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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Further geological and palaeoanthropological investigations at the Maludong hominin site, Yunnan Province, Southwest China

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Chinese science Bulletin 2013年第35期58卷 4472-4485页

作者： JI XuePing CURNOE Darren BAO ZhenDe HERRIES Andy I R FINK David ZHU YunSheng HELLSTROM John LUO Yun TACON Paul S C Yunnan Institute of Cultural Relics and Archaeology School of Biological Earth and Environmental Sciences University of New South Wales Sydney 2052 Australia Mengzi Institute of Cultural Relics Archaeomagnetism Laboratory Archaeology Program School of Historical and European Studies La Trobe University Melbourne 3086 Australia Institute for Environmental Research Australian Nuclear Science and Technology Organisation Sydney 2001 Australia Honghe Prefectural Institute of Cultural Relics School of Earth Sciences University of Melbourne Melbourne 3010 Australia Place Evolution and Rock Art Heritage Unit School of Humanities Gold Coast Campus Griffith University Gold Coast 4222 Australia

Three-dimensional mapping and section work undertaken by us in 2008 have identified 11 stratigraphic units at Maludong *** radiocarbon dating of charcoal established an accurate and internally consistent age profile for the sequence of 17.8±0.2 ka to 13.2±0.1 *** analysis showed changes in externally derived pedogenically enhanced material consistent with a warming in climate between the cold period of Henrich Event 1 and the B lling-Aller d *** remains recovered during the 1989 excavation were derived from a deposit dating to this interstadial,or between 14.3±0.3 ka and 13.5±0.1 *** features,including burnt rocks,baked sediment and thick charcoal and ash layers,were identified and examined through archaeomagnetic *** monkey fossils are described here,one of them being reassigned from Macaca robustus to *** confirm the young age of the site and also show signs of anthropogenic alteration in the form of *** human cranial remains are reported for the first time and new data are provided for some specimens described previously.A range of new features is identified that strengthen the affinities of the Maludong remains to archaic *** presence of this globally unique mosaic of archaic and modern features raises important questions about human evolutionary history in East Asia during the Late Upper Pleistocene.

关键词：古人类遗址中国西南地区古人类学云南省地质地层单位三维制图年龄分布

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Improving ITS sequence data for identification of plant pathogenic fungi

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Fungal Diversity 2014年第4期67卷 11-19页

作者： R.Henrik Nilsson Kevin D.Hyde Julia Pawlowska Martin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnmann Mohammad Bahram Johan Bengtsson-Palme Anna Berlin Sara Branco Putarak Chomnunti Asha Dissanayake Rein Drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs Martin Hartmann Beatrice Henricot Ruvishika Jayawardena Ari Jumpponen Havard Kauserud Sonja Koskela Tomasz Kulik Kare Liimatainen Bjorn D.Lindahl Daniel Lindner Jian-Kui Liu Sajeewa Maharachchikumbura Dimuthu Manamgoda Svante Martinsson Maria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini Pereira Danilo Batista Pinho Teresita M.Porter Valentin Queloz Taavi Riit Marisol Sánchez-García Filipe de Sousa Emil Stefańczyk Mariusz Tadych Susumu Takamatsu Qing Tian Dhanushka Udayanga Martin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urmas Koljalg Kessy Abarenkov Department of Biological and Environmental Sciences University of GothenburgBox 46140530 GothenburgSweden Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Systematics and Geography Faculty of BiologyUniversity of WarsawAl.Ujazdowskie 400-478 WarsawPoland Department of Organismal Biology Uppsala UniversityNorbyvagen 18D75236 UppsalaSweden Institute of Ecology and Earth Sciences University of TartuLai 40Tartu 51005Estonia Microbial Evolution Research Group University of OsloBlindernveien 310371 OsloNorway Institute of Biological Sciences University of Malaya50603 Kuala LumpurMalaysia Department of Biology CESAMUniversity of Aveiro3810-193 AveiroPortugal School of Plant Sciences The University of Arizona1140 E South Campus DriveForbes 303TucsonAZ 85721USA Laboratory of Environmental Microbiology Institute of Microbiology ASCRVídeňská108314220 Prague 4Czech Republic Department of Infectious Diseases Institute of BiomedicineSahlgrenska AcademyUniversity of GothenburgGuldhedsgatan 1041346 GoteborgSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden University of California at Berkeley 321 Koshland Hall University of CaliforniaBerkeleyCA 94720-3102USA Agriculture and Forestry Sciences Beijing 100097China Institute of Forestry and Rural Engineering Estonian University of Life SciencesKreutzwaldi551014 TartuEstonia Natural History Museum of Denmark Øster Voldgade 5-71350 København KDenmark Institute for Genomics and Bioinformatics Graz University of Technology8010 GrazAustria Core Facility Bioinformatics Austrian Centre of Industrial Biotechnology8010 GrazAustria Forest Soils and Biogeochemistry Swiss Federal Research Institute WSLZuercherstrasse 1118903 BirmensdorfSwitzerland Molecular Ecology Institute for Sustainability SciencesAgroscopeReckenholzstrasse 191

