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Drastic effect of Mo on diamond nucleation in the system of MgCO₃-CaCO₃-graphite at 7.7 GPa

JOURNAL OF CRYSTAL GROWTH 2000年第4期210卷 623-628页

作者： Sato, K Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST) Japan

Drastic effect of additional Mo on diamond nucleation was observed in the system of Mc60Cc40 (mixture of 60 mol% MgCO3 and 40 mol% CaCO3)-graphite at 7.7 GPa, 1700 and 1800 degrees C for 1 h. The decrease of temperature required for nucleation of diamond by addition of Mo is 200 degrees C, compared with the temperature in the system of Mc60Cc40-graphite (Sato et al., Diamond Related Mater. 8 (1999) 1900). These results indicate that a lower energy barrier is expected for the nucleation in the Mc60Cc40-Mo-graphite system. Therefore, this nucleation process in the system of Mc60Cc40-graphite-Mo can be considered to be different from the spontaneous nucleation in the system of Mc60Cc40-graphite. Two probable models for nucleation can be suggested: (1) heterogeneous nucleation in which nucleation is affected by MoC that is formed by the reaction between the carbonate and Mo and (2) achievement of enough concentration of carbon for formation of nuclei by the reaction between the carbonate and Mo. (C) 2000 Elsevier science B.V. All rights reserved.

关键词： diamond carbonate molybdenum nucleation

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Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

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science China(Life sciences) 2015年第10期58卷 976-984页

作者： Nobuhiro NAKAI Susumu OTSUKA Jihwan MYUNG Toru TAKUMI Graduate School of Biomedical Sciences Hiroshima University Graduate School of Biostudies Kyoto University RIKEN Brain Science Institute Core Research for Evolutional Science and Technology Japan Science and Technology Agency

Autism spectrum disorder(ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

关键词： copy number variations DNA methylation histone modification ASD model mouse

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Error-driven learning with bracketing constraints 5th

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Meeting on Finite State Methods and Natural Language Processing (FSMNLP05)

作者： Miyata, Takashi Hasida, Koiti Core Research for Evolutional Science and Technology Japan Science and Technology Agency Japan Information Technology Research Institute National Institute of Advanced Industrial Science and Technology Japan

ISBN: (纸本)9783540354673

A chunking algorithm with a Markov model is extended to accept bracketing constraints. The extended algorithm is implemented by modifying a state-of-the-art Japanese dependency parser. Then the effect of bracketing constraints in preventing parsing errors is evaluated. A method for improving the parser's accuracy is proposed. That method adds brackets according to a set of optimal brackets obtained from a training corpus. Although the method's coverage is limited, the F-measure for the sentences to which the method adds brackets is improved by about 7%.

关键词： Markov processes

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Development of light-driven h2/o2 generation chip for micro fuel cell devices

Development of light-driven h2/o2 generation chip for micro ...

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16th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2012

作者： Kajita, Yasuhito Pihosh, Yuriy Mawatari, Kazuma Kitamori, Takehiko University of Tokyo Japan Core Research for Evolutional Science and Technology Japan Science and Technology Agency Japan

ISBN: (纸本)9780979806452

At present work, we report on the development of fuel generation chip driven by the solar light for portable micro fuel cell devices. In the chip, fuel (H2 and O2) are generated by the integrated photocatalyic water splitting system utilizing bottom up and top down technologies. Generated gases are separated by specially designed hydrophobic modified channels. We describe the device concept and fabrication technologies to integrate the photocatalytic system (which is based on TiO2 brush type nanorods structure) in the microchip. Also we demonstrate the working principle of the H2/O2 generation microchip under the solar light and the maximum of photocurrent density ~35-20 μA/cm2 has been recorded during the gas generation and separation.

关键词： Titanium dioxide

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Ribosome display microarray using μ-intaglio printing and photo-crosslinking without removal of stop codons from DNA 18

Ribosome display microarray using μ-intaglio printing and p...

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18th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2014

作者： Kumal, Subhashini Raj Kobayashi, Ryo Ueno, Shingo Ichiki, Takanori University of Tokyo Japan Core Research of Evolutional Science and Technology JST Japan

ISBN: (纸本)9780979806476

Ribosome display is an in vitro protein evolution method conventionally used for the selection of novel proteins with high binding affinity to target molecules. A new procedure for the fabrication of a high-throughput ribosome display microarray is reported here. This procedure is anticipated to be more beneficial than the conventional procedure as DNA with a native sequence can be used without any modification. Further, the microarray format allows creation of a high throughput ribosome display platform which enables direct functional identification and comparison of proteins, followed by collection of desired proteins and mRNAs without any downstream processing. © 14CBMS.

关键词： Proteins

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Formation of parallel aq/org two-phase flows in extended-nanochannel by partial hydrophobic modification 19

Formation of parallel aq/org two-phase flows in extended-nan...

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19th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2015

作者： Kazoe, Y. Ugajin, T. Ohta, R. Mawatari, K. Kitamori, T. University of Tokyo Japan Japan Science and Technology Agency Core Research for Evolutional Science and Technology Japan

ISBN: (纸本)9780979806483

We report establishment of a nm-partial hydrophobic modification method by focused ion beam (FIB) and formation of parallel aqueous/organic two-phase flows in extended-nanochannels by control of liquid-liquid interface. Using the parallel two-phase flow, we demonstrated solvent extraction by integrating phase confluence, extraction and phase separation into 25 fL volume. Due to 103 times/sec interaction between solute molecules and surface by diffusion in 100 nm space, extraction of lipid into the organic phase was completed within 4.5 ms. The ultra high performance compared to microfluidics will greatly contribute to novel applications such as single cell analysis. © 15CBMS-0001.

