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Artificial intelligence in cancer target identification and drug discovery

Signal Transduction and Targeted Therapy 2022年第6期7卷 1951-1974页

作者： Yujie You Xin Lai Yi Pan Huiru Zheng Julio Vera Suran Liu Senyi Deng Le Zhang College of Computer Science Sichuan UniversityChengdu 610065China Laboratory of Systems Tumor Immunology Friedrich-Alexander-Universität Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenErlangen 91052Germany Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesRoom D5131068 Xueyuan AvenueShenzhen University TownShenzhen 518055China School of Computing Ulster UniversityBelfast BT151EDUK Institute of Thoracic Oncology Department of Thoracic SurgeryWest China HospitalSichuan UniversityChengdu 610065China Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying human diseases such as ***,we review and discuss how to employ artificial intelligence approaches to identify novel anticancer targets and discover ***,we describe the scope of artificial intelligence biology analysis for novel anticancer target ***,we review and discuss the basic principles and theory of commonly used network-based and machine learning-based artificial intelligence ***,we showcase the applications of artificial intelligence approaches in cancer target identification and drug *** together,the artificial intelligence models have provided us with a quantitative framework to study the relationship between network characteristics and cancer,thereby leading to the identification of potential anticancer targets and the discovery of novel drug candidates.

关键词： drugs cancer drug

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Continuous-Time LiDAR-Inertial-Vehicle Odometry Method with Lateral Acceleration Constraint

Continuous-Time LiDAR-Inertial-Vehicle Odometry Method with ...

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IEEE International Conference on Robotics and Automation (ICRA)

作者： Bin He Weichen Dai Zeyu Wan Hong Zhang Yu Zhang State Key Laboratory of Industrial Control Technology College of Control Science and Engineering Zhejiang University Hangzhou China School of Computer Science Hangzhou Dianzi University Hangzhou China Key Laboratory of Collaborative sensing and autonomous unmanned systems of Zhejiang Province Hangzhou China

In this paper, we propose a continuous-time-based LiDAR-inertial-vehicle odometry method, which can tightly fuse the data from Light Detection And Ranging (LiDAR), inertial measurement units (IMU), and vehicle measurements. The lateral acceleration constraint is further added to trajectory estimation to make the estimated trajectory follow the motion characteristics of vehicles. In addition, since vehicle model parameters vary with different motion conditions and tyre pressure, we estimate vehicle correction factors that rectify changes in vehicle model parameters online, and also analyze the observability of these vehicle correction factors. In experiments, the proposed method is evaluated and compared with state-of-the-art methods in the public dataset. The experimental results show that the proposed method achieves more accurate results in all sequences since we add additional sensor measurements and utilize the characteristic of vehicle motion to restrict the trajectory estimation. The ablation study also proved the effectiveness of continuous-time representation, online correction factor estimation, and incorporation of lateral acceleration constraint.

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Optimal Linear Deception Attacks on Remote State Estimation with Constrained Alarm Rates: A Low-Dimensional Case

Optimal Linear Deception Attacks on Remote State Estimation ...

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IEEE Conference on Decision and control

作者： Jun Shang Hanwen Zhang Jing Zhou Tongwen Chen Department of Control Science and Engineering Shanghai Research Institute for Intelligent Autonomous Systems National Key Laboratory of Autonomous Intelligent Unmanned Systems and Frontiers Science Center for Intelligent Autonomous Systems Tongji University Shanghai China Key Laboratory of Knowledge Automation for Industrial Processes of Ministry of Education School of Automation and Electrical Engineering University of Science and Technology Beijing Beijing China Department of Electrical and Computer Engineering University of Alberta Edmonton AB Canada

ISBN: (数字)9798350316339

ISBN: (纸本)9798350316346

This study addresses linear attacks on remote state estimation within the context of a constrained alarm rate. Smart sensors, which are equipped with local Kalman filters, transmit innovations instead of raw measurements through a wireless communication network. This transmission is vulnerable to malicious data interception and manipulation by attackers. The aim of this research is to identify the optimal attack strategy that degrades the system performance while adhering to stealthiness constraints. A notable innovation of this paper is the direct association of the attack’s stealthiness with the alarm rate, diverging from traditional approaches that rely on the covariance of the innovation or the Kullback–Leibler divergence, which are conventional metrics that have been extensively explored in previous studies. Our findings reveal that the optimal attack strategy exhibits some structural characteristics in systems of low dimensions. The performance of the proposed attack strategy is demonstrated through numerical examples.

