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IEEE EMBS International Conference on Information technology Applications in Biomedicine (ITAB)

作者： Elizabeth Healey Isaac Kohane Harvard-MIT Program in Health Sciences and Technology Cambridge MA USA

ISBN: (数字)9798350351552

ISBN: (纸本)9798350351569

In recent years, the number of patients using continuous glucose monitoring (CGM) has increased. In addition to helping patients manage their disease, CGM produces time series data that can be used for integration in control algorithms, predictive models, and for retrospective analyses. Through feature extraction, many digital biomarkers can be derived from CGM. In this work, we provide a tool to extract features derived from the frequency domain. We first introduce a novel open-source Python library, CGM-Freq, for the analysis of CGM data in the frequency domain. We then test the library on real data. This work provides an open-source tool to further investigate the frequency domain of CGM signals.

关键词： Continuous glucose monitoring Frequency-domain analysis Time series analysis Signal processing algorithms Signal processing Predictive models Feature extraction Prediction algorithms Libraries Diseases

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Clinical applications of optical coherence tomography for imaging diagnostics

Clinical applications of optical coherence tomography for im...

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Latin America Optics and Photonics Conference, LAOP 2016

作者： Uribe-Patarroyo, Néstor Villiger, Martin Bouma, Brett E. Wellman Center for Photomedicine Harvard Medical School and Massachusetts General Hospital 40 Blossom Street BostonMA02114 United States Harvard-MIT Program in Health Sciences and Technology CambridgeMA02139 United States

We present our latest developments in optical coherence tomography to complement tissue morphology information with molecular specificity and functional information in intravascular clinical applications, including ad... 详细信息

ISBN: (纸本)9781943580163

关键词： Optical tomography

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Hering's opponent-colors theory fails a key test in a non-Western culture 44

Hering's opponent-colors theory fails a key test in a non-We...

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44th Annual Meeting of the Cognitive Science Society: Cognitive Diversity, CogSci 2022

作者： Conway, Bevil R. Malik-Moraleda, Saima Gibson, Edward Laboratory of Sensorimotor Research National Eye Institute National Institute of Mental Health Program in Speech and Hearing Bioscience and Technology Harvard University United States Department of Brain and Cognitive Sciences MIT

Opponent Colors Theory advances that four colors have special status and are yoked in opponent fashion (yellow-versus-blue, and red-versus-green). Classic hue cancelation studies provide evidence for this theory: people readily pick out colors that are neither red nor green, usually yellow. Here we conducted a version of a hue-cancelation experiment with the Tsimane' people, a nonindustrialized culture in the Amazon. Tsimane' speakers readily identified reddish and greenish color chips, but they showed idiosyncratic choices when asked to identify a color that is neither reddish nor greenish, unlike English speakers who consistently select focal yellow. The Tsimane' participants who also spoke Spanish and had a consistent label for English "yellow" ("amarillo"), performed similarly to the Tsimane' monolinguals, suggesting that simply having a label for "yellow" is not sufficient to explain the consistency of English speakers. The results add to a growing body of evidence that does not support Opponent Colors Theory. © 2022 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY)

关键词： Color

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Hypoxia in extravillous trophoblasts links maternal obesity and offspring neurobehavior

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iScience 2025年第6期28卷

作者： Fatima Gunter-Rahman Shayna Mallett Frédérique White Pierre-Étienne Jacques Ravikiran M. Raju Marie-France Hivert Eunjung Alice Lee Harvard-MIT Program in Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA USA Division of Genetics and Genomics Boston Children’s Hospital Boston MA USA Department of Pediatrics Harvard Medical School Boston MA USA Département de Biologie Faculté des Sciences Université de Sherbrooke Sherbrooke QC Canada Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke Sherbrooke QC Canada Institut de Recherche sur le Cancer de l’Université de Sherbrooke Sherbrooke QC Canada Division of Newborn Medicine Boston Children’s Hospital Harvard Medical School Boston MA USA Picower Institute for Learning and Memory Massachusetts Institute of Technology Cambridge MA USA Department of Population Medicine Harvard Pilgrim Health Care Institute and Harvard Medical School Boston MA USA Diabetes Unit Endocrine Division Department of Medicine Massachusetts General Hospital Boston MA USA Broad Institute of MIT and Harvard Cambridge MA 02142 USA

While maternal obesity (MO) is associated with neurobehavioral impairment (NBI) in offspring, the underlying mechanisms remain unknown. The placenta is thought to play a role in fetal programming. To elucidate the association between MO and offspring NBI, we performed single-nucleus RNA-seq on maternal- and fetal-facing sides of human term placentas from MO and lean groups. MO placentas showed the upregulation of hypoxia response genes in multiple cell types, and maternal-facing hypoxia gene expression correlated with offspring NBI in an independent birth cohort, Gen3G. Extravillous trophoblasts (EVTs) showed the highest expression of NBI-correlated genes, and EVT NBI-gene expression correlated with hypoxia signatures in two cohorts. Exposing cultured EVTs to hypoxia increased NBI gene expression, and 44% of the association between maternal BMI and NBI-gene expression in EVTs was mediated by hypoxia. Our findings suggest that hypoxia in EVTs is a key process in the neurodevelopmental programming of fetal exposure to MO.

关键词： Molecular biology Neuroscience

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Corrigendum to 'Engineered cell-laden human protein-based elastomer' [34(2013), 5496-5505]

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Biomaterials 2025年 314卷 122850页

作者： Nasim Annabi Suzanne M mithieux Pinar Zorlutuna Gulden Camci-Unal Anthony S Weiss Ali Khademhosseini Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge MA 02139 USA. School of Molecular Bioscience University of Sydney Sydney 2006 Australia. Biomedical Engineering Program and Mechanical Engineering Department University of Connecticut 191 Auditorium Road Storrs CT 06269-3139 USA. Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA. School of Molecular Bioscience University of Sydney Sydney 2006 Australia Bosch Institute University of Sydney Sydney 2006 Australia Charles Perkins Centre University of Sydney Sydney 2006 Australia. Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge MA 02139 USA. Electronic address: khademh@***.

