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Restoring After Central Nervous System Injuries:Neural Mechanisms and Translational Applications of Motor Recovery

Neuroscience Bulletin 2022年第12期38卷 1569-1587页

作者： Zhengrun Gao Zhen Pang Yiming Chen Gaowei Lei Shuai Zhu Guotao Li Yundong Shen Wendong Xu Department of Hand Surgery Huashan HospitalFudan UniversityShanghai 200040China The National Clinical Research Center for Aging and Medicine Fudan UniversityShanghai 200040China Department of Hand and Upper Extremity Surgery Jing’an District Central HospitalFudan UniversityShanghai 200040China Institutes of Brain Science Fudan UniversityShanghai 200040China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200040China Institute of Automation State Key Laboratory of Management and Control for Complex SystemsChinese Academy of SciencesBeijing 100190China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China Research Unit of Synergistic Reconstruction of Upper and Lower Limbs after Brain Injury Chinese Academy of Medical SciencesShanghai 200400China

Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are leading causes of long-term *** is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated *** studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote ***,the ability to increase plasticity in the injured brain is restricted and difficult to ***,over several decades,researchers have been prompted to enhance the compensation by the unaffected *** experiments have revealed that regrowth of ipsilateral descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor *** addition,several clinical treatments have been designed to restore ipsilateral motor control,including brain stimulation,nerve transfer surgery,and brain–computer interface ***,we comprehensively review the neural mechanisms as well as translational applications of ipsilateral motor control upon rehabilitation after CNS injuries.

关键词： Stroke Traumatic brain injury Spinal cord injury Brain-computer interface system Neuroplasticity Ipsilateral motor control Axon regrowth

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A Seamless control Based on the State Follower for the Energy Balance of the Bipolar-Type Modular Solid-State Transformer

A Seamless Control Based on the State Follower for the Energ...

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IEEE International Symposium on Power Electronics for Distributed Generation Systems (PEDG)

作者： Hongming Li Jianqiao Zhou Jianwen Zhang Gang Shi Xu Cai Yong Wang Xiaofeng Dong Wei Bao Key Laboratory of Control of Power Transmission and Conversion Ministry of Education Shanghai Jiao Tong University Shanghai China HVDC Transmission and Power Electronics Business Unit Beijing Sifang Automation CO. Ltd Beijing China Facilities Management Suzhou Power Supply Company Suzhou China Shanghai Electrical Apparatus Research Institute Group CO. Ltd State Grid Shanghai Municipal Electric Power Company Shanghai China

A novel solid-state transformer, the bipolar-type modular solid-state transformer (BM-SST), is proposed to extend a bipolar type LVDC port from the modular multilevel converter-based solid-state transformer (MMC-SST). Compared with MMC-SST, BM-SST has the advantages of flexible power supply, high reliability and high safety. In particular, both arm voltage regulation (AVR) control and active circulating current injection (ACCI) control are used to cope with the unbalanced power between the positive and negative ports of the LVDC. The two control schemes are selected according to the different load conditions. However, the transition process between the two control schemes have not been investigated, which will affect the dynamic performance of BMSST. This paper proposes a seamless control based on state follower to achieve the seamless switching between AVR and ACCI. The proposed scheme has the advantages of good dynamic performance and simple control design. Finally, the feasibility and effectiveness of the proposed scheme is verified by a 1MW BM-SST simulation model based on Simulink MATLAB.

