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第三十五届国际光谱会议

作者： T.Seino S.Nishizawa N.Teramae Department of Chemistry Graduate School of Science Tohoku University and Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Agency Aoba-ku Sendai 980-8578 Japan Department of Chemistry Graduate School of Science Tohoku University and Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Agency Aoba-ku Sendai 980-8578 Japan Department of Chemistry Graduate School of Science Tohoku University and Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Agency Aoba-ku Sendai 980-8578 Japan

In recent years,large-scale sequencing of complete genomes has fueled the discovery of single-nucleotide polymorphisms(SNPs),which have been the representatives of genetic variants associated with susceptibility to various common diseases and response to various *** a number of methods have been proposed for SNPs mapping and typing[1],most of

关键词： Substituent Effects on the Nucleobase Recognition of 2-Amino-1,8-Naphthyridine Derivatives in Abasic Sites

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Substituent Effects on the Nucleobase Recognition of 2-Amino-1,8-Naphthyridine Derivatives in Abasic Sites

Substituent Effects on the Nucleobase Recognition of 2-Amino...

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第35届国际光谱会议(The Colloquium Spectroscopicum Internationale XXXV)

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Three-dimensional laser structuring of materials at tight focusing

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中国光学快报（英文版） 2007年第S1期5卷 198页

作者： Saulius Juodkazis Koichi Nishimura Hiroaki Misawa Research Institute for Electronic Science Hokkaido University Kita-ku Sapporo 001-0021 Japan Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Corporation (JST) Japan

Pulse shaping and phase control of femtosecond pulses are shown to have effect on the dielectric breakdown of sapphire. The influence of a pulse tilt on a dielectric breakdown is demonstrated. Three-dimensional struct... 详细信息

关键词： 220.4000 260.5210 320.5550 320.2250

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Bidirectional coincidence counting of correlated photons to determine the detection efficiency of a single-photon detector without a reference standard

Bidirectional coincidence counting of correlated photons to ...

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2007 Pacific Rim Conference on Lasers and Electro-Optics (CLEO/PACIFIC RIM 2007), vol.3

作者： A. Yoshizawa S. Odate D. Fukuda H. Tsuchida National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Umezono Tsukuba Ibaraki 305-8568 Japan Core Research for Evolution and Technology (CREST) Japan Science and Technology Agency 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan

Bidirectional coincidence counting of correlated photons was adopted to determine the detection efficiency of single-photon detectors operating at 1550nm without comparing to a reference standard. A self-calibration m... 详细信息

ISBN: (纸本)1424411742

关键词： Periodically poled lithium niobate Photon counting Single mode fibers Single photon detectors Transmission coefficient Tunable diode lasers

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In VitroandIn VivoTransfer of bcl-2 Gene into Keratinocytes Suppresses UVB-induced Apoptosis¶

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Photochemistry and Photobiology 2007年第4期74卷

作者： Hidetoshi Takahashi Masaru Honma Akemi Ishida-Yamamoto Kazuhiko Namikawa Akiko Miwa Haruo Okado Hiroshi Kiyama Hajime Iizuka Department of Dermatology Asahikawa Medical College Asahikawa Hokkaido Japan Department of Anatomy Asahikawa Medical College Asahikawa Hokkaido Japan Department of Neurobiology Tokyo Metropolitan Institute for Neuroscience Fuchu Tokyo Japan Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Kawaguchi Saitama Japan

