before and after a 6 week intervention with Virtual Reality. Copyright © 2020 by SCITEPRESS – Science and Technology Publications, Lda. All rights reserved.

关键词： Virtual reality

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FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare

arXiv

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arXiv 2023年

作者： Lekadir, Karim Feragen, Aasa Fofanah, Abdul Joseph Frangi, Alejandro F. Buyx, Alena Emelie, Anais Lara, Andrea Porras, Antonio R. Chan, An-Wen Navarro, Arcadi Glocker, Ben Botwe, Benard O. Khanal, Bishesh Beger, Brigit Wu, Carol C. Cintas, Celia Langlotz, Curtis P. Rueckert, Daniel Mzurikwao, Deogratias Fotiadis, Dimitrios I. Zhussupov, Doszhan Ferrante, Enzo Meijering, Erik Weicken, Eva González, Fabio A. Asselbergs, Folkert W. Prior, Fred Krestin, Gabriel P. Collins, Gary S. Tegenaw, Geletaw S. Kaissis, Georgios Misuraca, Gianluca Tsakou, Gianna Dwivedi, Girish Kondylakis, Haridimos Jayakody, Harsha Woodruf, Henry C. Mayer, Horst Joachim Aerts, Hugo JWL Walsh, Ian Chouvarda, Ioanna Buvat, Irène Tributsch, Isabell Rekik, Islem Duncan, James Kalpathy-Cramer, Jayashree Zahir, Jihad Park, Jinah Mongan, John Gichoya, Judy W. Schnabel, Julia A. Kushibar, Kaisar Riklund, Katrine Mori, Kensaku Marias, Kostas Amugongo, Lameck M. Fromont, Lauren A. Maier-Hein, Lena Alberich, Leonor Cerdá Rittner, Leticia Phiri, Lighton Marrakchi-Kacem, Linda Donoso-Bach, Lluís Martí-Bonmatí, Luis Cardoso, M. Jorge Bobowicz, Maciej Shabani, Mahsa Tsiknakis, Manolis Zuluaga, Maria A. Bielikova, Maria Fritzsche, Marie-Christine Camacho, Marina Linguraru, Marius George Wenzel, Markus De Bruijne, Marleen Tolsgaard, Martin G. Ghassemi, Marzyeh Ashrafuzzaman, Md Goisauf, Melanie Yaqub, Mohammad Abadía, Mónica Cano Mahmoud, Mukhtar M.E. Elattar, Mustafa Rieke, Nicola Papanikolaou, Nikolaos Lazrak, Noussair Díaz, Oliver Salvado, Olivier Pujol, Oriol Sall, Ousmane Guevara, Pamela Gordebeke, Peter Lambin, Philippe Brown, Pieta Abolmaesumi, Purang Dou, Qi Lu, Qinghua Osuala, Richard Nakasi, Rose Zhou, S. Kevin Napel, Sandy Colantonio, Sara Albarqouni, Shadi Joshi, Smriti Carter, Stacy Klein, Stefan Petersen, Steffen E. Aussó, Susanna Awate, Suyash Raviv, Tammy Riklin Cook, Tessa Mutsvangwa, Tinashe E.M. Rogers, Wendy A. Niessen, Wiro J. Puig-Bosch, Xènia Zeng, Yi Mohammed, Yunusa G. Aquino, Yves Saint James Salahuddin, Zohaib Starmans, Martijn P.A. Department de Matemàtiques i Informàtica Universitat de Barcelona Barcelona Spain Barcelona Spain DTU Compute Technical University of Denmark Kgs Lyngby Denmark Department of Mathematics and Computer Science Faculty of Science and Technology Milton Margai Technical University Freetown Sierra Leone Center for Computational Imaging & Simulation Technologies in Biomedicine Schools of Computing and Medicine University of Leeds Leeds United Kingdom Cardiovascular Science and Electronic Engineering Departments KU Leuven Leuven Belgium Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Faculty of Engineering of Systems Informatics and Sciences of Computing Galileo University Guatemala City Guatemala Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Department of Medicine Women’s College Research Institute University of Toronto Toronto Canada Universitat Pompeu Fabra BarcelonaBeta Brain Research Center Barcelona Spain Department of Computing Imperial College London London United Kingdom School of Biomedical & Allied Health Sciences University of Ghana Accra Ghana Department of Midwifery & Radiography School of Health & Psychological Sciences City University of London United Kingdom Kathmandu Nepal European Heart Network Brussels Belgium Department of Thoracic Imaging University of Texas MD Anderson Cancer Center Houston United States IBM Research Africa Nairobi Kenya Departments of Radiology Medicine and Biomedical Data Science Stanford University School of Medicine Stanford United States Institute for AI and Informatics in Medicine Klinikum rechts der Isar Technical University Munich Munich Germany Department of Computing Imperial College London London United Kingdom Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania United Republic of Ioannina Greece Almaty AI Lab Almaty Kazakhstan