关键词： Wireless communication Measurement Technological innovation System performance Kalman filters State estimation Intelligent sensors

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computer vision for road imaging and pothole detection:a state-of-the-art review of systems and algorithms

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Transportation Safety and Environment 2022年第4期4卷 3-18页

作者： Nachuan Ma Jiahe Fan Wenshuo Wang JinWu Yu Jiang Lihua Xie Rui Fan Department of Control Science and Engineering Frontiers Science Center for Intelligent Autonomous Systemsand State Key Laboratory of Intelligent Autonomous SystemsTongji UniversityShanghai 201804P.R.China Department of Civil Engineering McGill UniversityMontréalQC H3A 0C3Canada Department of Electronics and Computer Engineering the Hong Kong University of Science and TechnologyHong Kong SAR 999077P.R.China CTO Office ClearMotion Inc.BillericaMA 01821USA School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore

computer vision algorithms have been utilized for 3-D road imaging and pothole detection for over two ***,there is a lack of systematic survey articles on state-of-the-art(SoTA)computer vision techniques,especially deep learningmodels,developed to tackle these *** article first introduces the sensing systems employed for 2-D and 3-D road data acquisition,including camera(s),laser scanners and Microsoft *** then comprehensively reviews the SoTA computer vision algorithms,including(1)classical 2-D image processing,(2)3-D point cloud modelling and segmentation and(3)machine/deep learning,developed for road pothole *** article also discusses the existing challenges and future development trends of computer vision-based road pothole detection approaches:classical 2-D image processing-based and 3-D point cloud modelling and segmentation-based approaches have already become history;and convolutional neural networks(CNNs)have demonstrated compelling road pothole detection results and are promising to break the bottleneck with future advances in self/un-supervised learning for multi-modal semantic *** believe that this survey can serve as practical guidance for developing the next-generation road condition assessment systems.

关键词： computer vision road imaging pothole detection deep learning image processing point cloud modelling convolutional neural networks

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Skin-like cryogel electronics from suppressed-freezing tuned polymer amorphization

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Nature Communications 2023年第1期14卷 1-10页

作者： Zhang, Xiansheng Yan, Hongwei Xu, Chongzhi Dong, Xia Wang, Yu Fu, Aiping Li, Hao Lee, Jin Yong Zhang, Sheng Ni, Jiahua Gao, Min Wang, Jing Yu, Jinpeng Ge, Shuzhi Sam Jin, Ming Liang Wang, Lili Xia, Yanzhi State Key Laboratory of Bio-Fibers and Eco-Textiles College of Textiles and Clothing Qingdao University Qingdao 266071 China Institute for Future Shandong Key Laboratory of Industrial Control Technology School of Automation Qingdao University Qingdao 266071 China College of Materials Science and Engineering Qingdao University Qingdao 266071 China CAS Key Laboratory of Engineering Plastics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Department of Chemistry SungKyunKwan University Suwon 16419 South Korea State Key Laboratory of Fluid Power and Mechatronic Systems College of Mechanical Engineering Zhejiang University Hangzhou 310027 China College of Biological Science and Medical Engineering Donghua University Shanghai 201620 China Institute of Environmental Engineering ETH Zürich Zürich 8093 Switzerland Department of Electrical and Computer Engineering National University of Singapore Singapore 117576 Singapore