Bcl-2 is a member of the large Bcl-2 family and protects cells from apoptosis. Ultraviolet B (UVB) irradiation induces apoptosis of keratinocytes that is known as “sunburn cells.” Previously we reported that UVB irradiation induces apoptosis accompanied by sequential activation of caspase 8, 3 and 1 in keratinocytes, and that the process is inhibited by various caspase inhibitors. Using bcl-2–expressing adenovirus vector we investigated the effect of Bcl-2 on UVB-induced apoptosis. Adenovirus vector efficiently introduced bcl-2 gene in cultured normal mouse keratinocytes (NMK cells); almost all NMK cells (1 × 10 6 ) were transfected at 1 × 10 8 plaque-forming unit (PFU)/mL. Bcl-2–transfected NMK cells were significantly resistant to UVB-induced apoptosis with the suppressive effect dependent on the Bcl-2 expression level. Following UVB irradiation caspase 8, 3 and 9 activities were stimulated in NMK cells, whereas in bcl-2–transfected cells only caspase 8, but not caspase 3 or 9, activity was stimulated. In order to investigate the effect of Bcl-2 in vivo topical application of Ad-bcl-2 on tape-stripped mouse skin was performed. Following the application Bcl-2 was efficiently overexpressed in almost all viable keratinocytes. The expression was transient with the maximal expression of Bcl-2 on the first day following the application of 1 × 10 9 PFU in 200 μL. The introduced Bcl-2 remained at least for 6 days. UVB irradiation (1250 J/m 2 ) induced apoptosis within 12 h and the maximal effect was observed at 24 h in control mouse skin. Both bcl-2–transfected and topical caspase 3 inhibitor-treated mice skin were resistant to UVB-induced apoptosis. The suppressive effect of Bcl-2 was more potent than that of caspase 3 inhibitor application. Topical application of empty adenovirus vector alone had no effect on Bcl-2 expression or UVB-induced apoptosis. These results indicate that adenovirus vector is an efficient gene delivery system into keratinocytes and that Bcl-2 is

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Optical buffer memory using a polarization bistable VCSEL

Optical buffer memory using a polarization bistable VCSEL

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Conference on Lasers and Electro-Optics (CLEO)

作者： Hitoshi Kawaguchi Takashi Mori Yuuki Sato Yasuhiro Yamayoshi Faculty of Engineering Yamagata University Yonezawa Yamagata Japan Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Agency Japan

A novel optical buffer memory with a shift register function using a two-dimensional array of polarization bistable VCSELs is proposed. 1-bit optical buffering, which is an essential part of the memory, has been exper... 详细信息

ISBN: (纸本)1557528136

关键词： Vertical cavity surface emitting lasers Optical buffering Optical pulses Optical polarization Ultrafast optics Optical bistability Optical switches

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Crystallographic Analysis of Primary Visual Photochemistry†

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Angewandte Chemie 2006年第26期118卷

作者： Hitoshi Nakamichi Tetsuji Okada Biological Information Research Center National Institute of Advanced Industrial Science and Technology 2‐41‐6 Aomi Koto‐ku Tokyo 135‐0064 Japan Fax: (+81) 3‐3529‐5379 Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Agency Japan

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Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions (vol 30, pg 149, 2005)

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MOLECULAR AND CELLULAR NEUROscience 2005年第4期30卷 559-559页

作者： Mizui, T Takahashi, H Sekino, Y Shirao, T [a]Department of Neurobiology and Behavior Gunma University Graduate School of Medicine 3-39-22 Showa-machi Maebashi 371-8511 Japan[b]Core Research for Evolution Science and Technology Japan Science and Technology Corporation Kawaguchi Japan

Drebrin A is a neuron-specific F-actin binding protein, and plays a pivotal role in the spine formation. In this study, we expressed drebrin A tagged with green fluorescent protein (GFP-DA) in hippocampal neurons at 7¨C9 days in vitro when presynaptic terminals are not fully maturated. GFP-DA was accumulated in dendritic protrusions and formed large abnormal structures. Since these structures were similar to filopodia in terms of lack of MAP2 immunostaining, we named them ?°megapodia?± meaning large dendritic filopodia. F-actin and PSD-95 were also accumulated in megapodia, and their amounts were significantly correlated with that of GFP-DA. However, the expression of GFP-DA did not result in the promotion of the morphological change from filopodia into spines. These results demonstrate that drebrin A accumulates spine-resident proteins via protein¨Cprotein interaction in filopodia, and suggest that the spine formation requires the concurrence of the increase of drebrin-A expression and the functional presynaptic contact.

