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NPJ Biodiversity 2024年第1期3卷 28页

作者： Mc Cartney, Ann M. Formenti, Giulio Mouton, Alice De Panis, Diego Marins, Luísa S. Leitão, Henrique G. Diedericks, Genevieve Kirangwa, Joseph Morselli, Marco Salces-Ortiz, Judit Escudero, Nuria Iannucci, Alessio Natali, Chiara Svardal, Hannes Fernández, Rosa De Pooter, Tim Joris, Geert Strazisar, Mojca Wood, Jonathan M. D. Herron, Katie E. Seehausen, Ole Watts, Phillip C. Shaw, Felix Davey, Robert P. Minotto, Alice Fernández, José M. Böhne, Astrid Alegria, Carla Alioto, Tyler Alves, Paulo C. Amorim, Isabel R. Aury, Jean-Marc Backstrom, Niclas Baldrian, Petr Baltrunaite, Laima Barta, Endre Bedhom, Bertrand Belser, Caroline Bergsten, Johannes Bertrand, Laurie Bilandija, Helena Binzer-Panchal, Mahesh Bista, Iliana Blaxter, Mark Borges, Paulo A. V. Dias, Guilherme Borges Bosse, Mirte Brown, Tom Bruggmann, Rémy Buena-Atienza, Elena Burgin, Josephine Buzan, Elena Cariani, Alessia Casadei, Nicolas Chiara, Matteo Chozas, Sergio Jr, Fedor Čiampor Crottini, Angelica Cruaud, Corinne Cruz, Fernando Dalen, Love Biase, Alessiode Delcampo, Javier Delic, Teo Dennis, Aliceb. Derks, Martijn F. L. Diroma, Maria Angela Djan, Mihajla Duprat, Simone Eleftheriadi, Klara Feulner, Philine G. D. Flot, Jean-François Forni, Giobbe Fosso, Bruno Fournier, Pascal Fournier-Chambrillon, Christine Gabaldon, Toni Garg, Shilpa Gissi, Carmela Giupponi, Luca Gomez-Garrido, Jessica González, Josefa Grilo, Miguel L. Grüning, Björn Guerin, Thomas Guiglielmoni, Nadege Gut, Marta Haesler, Marcel P. Hahn, Christoph Halpern, Balint Harrison, Peter W. Heintz, Julia Hindrikson, Maris Höglund, Jacob Howe, Kerstin Hughes, Graham M. Istace, Benjamin Cock, Mark J. Janžekovič, Franc Jonsson, Zophonias O. Joye-Dind, Sagane Koskimäki, Janne J. Krystufek, Boris Kubacka, Justyna Kuhl, Heiner Kusza, Szilvia Labadie, Karine Lähteenaro, Meri Lantz, Henrik Lavrinienko, Anton Leclère, Lucas Lopes, Ricardo Jorge Madsen, Ole Magdelenat, Ghislaine Magoga, Giulia Manousaki, Tereza Mappes, Tapio Marques, Joao Pedro Redondo, Gemma I. Martinez Maumus, Florian McCarthy, Shane A. M Genomics Institute University of California SantaCruz CA United States TheVertebrate Genome Laboratory The Rockefeller University NewYork NY United States Department of Biology University of Florence Sesto Fiorentino Italy InBios-Conservation Genetics Laboratory University of Liege Liege Belgium Leibniz Institut für Zoo und Wildtierforschung Berlin Germany Berlin Center for Genomics in Biodiversity Research Berlin Germany Department of Biology University of Antwerp Antwerp Belgium Institute of Zoology University of Cologne Cologne Germany Department of Chemistry Life Sciences and Environmental Sustainability University of Parma Parma Italy Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra Barcelona Spain Naturalis Biodiversity Center Leiden Netherlands Neuromics Support Facility VIB Center for Molecular Neurology VIB Antwerp Belgium Neuromics Support Facility Department of Biomedical SciencesUniversity ofAntwerp Antwerp Belgium Tree of Life WellcomeSanger Institute Cambridge Hinxton United Kingdom School of Biology and Environmental Science University College Dublin Belfield Ireland Aquatic Ecology & Evolution Institute of Ecology & Evolution University of Bern Bern Switzerland Department of Fish Ecology & Evolution Eawag Kastanienbaum Switzerland Department of Biological and Environmental Science University of Jyvaskyla Jyvaskyla Finland The EarlhamInstitute NorwichResearchPark Norwich United Kingdom Digital Science London United Kingdom Barcelona Supercomputing Center Spanish National Bioinformatics Institute ELIXIR Spain Getafe Spain Leibniz Institute for the Analysis of Biodiversity Change Museum Koenig Bonn Bonn Germany CE3C—Centre for Ecology Evolution and Environmental Changes & CHANGE—Global Change and Sustainability Institute Faculdade de Ciências Universidade de Lisboa Campo Grande Lisboa Portugal Centro Nacional de Análisis Genómico (CNAG) Barcelona Spain Universitat de Barcelona (UB) Barcelona Spain CIBIO Cen

A genomic database of all Earth’s eukaryotic species could contribute to many scientific discoveries;however, only a tiny fraction of species have genomic information available. In 2018, scientists across the world united under the Earth BioGenome Project (EBP), aiming to produce a database of highquality reference genomes containing all ~1.5 million recognized eukaryotic species. As the European node of the EBP, the European Reference Genome Atlas (ERGA) sought to implement a new decentralised, equitable and inclusive model for producing reference genomes. For this, ERGA launched a Pilot Project establishing the first distributed reference genome production infrastructure and testing it on 98 eukaryotic species from 33 European countries. Here we outline the infrastructure and explore its effectiveness for scaling high-quality reference genome production, whilst considering equity and inclusion. The outcomes and lessons learned provide a solid foundation for ERGA while offering key learnings to other transnational, national genomic resource projects and the EBP. © The Author(s) 2024, corrected publication 2024.