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Optical Imaging of Epigenetic Modifications in Cancer:A Systematic Review

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Phenomics 2022年第2期2卷 88-101页

作者： Yang Du Pei Zhang Wei Liu Jie Tian CAS Key Laboratory of Molecular Imaging Beijing Key Laboratory of Molecular Imagingthe State Key Laboratory of Management and Control for Complex SystemsInstitute of AutomationChinese Academy of SciencesBeijing 100190China The University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Supportive Care Center and Day Oncology UnitPeking University Cancer Hospital and InstituteBeijing 100142China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100191China School of Life Science and Technology Xidian UniversityXi’an 710071ShaanxiChina

Increasing evidence has demonstrated that abnormal epigenetic modifications are strongly related to cancer ***,sensitive and specific detection of epigenetic modifications could markedly improve biological investigations and cancer precision medicine.A rapid development of molecular imaging approaches for the diagnosis and prognosis of cancer has been observed during the past few *** biomarkers unique to epigenetic modifications and targeted imaging probes have been characterized and used to discriminate cancer from healthy tissues,as well as evaluate therapeutic *** this study,we summarize the latest studies associated with optical molecular imaging of epigenetic modification targets,such as those involving DNA methylation,histone modification,noncoding RNA regulation,and chromosome remodeling,and further review their clinical application on cancer diagnosis and ***,we further propose the future direc-tions for precision imaging of epigenetic modification in *** by promising clinical and preclinical studies associated with optical molecular imaging technology and epigenetic drugs,the central role of epigenetics in cancer should be increasingly recognized and accepted.

关键词： Epigenetic modification Optical imaging Cancer Imaging probe

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Application of a MBSE Approach to Improve the Dynamic Performance of a Scara Robot

Application of a MBSE Approach to Improve the Dynamic Perfor...

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International Conference on Emerging Technologies and Factory automation (ETFA)

作者： Diego Gonzalez Javier Arenas Olivier Schmidt Mikel Armendia Automation and Control Unit TEKNIKER Basque Research and Technology Alliance (BRTA) Eibar Spain Regulation and Control Unit FAGOR AOTEK Mondragón Spain Simulation and Test solutions Siemens Digital Industries Software Lyon France

ISBN: (数字)9781728189567

ISBN: (纸本)9781728189574

Model Based System Engineering (MBSE) allows an optimized development of new mechatronic systems and/or functionalities. In this paper a MBSE approach is proposed where two control functionalities are applied to improve the dynamic performance of a Scara Robot. Acceleration feedback is used to increase vibration damping capacity and Iterative Learning control is applied to reduce path errors. A simulation model combining Scara Robot mechanics, developed in Simcenter Amesim™ software from Siemens Digital Industries Software, and control loops, developed in Simulink, has been used to implement and evaluate the functionalities. Finally, both algorithms were implemented in a real Scara robot that was previously adapted to be controlled by a FAGOR CNC.

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Parallel Virtual Impedance Based Fluctuation Power Delivery Strategy For MMC Based SST

Parallel Virtual Impedance Based Fluctuation Power Delivery ...

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IEEE International Symposium on Power Electronics for Distributed Generation Systems (PEDG)

作者： Jaiyi Li Jianqiao Zhou Jianwen Zhang Gang Shi Xu Cai Yong Wang Xiaofeng Dong Wei Bao College of Information Science and Technology Donghua University Shanghai China Key Laboratory of Control of Power Transmission and Conversion Ministry of Education Shanghai Jiao Tong University Shanghai China HVDC Transmission and Power Electronics Business Unit Beijing Sifang Automation CO. Ltd. Beijing China Facilities Management Suzhou Power Supply Company Suzhou China Shanghai Electrical Apparatus Research Institute Group CO. Ltd. State Grid Shanghai Municipal Electric Power Company Shanghai China

Modular multilevel converter (MMC) based solid state transformer (MMC-SST) shows promise in hybrid AC/DC distribution grid. This paper introduces a topology consisting of cells made of directly coupled MMC sub-modules (SMs) and isolated SAB modules forming a multi-port SST for grid interconnection. Due to the large SM capacitors for low frequency fluctuation power handling, the device power density is low, which will limit its application. This paper proposes an MMC-SST SM capacitor optimization method based on fluctuation power delivery. It reduces the equivalent low frequency impedance of the SAB by parallel virtual impedance. Low frequency fluctuation power will be delivered into SAB circuit and naturally eliminated in low-voltage DC side due to three-phase symmetrical MMC-SST structure. Therefore, the SM capacitance could be optimized where the power fluctuation flowing into it are reduced. The feasibility of the proposed method is verified by a simulation model.