The sole situation of semi-crystalline structure induced single performance remarkably limits the green cryogels in the application of soft devices due to uncontrolled freezing field. Here, a facile strategy for achieving multifunctionality of cryogels is proposed using total amorphization of polymer. Through precisely lowering the freezing point of precursor solutions with an antifreezing salt, the suppressed growth of ice is achieved, creating an unusually weak and homogenous aggregation of polymer chains upon freezing, thereby realizing the tunable amorphization of polymer and the coexistence of free and hydrogen bonding hydroxyl groups. Such multi-scale microstructures trigger the integrated properties of tissue-like ultrasoftness (Young’s modulus <10 kPa) yet stretchability, high transparency (~92%), self-adhesion, and instantaneous self-healing (<0.3 s) for cryogels, along with superior ionic-conductivity, antifreezing (−58 °C) and water-retention abilities, pushing the development of skin-like cryogel electronics. These concepts open an attractive branch for cryogels that adopt regulated crystallization behavior for on-demand functionalities. © 2023, Springer Nature Limited.

关键词： Gels and hydrogels Polymers

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Boolean matrix compressed sensing

Boolean matrix compressed sensing

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： Qiang Liu Mahdi Soleymani Hessam Mahdavifar National Laboratory of Industrial Control Technology Institute of Cyber-Systems and Control Zhejiang University Hangzhou China Halıcıoğlu Data Science Institute University of California San Diego La Jolla CA USA Department of Electrical and Computer Engineering Northeastern University Boston MA USA

ISBN: (数字)9798350368741

ISBN: (纸本)9798350368758

In real-world datasets, leveraging the low-rank and sparsity properties enables developing efficient algorithms across a diverse array of data-related tasks, including compression, compressed sensing, matrix completion, etc. Notably, these two properties often coexist in certain real-world datasets, especially in Boolean datasets and quantized real-valued datasets. To harness the advantages of low-rank and sparsity simultaneously, we adopt a technique inspired by compressed sensing and Boolean matrix completion. Our approach entails compressing a low-rank sparse Boolean matrix by performing inner product operations with a randomly generated Boolean matrix. We then propose a decoding algorithms based on message-passing techniques to recover the original matrix. Our experiments demonstrate superior recovery performance of our proposed algorithms compared to Boolean matrix completion, with equal measurement requirements.

关键词： Image coding Signal processing algorithms Signal processing Acoustics Sensors Decoding Sparse matrices Speech processing Compressed sensing

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Formulation of Optimization Problems with Radiation Field Phases as Design Variables for Pattern Synthesis of Linear Antenna Arrays

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China Communications 2022年第12期19卷 86-100页

作者： Fei Zhao Jun He Sanyou Zeng Changhe Li Qinghui Xu Zhigao Zeng School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China Science and Technology on Blind Signal Processing Laboratory Southwest Electronics and Telecommunication Technology Research InstituteChengdu 610041China School of Automation China University of GeosciencesWuhan 430074China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan 430074China College of Computer Hunan University of TechnologyZhuzhou CityHunan Province412007China

Pattern synthesise of antenna arrays is usually complicated optimization problems,while evolutionary algorithms(EAs)are promising in solving these *** paper does not propose a new EA,but does construct a new form of optimization *** new optimization formulation has two differences from the common *** is the objective function is the field error between the desired and the designed,not the usual amplitude error between the desired and the *** difference is beneficial to decrease complexity in some *** second difference is that the design variables are changed as phases of desired radiation field within shaped-region,instead of excitation *** difference leads to the reduction of the number of design variables.A series of synthesis experiments including equally and unequally spaced linear arrays with different pattern shape requirements are applied,and the effectiveness and advantages of the proposed new optimization problems are *** results show that the proposing a new optimization formulation with less complexity is as significant as proposing a new algorithm.

关键词： pattern synthesis evolutionary algorithms linear antenna arrays

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Reinforcement Learning-Based Optimal Multiple Waypoint Navigation

Reinforcement Learning-Based Optimal Multiple Waypoint Navig...

