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SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES). V. Confusion-limited Submillimeter Galaxy Number Counts at 450 μm and Data Release for the COSMOS Field

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The Astrophysical Journal 2024年第1期971卷 117-117页

作者： Zhen-Kai Gao Chen-Fatt Lim Wei-Hao Wang Chian-Chou Chen Ian Smail Scott C. Chapman Xian Zhong Zheng Hyunjin Shim Tadayuki Kodama Yiping Ao Siou-Yu Chang David L. Clements James S. Dunlop Luis C. Ho Yun-Hsin Hsu Chorng-Yuan Hwang Ho Seong Hwang M. P. Koprowski Douglas Scott Stephen Serjeant Yoshiki Toba Sheona A. Urquhart Academia Sinica Institute of Astronomy and Astrophysics (ASIAA) No. 1 Section 4 Roosevelt Rd. Taipei 10617 Taiwan Graduate Institute of Astronomy National Central University 300 Zhongda Road Zhongli Taoyuan 32001 Taiwan Centre for Extragalactic Astronomy Department of Physics Durham University South Road Durham DH1 3LE UK Department of Physics and Atmospheric Science Dalhousie University Halifax Halifax NS B3H 3J5 Canada Purple Mountain Observatory and Key Laboratory for Radio Astronomy Chinese Academy of Sciences 10 Yuanhua Road Nanjing 210023 People's Republic of China School of Astronomy and Space Science University of Science and Technology of China Hefei 230026 Anhui People's Republic of China Department of Earth Science Education Kyungpook National University 80 Daehak-ro Buk-gu Daegu 41566 Republic of Korea Astronomical Institute Tohoku University 6-3 Aramaki Aoba Sendai Miyagi 980-8578 Japan Institute of Astronomy and Department of Physics National Tsing Hua University Hsinchu 30013 Taiwan Imperial College London Blackett Laboratory Prince Consort Road London SW7 2AZ UK SUPA Institute for Astronomy University of Edinburgh Royal Observatory Edinburgh EH9 3HJ UK Kavli Institute for Astronomy and Astrophysics Peking University Beijing 100871 People's Republic of China Department of Astronomy School of Physics Peking University Beijing 100871 People's Republic of China Department of Philosophy National Taiwan University No. 1 Section 4 Roosevelt Rd. Taipei 10617 Taiwan Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea Institute of Astronomy Faculty of Physics Astronomy and Informatics Nicolaus Copernicus University Grudziadzka 5 87-100 Torun Poland Department of Physics and Astronomy University of British Columbia 6224 Agricultural Road V

We present confusion-limited SCUBA-2 450 μm observations in the COSMOS-CANDELS region as part of the James Clerk Maxwell Telescope Large program SCUBA-2 Ultra Deep Imaging EAO Survey. Our maps at 450 and 850 μm cover an area of 450 arcmin². We achieved instrumental noise levels of σ₄₅₀ = 0.59 mJy beam⁻¹ and σ₈₅₀ = 0.09 mJy beam⁻¹ in the deepest area of each map. The corresponding confusion noise levels are estimated to be 0.65 and 0.36 mJy beam⁻¹. Above the 4σ (3.5σ) threshold, we detected 360 (479) sources at 450 μm and 237 (314) sources at 850 μm. We derive the deepest blank-field number counts at 450 μm, covering the flux-density range of 2–43 mJy. These are in agreement with other SCUBA-2 blank-field and lensing-cluster observations but are lower than various model counts. We compare the counts with those in other fields and find that the field-to-field variance observed at 450 μm at the $R=6^{\prime}$

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Third data release of the hyper suprime-cam subaru strategic program

arXiv

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arXiv 2021年

作者： Aihara, Hiroaki AlSayyad, Yusra Ando, Makoto Armstrong, Robert Bosch, James Egami, Eiichi Furusawa, Hisanori Furusawa, Junko Harasawa, Sumiko Harikane, Yuichi Hsieh, Bau-Ching Ikeda, Hiroyuki Ito, Kei Iwata, Ikuru Kodama, Tadayuki Koike, Michitaro Kokubo, Mitsuru Komiyama, Yutaka Li, Xiangchong Liang, Yongming Lin, Yen-Ting Lupton, Robert H. Lust, Nate B. MacArthur, Lauren A. Mawatari, Ken Mineo, Sogo Miyatake, Hironao Miyazaki, Satoshi More, Surhud Morishima, Takahiro Murayama, Hitoshi Nakajima, Kimihiko Nakata, Fumiaki Nishizawa, Atsushi J. Oguri, Masamune Okabe, Nobuhiro Okura, Yuki Ono, Yoshiaki Osato, Ken Ouchi, Masami Pan, Yen-Chen Malagón, Andrés A. Plazas Price, Paul A. Reed, Sophie L. Rykoff, Eli S. Shibuya, Takatoshi Simunovic, Mirko Strauss, Michael A. Sugimori, Kanako Suto, Yasushi Suzuki, Nao Takada, Masahiro Takagi, Yuhei Takata, Tadafumi Takita, Satoshi Tanaka, Masayuki Tang, Shenli Taranu, Dan S. Terai, Tsuyoshi Toba, Yoshiki Turner, Edwin L. Uchiyama, Hisakazu Vijarnwannaluk, Bovornpratch Waters, Christopher Z. Yamada, Yoshihiko Yamamoto, Naoaki Yamashita, Takuji Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan The University of Tokyo 5-1-5 Kashiwanoha Kashiwa Chiba277-8583 Japan Department of Astrophysical Sciences Princeton University 4 Ivy Lane PrincetonNJ08544 United States Department of Astronomy Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan Lawrence Livermore National Laboratory LivermoreCA94551 United States Steward Observatory The University of Arizona 933 North Cherry Avenue TucsonAZ85721-0065 United States National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwanoha Chiba Kashiwa277-8582 Japan Department of Physics and Astronomy University College London Gower Street LondonWC1E 6BT United Kingdom Institute of Astronomy and Astrophysics Academia Sinica 11F of Astronomy-Mathematics Building AS/NTU No.1 Sec. 4 Taipei10617 Taiwan National Institute of Technology Wakayama College 77 Noshima Nada-cho Gobo Wakayama644-0023 Japan Department of Astronomical Science The Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Astronomical Institute Tohoku University 6-3 Aramaki Aoba-ku Miyagi Sendai980-8578 Japan Nagoya University Nagoya464-8602 Japan Inter University Centre for Astronomy and Astrophysics Ganeshkhind Pune411007 India Department of Physics Center for Japanese Studies University of California BerkeleyCA94720 United States Theoretical Physics Group Lawrence Berkeley National Laboratory MS 50A-5104 BerkeleyCA94720 United States Institute for Advanced Research Nagoya University Furocho Chikusa-ku Nagoya464-8602 Japan Division of Particle and Astrophysical Science Graduate School of Science Nagoya University Furo-cho Nagoya464-8602 Japan Research Center for the Early Universe The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033