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Numerical Investigation of Localized Surface Plasmon Resonance (LSPR) based Sensor for Glucose Level Monitoring

Numerical Investigation of Localized Surface Plasmon Resonan...

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First International Symposium on Instrumentation, control, Artificial Intelligence, and Robotics (ICA-SYMP)

作者： Kawintida Santavanond Charusluk Viphavakit Wisarn Patchoo Hala El-Khozondar Waleed Mohammed Faculty of Engineering International School of Engineering Chulalongkorn University Bangkok Thailand Faculty of Engineering International School of Engineering Intelligent Control Automation of Process Systems Research Unit Chulalongkorn University Bangkok Thailand The Bangkok University Center of Research in Optoelectronics Communications and Computational Systems School of Engineering Bangkok University Pathumthani Thailand Islamic University of Gaza Gaza Palestine The Bangkok University Center of Research in Optoelectronics Communications and Computational Systems School of Engineering Bangkok University Pathumthani Thailand

ISBN: (数字)9781728187600

ISBN: (纸本)9781728187617

This study aims to apply Localized Surface Plasmon Resonance (LSPR), Maxwell Garnett's formula, and Fabry-Perot theory together to design and develop a LSPR enhanced gold colloidal nanoparticles (AuNPs) sensor to be used in biomedical applications such as detection of glucose level in urine for early stage screening of diabetic patients. In this work, the LSPR based sensor has been designed and studied numerically to detect the glucose level from the change in the effective index resulting in a red shift of the absorption peak. The sensors were designed to have various sizes of the gold nanoparticles in a range between 20 nm and 100 nm by having different molar ratio with Trisodium Citrate (TSC) which acts as stabilizer in the synthesis. The maximum possible sensitivity of the sensor can be achieved with 70 nm diameter of gold nanoparticles at 0.2 volume fraction of AuNP to glucose solution.

关键词： Nanoparticles Gold Sensitivity Robot sensing systems Glucose Optical sensors Surface plasmons

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Emergence of steady quantum transport in a superconducting processor

arXiv

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arXiv 2024年

作者： Zhang, Pengfei Gao, Yu Xu, Xiansong Wang, Ning Dong, Hang Guo, Chu Deng, Jinfeng Zhang, Xu Chen, Jiachen Xu, Shibo Wang, Ke Wu, Yaozu Zhang, Chuanyu Jin, Feitong Zhu, Xuhao Zhang, Aosai Zou, Yiren Tan, Ziqi Cui, Zhengyi Zhu, Zitian Shen, Fanhao Li, Tingting Zhong, Jiarun Bao, Zehang Zhao, Liangtian Hao, Jie Li, Hekang Wang, Zhen Song, Chao Guo, Qiujiang Wang, H. Poletti, Dario School of Physics ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang Key Laboratory of Micro-nano Quantum Chips and Quantum Control Zhejiang University Hangzhou China Science Mathematics and Technology Cluster Singapore University of Technology and Design 8 Somapah Road Singapore487372 Singapore College of Physics and Electronic Engineering Center for Computational Sciences Sichuan Normal University Chengdu610068 China Henan Key Laboratory of Quantum Information and Cryptography Zhengzhou450001 China Institute of Automation Chinese Academy of Sciences Beijing100190 China Engineering Product Development Pillar Singapore University of Technology and Design 8 Somapah Road Singapore487372 Singapore Centre for Quantum Technologies National University of Singapore Singapore117543 Singapore MajuLab CNRS-UNS-NUS-NTU International Joint Research Unit UMI 3654 Singapore Singapore