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IEEE International Conference on Robotics and Automation (ICRA)

作者： Christos Vlachos Panagiotis Rousseas Charalampos P. Bechlioulis Kostas J. Kyriakopoulos Department of Electrical and Computer Engineering University of Patras Greece School of Mechanical Engineering Control Systems Laboratory National Technical University of Athens Greece Center of AI & Robotics (CAIR) New York University Abu Dhabi

In this paper, a novel method based on Artificial Potential Field (APF) theory is presented, for optimal motion planning in fully-known, static workspaces, for multiple final goal configurations. Optimization is achieved through a Reinforcement Learning (RL) framework. More specifically, the parameters of the underlying potential field are adjusted through a policy gradient algorithm in order to minimize a cost function. The main novelty of the proposed scheme lies in the method that provides optimal policies for multiple final positions, in contrast to most existing methodologies that consider a single final configuration. An assessment of the optimality of our results is conducted by comparing our novel motion planning scheme against a RRT* method.

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Stealthy Attacks on Sampled-Data control and Encryption-Based Countermeasures

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IEEE Transactions on Automatic control 2025年

作者： Shang, Jun Li, Yuzhe Chen, Tongwen Tongji University Department of Control Science and Engineering Shanghai Institute of Intelligent Science and Technology National Key Laboratory of Autonomous Intelligent Unmanned Systems Frontiers Science Center for Intelligent Autonomous Systems Shanghai200092 China Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Shenyang110004 China University of Alberta Department of Electrical and Computer Engineering EdmontonABT6G 1H9 Canada

This paper investigates stealthy attacks on sampled-data control systems, where a continuous process is sampled periodically, and the resultant discrete output and control signals are transmitted through dual channels in wireless communication networks. Acknowledging the vulnerability of these transmitted data to cyber threats, we analyze two types of stealthy attacks that compromise either one or both channels. We explicitly present the necessary and sufficient conditions for the existence of stealthy single-channel attacks. To mitigate these security risks, we implement encryption-based countermeasures, including linear time-invariant and periodic encryption methods. We detail sufficient conditions under which these encryption strategies effectively thwart single- and dual-channel stealthy attacks. The effectiveness of these approaches and the theoretical findings are demonstrated through numerical simulations. © 1963-2012 IEEE.

关键词： Cyber attacks

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Contrast enhancement of optical videoscope images

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Iran Journal of computer Science 2023年第3期6卷 261-275页

作者： Ammar, Reda Aboshosha, Sahar El-Hag, Noha A. Saifeldeen, Reda El-Shafai, Walid El-Banby, Ghada M. Ashiba, Huda I. Khalaf, Ashraf A. M. Elazm, Atef Abou El-Rabaie, El-Sayed M. Abd El-Samie, Fathi E. El-Safrawey, Amir Department of Electronics and Electrical Communications Engineering Faculty of Electronic Engineering Menoufia University Menouf 32952 Egypt Department of Electronics and Electrical Comm. Faculty of Engineering Minia University Minya Egypt Department of Management of Information Systems Higher Institute of Commercial Science El-Mahala El-Kobra Egypt Department of Industrial Electronics and Control Engineering Faculty of Electronic Engineering Menoufia University Menouf 32952 Egypt Department of Electronics and Electrical Communications Engineering Bilbis Higher Institute of Engineering Sharqia Bilbis Egypt Security Engineering Laboratory Computer Science Department Prince Sultan University Riyadh 11586 Saudi Arabia Department of Information Technology College of Computer and Information Sciences Princess Nourah Bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia

The videoscope (VS) images have poor quality and low contrast. Hence, in this paper, three proposed frameworks to improve the quality of VS images are presented. The first framework depends on contrast-limited adaptive histogram equalization (CLAHE) with adaptive gamma correction. The second framework depends on homomorphic processing. The third framework is based on the homomorphic enhancement with histogram equalization. The first one is superior from the entropy perspective, while the third one is superior from the contrast perspective. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023.

关键词： Fuzzy enhancement Histogram equalization Homomorphic enhancement Spectral entropy

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