The paper presents the third data release of Hyper Suprime-Cam Subaru Strategic program (HSC-SSP), a wide-field multi-band imaging survey with the Subaru 8.2m telescope. HSC-SSP has three survey layers (Wide, Deep, and UltraDeep) with different area coverages and depths, designed to address a wide array of astrophysical questions. This third release from HSC-SSP includes data from 278 nights of observing time and covers about 670 square degrees in all five broad-band filters at the full depth (∼ 26 mag at 5σ) in the Wide layer. If we include partially observed area, the release covers 1,470 square degrees. The Deep and UltraDeep layers have ∼ 80% of the originally planned integration times, and are considered done, as we have slightly changed the observing strategy in order to compensate for various time losses. There are a number of updates in the image processing pipeline. Of particular importance is the change in the sky subtraction algorithm;we subtract the sky on small scales before the detection and measurement stages, which has significantly reduced false detections. Thanks to this and other updates, the overall quality of the processed data has improved since the previous release. However, there are limitations in the data (for example, the pipeline is not optimized for crowded fields), and we encourage the user to check the quality assurance plots as well as a list of known issues before exploiting the data. Copyright © 2021, The Authors. All rights reserved.

关键词： Surveys

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Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses

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npj Genomic Medicine 2024年第1期9卷 49页

作者： Demidov, German Yaldiz, Burcu Garcia-Pelaez, José de Boer, Elke Schuermans, Nika Van de Vondel, Liedewei Paramonov, Ida Johansson, Lennart F. Musacchia, Francesco Benetti, Elisa Bullich, Gemma Sablauskas, Karolis Beltran, Sergi Gilissen, Christian Hoischen, Alexander Ossowski, Stephan de Voer, Richarda Lohmann, Katja Oliveira, Carla Topf, Ana Vissers, Lisenka E. L. M. Zguro, Kristina Zara, Federico Zaganas, Ioannis Yépez, Vicente A. Wirth, Brunhilde Webb, David Verdin, Hannah Van Nieuwenhove, Erika van Montfrans, Joris van Heurck, Roxane van der Veken, Lars Valle, Laura Uva, Paolo Udd, Bjarne Trimouille, Aurelien Thompson, Rachel Tartaglia, Marco Sznajer, Yves Striano, Pasquale Steinke-Lange, Verena Spilioti, Martha Scudieri, Paolo Schröck, Evelin Schon, Katherine Scala, Marcello Savarese, Marco Santen, Gijs W. E. Rump, Andreas Ruivenkamp, Claudia A. L. Roos, Andreas Rooryck, Caroline Riva, Antonella Renieri, Alessandra Ratnaike, Thiloka Radio, Francesca Clementina Privitera, Flavia De la Paz, Manuel Posada Poppe, Bruce Polavarapu, Kiran Platzer, Konrad Peterlin, Borut Pérez-Dueñas, Belén Pauly, Martje Parrini, Elena Olimpio, Catarina Reghan, Mary O. de Benito, Daniel Natera Osorio, Andrés Nascimento Munell, Francina Münchau, Alexander Moortgat, Stéphanie Monestier, Olivier Molnar, Maria Judit Meunier, Colombine Mertes, Christian Mei, Davide Maystadt, Isabelle May, Patrick Maver, Ales Mathioudakis, Lambros Masclaux, Frédéric Mary, Sandrine Delgado, Beatriz Martínez Marcé-Grau, Anna Malaichamy, Sivasankar Macaya, Alfons Luknárová, Rebeka Martín, Estrella López Lochmüller, Hanns Leitão, Elsa Lederer, Damien Leavis, Helen Laner, Andreas Lacombe, Didier Krass, Leon Korff, Christian Kokosali, Evgenia Karakaya, Mert Karadurmus, Deniz Kapaki, Elisabeth Johari, Mridul Iacomino, Michele Huibers, Manon Horvath, Rita Holinski-Feder, Elke Hoffer, Mariette J. V. Herzog, Rebecca Hemelsoet, Dimitri Bouveret, Eva Hammar Haimel, Matthias Hackman, Peter Guerrini, Renzo Grimbacher, Bodo Greally, Marie Ghani, Hamidah Gagneur, Julien Institute of Medical Genetics and Applied Genomics University of Tübingen Tübingen Germany Institute for Bioinformatics and Medical Informatics (IBMI) University of Tübingen Tübingen Germany Department of Human Genetics Radboud University Medical Center Nijmegen Netherlands Department of Clinical Genetics Maastricht University Medical Center Maastricht Netherlands i3S - Instituto de Investigação e Inovação em Saúde Rua Alfredo Allen 208 Porto 4200-135 Portugal IPATIMUP - Institute of Molecular Pathology and Immunology University of Porto Porto Portugal Faculty of Medicine University of Porto Porto Portugal Donders Institute for Brain Cognition and Behaviour Radboud University Nijmegen Netherlands Department of Clinical Genetics Erasmus MC University Medical Center Rotterdam Netherlands Center for Medical Genetics Ghent University Hospital Ghent Belgium Translational Neurosciences Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium Laboratory of Neuromuscular Pathology Institute Born-Bunge University of Antwerp Antwerp Belgium Centro Nacional de Análisis Genómico (CNAG) C/Baldiri Reixac 4 Barcelona 08028 Spain Universitat de Barcelona (UB) Barcelona Spain University of Groningen University Medical Center Groningen Department of Genetics Groningen Netherlands Center for Human Technologies Italian Institute of Technology (IIT) Genova Italy Telethon Institute for Genetics and Medicine Pozzuoli (Napoli) 80078 Italy Department of Medical Biotechnologies Med Biotech Hub and Competence Center University of Siena Siena 53100 Italy Institute of Data Science and Digital Technologies Vilnius University Vilnius Lithuania Departament de Genètica Microbiologia i Estadística Facultat de Biologia Universitat de Barcelona (UB) Barcelona Spain Radboud Institute for Molecular Life Sciences Nijmegen Netherlands Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI) Radboud University Medical Center Nijmegen N