Non-equilibrium quantum transport is crucial to technological advances ranging from nanoelectronics to thermal management. In essence, it deals with the coherent transfer of energy and (quasi-)particles through quantum channels between thermodynamic baths. A complete understanding of quantum transport thus requires the ability to simulate and probe macroscopic and microscopic physics on equal footing. Using a superconducting quantum processor, we demonstrate the emergence of non-equilibrium steady quantum transport by emulating the baths with qubit ladders and realising steady particle currents between the baths. We experimentally show that the currents are independent of the microscopic details of bath initialisation, and their temporal fluctuations decrease rapidly with the size of the baths, emulating those predicted by thermodynamic baths. The above characteristics are experimental evidence of pure-state statistical mechanics and prethermalisation in non-equilibrium many-body quantum systems. Furthermore, by utilising precise controls and measurements with single-site resolution, we demonstrate the capability to tune steady currents by manipulating the macroscopic properties of the baths, including filling and spectral properties. Our investigation paves the way for a new generation of experimental exploration of non-equilibrium quantum transport in strongly correlated quantum matter. © 2024, CC BY.

关键词： Statistical mechanics

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Nonlinear optimal control for autonomous hypersonic vehicles

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Aerospace Systems 2019年第2期2卷 197-213页

作者： Rigatos, G. Wira, P. Abbaszadeh, M. Busawon, K. Dala, L. Unit of Industrial Automation Industrial Systems Institute Rion Patras 26504 Greece IRIMAS Université d’ Haute Alsace Mulhouse 68093 France GE Global Research General Electric Niskayuna 12309 NY United States Nonlinear Control Group University of Northumbria Newcastle NE1 8ST United Kingdom Department of Mechanical Engineering University of Northumbria Newcastle NE1 8ST United Kingdom

The article proposes a nonlinear optimal (H-infinity) control method for a hypersonic aerial vehicle (HSV). The dynamic model of the hypersonic vehicle undergoes approximate linearization around a temporary operating point which is recomputed at each iteration of the control method. This operating point consists of the present value of the system’s state vector and of the last value of the control inputs vector that was applied on the HSV. The linearization relies on Taylor series expansion and on the computation of the associated Jacobian matrices. For the approximately linearized model of the hypersonic aerial vehicle, an optimal (H-infinity) feedback controller was designed. To compute the controller’s feedback gains, an algebraic Riccati equation had to be repetitively solved at each iteration of the control algorithm. The global asymptotic stability of the control method is proven through Lyapunov analysis. The control scheme remains robust against model uncertainties an external perturbations. © 2019, Shanghai Jiao Tong University.

关键词： Approximate linearization Asymptotic stability Autonomous hypersonic vehicle Jacobian matrices Nonlinear H-infinity control Riccati equation Robust control Taylor series expansion

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A consensus protocol for functional connectivity analysis in the rat brain (vol 26, pg 673, 2023)

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NATURE NEUROSCIENCE 2023年第6期26卷 1127-1128页