关键词： Two phase flow

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Development of H2/O2 generation chip for micro fuel cell devices

Development of H2/O2 generation chip for micro fuel cell dev...

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15th International Conference on Miniaturized Systems for Chemistry and Life sciences 2011, MicroTAS 2011

作者： Kajita, Yasuhito Pihosh, Yuriy Mawatari, Kazuma Kitamori, Takehiko University of Tokyo Japan Japan Science and Technology Agency Core Research for Evolutional Science and Technology Japan

ISBN: (纸本)9781618395955

We here report on the development of the fuel generation chip for micro fuel cell devices. In the chip, H2 and O2 are generated by the photocatalyic water splitting and the generated gases are separated by hydrophobic modified channels. To verify the basic concept that water splitting and the gas-liquid separation are driven solely by light energy, we prepare a chip in which electrodes (TiO2 photoanode and Pt cathode) and partial surface modification are integrated. The photocatalytic water splitting and the gas-liquid separation were verified, respectively. Copyright © (2011) by the Chemical and Biological Microsystems Society.

关键词： Surface treatment

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BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death (vol 97, pg 3100, 2000)

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PROCEEDINGS OF THE NATIONAL ACADEMY OF scienceS OF THE UNITED STATES OF AMERICA 2000年第16期97卷 9347-9347页

作者： Shimizu, S Konishi, A Kodama, T Tsujimoto, Y Osaka University Graduate School of Medicine Biomedical Research Center Department of Medical Genetics and Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation 2-2 Yamadaoka Suita

A change of mitochondrial membrane permeability is essential for apoptosis, leading to translocation of apoptogenic cytochrome c and apoptosis-inducing factor into the cytoplasm. We recently showed that the Bcl-2 family of proteins regulate cytochrome c release and the mitochondrial membrane potential (ΔΨ) by directly modulating the activity of the voltage-dependent anion channel (VDAC) through binding. Here we investigated the biochemical role of the conserved N-terminal homology domain (BH4) of Bcl-xL, which has been shown to be essential for inhibition of apoptosis, with respect to the regulation of mitochondrial membrane permeability and found that BH4 was required for Bcl-xL to prevent cytochrome c release and ΔΨ loss. A study using VDAC liposomes revealed that Bcl-xL, but not Bcl-xL lacking the BH4 domain, inhibited VDAC activity. Furthermore, BH4 oligopeptides of Bcl-2 and Bcl-xL, but not mutant peptides, were able to inhibit both VDAC activity on liposomes even in the presence of Bax and apoptotic ΔΨ loss in isolated mitochondria. It was also shown that the BH4 domain, fused to the protein transduction domain of HIV TAT protein (TAT-BH4), efficiently prevented apoptotic cell death. These results indicate that the BH4 of Bcl-2/Bcl-xL is essential and sufficient for inhibiting VDAC activity, which in turn prevents apoptotic mitochondrial changes, and for preventing apoptotic cell death. Finally, the data suggest that the TAT-BH4 peptide is potentially useful as a therapeutic agent for diseases caused by accelerated apoptosis.

关键词：细胞凋亡/生理学碱基序列 DNA引物离子通道闸门/生理学线粒体/生理学孔蛋白质类/生理学原癌基因蛋白质c-bcl-2/化学原癌基因蛋白质c-bcl-2/生理学电压依赖性阴离子通道人类

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Proposition and fabrication of Amplified Redox Sensor (ARS) for high sensitive chemical analysis

Proposition and fabrication of Amplified Redox Sensor (ARS) ...

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2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013

作者： Takahashi, S. Futagawa, M. Ishida, M. Sawada, K. Toyohashi University of Technology Aichi Japan Core Research Evolutional Science and Technology JST Japan

ISBN: (纸本)9781467359818

In recent years, many groups have been studying redox sensor for chemical analysis. The Redox sensor has some strong points such as detecting multi-ion at a sensing area and detecting concentration of materials by voltage and current signal. For the redox sensor, decrements of sensing area size and detection limit of ion concentration are the competing demands. In this study, proposed Amplified Redox Sensor (ARS) is achieved 75 times of amplification than without bipolar transistor and as low as 100μM potassium ferricyanide (K3 [Fe (CN) 6]) of concentration. © 2013 IEEE.

关键词： Chemical analysis

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Open/close valve for extended-nanochannel by glass deformation 19

Open/close valve for extended-nanochannel by glass deformati...

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19th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2015

作者： Kazoe, Y. Ohyama, T. Pihosh, Y. Mawatari, K. Kitamori, T. University of Tokyo Japan Japan Science and Technology Agency Core Research for Evolutional Science and Technology Japan

ISBN: (纸本)9780979806483

We report a novel open/close fluidic valve for nanochannels, exploiting smallness of extended nanospace (10-1000 nm) and tiny glass deformation. The working principle using deformation of rigid glass to open/close 100 nm channels, which has been difficult in conventional microchannels, was verified for the first time. This extended-nano fluidic valve without embedding any MEMS structure is a breakthrough in sophisticated fluidic control such as switching channels and integration of various unit operations (mixing, reaction, separation, etc.) to develop highly-integrated nanofluidic devices for various fields such as biology and energy engineering. © 15CBMS-0001.

关键词： Nanofluidics

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