We report the results of a comprehensive copy number variant (CNV) reanalysis of 9171 exome sequencing datasets from 5757 families affected by a rare disease (RD). The data reanalysed was extremely heterogeneous, having been generated using 28 different enrichment kits by 42 different research groups across Europe partnering in the Solve-RD project. Each research group had previously undertaken their own analysis of the data but failed to identify disease-causing variants. We applied three CNV calling algorithms to maximise sensitivity, and rare CNVs overlapping genes of interest, provided by four partner European Reference Networks, were taken forward for interpretation by clinical experts. This reanalysis has resulted in a molecular diagnosis being provided to 51 families in this sample, with ClinCNV performing the best of the three algorithms. We also identified partially explanatory pathogenic CNVs in a further 34 individuals. This work illustrates the value of reanalysing ES cold cases for CNVs. © The Author(s) 2024.

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AI is a viable alternative to high throughput screening: a 318-target study

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Scientific reports 2024年第1期14卷 7526-7526页

作者： Izhar Wallach Denzil Bernard Kong Nguyen Gregory Ho Adrian Morrison Adrian Stecula Andreana Rosnik Ann Marie O’Sullivan Aram Davtyan Ben Samudio Bill Thomas Brad Worley Brittany Butler Christian Laggner Desiree Thayer Ehsan Moharreri Greg Friedland Ha Truong Henry van den Bedem Ho Leung Ng Kate Stafford Krishna Sarangapani Kyle Giesler Lien Ngo Michael Mysinger Mostafa Ahmed Nicholas J. Anthis Niel Henriksen Pawel Gniewek Sam Eckert Saulo de Oliveira Shabbir Suterwala Srimukh Veccham Krishna PrasadPrasad Stefani Shek Stephanie Contreras Stephanie Hare Teresa Palazzo Terrence E. O’Brien Tessa Van Grack Tiffany Williams Ting-Rong Chern Victor Kenyon Abraham Heifets Andreia H. Lee Andrew B. Cann Bastiaan Bergman Brandon M. Anderson Bryan D. Cox Jeffrey M. Warrington Jon M. Sorenson Joshua M. Goldenberg Matthew A. Young Tigran M. Abramyan Nicholas DeHaan Ryan P. Pemberton Stefan Schroedl Tushita Gupta Venkatesh Mysore Adam G. Presser Eric J. Rubin Adolfo A. Ferrando Angelo Taglialatela Clara Reglero Giuseppe Leuzzi Hui Zhou Joseph B. Rayman Manu Ben-Johny Adriano D. Andricopulo Guilherme Eduardo de Souza Marilia Valli Rafael V. C. Guido Agnidipta Ghosh Ashleigh S. Paparella Bogos Agianian Evripidis Gavathiotis Niusha Mahmoodi Rajesh K. Harijan Aicha Gharbi Ayachi Dahai Luo Julien Lescar Nguyen Mai Trinh Nikhil Bharambe Zara Chung Aisha Mushtaq Ala M. Shaqra Alan Kie Leong Toh Erik W. Thompson Larisa M. Haupt Neha S. Gandhi Alan V. Smrcka Alberto Ciccia Charles Karan Hai Li Howard B. Lieberman Kevin M. Hopkins Zhiguo Zhang Aldo Sena de Oliveira Aleksandr Sverzhinsky John M. Pascal Alessandra Mara de Sousa Paulo Otávio Lourenço Moreira Rubens Lima do Monte-Neto Alexander I. Agoulnik Courtney Myhr Alexander Kushnir Alexander N. Freiberg Bin Gong Cigdem Alkan Jia Zhou Kathryn A. Cunningham Noelle C. Anastasio Olivier Escaffre Tetsuro Ikegami Zhengchen Su Alexander V. Statsyuk Alexandre R. Gingras Amit K. Patel Anthony J. O’Donoghue Brendan M. Duggan Carlo Ballatore Derek S. Welsbie Evgenia Glukhov Jair L. Siqueira-Neto J Atomwise Inc. San Fransico USA Amgen Thousand Oaks USA OpenAI San Francisco USA Model Medicines La Jolla USA Atomic.AI San Francisco USA Edifice Health Inc. San Mateo USA METiS Therapeutics Cambridge USA Genentech San Mateo USA US Navy Medical Service Corps Officer (2300/1810D) San Mateo USA Totus Medicines Inc. Emeryville USA The University of North Carolina at Chapel Hill Eshelman School of Pharmacy Chapel Hill USA Cytokinetics Inc. South San Francisco USA Nurix Therapeutics San Francisco USA Amazon Alexa Suite USA Refibered Inc. Cupertino USA NVIDIA Santa Clara USA Harvard TH Chan School of Public Health Boston USA Columbia University New York USA University of São Paulo São Paulo Brazil Albert Einstein College of Medicine Bronx USA Nanyang Technological University Singapore Singapore University of Washington Seattle USA Chan Medical School University of Massachusetts Worcester USA Queensland University of Technology Brisbane USA