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External exposome and incident asthma across the life course in 14 European cohorts: a prospective analysis within the EXPANSE project

The Lancet Regional Health - Europe

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The Lancet Regional Health - Europe 2025年 54卷

作者： Yu, Zhebin Kress, Sara Blay, Natalia Gregor, Petr Kukk, Hanna-Maria Leskien, Miriam Majewska, Renata Oosterwegel, Max J. Szabó, Daniel ten Have, Margreet Klánová, Jana Mikeš, Ondřej Bergström, Anna Bussalleu, Alonso de Cid, Rafael Dalecka, Andrea Dadvand, Payam van Dorsselaer, Saskia Fischer, Krista de Hoogh, Kees Koppelman, Gerard H. Kronberg, Jaanika Metspalu, Andres Milani, Lili Esko, Tõnu Metspalu, Mait Lakerveld, Jeroen Ljungman, Petter Merid, Simon Kebede Macek, Pawel Manczuk, Marta Merritt, Anne-Sophie Pac, Agnieszka Palta, Priit Pershagen, Göran Peters, Annette Pikhart, Hynek Saucy, Apolline Schikowski, Tamara Shen, Youchen Standl, Marie Tonne, Cathryn Vermeulen, Roel Vlaanderen, Jelle Vonk, Judith M. Wolf, Kathrin Ek, Carl Henrik Gruzieva, Olena Gehring, Ulrike Melén, Erik Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden IUF – Leibniz Research Institute for Environmental Medicine Düsseldorf Germany Genomes for Life-GCAT Lab CORE Program Germans Trias I Pujol Research Institute (IGTP) Badalona Spain Grup de Recerca en Impacte de Les Malalties Cròniques I Les Seves Trajectòries (GRIMTra) (IGTP) Badalona Spain RECETOX Faculty of Science Masaryk University Brno Czech Republic Institute of Genomics University of Tartu Estonia Institute of Mathematics and Statistics University of Tartu Estonia Institute of Epidemiology Helmholtz Zentrum München - German Research Center for Environmental Health Neuherberg Germany Institute for Medical Information Processing Biometry and Epidemiology Medical Faculty Ludwig-Maximilians-Universität München Munich Germany Chair of Epidemiology and Preventive Medicine Jagiellonian University Medical College Kraków Poland Institute for Risk Assessment Sciences Utrecht University Utrecht Netherlands Netherlands Institute of Mental Health and Addiction Utrecht Netherlands Centre for Occupational and Environmental Medicine Region Stockholm Stockholm Sweden Swiss Tropical and Public Health Institute Allschwil Switzerland University of Basel Basel Switzerland ISGlobal Barcelona Spain Universitat Pompeu Fabra (UPF) Barcelona Spain CIBER Epidemiología y Salud Pública Spain University of Groningen University Medical Center Groningen Beatrix Children's Hospital Department of Pediatric Pulmonology and Pediatric Allergology Groningen Netherlands University of Groningen University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen Netherlands Department of Epidemiology and Data Science Amsterdam UMC Location Vrije Universiteit Amsterdam Amsterdam Netherlands Department of Cardiology Danderyd Hospital Stockholm Sweden Department of Clinical Sciences and Education Södersjukhuset Karolinska Institutet Stockholm Sweden Collegium Medicum Jan Koc

Background: The joint impact of exposure to multiple urban environmental factors on asthma remains unclear. Methods: We analysed data from 14 European cohorts to assess the impact of the urban exposome on asthma incidence across the life course. We linked three external exposome domains (air pollution, built environment, ambient temperature) to the participants’ home addresses at baseline. We performed k-means clustering within each domain and assessed associations of clusters with asthma adjusting for potentially relevant covariates in cohort-specific analyses, with subsequent separate meta-analyses for birth and adult cohorts. An environmental risk score using a coefficient-weighted sum approach was used to assess the impact of combining the three domains. Findings: A total of 7428 incident asthma cases were identified among 349,037 participants (from birth up to age 70+). Overall, we observed higher risks of asthma for clusters characterized by high particulate matter and nitrogen dioxide exposure in adults (OR_meta = 1.13, 95%CI:1.01–1.25), and clusters characterized by high built-up area and low levels of greenness in both children and adults (OR_meta = 1.36, 95%CI: 1.14–1.64 for birth cohorts and OR_meta = 1.15, 95%CI: 1.03–1.28 for adult cohorts, respectively). The joint exposure using the environment risk score combining the three domains was consistently associated with higher risks of incident asthma (OR_meta = 1.13, 95%CI: 1.07–1.20 for birth cohorts, OR_meta = 1.15, 95%CI: 1.10–1.20 for adult cohorts per 20% increase). On average 11.6% of the incident asthma cases could be attributed to environmental risk score above cohort-specific median levels. Interpretation: Multiple environmental exposures jointly contribute to incident asthma risk across the life course. Urban planning accounting for these factors may help mitigate asthma development. Funding: This study was funded by the European Union's Horizon 2

关键词： Asthma Cohort Exposome Life course

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Revised model for cell cycle regulation by iron: differential roles between transferrin and ferritin

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Redox biology 2025年 85卷 103727页