关键词： Actins Dendrites Nerve Tissue Proteins Neurons Neuropeptides 肌动蛋白类树突神经组织蛋白质类神经元神经肽类 Actins Pseudopodia postsynaptic density proteins drebrin A Protein Overexpression F-Actin Nerve Tissue Proteins Protein-Protein Interaction Neuropeptides Neurons Protrusion

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NUCLEOBASE RECOGNITION USING FLUORESCENT LIGANDS AND OLIGO-DNA DUPLEXES CONTAINING AN ABASIC-SITE

NUCLEOBASE RECOGNITION USING FLUORESCENT LIGANDS AND OLIGO-D...

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第十一届北京分析测试学术报告会暨展览会(BCEIA 2005)

作者： Norio Teramae Department of Chemistry Tohoku University Core Research for Evolution Science and Technology(CREST) Japan Science Technology Agency

Detection of single-nucleotide polymorphisms(SNPs)in human genome has become increasingly important in the fields of genetics,molecular diagnostics and cancer research.1 Various methods for SNPs detection,including hi... 详细信息

关键词： profile NUCLEOBASE RECOGNITION USING FLUORESCENT LIGANDS AND OLIGO-DNA DUPLEXES CONTAINING AN ABASIC-SITE DNA

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Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. (vol 483, pg 383, 2005)

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JOURNAL OF COMPARATIVE NEUROLOGY 2005年第4期486卷 384-384页

作者： Aoki, C Sekino, Y Hanamura, K Fukisawa, S Mahadomrongkul, V Ren, Y Shirao, T Center for Neural Science New York University New York New York 10003 Tomoaki Shirao Dept. of Neurobiology and Behavior Gunma University Graduate School of Medicine 3-39-22 Showamachi Maebashi 3718511 Department of Neurobiology and Behavior Gunma University Graduate School of Medicine Maebashi Gunma 371-8511 Japan Core Research for Evolution Science and Technology Japan Science and Technology Corporation Kawaguchi 332-0012 Japan Chiye Aoki Center for Neural Science New York University 4 Washington Place New York NY 10003

Drebrin A is a neuron-specific, actin binding protein. Evidence to date is from in vitro studies, consistently supporting the involvement of drebrin A in spinogenesis and synaptogenesis. We sought to determine whether drebrin A arrives at the plasma membrane of neurons, in vivo, in time to orchestrate spinogenesis and synaptogenesis. To this end, a new antibody was used to locate drebrin A in relation to electron microscopically imaged synapses during early postnatal days. Western blotting showed that drebrin A emerges at postnatal day (PNd) 6 and becomes progressively more associated with F-actin in the pellet fraction. Light microscopy showed high concentrations of drebrin A in the synaptic layers of the hippocampus and cortex. Electron microscopy revealed that drebrin A in these regions is located exclusively in dendrites both neonatally and in adulthood. In adulthood, nearly all of the synaptic drebrin A is within spines forming asymmetric excitatory synapses, verified by γ-aminobutyric acid (GABA) negativity. At PNd7, patches of drebrin A immunoreactivity were discretely localized to the submembranous surfaces of dendrites forming slight protrusions—protospines. The drebrin A sites exhibited only thin postsynaptic densities and lacked axonal associations or were contacted by axons that contained only a few vesicles. Yet, because of their immunoreactivity to the NR2B subunit of N -methyl- D -aspartate receptors and immunonegativity of axon terminals to GABA, these could be presumed to be nascent, excitatory synapses. Thus, drebrin A may be involved in organizing the dendritic pool of actin for the formation of spines and of axospinous excitatory synapses during early postnatal periods. J. Comp. Neurol. 483:383–402, 2005. © 2005 Wiley-Liss, Inc.

关键词： synaptogenesis F-actin NR2B NHDA receptor cortex hippocampus electron microscopy spinogenesis proto-spines

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