University of Michigan Medical School Ann Arbor USA Columbia University Irving Medical Center New York USA Universidade Federal de Santa Catarina Florianópolis Brazil Université de Montréal Montreal Canada Instituto René Rachou-Fundação Oswaldo Cruz/Fiocruz Minas Belo Horizonte Brazil Herbert Wertheim College of Medicine Biomolecular Science Institute Florida International University Miami USA NYU Langone Health New York USA The University of Texas Medical Branch at Galveston Galveston USA University of Houston Galveston USA University of California San Diego USA School of Medicine Tufts University Medford USA University of California Davis Davis USA University of Western Australia Crawley Australia University of Groningen Groningen The Netherlands Wayne State University Detroit USA University of Zurich Zürich Switzerland Stanford University Stanford USA University of Antwerp Antwerp Belgium University of Rome Tor Vergata Rome Italy University of Edinburgh Edinburgh UK Department of Plant M

High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery. © 2024. The Author(s).

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Building a Portuguese coalition for biodiversity genomics

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npj biodiversity 2024年第1期3卷 27页

作者： João P Marques Paulo C Alves Isabel R Amorim Ricardo J Lopes Monica Moura Eugene Myers Manuela Sim-Sim Carla Sousa-Santos M Judite Alves Paulo A V Borges Thomas Brown Miguel Carneiro Carlos Carrapato Luís M P Ceríaco Claúdio Ciofi Luís P da Silva Genevieve Diedericks Maria Angela Diroma Liliana Farelo Giulio Formenti Fátima Gil Miguel Grilo Alessio Iannucci Henrique G Leitão Cristina Máguas Ann M Mc Cartney Sofia L Mendes João M Moreno Marco Morselli Alice Mouton Chiara Natali Fernando Pereira Rúben M C Rego Roberto Resendes Guilherme Roxo Hannes Svardal Helena Trindade Sara Vicente Sylke Winkler Marcela Alvarenga Andreia J Amaral Agostinho Antunes Paula F Campos Adelino V M Canário Rita Castilho L Filipe C Castro Angelica Crottini Mónica V Cunha Gonçalo Espregueira Themudo Pedro J Esteves Rui Faria Carlos Rodríguez Fernandes Jean-Baptiste Ledoux Bruno Louro Sara Magalhaes Octávio S Paulo Gareth Pearson João Pimenta Francisco Pina-Martins Teresa L Santos Ester Serrão José Melo-Ferreira Vítor C Sousa CIBIO Centro de Investigação em Biodiversidade e Recursos Genéticos InBIO Laboratório Associado Campus de Vairão Universidade do Porto 4485-661 Vairão Portugal. joao.marques@cibio.up.pt. BIOPOLIS Program in Genomics Biodiversity and Land Planning CIBIO Campus de Vairão 4485-661 Vairão Portugal. joao.marques@cibio.up.pt. BIOPOLIS Program in Genomics Biodiversity and Land Planning CIBIO Campus de Vairão 4485-661 Vairão Portugal. Departamento de Biologia Faculdade de Ciências Universidade do Porto 4169-007 Porto Portugal. University of the Azores CE3C- Centre for Ecology Evolution and Environmental Changes Azorean Biodiversity Group CHANGE Rua Capitão João d´Ávila Pico da Urze 9700-042 Angra do Heroísmo Portugal. CE3C Center for Ecology Evolution and Environmental Change & CHANGE Departamento de Biologia Animal Faculdade de Ciências Universidade de Lisboa Lisboa Portugal. MHNC-UP Natural History and Science Museum of the University of Porto 4099-002 Porto Portugal. CIBIO Research Centre in Biodiversity and Genetic Resources InBIO Associated Laboratory Azores Unit University of the Azores Campus of Ponta Delgada Rua da Mãe de Deus 13A 9500-321 Ponta Delgada Portugal. UNESCO Chair-Land Within Sea: Biodiversity & Sustainability in Atlantic Islands Ponta Delgada Portugal. Max Planck Institute of Molecular Cell Biology and Genetics Pfotenhauerstraße 108 01307 Dresden Germany. Okinawa Institute of Science and Technology Onna Son Japan. CE3C-Centre for Ecology Evolution and Environmental Changes & CHANGE-Global Change and Sustainability Institute Faculdade de Ciências Universidade de Lisboa Lisboa Portugal. MUHNAC-Museu Nacional de História Natural e da Ciência Universidade de Lisboa Rua da Escola Politécnica 58 1250-102 Lisboa Portugal. MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network ISPA-Instituto Superior de Ciências Psicológicas Sociais e da Vida Rua Jardim do Tabaco 34 1149-041 Lisbon Portugal. CE3C-Centre for E

The diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes, overexploitation, or pathogen (re)emergence. The inventory, characterisation, and study of biodiversity at inter- and intra-specific levels using genomics is crucial to promote its preservation and recovery by informing biodiversity conservation policies, management measures, and research. The participation of researchers from Portuguese institutions in the European Reference Genome Atlas (ERGA) initiative and its pilot effort to generate reference genomes for European biodiversity has reinforced the establishment of Biogenome Portugal. This nascent institutional network will connect the national community of researchers in genomics. Here, we describe the Portuguese contribution to ERGA’s pilot effort, which will generate high-quality reference genomes of six species from Portugal that are endemic, iconic, and/or endangered and include plants, insects, and vertebrates (fish, birds, and mammals) from mainland Portugal or the Azores islands. In addition, we outline the objectives of Biogenome Portugal, which aims to (i) promote scientific collaboration, (ii) contribute to advanced training, (iii) stimulate the participation of institutions and researchers based in Portugal in international biodiversity genomics initiatives, and (iv) contribute to the transfer of knowledge to stakeholders and engaging the public to preserve biodiversity. This initiative will strengthen biodiversity genomics research in Portugal and fuel the genomic inventory of Portuguese eukaryotic species. Such efforts will be critical to the conservation of the country’s rich biodiversity an

关键词： Genomics Biodiversity

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Author Correction: Genomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms

Communications biology

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Communications biology 2021年第1期4卷 459页

作者： Yongxin Li Akihito Omori Rachel L Flores Sheri Satterfield Christine Nguyen Tatsuya Ota Toko Tsurugaya Tetsuro Ikuta Kazuho Ikeo Mani Kikuchi Jason C K Leong Adrian Reich Meng Hao Wenting Wan Yang Dong Yaondong Ren Si Zhang Tao Zeng Masahiro Uesaka Yui Uchida Xueyan Li Tomoko F Shibata Takahiro Bino Kota Ogawa Shuji Shigenobu Mariko Kondo Fayou Wang Luonan Chen Gary Wessel Hidetoshi Saiga R Andrew Cameron Brian Livingston Cynthia Bradham Wen Wang Naoki Irie State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China. Sado Island Center for Ecological Sustainability Niigata University Niigata Japan. Dept. of Biological Sciences California State Univesity Long Beach CA USA. SOKENDAI Kanagawa Japan. Urawa University Saitama Japan. Japan Agency for Marine-Earth Science and Technology (JAMSTEC) Kanagawa Japan. Tokyo Metropolitan University Yokosuka Tokyo Japan. Hokkaido University Sapporo Hokkaido Japan. Dept. of Biological Sciences Graduate School of Science The University of Tokyo Tokyo Japan. Providence Institute of Molecular Oogenesis Brown University Providence RI USA. Yunnan Agricultural University Kunming China. Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai China. RIKEN Center for Biosystems Dynamics Research (BDR) Kobe Hyogo Japan. Universal Biology Institute University of Tokyo Tokyo Japan. NIBB Core Research Facilities National Institute of Basic Biology Okazaki Aichi Japan. Faculty of Social and Cultural Studies Kyushu University Fukuoka Japan. Key Laboratory of Systems Biology Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Chinese Academy of Sciences Hangzhou China. Chuo University Tokyo Japan. Beckman Institute Division of Biology and Biological Engineering California Institute of Technology Pasadena CA USA. Department of Biology Boston Univerisity Boston MA USA. State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China. wwang@***. School of Ecology and Environment Northwestern Polytechnical University Xi'an China. wwang@***. Dept. of Biological Sciences Graduate School of Science The University of Tokyo Tokyo Japan. irie@bs.s.u-tokyo.ac.jp. Universal Biology Institute University of Tokyo Tokyo Japan. irie@bs.s.u-tokyo.ac.jp