作者： Ryo Yanagiya Hiroko Kato Akinori Ninomiya Masaya Ueno Akane Kanamori Yuji Miyatake Masahiro Oka Keisuke Ishii Tadashi Matsuura So Nakagawa Atsushi Hirao Makoto Onizuka Ai Kotani Department of Regulation of Infectious Cancers Research Institute for Microbial Diseases The University of Osaka Suita Japan Department of Hematology and Oncology Tokai University School of Medicine Isehara Japan Department of Drug Discovery and Biomedical Sciences Faculty of Medicine Saga University Saga Japan. Core Instrumentation Facility Immunology Frontier Research Center The University of Osaka Suita Japan. Central Instrumentation Laboratory Research Institute for Microbial Diseases The University of Osaka Suita Japan. Division of Molecular Genetics Cancer and Stem Cell Research Program Cancer Research Institute Kanazawa University Kakuma-machi Kanazawa Japan WPI Nano Life Science Institute (WPI-Nano LSI) Kanazawa University Kakuma-machi Kanazawa Japan. Department of Regulation of Infectious Cancers Research Institute for Microbial Diseases The University of Osaka Suita Japan. Perseus Proteomics Inc. Tokyo Japan. Department of Molecular Life Science Tokai University School of Medicine Isehara Japan Division of Omics Sciences Institute of Medical Sciences Tokai University Isehara Japan Division of Interdisciplinary Merging of Health Research Micro/Nano Technology Center Tokai University Hiratsuka Japan. Department of Hematology and Oncology Tokai University School of Medicine Isehara Japan. Department of Regulation of Infectious Cancers Research Institute for Microbial Diseases The University of Osaka Suita Japan. Electronic address: aikotani@k-lab.jp.

Iron is essential for neoplasms including natural killer (NK) cell lymphoma, and mainly supplemented by transferrin and stored by ferritin. Although accumulating studies had demonstrated that iron chelation arrests cell cycle progression at G1 phase, our previous studies showed the induction of DNA double strand break at S phase cell cycle without G1 arrest by selective inhibition of cellular transferrin uptake, indicating that the existence of some undiscovered differences in the roles of the two major iron sources for cell cycle regulation. In this study, we identified a novel cell cycle regulation of transferrin binding iron in NK cell lymphoma. Blocking transferrin uptake induced S phase arrest owing to the dysfunction of nascent DNA synthesis. Moreover, canonical G1 arrest was observed with mitochondrial dysfunction followed by downregulation of mTORC1 and dephosphorylation of Rb only when intracellular iron storage was deprived by iron chelation. These results suggested that iron is critically involved in at least two steps of the cell cycle: the S phase and G1/S transition. Especially, considering the toxicity of mitochondrial dysfunction to normal cells and cell cycle dependent manner of S phase-specific DNA damage due to selective inhibition of transferrin uptake, transferrin receptor blockers are thought to be more suitable than iron chelators as antineoplastic agents. Overall, the current canonical model of cell cycle regulation by iron requires revision.

关键词： Cell cycle Iron Mitochondria Nascent DNA synthesis S phase arrest Transferrin

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Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk (vol 54, pg 804, 2022)

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NATURE GENETICS 2022年第8期54卷 1259-1259页

作者： Turner, Adam W. Hu, Shengen Shawn Mosquera, Jose Verdezoto Ma, Wei Feng Hodonsky, Chani J. Wong, Doris Auguste, Gaelle Song, Yipei Sol-Church, Katia Farber, Emily Kundu, Soumya Kundaje, Anshul Lopez, Nicolas G. Ma, Lijiang Ghosh, Saikat Kumar B. Onengut-Gumuscu, Suna Ashley, Euan A. Quertermous, Thomas Finn, Aloke V. Leeper, Nicholas J. Kovacic, Jason C. Bjorkegren, Johan L. M. Zang, Chongzhi Miller, Clint L. Center for Public Health Genomics University of Virginia Charlottesville VA USA Department of Biochemistry and Molecular Genetics University of Virginia Charlottesville VA USA Medical Scientist Training Program University of Virginia Charlottesville VA USA Department of Pathology University of Virginia Charlottesville VA USA Robert M. Berne Cardiovascular Research Center University of Virginia Charlottesville VA USA Genome Analysis & Technology Core University of Virginia Charlottesville VA USA Genome Sciences Laboratory University of Virginia Charlottesville VA USA Department of Genetics Stanford University School of Medicine Stanford CA USA Department of Computer Science Stanford University Stanford CA USA Division of Vascular Surgery Department of Surgery Stanford University Stanford CA USA Department of Genetics and Genomic Sciences Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA CVPath Institute Gaithersburg MD USA Department of Public Health Sciences University of Virginia Charlottesville VA USA Division of Cardiovascular Medicine Department of Medicine Stanford University Stanford CA USA Cardiovascular Research Institute Icahn School of Medicine at Mount Sinai New York NY USA Victor Chang Cardiac Research Institute Darlinghurst New South Wales Australia St. Vincent’s Clinical School University of New South Wales Sydney New South Wales Australia Integrated Cardio Metabolic Centre Department of Medicine Karolinska Institutet Huddinge Sweden

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across cell types. Genome-wide association studies have identified over 200 loci associated with CAD, where the majority of risk variants reside in noncoding DNA sequences impacting cis-regulatory elements. Here, we applied single-nucleus assay for transposase-accessible chromatin with sequencing to profile 28,316 nuclei across coronary artery segments from 41 patients with varying stages of CAD, which revealed 14 distinct cellular clusters. We mapped ~320,000 accessible sites across all cells, identified cell-type-specific elements and transcription factors, and prioritized functional CAD risk variants. We identified elements in smooth muscle cell transition states (for example, fibromyocytes) and functional variants predicted to alter smooth muscle cell- and macrophage-specific regulation of MRAS (3q22) and LIPA (10q23), respectively. We further nominated key driver transcription factors such as PRDM16 and TBX2. Together, this single-nucleus atlas provides a critical step towards interpreting regulatory mechanisms across the continuum of CAD risk.