Plant pathogenic fungi are a large and diverse assemblage of eukaryotes with substantial impacts on natural ecosystems and human *** taxa often have complex and poorly understood life cycles,lack observable,discriminatory morphological characters,and may not be amenable to in vitro *** a result,species identification is frequently ***(DNA sequence)data have emerged as crucial information for the taxonomic identification of plant pathogenic fungi,with the nuclear ribosomal internal transcribed spacer(ITS)region being the most popular ***,international nucleotide sequence databases are accumulating numerous sequences of compromised or low-resolution taxonomic annotations and substandard technical quality,making their use in the molecular identification of plant pathogenic fungi *** we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from these fungal lineages.A third objective was to enrich the sequences with geographical and ecological *** results-a total of 31,954 changes-are incorporated in and made available through the UNITE database for molecular identification of fungi(http://***),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platforms QIIME and mothur,and related *** present initiative is just a beginning to cover the wide spectrum of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort.

关键词： Phytopathogenic fungi Molecular identification ITS Taxonomy Annotation

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Fabrication of zinc oxide nano-patterns by quick gel-nanoimprint process toward optical switching devices

Fabrication of zinc oxide nano-patterns by quick gel-nanoimp...

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International Workshop on Active-Matrix Flatpanel Displays and Devices (AM-FPD)

作者： Shinji Araki Min Zhang Takahiro Doe Li Lu Masahiro Horita Takashi Nishida Yasuaki Ishikawa Yukiharu Uraoka Nara Institute of Science and Technology (NAIST) Graduate School of Materials Science Nara Japan Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Agency Saitama Japan

We investigated a quick patterning using a gel-nanoimprint process for zinc oxide (ZnO) thin films. The X-ray diffraction measurement revealed that the ZnO thin films had wurtzite structure by annealing in the ambient air or oxygen. The ZnO thin film annealed in oxygen exhibited higher refractive index of 1.92 (at 720 nm for wavelength of light) which is close to that of a conventional ZnO thin film, whereas that of ZnO thin film annealed in air atmosphere provided very low value of 1.64. We demonstrated the nano-patterning with quite short imprinting time in 5 min by the gel-nanoimprint process. We achieved that the shrinkage factor of ZnO nano-patterns was as low as 8% and 3% in the width-and height-directions, respectively.

关键词： Zinc oxide Annealing Films Substrates Refractive index Solvents Heating

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Fabrication of nano-patterns using quick gel-nanoimprint process

Fabrication of nano-patterns using quick gel-nanoimprint pro...

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International Meeting for Future of Electron Devices

作者： Shinji Araki Min Zhang Takahiro Doe Li Lu Masahiro Horita Takashi Nishida Yasuaki Ishikawa Yukiharu Uraoka Graduate School of Materials Science Nara Institute of Science and Technology Ikoma Nara Japan Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Agency Kawaguchi Saitama Japan

We investigated a quick patterning using gel-nanoimprint process for zinc oxide (ZnO) thin films. The X-ray diffraction measurement revealed that the ZnO films had wurtzite structure by annealing in the ambient air or oxygen. The ZnO film annealed in oxygen exhibited higher refractive index of 1.92 (at 720 nm for wavelength of light) which is close to that of a conventional ZnO film, whereas that of ZnO film annealed in air atmosphere provided very low value of 1.64. The width of ZnO patterns was in good agreement with that of a polydimethylsiloxane mold.

关键词： Zinc oxide Annealing Films Glass Fabrication Refractive index Lithography

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CCD based ion image sensors for novel bio imaging — Fusion of Sensor technology and LSI technology

CCD based ion image sensors for novel bio imaging — Fusion ...

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IEEE/LEOS International Conference on Optical MEMS

作者： Kazuaki Sawada JST-CREST (Core Research for Evolution Science and Technology Japan Science and Technology Agency Chiyoda Tokyo Japan Department of Electrical and Electronic Information Engineering EIIRIS (Electronics-Inspired Interdisciplinary Research Institute) Toyohashi University of Technology Toyohashi Japan

The ion image sensor was invented. The device enables two dimensional visualization of both the ion and optical imaging of chemical activity of solutions and cell activity. The CMOS device consists of an array of CCDs covered with functionalized membrane. Changes in the concentration and two dimensional distributions of several ions are detected by charge accumulation. We have recently reported on the use of the sensor for real time imaging of acetylcholine (ACh) enzyme reactions. Insights in the variation of the concentration of ACh may lead to new methods for the treatment of Alzheimer's disease.