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The Fourth Catalog of Active Galactic Nuclei Detected by the Fermi Large Area Telescope - Data Release 3

arXiv

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arXiv 2022年

作者： Ajello, Marco Baldini, Luca Ballet, Jean Bastieri, Denis Gonzalez, Joseff Becerra Bellazzini, Ronaldo Berretta, Alessandra Bissaldi, Elisabetta Bonino, Raffaella Brill, Ari Bruel, Philippe Buson, Sara Caputo, Regina Caraveo, Patrizia A. Cheung, C.C. Chiaro, Graziano Cibrario, Nicolo Ciprini, Stefano Crnogorcevic, Milena Cutini, Sara D’Ammando, Filippo De Gaetano, Salvatore Di Lalla, Niccolo Di Venere, Leonardo Domínguez, Alberto Ramazani, Vandad Fallah Ferrara, Elizabeth C. Fiori, Alessio Fukazawa, Yasushi Funk, Stefan Fusco, Piergiorgio Gammaldi, Viviana Gargano, Fabio Garrappa, Simone Gasparrini, Dario Giglietto, Nico Giordano, Francesco Giroletti, Marcello Green, David Grenier, Isabelle A. Guiriec, Sylvain Horan, Deirdre Hou, Xian Kayanoki, Taishu Kuss, Michael Larsson, Stefan Latronico, Luca Lewis, Tiffany Li, Jian Liodakis, Ioannis Longo, Francesco Loparco, Francesco Lott, Benoit Lovellette, Michael N. Lubrano, Pasquale Madejski, Grzegorz M. Maldera, Simone Manfreda, Alberto Martí-Devesa, Guillem Mazziotta, Mario Nicola Mereu, Isabella Michelson, Peter F. Mirabal, Nestor Mitthumsiri, Warit Mizuno, Tsunefumi Monzani, Maria Elena Morselli, Aldo Moskalenko, Igor V. Negro, Michela Ojha, Roopesh Orienti, Monica Orlando, Elena Ormes, Jonathan F. Pei, Zhiyuan Peña-Herazo, Harold A. Persic, Massimo Pesce-Rollins, Melissa Petrosian, Vahe Pillera, Roberta Poon, Helen Porter, Troy A. Principe, Giacomo Rainò, Silvia Rando, Riccardo Rani, Bindu Razzano, Massimiliano Razzaque, Soebur Reimer, Anita Reimer, Olaf Scotton, Lorenzo Serini, Davide Sgrò, Carmelo Siskind, Eric J. Spandre, Gloria Spinelli, Paolo Suson, Dan J. Tajima, Hiro Torres, Diego F. Valverde, Janeth Yassin, Hend Zaharijas, Gabrijela Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy AIM CEA CNRS Université Paris-Saclay Université de Paris Gif-sur-YvetteF-91191 France Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova Via F. Marzolo 8 PadovaI-35131 Italy Center for Space Studies and Activities "G. Colombo" University of Padova Via Venezia 15 PadovaI-35131 Italy Instituto de Astrofísica de Canarias Observatorio del Teide C/Via Lactea s/n La Laguna TenerifeE-38205 Spain Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Dipartimento di Fisica Università degli Studi di Perugia PerugiaI-06123 Italy Dipartimento di Fisica "M. Merlin" Università e del Politecnico di Bari via Amendola 173 BariI-70126 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy NASA Postdoctoral Program United States NASA Goddard Space Flight Center GreenbeltMD20771 United States Laboratoire Leprince-Ringuet École polytechnique CNRS IN2P3 PalaiseauF-91128 France Institut für Theoretische Physik and Astrophysik Universität Würzburg WürzburgD-97074 Germany INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Space Science Division Naval Research Laboratory WashingtonDC20375-5352 United States Istituto Nazionale di Fisica Nucleare Sezione di Roma "Tor Vergata" RomaI-00133 Italy Space Science Data Center - Agenzia Spaziale Italiana Via del Politecnico snc RomaI-00133 Italy Department of Astronomy University of Maryland College ParkMD20742 United States Istituto Nazionale di Fisica Nucleare Sezio

An incremental version of the fourth catalog of active galactic nuclei (AGNs) detected by the Fermi-Large Area Telescope is presented. This version (4LAC-DR3) derives from the third data release of the 4FGL catalog based on 12 years of E>50 MeV gamma-ray data, where the spectral parameters, spectral energy distributions (SEDs), yearly light curves, and associations have been updated for all sources. The new reported AGNs include 587 blazar candidates and four radio galaxies. We describe the properties of the new sample and outline changes affecting the previously published one. We also introduce two new parameters in this release, namely the peak energy of the SED high-energy component and the corresponding flux. These parameters allow an assessment of the Compton dominance, the ratio of the Inverse-Compton to the synchrotron peak luminosities, without relying on X-ray data. © 2022, CC BY.

关键词： Active Galactic Nuclei

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Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

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四川生理科学杂志 2022年第12期44卷 2223-2223页

作者： Danyel Lee St. Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA. Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Paris France. Paris City University Imagine Institute Paris France. Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA. Department of Cancer Biology Lerner Research Institute Cleveland Clinic Cleveland OH USA. Human Evolutionary Genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France. Doctoral College Sorbonne University Paris France. Laboratory of Immunology Lyon Sud Hospital Lyon France. Pediatric Intensive Care Department Hospital Sant Joan de Déu Barcelona Spain. Kids Corona Platform Barcelona Spain. Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain. Department of Surgery and Surgical Specializations Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain. Respiratory and Immunological Dysfunction in Pediatric Critically Ill Patients Institute of Recerca Sant Joan de Déu Barcelona Spain. Bursa City Hospital Bursa Turkey. Ankara City Hospital Yildirim Beyazit University Ankara Turkey. Immunology and Rheumatology Division Department of Pediatrics University of Montreal CHU Sainte-Justine Montreal QC Canada. Center for Translational Research Institut Pasteur Paris City University Paris France. Department of Biochemistry and Center for RNA Science and Therapeutics Case Western Reserve University Cleveland OH USA. Department of Surgery Weill Cornell Medical College New York NY USA. Department of Pediatrics School of Medicine Emory University Atlanta GA USA. International Center of Infectiology Research (CIRI) University of Lyon INSERM U1111 Claude Bernard University Lyon 1 CNRS UMR5308 ENS of Lyon Lyon France. Departments of Neurosurgery and Genetics and Yale Center for G