关键词： Atherosclerosis Epigenomics Gene regulation

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Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes

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Journal of Diabetes research 2021年第1期2021卷 9961612页

作者： Midorikawa, Manabu Suzuki, Hiroaki Suzuki, Yasuhiro Yamauchi, Kazuyoshi Sato, Hiroyuki Nemoto, Kiyotaka Sugano, Yoko Iwasaki, Hitoshi Sekiya, Motohiro Yatoh, Shigeru Yahagi, Naoya Hada, Yasushi Arai, Tetsuaki Shimano, Hitoshi Doctoral Program in Clinical Sciences Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba 305-8575 Japan Department of Internal Medicine (Endocrinology and Metabolism) Faculty of Medicine University of Tsukuba Tsukuba 305-8575 Japan Department of Rehabilitation Medicine University of Tsukuba Hospital Tsukuba 305-8596 Japan Department of Laboratory Medicine Faculty of Medicine University of Tsukuba Tsukuba 305-8575 Japan Department of Psychiatry Faculty of Medicine University of Tsukuba Tsukuba 305-8575 Japan Department of Rehabilitation Medicine Faculty of Medicine University of Tsukuba Tsukuba 305-8575 Japan International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba 305-8575 Japan Life Science Center of Tsukuba Advanced Research Alliance (TARA) University of Tsukuba Tsukuba 305-8575 Japan Japan Agy. for Medical Research and Development-Core Research for Evolutional Science and Technology Chiyoda-ku 100-0004 Japan

Aim. We investigated the relationship between cognitive function and olfactory and physical functions in middle-aged persons with and without type 2 diabetes (T2D) to examine the potential of olfactory and physical functions as biomarkers for early cognitive impairment. Methods. Enrolled were 70 T2D patients (age 40 to <65 y) and 81 age-matched control participants without diabetes. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCA), Trail Making Test parts A and B (TMT-A/-B), Wisconsin Card Sorting Test (WCST), Quick Inventory of Depressive Symptomatology Self-Report (QIDS), and Starkstein Apathy Scale (SAS). Multiple linear regression analyses were performed. Results. Odor identification was an independent determinant shown in the results of the TMT-A in the entire participant group and was independently associated with the MoCA and TMT-B in the T2D group. Balance capability assessed with a stabilometer was independently associated with all cognitive function tests except for QISD and SAS in the entire participant group and the T2D group and was independently associated with TMT-A in the control group. Knee extension strength was independently associated with the SAS in the entire participant group and the T2D group. Conclusions. Odor identification, balance capability, and knee extension strength were potential markers for cognitive decline in middle-aged persons with T2D. © 2021 Manabu Midorikawa et al.

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SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES). V. Confusion-limited Submillimeter Galaxy Number Counts at 450 µm and Data Release for the COSMOS Field

arXiv

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arXiv 2024年

作者： Gao, Zhen-Kai Lim, Chen-Fatt Wang, Wei-Hao Chen, Chian-Chou Smail, Ian Chapman, Scott C. Zheng, Xian Zhong Shim, Hyunjin Kodama, Tadayuki Ao, Yiping Chang, Siou-Yu Clements, David L. Dunlop, James S. Ho, Luis C. Hsu, Yun-Hsin Hwang, Chorng-Yuan Hwang, Ho Seong Koprowski, M.P. Scott, Douglas Serjeant, Stephen Toba, Yoshiki Urquhart, Sheona A. No. 1 Section 4 Roosevelt Rd. Taipei10617 Taiwan Graduate Institute of Astronomy National Central University 300 Zhongda Road Zhongli Taoyuan32001 Taiwan Centre for Extragalactic Astronomy Department of Physics Durham University South Road DurhamDH1 3LE United Kingdom Department of Physics and Atmospheric Science Dalhousie University Halifax HalifaxNSB3H 3J5 Canada Purple Mountain Observatory Key Laboratory for Radio Astronomy Chinese Academy of Sciences 10 Yuanhua Road Nanjing210023 China School of Astronomy and Space Science University of Science and Technology of China Anhui Hefei230026 China Department of Earth Science Education Kyungpook National University 80 Daehak-ro Buk-gu Daegu41566 Korea Republic of Astronomical Institute Tohoku University 6-3 Aramaki Aoba Miyagi Sendai980-8578 Japan Institute of Astronomy Department of Physics National Tsing Hua University Hsinchu30013 Taiwan Imperial College London Blackett Laboratory Prince Consort Road LondonSW7 2AZ United Kingdom SUPA Institute for Astronomy University of Edinburgh Royal Observatory EdinburghEH9 3HJ United Kingdom Kavli Institute for Astronomy and Astrophysics Peking University Beijing100871 China Department of Astronomy School of Physics Peking University Beijing100871 China Department of Philosophy National Taiwan University No. 1 Section 4 Roosevelt Rd. Taipei10617 Taiwan Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Institute of Astronomy Faculty of Physics Astronomy and Informatics Nicolaus Copernicus University Grudziadzka 5 Torun87-100 Poland Department of Physics and Astronomy University of British Columbia 6224 Agricultural Road VancouverBCV6T 1Z1 Canada School of Physical Sciences The Open University Milton KeynesMK7 6AA United Kingdom