Background: Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. In recent years, concerns have been raised about the clinical, technical, ethical and legal risks associated with healthcare AI. To increase adoption in the real world, it is essential that AI technologies are trusted and accepted by patients, clinicians, health organisations and authorities. This paper describes the FUTURE-AI framework as the first international consensus guideline for trustworthy AI in healthcare. Methods: The FUTURE-AI consortium was founded in 2021 and now comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two-year period, the consortium established guiding principles and best practices for trustworthy and deployable AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. Findings: The FUTURE-AI framework was established based on six guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 30 best practices were defined, addressing technical, clinical, socio-ethical and legal dimensions of trustworthy AI. The recommendations cover the entire lifecycle of healthcare AI, from design, development and validation to regulation, deployment, and monitoring. Interpretation: FUTURE-AI is a structured, risk-informed framework which provides guidance for constructing healthcare AI tools that will be trusted, deployed and adopted in real-world clinical practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of healthcare AI. Copyright © 2023, The Authors. All rights

关键词： Clinical research

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The ACROBAT 2022 challenge: Automatic registration of breast cancer tissue

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Medical Image Analysis 2024年 97卷 103257页

作者： Weitz, Philippe Valkonen, Masi Solorzano, Leslie Carr, Circe Kartasalo, Kimmo Boissin, Constance Koivukoski, Sonja Kuusela, Aino Rasic, Dusan Feng, Yanbo Pouplier, Sandra Sinius Sharma, Abhinav Eriksson, Kajsa Ledesma Robertson, Stephanie Marzahl, Christian Gatenbee, Chandler D. Anderson, Alexander R.A. Wodzinski, Marek Jurgas, Artur Marini, Niccolò Atzori, Manfredo Müller, Henning Budelmann, Daniel Weiss, Nick Heldmann, Stefan Lotz, Johannes Wolterink, Jelmer M. De Santi, Bruno Patil, Abhijeet Sethi, Amit Kondo, Satoshi Kasai, Satoshi Hirasawa, Kousuke Farrokh, Mahtab Kumar, Neeraj Greiner, Russell Latonen, Leena Laenkholm, Anne-Vibeke Hartman, Johan Ruusuvuori, Pekka Rantalainen, Mattias Department of Medical Epidemiology and Biostatistics Karolinska Insitutet Stockholm Sweden Institute of Biomedicine University of Turku Turku Finland Institute of Biomedicine University of Eastern Finland Kuopio Finland Department of Surgical Pathology Zealand University Hospital Roskilde Denmark Department of Oncology and Pathology Karolinska Institutet Stockholm Sweden Gestalt Diagnostics Spokane United States Department of Integrated Mathematical Oncology Moffitt Cancer Center Tampa United States Informatics Institute University of Applied Sciences Western Switzerland Switzerland Department of Measurement and Electronics AGH University of Kraków Poland Department of Computer Science University of Geneva Geneva Switzerland Department of Neuroscience University of Padova Italy Medical Faculty University of Geneva Switzerland Fraunhofer Institute for Digital Medicine MEVIS Lübeck Germany Department of Applied Mathematics Technical Medical Centre University of Twente Enschede Netherlands Multimodality Medical Imaging Technical Medical Centre University of Twente Enschede Netherlands Department of Electrical Engineering Indian Institute of Technology Bombay India Graduate School of Engineering Muroran Institute of Technology Hokkaido Japan Faculty of Medical Technology Niigata University of Health and Welfare Niigata Japan FORXAI Business Operations Konica Minolta Inc. Osaka Japan Department of Computing Science University of Alberta EdmontonAlberta United States Alberta Machine Intelligence Institute Edmonton Canada MedTechLabs BioClinicum Karolinska University Hospital Stockholm Sweden Faculty of Medicine and Health Technology Tampere University Tampere Finland

The alignment of tissue between histopathological whole-slide-images (WSI) is crucial for research and clinical applications. Advances in computing, deep learning, and availability of large WSI datasets have revolutionised WSI analysis. Therefore, the current state-of-the-art in WSI registration is unclear. To address this, we conducted the ACROBAT challenge, based on the largest WSI registration dataset to date, including 4,212 WSIs from 1,152 breast cancer patients. The challenge objective was to align WSIs of tissue that was stained with routine diagnostic immunohistochemistry to its H&E-stained counterpart. We compare the performance of eight WSI registration algorithms, including an investigation of the impact of different WSI properties and clinical covariates. We find that conceptually distinct WSI registration methods can lead to highly accurate registration performances and identify covariates that impact performances across methods. These results provide a comparison of the performance of current WSI registration methods and guide researchers in selecting and developing methods. © 2024

关键词： Tissue

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