关键词： Image sensors Optical imaging Optical sensors Biomedical optical imaging Optical device fabrication

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A fire alarm vision system based on IR image processing

A fire alarm vision system based on IR image processing

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5th International Conference on New Trends in Information science and Service science, NISS 2011

作者： Kim, Won-Ho Kim, Seung-Kyeom Lee, Jong-Ho Hyun, Chang-Ho Division of Electrical Electronic and Control Engineering College of Engineering Kongju National University Cheonan Korea Republic of Grant of the Korean Ministry of Education Science and Technology Regional Core Research Program Zero Energy Green Village Technology Center Korea Republic of Research-year Program of Kongju National University Korea Republic of

ISBN: (纸本)9788988678626

This paper presents a fire alarm vision system based on flame detection algorithm of infrared image. The presented flame detection algorithm measures the luminance variation of candidate flame blocks of the IR image and it determines existence of the fire according to the amount of variation of luminance. By using the test images, the simulation of flame detection algorithm was performed and implemented fire alarm vision system was tested. As a result, the evaluated correct detection ratio was 85.7%. © 2011 AICIT.

关键词： Luminance

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Fabrication of Three-Dimensional Photonic Crystal by Wafer Fusion Approach

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MRS Online Proceedings Library (OPL) 2011年第1期681卷 I6.4-I6.4页

作者： Noritsugu Yamamoto Katsuhiro Tomoda Susumu Noda Research Institute of Photonics National Institute of Advanced Industrial Science and Technology AIST Tsukuba Central 2 1-1-1 Umezono Tsukuba 303-8568 Japan Dept. of Electronic Science and Engineering Kyoto University Yoshidahonmachi Sakyo-ku Kyoto 606-8501 Japan Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Corporation (JST)

Based on a set of requirements identified for photonic crystals intended for use in optoelectronic devices, we have developed a method of fabricating three-dimensional photonic crystals that involves stacking air/semiconductor gratings by wafer fusion approach. Precise alignment of the stacked layers is achieved through the use of a laser beam assisted very precise alignment system, and three-dimensional photonic crystal has been successfully fabricated for the infrared and optical communication wavelength regions. We have also developed a photonic crystal waveguide providing sharp 90° bend.

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Structure of Frilled Carbon Nanowires Synthesized by Sulfur-assisted Chemical Vapor Deposition

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MRS Online Proceedings Library 2011年第1期706卷 1-6页

作者： Tadashi Mitsui Takashi Sekiguchi Mikka Nishitani-Gamo Yafei Zhang Toshihiro Ando Nanomaterials Laboratory National Institute for Materials Science (NIMS) Tsukuba Ibaraki Japan Insititute of Applied Physics and Center for Tsukuba Advanced Research Alliance (TARA) University of Tsukuba Tsukuba Ibaraki Japan Core Research for Evolution Science and Technology (CREST) of Japan Science and Technology Cooperation (JST) c/o Advanced Materials Laboratory Tsukuba Ibaraki Japan

Effects of hydrogen sulfide on the structure of carbon nanotubes (CNTs) were studied using high-resolution transmission electron microscopy (HRTEM) and electron energy loss spectroscopy (EELS). The CNTs were synthesized with an iron thin-film catalyst by microwave plasma-assisted CVD on the diamond substrate. The HRTEM images revealed that essentially all of the CNTs obtained in this study were multiwall (MWCNT). The addition of H2S resulted in nanotubes with split skins as cornhusks and/or frills. Electron energy loss spectra of the cornhusks indicated that they consist of sp2, sp3 and amorphous carbon phase. The spectra revealed that the sp3 to sp2 ratio at the points where cornhusks divide from the main stem was more than that at the edge of the cornhusks. No evidence of sulfur incorporation into the MWCNTs grown with the H2S addition was found. We speculate that the chemical nature of sulfur on the CNT growth yields such anomalous structure.

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Multifunctional Hyper-Structured Molecules

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MRS Online Proceedings Library (OPL) 2011年第1期488卷 255-255页

作者： T. Wada Y. Zhang T. Aoyama Y. Kubo H. Sasabe Core Research for Evolutional Science and Technology (CREST) Frontier Research Program The Institute of Physical and Chemical Research (RIKEN) JST Wako Saitama 351-0198 Japan tatsuow@postman.riken.go.jp Dept. of Applied Chemistry Saitama University Urawa Saitama 338 Japan

To fill the gap between molecular design and the architecture of three-dimensional functional structures, we propose novel hyper-structured molecules (HSMs) based on welldefined and topologically controlled molecular systems. To this end we have developed carbazole dendrimers, trimers, cyclic oligomers and chromogenic calix[4]arenes as HSMs. Photorefractivity was selected as the primary target function of these HSMs. Oligomers developed in our laboratory exhibit intrinsic photocarrier generation, transport, electro-optic, film-forming and poling properties. These multifunctional properties allow us to demonstrate optical image processing using optical phase conjugation. The topological shapes of indoaniline-derived calix[4]arenes were studied by hyper-Rayleigh scattering. The two indoaniline moieties in calix[4]arene derivatives were pre-aligned so as to enhance the net molecular hyperpolarizability. Besides dendric oligomers, cyclic oligomers can be used as a molecular platform which allows molecular level tuning of shape, size and topology for superior opto-electronic functions.

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