We present confusion-limited SCUBA-2 450-µm observations in the COSMOS-CANDELS region as part of the JCMT Large program, SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES). Our maps at 450 and 850 µm cover an area of 450 arcmin2. We achieved instrumental noise levels of σ450 = 0.59 mJy beam−1 and σ850 = 0.09 mJy beam−1 in the deepest area of each map. The corresponding confusion noise levels are estimated to be 0.65 and 0.36 mJy beam−1. Above the 4 (3.5) σ threshold, we detected 360 (479) sources at 450 µm and 237 (314) sources at 850 µm. We derive the deepest blank-field number counts at 450 µm, covering the flux-density range of 2 to 43 mJy. These are in agreement with other SCUBA-2 blank-field and lensing-cluster observations, but are lower than various model counts. We compare the counts with those in other fields and find that the field-to-field variance observed at 450 µm at the R = 6′ scale is consistent with Poisson noise, so there is no evidence of strong 2-D clustering at this scale. Additionally, we derive the integrated surface brightness at 450 µm down to 2.1 mJy to be (Equation presented) Jy deg−2, contributing to (41±4)% of the 450-µm extragalactic background light (EBL) measured by COBE and Planck. Our results suggest that the 450-µm EBL may be fully resolved at (Equation presented) mJy, which extremely deep lensing-cluster observations and next-generation submillimeter instruments with large aperture sizes may be able to achieve. © 2024, CC BY.

关键词： Galaxies

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Global tracking of marine megafauna space use reveals how to achieve conservation targets

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science (New York, N.Y.) 2025年第6751期388卷 1086-1097页

作者： Ana M M Sequeira Jorge P Rodríguez Sarah A Marley Hannah J Calich Mirjam van der Mheen Michelle VanCompernolle Lucy M Arrowsmith Lauren R Peel Nuno Queiroz Marisa Vedor Ivo da Costa Gonzalo Mucientes Ana Couto Nicolas E Humphries Sara Abalo-Morla Francisco J Abascal Debra L Abercrombie Katya Abrantes F Alberto Abreu-Grobois André S Afonso Pedro Afonso Heidi Ahonen Susanne Åkesson Joanna Alfaro-Shigueto Russel D Andrews Frédéric Angelier Marina Antonopoulou Javier A Arata Gonzalo Araujo Randall Arauz José Manuel Arcos Igor Arregui Haritz Arrizabalaga Marie Auger-Méthé Steffen Bach Fred Bailleul Robin W Baird George H Balazs Susan G Barco Adam Barnett Warren Baverstock Alastair M M Baylis Annalea Beard Juan Bécares Eduardo J Belda Ian Bell Ashley Bennison Scott R Benson Diego Bernal Michael L Berumen Sandra Bessudo Natalia P A Bezerra Antonin V Blaison Gabriela S Blanco Barbara A Block Mark Bolton Mark E Bond Ramón Bonfil Camrin D Braun Annette C Broderick Michael de L Brooke Annabelle M L Brooks Edward J Brooks Ignacio M Bruno Jennifer M Burns Michael E Byrne Steven E Campana Hamish A Campbell Richard A Campbell Aaron Carlisle Ruth H Carmichael Gemma Carroll Paolo Casale Filipe R Ceia Demian D Chapman Taylor K Chapple Jean-Benoit Charrassin Andre Chiaradia John Chisholm Christopher R Clarke Thomas A Clay Christophe Cleguer Elizabeth Clingham Eric E G Clua Jesse E M Cochran Rochelle Constantine Robert W Cooper Estelle Crochelet Michelle Cronin Eduardo Cuevas Kayla P DaCosta Laurent Dagorn Ryan Daly Randall W Davis P J Nico de Bruyn Carlos Delgado-Trejo Thomas Dellinger Solène Derville Stella Diamant Andrew DiMatteo Kara L Dodge Philip D Doherty Michael C Double Alistair D M Dove Thomas K Doyle Michael J Drew Lindsay L Dubbs Clinton A J Duffy Peter H Dutton Ewan W J Edwards Luke D Einoder Mark V Erdmann Eduardo Espinoza Nicole Esteban Ana Isabel Fagundes Chris Feare Steven H Ferguson Luciana C Ferreira Francesco Ferretti John Filmalter Brittany Finucci G Chris Fischer Richard J Fitzpatrick Jorge Fontes Angela Formia Division of Ecology and Evolution Research School of Biology The Australian National University Canberra (Australian Capital Territory) Australia. UWA Oceans Institute and the School of Biological Sciences The University of Western Australia Perth (Western Australia) Australia. Instituto de Física Interdisciplinar y Sistemas Complejos (IFISC) CSIC-UIB Palma de Mallorca Spain. Instituto Mediterráneo de Estudios Avanzados (IMEDEA) CSIC-UIB Esporles Illes Balears Spain. C.A. Illes Balears Universidad Nacional de Educación a Distancia (UNED) Palma Spain. Delegación Territorial en Illes Balears Agencia Estatal de Meteorología (AEMET) Muelle de Poniente s/n Palma Spain. Scotland's Rural College (SRUC) Craibstone Estate Bucksburn Aberdeen UK. Oceans Graduate School and the UWA Oceans Institute The University of Western Australia Perth (Western Australia) Australia. School of Engineering and the UWA Oceans Institute The University of Western Australia Perth (Western Australia) Australia. Department of Biodiversity Conservation and Attractions Biodiversity and Conservation Science Kensington (Western Australia) Australia. Save Our Seas Foundation Geneva Switzerland. The Manta Trust Catemwood House Norwood Lane Corscombe Dorset UK. Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO) InBIO Laboratório Associado Campus de Vairão Universidade do Porto Vairão Portugal. BIOPOLIS Program in Genomics Biodiversity and Land Planning Campus de Vairao Vairão Portugal. Instituto de Investigaciones Marinas Consejo Superior de Investigaciones Científicas (IIM-CSIC) Vigo Pontevedra Spain. School of Biological Sciences University of Aberdeen Aberdeen UK. Biomathematics and statistics Scotland The kings building Edinburgh Scotland. Marine Biological Association (MBA) The Laboratory Citadel Hill Plymouth UK. Instituto de Investigación para la Gestión Integrada de Zonas Costeras Universitat Politècnica de València Gandia València Spain. Instituto Español de O