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The Future of Drug Delivery

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CHEMISTRY OF MATERIALS 2023年第2期35卷 359-363页

作者： Gao, Jingjing Karp, Jeffrey Langer, Robert Joshi, Nitin Center for Nanomedicine Department of Anesthesiology Perioperative and Pain Medicine Brigham and Women’s Hospital Boston Massachusetts 02115 United States Harvard Medical School Boston Massachusetts 02115 United States Harvard-MIT Program in Health Sciences and Technology MIT Cambridge Massachusetts 02139 United States Harvard Stem Cell Institute Cambridge Massachusetts 02138 United States Broad Institute of MIT and Harvard Cambridge Massachusetts 02142 United States Department of Chemical Engineering Massachusetts Institute of Technology Cambridge Massachusetts 02142 United States Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge Massachusetts 02142 United States

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Exploiting temporal change of pitch in formant estimation

Exploiting temporal change of pitch in formant estimation

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： Tianyu T. Wang Thomas F. Quatieri Speech & Hearing Bioscience & Technology Program Harvard-MIT Division of Health Sciences and Technology MIT Lincoln Laboratories USA

This paper considers the problem of obtaining an accurate spectral representation of speech formant structure when the voicing source exhibits a high fundamental frequency. Our work is inspired by auditory perception and physiological modeling studies implicating the use of temporal changes in speech by humans. Specifically, we develop and assess signal processing schemes aimed at exploiting temporal change of pitch as a basis for formant estimation. Our methods are cast in a generalized framework of two-dimensional processing of speech and show quantitative improvements under certain conditions over representations derived from traditional and homomorphic linear prediction. We conclude by highlighting potential benefits of our framework in the particular application of speaker recognition with preliminary results indicating a performance gender-gap closure on subsets of the TImit corpus.

关键词： Frequency estimation Humans Speaker recognition Speech processing Two dimensional displays Time frequency analysis Power harmonic filters Laboratories Auditory system Frequency conversion

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Selective Attention in Normal and Impaired Hearing

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Trends in Amplification 2008年第4期12卷 283-299页

作者： Shinn-Cunningham, Barbara G. Best, Virginia Hearing Research Center Departments of Cognitive and Neural Systems and Biomedical Engineering Boston University Boston United States Speech and Hearing Bioscience and Technology Program Harvard-MIT Division of Health Sciences and Technology Cambridge Massachusetts United States University of Sydney Sydney Australia

A common complaint among listeners with hearing loss (HL) is that they have difficulty communicating in common social settings. This article reviews how normal-hearing listeners cope in such settings, especially how they focus attention on a source of interest. Results of experiments with normal-hearing listeners suggest that the ability to selectively attend depends on the ability to analyze the acoustic scene and to form perceptual auditory objects properly. Unfortunately, sound features important for auditory object formation may not be robustly encoded in the auditory periphery of HL listeners. In turn, impaired auditory object formation may interfere with the ability to filter out competing sound sources. Peripheral degradations are also likely to reduce the salience of higher-order auditory cues such as location, pitch, and timbre, which enable normal-hearing listeners to select a desired sound source out of a sound mixture. Degraded peripheral processing is also likely to increase the time required to form auditory objects and focus selective attention so that listeners with HL lose the ability to switch attention rapidly (a skill that is particularly important when trying to participate in a lively conversation). Finally, peripheral deficits may interfere with strategies that normal-hearing listeners employ in complex acoustic settings, including the use of memory to fill in bits of the conversation that are missed. Thus, peripheral hearing deficits are likely to cause a number of interrelated problems that challenge the ability of HL listeners to communicate in social settings requiring selective attention. © 2008, SAGE Publications. All rights reserved.

关键词： attention auditory object auditory scene analysis segregation

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Personally controlled health records: The US landscape and the indivo project

Personally controlled health records: The US landscape and t...

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International Symposium on Electronic Personal health Records 2006, ISePHR 2006

作者： Crawford, William Office of Policy Centers for Medicare and Medicaid Services 200 Independence Avenue SW Washington DC 20021 United States MIT Sloan School of Management Harvard-MIT Division of Health Sciences and Technology Children's Hospital Informatics Program United States

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Designing enhanced classifiers using prior process knowledge: Regularized maximum-likelihood

Designing enhanced classifiers using prior process knowledge...

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2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11

作者： Esfahani, Mohammad Shahrokh Zollanvari, Amin Yoon, Byung-Jun Dougherty, Edward R. Department of Electrical and Computer Engineering Texas A and M University United States Childrens Hospital Informatics Program at Harvard-MIT Division of Health Sciences and Technology Harvard Medical School Brigham and Womens Hospital United States Phoenix AZ United States

ISBN: (纸本)9781467304900

We propose a novel optimization-based paradigm for designing enhanced classifiers. The proposed paradigm allows us to incorporate available prior process knowledge into classifier design, thereby improving the performance of the resulting classifiers. In this work, we focus on dynamical systems that can be represented as finite-state multi-dimensional stochastic processes that possess labeled steady-state distributions. Given prior operational knowledge of the process, our goal is to build a classifier that can accurately label future observations obtained from the steady-state, by utilizing both the available prior knowledge and the training data. Simulation results show that the proposed paradigm yields improved classifiers that outperform traditional classifiers that use only training data. ©2011 IEEE.

关键词： Random processes

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