Multisystem inflammatory syndrome in children(MIS-C)is a rare and severe condition that follows benign *** report autosomal recessive deficiencies of OAS1,OAS2,or RNASEL in five unrelated children with *** cytosolic d... 详细信息

关键词： inflammatory children multisystem

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Author Correction: A global biodiversity observing system to unite monitoring and guide action

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Nature ecology & evolution 2023年第12期7卷 2173页

作者： Andrew Gonzalez Petteri Vihervaara Patricia Balvanera Amanda E Bates Elisa Bayraktarov Peter J Bellingham Andreas Bruder Jillian Campbell Michael D Catchen Jeannine Cavender-Bares Jonathan Chase Nicholas Coops Mark J Costello Bálint Czúcz Aurélie Delavaud Maria Dornelas Grégoire Dubois Emmett J Duffy Hilde Eggermont Miguel Fernandez Nestor Fernandez Simon Ferrier Gary N Geller Michael Gill Dominique Gravel Carlos A Guerra Robert Guralnick Michael Harfoot Tim Hirsch Sean Hoban Alice C Hughes Wim Hugo Margaret E Hunter Forest Isbell Walter Jetz Norbert Juergens W Daniel Kissling Cornelia B Krug Peter Kullberg Yvan Le Bras Brian Leung Maria Cecilia Londoño-Murcia Jean-Michel Lord Michel Loreau Amy Luers Keping Ma Anna J MacDonald Joachim Maes Melodie McGeoch Jean Baptiste Mihoub Katie L Millette Zsolt Molnar Enrique Montes Akira S Mori Frank E Muller-Karger Hiroyuki Muraoka Masahiro Nakaoka Laetitia Navarro Tim Newbold Aidin Niamir David Obura Mary O'Connor Marc Paganini Dominique Pelletier Henrique Pereira Timothée Poisot Laura J Pollock Andy Purvis Adriana Radulovici Duccio Rocchini Claudia Roeoesli Michael Schaepman Gabriela Schaepman-Strub Dirk S Schmeller Ute Schmiedel Fabian D Schneider Mangal Man Shakya Andrew Skidmore Andrew L Skowno Yayioi Takeuchi Mao-Ning Tuanmu Eren Turak Woody Turner Mark C Urban Nicolás Urbina-Cardona Ruben Valbuena Anton Van de Putte Basile van Havre Vladimir Ruslan Wingate Elaine Wright Carlos Zambrana Torrelio Department of Biology Group on Earth Observations Biodiversity Observation Network McGill University Montreal Quebec Canada. andrew.gonzalez@mcgill.ca. Finnish Environment Institute Helsinki Finland. Instituto de Investigaciones en Ecosistemas y Sustentabilidad (IIES) Universidad Nacional Autónoma de México Morelia Mexico. Biology Department University of Victoria Victoria British Columbia Canada. EcoCommons Australia Research Specialised and Data Foundations Griffith University Nathan Queensland Australia. Manaaki Whenua - Landcare Research Lincoln New Zealand. Institute of Microbiology University of Applied Sciences and Arts of Southern Switzerland Mendrisio Switzerland. Secretariat of the Convention on Biological Diversity Montreal Quebec Canada. Department of Biology Group on Earth Observations Biodiversity Observation Network McGill University Montreal Quebec Canada. Department of Ecology Evolution and Behavior University of Minnesota Saint Paul MN USA. German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig Halle Germany. Department of Computer Sciences Martin Luther University Halle-Wittenberg Halle Germany. University of British Columbia Vancouver British Columbia Canada. Faculty of Biosciences and Aquaculture Nord Universitet Bodø Norway. Norwegian Institute for Nature Research (NINA) Trondheim Norway. Fondation for Research on Biodiversity (FRB) Paris France. Centre for Biological Diversity University of St Andrews St Andrews UK. Guia Marine Lab MARE Faculdade de Ciências da Universidade de Lisboa Cascais Portugal. Knowledge Centre for Biodiversity Joint Research Centre of the European Commission Ispra Italy. Tennenbaum Marine Observatories Network and MarineGEO program Smithsonian Environmental Research Center Edgewater MD USA. Belgian Science Policy Office Belgian Biodiversity Platform/Biodiversa+ Brussels Belgium. German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig Leipzig Germany.