The recent Kunming-Montreal Global Biodiversity Framework (GBF) sets ambitious goals but no clear pathway for how zero loss of important biodiversity areas and halting human-induced extinction of threatened species will be achieved. We assembled a multi-taxa tracking dataset (11 million geopositions from 15,845 tracked individuals across 121 species) to provide a global assessment of space use of highly mobile marine megafauna, showing that 63% of the area that they cover is used 80% of the time as important migratory corridors or residence areas. The GBF 30% threshold (Target 3) will be insufficient for marine megafauna's effective conservation, leaving important areas exposed to major anthropogenic threats. Coupling area protection with mitigation strategies (e.g., fishing regulation, wildlife-traffic separation) will be essential to reach international goals and conserve biodiversity.

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I see sick people: Beliefs about sensory detection of infectious disease are largely consistent across cultures

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Brain, Behavior, and Immunity 2025年 128卷 737-750页

作者： Ackerman, Joshua M. Samore, Theodore Fessler, Daniel M.T. Kupfer, Tom R. Choi, Soyeon Merrell, Wilson N. Aarøe, Lene Aavik, Toivo Acabado, Stephen Akello, Grace Alfian, Ilham N. Al-Shawaf, Laith Alvarez, Marinés M. Ammann, Jeanine Arikan, Gizem Asha, Saiyeda A. Astobiza, Anibal M. Baeza-Ugarte, Carmen G. Barclay, Pat Barlow, Fiona Kate Bizarro, Lisiane Bressan, Paola Castellanos-Chacón, Andres Choy, Bryan K.C. Chusairi, Achmad Contreras-Garduño, Jorge Chávez Cosamalón, Brenda L. Costa-Neves, Bernardo De, Mallika de Lima, Tiago J.S. de Zoysa, Piyanjali Dryžaitė, Ieva Elbæk, Christian T. Fedor, Peter Fernández, Ana M. Fernandez-Morales, Regina Fülöp, Márta Gamsakhurdia, Vladimer Lado Garcia-Gómez, Leonor Garcia-Marques, Leonel Garduño-Franco, Jimena Pilar Grazioso, María del Habacht, Fanny Hasan, Youssef Haugestad, Camila P. Haugestad, Christian A.P. Havlíček, Jan Hernandez, Earl J. Hoang, Vu M. Hong, Minsung Hromatko, Ivana Iliško, Dzintra Imada, Hirotaka Jakšić, Ivana Jarmakowski, Tomasz Hjördísar Jónsdóttir, Harpa L. Kajokaite, Kotrina Kaňková, Šárka Kervyn, Nicolas Kim, Jinseok P. Kunst, Jonas R. Laakasuo, Michael Leongómez, Juan David Li, Norman P. Lu, Junsong Lynch, Nathan Maegli, María A. Manley, Harry Marcu, Gabriela McAfee, Thea Mitkidis, Panagiotis Molnár, Nándor B. Morvinski, Coby Muhamad, Haslina Nejat, Pegah Huy, Hoang Nguyen Oliveira, Angelica N. Olsson, Mats J. Onyishi, Charity N. Onyishi, Ike E. Orozco, Reegan Otterbring, Tobias Ottersen, Ida S. Pacheco-López, Gustavo Panagiotopoulou, Penny Paniagua, Walter Parvin, Roksana Pavlović, Zoran Prokop, Pavol Raffman, Emma Rizwan, Muhammad Rojas, Sheila Różycka-Tran, Joanna Sánchez, Oscar R. Selim, Heyla Sevi, Barış Shani, Yaniv Shastry, Madhulika S. Stieger, Stefan Suh, Eunkook M. Sumari, Melati Takemura, Kosuke Tognetti, Arnaud Trombetta, Roberta Z.R. Tybur, Joshua M. Ucak, Eylul B. Uchida, Yukiko Valentova, Jaroslava V. Viciana, Hugo Visine, Amandine Wang, Jin Wang, XT Yahiiaiev, Illia I. Zein, Rizqy A. Žeželj, Iris Department of Psychology University of Michigan Ann Arbor MI United States Religion Programme University of Otago Dunedin New Zealand Department of Anthropology University of California Los Angeles Los Angeles CA United States Center for Behavior Evolution & Culture University of California Los Angeles Los Angeles CA United States Bedari Kindness Institute University of California Los Angeles Los Angeles CA United States Department of Psychology Nottingham Trent University England Nottingham United Kingdom Department of Psychology University of Wisconsin-Madison Madison WI United States Center for the Experimental-Philosophical Study of Discrimination Aarhus University Aarhus Denmark Department of Political Science Aarhus University Aarhus Denmark Institute of Psychology University of Tartu Tartu Estonia Department of Mental Health Faculty of Medicine Gulu University Gulu Uganda Department of Psychology Universitas Airlangga East Java Indonesia Department of Psychology University of Colorado Colorado Springs Colorado Springs CO United States Department of Psychology Universidad del Valle Guatemala Guatemala City Guatemala Agroscope Research group Economic Modelling and Policy Analysis Ettenhausen Switzerland Department of Political Science Trinity College Dublin Dublin Ireland Department of Psychology International University of Business Agriculture and Technology Dhaka Bangladesh Department of Philosophy University of Granada Granada Spain Department of Psychology University of Guelph Guelph ON Canada School of Psychology University of Queensland Brisbane QLD Australia Graduate Program in Psychology Universidade Federal do Rio Grande Do Sul RS Porto Alegre Brazil Department of General Psychology University of Padova Padova Italy Faculty of Psychology Universidad El Bosque Bogotá Colombia Ministry of Defence Singapore Sustainability and Education Policy Network Saskatoon SK Canada Escuela Nacional de Estudios Superiores unid