作者： Grandjean, Joanes Desrosiers-Gregoire, Gabriel Anckaerts, Cynthia Angeles-Valdez, Diego Ayad, Fadi Barriere, David A. Blockx, Ines Bortel, Aleksandra Broadwater, Margaret Cardoso, Beatriz M. Celestine, Marina Chavez-Negrete, Jorge E. Choi, Sangcheon Christiaen, Emma Clavijo, Perrin Colon-Perez, Luis Cramer, Samuel Daniele, Tolomeo Dempsey, Elaine Diao, Yujian Doelemeyer, Arno Dopfel, David Dvorakova, Lenka Falfan-Melgoza, Claudia Fernandes, Francisca F. Fowler, Caitlin F. Fuentes-Ibanez, Antonio Garin, Clement M. Gelderman, Eveline Golden, Carla E. M. Guo, Chao C. G. Henckens, Marloes J. A. G. Hennessy, Lauren A. Herman, Peter Hofwijks, Nita Horien, Corey Ionescu, Tudor M. Jones, Jolyon Kaesser, Johannes Kim, Eugene Lambers, Henriette Lazari, Alberto Lee, Sung-Ho Lillywhite, Amanda Liu, Yikang Liu, Yanyan Y. Lopez-Castro, Alejandra Lopez-Gil, Xavier Ma, Zilu MacNicol, Eilidh Madularu, Dan Mandino, Francesca Marciano, Sabina McAuslan, Matthew J. McCunn, Patrick McIntosh, Alison Meng, Xianzong Meyer-Baese, Lisa Missault, Stephan Moro, Federico Naessens, Daphne M. P. Nava-Gomez, Laura J. Nonaka, Hiroi Ortiz, Juan J. Paasonen, Jaakko Peeters, Lore M. Pereira, Mickael Perez, Pablo D. Pompilus, Marjory Prior, Malcolm Rakhmatullin, Rustam Reimann, Henning M. Reinwald, Jonathan Del Rio, Rodrigo Triana Rivera-Olvera, Alejandro Ruiz-Perez, Daniel Russo, Gabriele Rutten, Tobias J. Ryoke, Rie Sack, Markus Salvan, Piergiorgio Sanganahalli, Basavaraju G. Schroeter, Aileen Seewoo, Bhedita J. Selingue, Erwan Seuwen, Aline Shi, Bowen Sirmpilatze, Nikoloz Smith, Joanna A. B. Smith, Corrie Sobczak, Filip Stenroos, Petteri J. Straathof, Milou Strobelt, Sandra Sumiyoshi, Akira Takahashi, Kengo Torres-Garcia, Maria E. Tudela, Raul van den Berg, Monica van der Marel, Kajo van Hout, Aran T. B. Vertullo, Roberta Vidal, Benjamin Vrooman, Roel M. Wang, Victora X. Wank, Isabel Watson, David J. G. Yin, Ting Zhang, Yongzhi Zurbruegg, Stefan Achard, Sophie Alcauter, Sarael Auer, Dorothee P. Barbier, Emmanuel L. Baudewig, Juergen Beckmann, Chri Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Bio-imaging Lab University of Antwerp Antwerp Belgium µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico Biological and Biomedical Engineering McGill University Montreal QC Canada McConnell Brain Imaging Centre McGill University Montreal QC Canada Montreal Neurological Institute McGill University Montreal QC Canada UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France Department of Neurology and Neurosurgery McGill University Montreal QC Canada Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cybernetics Tuebingen Germany Graduate Training Centre of Neuroscience International Max

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

关键词： Databases Neural circuits

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Supervisory Robust Model Predictive control for Linear Systems Subject to Parametric Uncertainty and Application to Level control Process

Supervisory Robust Model Predictive Control for Linear Syste...

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International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology, ECTI-CON

作者： Pongsorn Keadtipod David Banjerdpongchai Dept. of Electrical Engineering Chulalongkorn University Intelligent Control Automation of Process Systems (iCAPS) Research Unit Bangkok Thailand

ISBN: (纸本)9781538635568;9781538635551

This paper presents supervisory robust model predictive control (RMPC) for linear systems in the presence of parametric uncertainty. The control structure is cascade control where the outer loop controller is RMPC and the inner loop controller as proportional-integral (PI) controller. The parametric uncertainty appears in the dynamic matrix and input matrix and satisfies norm-bounded condition. First, we derive inner closed-loop model and use this model to design RMPC. The design of RMPC involves a min-max optimization problem which aims to find the optimal solution minimizing the worst case performance. We derive an upper bound of the worst case performance and apply Linear Matrix Inequality to determine the control input. We conduct the step tests on the level control loop and obtain 4 dynamic models. Numerical results reveal that supervisory RMPC can ensure reference tracking regardless of uncertain dynamics.

关键词： Process control Uncertainty Level control Computational modeling Linear systems Telecommunications Information technology

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