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BioTIME 2.0: Expanding and Improving a Database of Biodiversity Time Series

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Global Ecology and Biogeography 2025年第5期34卷

作者： Maria Dornelas Laura H. Antão Amanda E. Bates Viviana Brambilla Jonathan M. Chase Cher F. Y. Chow Ada Fontrodona-Eslava Anne E. Magurran Inês S. Martins Faye Moyes Alban Sagouis Samuel Adu-Acheampong Daniel Acquah-Lamptey Dušan Adam Penelope A. Ajani Aitor Albaina Pablo Almaraz Jeongseop An Roger Sigismund Anderson Madelaine Jean Robertson Anderson Alexsander Z. Antunes Ivan Arismendi Linda Armbrecht Pedro Aros-Mardones Sreejith Kalpuzha Ashtamoorthy Narayanan Ayyappan Gal Badihi Joseph J. Bailey Andrew H. Baird Mark Edward Baird Sreekumar Vadakkethil Balakrishnan José António L. Barão-Nóbrega Adi Barash Miguel Barbosa Jos Barlow Claus Bässler Matthieu Beaumont Natalie Beenaerts Tiago Octavio Begot Wallace Beiroz Ricardo Beldade David M. Bell Alecia Bellgrove Jonathan Belmaker Lisandro Benedetti-Cecchi Cassandra E. Benkwitt Pamela Medina-van Berkum Brandon T. Bestelmeyer Matthew G. Betts Maxwell Kelvin Billah Anne D. Bjorkman Magdalena Błażewicz Christopher P. Bloch Shane A. Blowes Antonio Bode Juliano A. Bogoni Thomas Bolger Timothy C. Bonebrake Erik Bonsdorff Roberta Bottarin Luke N. Brokensha Rob W. Brooker Andrew J. Brooks Helge Bruelheide Thiago Almeida Bueno Claire Laguionie Mariana Lopes Campagnoli James Cant Erica Pellegrini Caramaschi Alexandre Caron Tadhg Carroll Tancredi Caruso Juan Carvajal-Quintero Giuseppe Castaldelli Edward Castañeda-Moya Pedro V. Castilho Sonia Zanini Cechin Shahar Chaikin Uchangi Manjunatha Chandrashekara Tory J. Chase Chaolun Allen Chen Jorge José Cherem Sei-Woong Choi Erica M. Christensen Alexander V. Christianini Jackson Wing Four Chu Peter Coad Carl Van Colen Lise Comte Elisabeth J. Cooper J. Hans C. Cornelissen Eddy Cosson Unai Cotano Luc Crevecoeur Shannan Kyle Crow Graeme S. Cumming Vanessa S. Daga Gabriella Damasceno Gergana N. Daskalova Claire H. Davies Robert A. Davis Frank P. Day Sussy De-La-Zerda Amy Elizabeth Deacon Indradatta de Castro-Arrazola Steven Degraer Kharran Deonarinesingh Juan C. Diaz-Ricaurte Christopher R. Dickman Tara Dirilgen Ciaran John Dolan J. Emmet Centre for Biological Diversity School of Biology University of St Andrews Fife UK MARE—Centro de Ciências do Mar e do Ambiente Faculdade de Ciências Universidade de Lisboa Lisboa Portugal Research Centre for Ecological Change Organismal and Evolutionary Biology Research Programme Faculty of Biological and Environmental Sciences University of Helsinki Helsinki Finland Department of Biology University of Victoria Victoria British Columbia Canada German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig Leipzig Germany Department of Computer Science Martin Luther University Halle-Wittenberg Halle (Saale) Germany Leverhulme Centre for Anthropocene Biodiversity Department of Biology University of York York UK Department of Animal Biology and Conservation Science University of Ghana Accra Ghana Philipps Universität Marburg Marburg Germany Department of Forest Ecology Silva Tarouca Research Institute Brno Czech Republic School of Life Sciences University of Technology Sydney Sydney New South Wales Australia Zoology and Animal Cell Biology Department University of the Basque Country (UPV/EHU) Leioa Spain Grupo de Oceanografía de Ecosistemas Instituto de Ciencias Marinas de Andalucía CSIC Campus Universitario de Puerto Real Puerto Real Spain National Institute of Ecology Seocheon Republic of Korea African Regional Postgraduate Programme in Insect Science University of Ghana Accra Ghana Département de Biologie Université de Sherbrooke Sherbrooke Quebec Canada Núcleo de Conservação da Biodiversidade Instituto de Pesquisas Ambientais Secretaria de Meio Ambiente Infraestrutura e Logística do Estado de São Paulo São Paulo Brazil Department of Fisheries Wildlife and Conservation Sciences Oregon State University Corvallis Oregon USA Institute for Marine and Antarctic Studies Ecology & Biodiversity Centre University of Tasmania Hobart Tasmania Australia Graduate Program in Oceanography Department of Oceanography Faculty of Natural Scienc

Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R package (BioTIMEr) to facilitate use of the database. Main Types of Variables Included The database is composed of one main data table containing the abundance records and 11 metadata tables. The data are organised in a hierarchy of scales where 11,989,233 records are nested in 1,603,067 sample events, from 553,253 sampling locations, which are nested in 708 studies. A study is defined as a sampling methodology applied to an assemblage for a minimum of 2 years. Spatial Location and Grain Sampling locations in BioTIME are distributed across the planet, including marine, terrestrial and freshwater realms. Spatial grain size and extent vary across studies depending on sampling methodology. We recommend gridding of sampling locations into areas of consistent size. Time Period and Grain The earliest time series in BioTIME start in 1874, and the most recent records are from 2023. Temporal grain and duration vary across studies. We recommend doing sample-level rarefaction to ensure consistent sampling effort through time before calculating any diversity metric. Major Taxa and Level of Measurement The database includes any eukaryotic taxa, with a combined total of 56,400 taxa. Software Format csv and. SQL.

关键词： assemblage biodiversity community database ecoinformatics species taxa time

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