Identifying cues to contagious disease is critical for effectively tracking and defending against interpersonal infection threats. People hold lay beliefs about the types of sensory information most relevant for identifying whether others are sick with transmissible illnesses. Are these beliefs universal, or do they vary along cultural and ecological dimensions? Participants in 58 countries (N = 19,217) judged how effective, and how likely they were to use, cues involving each of the five major sensory modalities in an imagined social interaction during a flu outbreak. Belief patterns were strongly consistent across countries (sight > audition > touch > smell > taste), suggesting a largely universal conceptualization of the role of sensory information for interpersonal respiratory disease detection. Results also support a safe senses hypothesis, with perceivers reporting that they would use senses that function at a distance—and thus reduce pathogen transmission risk—more than would be expected given participants’ beliefs as to the efficacy of these senses for disease detection. Where societal variation did emerge, it was captured by a cohesive set of socio-ecological factors, including human development, latitude, pathogen prevalence, and population density. Together, these findings reveal a shared lens through which contagious respiratory disease is assessed, one that prioritizes minimizing risk to perceivers, and may offer leverage for designing interventions to improve public health. © 2025 Elsevier Inc.

关键词： Behavioral immune system Culture Iterpersonal perception Pathogen threat Sensation Threat detection

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Toward the integration of speciation research

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evolutionary Journal of the Linnean Society 2024年第1期3卷

作者： Stankowski, Sean Cutter, Asher D Satokangas, Ina Lerch, Brian A Rolland, Jonathan Smadja, Carole M Segami Marzal, J Carolina Cooney, Christopher R Feulner, Philine G D Domingos, Fabricius Maia Chaves Bicalho North, Henry L Yamaguchi, Ryo Butlin, Roger K Wolf, Jochen B W Coughlan, Jenn Heidbreder, Patrick Hernández-Gutiérrez, Rebeca Barnard-Kubow, Karen B Peede, David Rancilhac, Loïs Salvador, Rodrigo Brincalepe Thompson, Ken A Stacy, Elizabeth A Moyle, Leonie C Garlovsky, Martin D Maulana, Arif Kantelinen, Annina Cacho, N Ivalú Schneemann, Hilde Domínguez, Marisol Dopman, Erik B Lohse, Konrad Rometsch, Sina J Comeault, Aaron A Merrill, Richard M Scordato, Elizabeth S C Singhal, Sonal Pärssinen, Varpu Lackey, Alycia C R Kumar, Sanghamitra Meier, Joana I Barton, Nicholas Fraïsse, Christelle Ravinet, Mark Kulmuni, Jonna Institute of Science and Technology Austria (ISTA) Klosterneuburg Austria Department of Ecology and Evolution University of Sussex Brighton United Kingdom Ecology & Evolutionary Biology University of Toronto Toronto Canada Organismal and Evolutionary Biology Research Programme University of Helsinki Helsinki Finland Department of Biology University of North Carolina at Chapel Hill Chapel Hill NC United States Centre de Recherche sur la Biodiversité et l’Environnement (CRBE) Université de Toulouse CNRS IRD Toulouse INP Université Toulouse 3 – Paul Sabatier (UT3) Toulouse France Institut des Sciences de l’Evolution de Montpellier ISEM Univ. Montpellier CNRS IRD Montpellier France Department of Biology Duke University Durham NC United States Ecology and Evolutionary Biology School of Biosciences University of Sheffield Sheffield United Kingdom Department of Fish Ecology and Evolution Centre of Ecology Evolution and Biogeochemistry EAWAG Swiss Federal Institute of Aquatic Science and Technology Kastanienbaum Switzerland Division of Aquatic Ecology and Evolution Institute of Ecology and Evolution University of Bern Bern Switzerland Departamento de Zoologia Universidade Federal do Paraná Curitiba PR Brazil Department of Zoology University of Cambridge Cambridge United Kingdom Department of Advanced Transdisciplinary Sciences Hokkaido University Sapporo Japan Department of Zoology & Biodiversity Research Centre University of British Columbia Vancouver Canada Department of Marine Sciences University of Gothenburg Gothenburg Sweden Division of Evolutionary Biology LMU Munich Munich Germany Department of Ecology & Evolutionary Biology Yale University New Haven CT United States Department of Evolution Ecology and Organismal Biology University of California Riverside Riverside CA United States Department of Biology James Madison University Harrisonburg VA United States Department of Ecology Evolution and Organismal Biology Brown University Provi

Speciation research—the scientific field focused on understanding the origin and diversity of species—has a long and complex history. While relevant to one another, the specific goals and activities of speciation researchers are highly diverse, and scattered across a collection of different perspectives. Thus, our understanding of speciation will benefit from efforts to bridge scientific findings and the diverse people who do the work. In this paper, we outline two ways of integrating speciation research: (i) scientific integration, through the bringing together of ideas, data, and approaches; and (ii) social integration, by creating ways for a diversity of researchers to participate in the scientific process. We then discuss five challenges to integration: (i) the multidisciplinary nature of speciation research, (ii) the complex language of speciation; (iii) a bias toward certain study systems; (iv) the challenges of working across scales; and (v) inconsistent measures and reporting standards. We provide practical steps that individuals and groups can take to help overcome these challenges, and argue that integration is a team effort in which we all have a role to play.

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EMPRESS. IX. Extremely Metal-Poor Galaxies are Very Gas-Rich Dispersion-Dominated Systems: Will JWST Witness Gaseous Turbulent High-z Primordial Galaxies?

arXiv

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arXiv 2022年

作者： Isobe, Yuki Ouchi, Masami Nakajima, Kimihiko Ozaki, Shinobu Bouché, Nicolas F. Wise, John H. Xu, Yi Emsellem, Eric Kusakabe, Haruka Hattori, Takashi Nagao, Tohru Chiaki, Gen Fukushima, Hajime Harikane, Yuichi Hayashi, Kohei Hirai, Yutaka Kim, Ji Hoon Maseda, Michael V. Nagamine, Kentaro Shibuya, Takatoshi Sugahara, Yuma Yajima, Hidenobu Aoyama, Shohei Fujimoto, Seiji Fukushima, Keita Hatano, Shun Inoue, Akio K. Ishigaki, Tsuyoshi Kawasaki, Masahiro Kojima, Takashi Komiyama, Yutaka Koyama, Shuhei Koyama, Yusei Lee, Chien-Hsiu Matsumoto, Akinori Mawatari, Ken Moriya, Takashi J. Motohara, Kentaro Murai, Kai Nishigaki, Moka Onodera, Masato Ono, Yoshiaki Rauch, Michael Saito, Tomoki Sasaki, Rin Suzuki, Akihiro Takeuchi, Tsutomu T. Umeda, Hiroya Umemura, Masayuki Watanabe, Kuria Yabe, Kiyoto Zhang, Yechi Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwanoha Chiba Kashiwa277-8582 Japan Department of Physics Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan University of Tokyo Chiba Kashiwa277-8583 Japan Univ Lyon Univ Lyon1 ENS de Lyon CNRS Centre de Recherche Astrophysique de Lyon UMR5574 Saint-Genis-LavalF-69230 France Center for Relativistic Astrophysics School of Physics Georgia Institute of Technology AtlantaGA30332 United States Department of Astronomy Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo Tokyo113-0033 Japan European Southern Observatory Karl-Schwarzschild-Straße 2 Garching85748 Germany Observatoire de Genéve Université de Genéve 51 Ch. des Maillettes Versoix1290 Switzerland 650 North A'ohoku Place HiloHI96720 United States Research Center for Space and Cosmic Evolution Ehime University Bunkyo-cho 2-5 Ehime Matsuyama790-8577 Japan Center for Computational Sciences University of Tsukuba Ten-nodai 1-1-1 Tsukuba Ibaraki305-8577 Japan Department of Physics and Astronomy University College London Gower Street LondonWC1E 6BT United Kingdom National Institute of Technology Ichinoseki College Hagisho Ichinoseki021-8511 Japan Astronomical Institute Tohoku University 6-3 Aoba Aramaki Aoba-ku Miyagi Sendai980-8578 Japan Department of Physics and Astronomy University of Notre Dame 225 Nieuwland Science Hall Notre DameIN46556 United States Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Department of Astronomy University of Wisconsin-Madison 475 N. Charter Street MadisonWI53706 United States Theoretical Astrophysics Department of Earth & Space S

We present kinematics of 6 local extremely metal-poor galaxies (EMPGs) with low metallicities (0.016 − 0.098 Z☉) and low stellar masses (104.7 − 107.6M☉). Taking deep medium-high resolution (R ∼ 7500) integral-field spectra with 8.2-m Subaru, we resolve the small inner velocity gradients and dispersions of the EMPGs with Hα emission. Carefully masking out sub-structures originated by inflow and/or outflow, we fit 3-dimensional disk models to the observed Hα flux, velocity, and velocity-dispersion maps. All the EMPGs show rotational velocities (vrot) of 5-23 km s−1 smaller than the velocity dispersions (σ0) of 17-31 km s−1, indicating dispersion-dominated (vrot/σ0 = 0.29−0.80 gas 0.9 − 1.0. Comparing our results with other Hα kinematics studies, we find that vrot/σ0 decreases and fgas increases with decreasing metallicity, decreasing stellar mass, and increasing specific star-formation rate. We also find that simulated high-z (z ∼ 7) forming galaxies have gas fractions and dynamics similar to the observed EMPGs. Our EMPG observations and the simulations suggest that primordial galaxies are gas-rich dispersion-dominated systems, which would be identified by the forthcoming James Webb Space Telescope (JWST) observations at z ∼ 7. Copyright © 2022, The Authors. All rights reserved.

关键词： Galaxies

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