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science signaling podcast: 21 January 2014

science Signaling 2014年第309期7卷 pc3页

作者： Oike, Yuichi VanHook, Annalisa M. Department of Molecular Genetics Graduate School of Medical Sciences Kumamoto University Chuo-ku Kumamoto 860-8556 1-1-1 Honjo Japan Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency Chiyoda-ku Tokyo 102-0075 Japan Science Signaling American Association for the Advancement of Science NW Washington DC 20005 1200 New York Avenue United States

This Podcast features an interview with Yuichi Oike, author of a research Article that appears in the 21 January 2014 issue of science Signaling, about how the tumor microenvironment affects the aggressiveness of osteosarcoma cells through a secreted factor called angiopoietinlike protein 2 (ANGPTL2). As tumors grow, the tumor microenvironment becomes depleted of oxygen and nutrients, which limits further growth of the tumor. Cancer cells may then metastasize, leaving the primary tumor and colonizing a secondary site where growth conditions are favorable. Odagiri et al. investigated how the tumor microenvironment influences expression of ANGPTL2, which has been implicated in metastasis. The authors found that hypoxic, nutrient-limited growth conditions stimulated the expression of ANGPTL2 by promoting demethylation of the ANGPTL2 promoter. Increased expression of ANGPTL2 correlated with increased metastasis of osteosarcoma cells grown as xenografts in mice and inversely correlated with human osteosarcoma patient survival. ANGPTL2 was cleaved into inactive fragments by tolloid-like 1 (TLL1), which is a protease that was not abundant in human osteosarcoma samples. Thus, increasing the abundance or activity of TLL1 may be a useful strategyfor decreasing the likelihood of metastasis in osteosarcoma patients. © 2014 American Association for the Advancement of science. All Rights Reserved.

关键词： Angiopoietin-like protein 2 ANGPTL2 Cancer Demethylase DNA methylation Epigenetics Matrix metalloprotease Matrix metalloproteinase Metastasis MMP Osteosarcoma science Signaling TLL1 Toilloid-like 1 Tumor microenvironment

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Production of 16 K pixel hydrogen ion image sensors with 0.01pH resolution

Production of 16 K pixel hydrogen ion image sensors with 0.0...

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2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013

作者： Otake, R. Futagawa, M. Dasai, F. Suzuki, D. Ishida, M. Sawada, K. Integrated Circuit and Sensor System Group Toyohashi University of Technology Aichi Japan Core Research Evolutional Science and Technology JST Japan Electronics-Inspired Interdisciplinary Research Institute Toyohashi University of Technology Aichi Japan

ISBN: (纸本)9781467359818

The high sensitive pH image sensor is required in biology and cytology field. In our previous work, highly sensitive pH sensor, which is capable to measure 0.01pH, with a Q-trap structure had been fabricated. However, two-dimensional array sensor couldn't be realized due to large threshold voltage variability between each pixel. In this study, a multi ICG measurement method was proposed for ion image sensor with high pH sensitivity. The method was a measurement procedure to reduce the threshold voltage variability by controlling VICG at each pixel. A 16k pH image sensor with the Q-trap was fabricated. We successively took a ion image with small pH difference using multi ICG system. © 2013 IEEE.

关键词： Pixels

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Fabrication of planar microfluidic device for artificial Darwinian selection technology

Fabrication of planar microfluidic device for artificial Dar...

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17th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2013

作者： Sato, Shusuke Fukuda, Takumi Hirai, Tatsunori Ueno, Shingo Biyani, Manish Akagi, Takanori Ichiki, Takanori Graduate School of Engineering University of Tokyo 2-11-16 Yatoi Bunkyo-ku Tokyo 113-8656 Japan Core Research of Evolutional Science and Technology JST Japan

ISBN: (纸本)9781632666246

Aplanar microfluidic device was developed as an interface for the robust one-step synthesis of a wide variety of mutant proteins from a DNA library on a microarray chip. The on-chip synthesis and evaluation of stability of proteins at high temperatures were successfully demonstrated using wild-type GFP (green fluorescent protein: uv4) technology using a microarray. The developed technology provides as an essential tool for artificial Darwinian selection technology towards directed molecular evolution.

关键词： Fluidic devices

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Redox‐Responsive Macroscopic Gel Assembly Based on Discrete Dual Interactions†

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Angewandte Chemie 2014年第14期126卷

作者： Masaki Nakahata Yoshinori Takashima Akira Harada Department of Macromolecular Science Graduate School of Science Osaka University Toyonaka Osaka 560–0043 (Japan) Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) (Japan)

The macroscopic self‐assembly of polymeric hydrogels modified with β‐cyclodextrin (βCD gel), ferrocene (Fc gel), and styrenesulfonic acid sodium salt (SSNa gel) was investigated. Under reductive conditions, the Fc gel selectively adhered to the βCD gel through a host–guest interaction. On the other hand, the oxidized ferrocenium (Fc + ) gel selectively adhered to the SSNa gel through an ionic interaction under oxidative conditions. The adhesion strength was estimated by a tensile test. We finally succeeded in forming an ABC‐type macroscopic assembly of all three gels through two discrete noncovalent interactions.

关键词： Cyclodextrine Ferrocen Ionische Wechselwirkungen Makroskopische Aggregate Wirt‐Gast‐Systeme

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Thermal distribution in amorphous InSnZnO thin-film transistor

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Physica Status Solidi (C) Current Topics in Solid State Physics 2013年第11期10卷 1561-1564页

作者： Urakawa, Satoshi Tomai, Shigekazu Ueoka, Yoshihiro Yamazaki, Haruka Kasami, Masashi Yano, Koki Wang, Dapeng Furuta, Mamoru Horita, Masahiro Ishikawa, Yasuaki Uraoka, Yukiharu Graduate School of Materials Science Nara Institute of Science and Technology 8916-5 Takayama Ikoma Nara 630-0192 Japan Advanced Technology Research Laboratories Idemitsu Kosan Co. Ltd. Sodegaura Chiba 299-0293 Japan Environmental Science and Engineering Kochi University of Technology Kami Kochi 782-8502 Japan JSPS Core Research for Evolutional Science and Technology Japan Science and Technology Agency 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan

We have investigated thermal distribution of an amorphous InSnZnO thin-film transistor (TFT) under voltage stress by using thermal imaging system. To clarify an influence of only self-heating phenomenon on reliability, we have focused on a channel scale dependence of heating. As the result, heating effect were strongly depended on channel scale and showed two types of dependences on channel length and width. When positive bias stress was applied to TFT, severe threshold voltage shift and high heating temperature were observed for wider TFT. Moreover, reliability under voltage stress was seems to be affected by accumulation of heating in wider TFT. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

关键词： Thin film transistors

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Erratum: 'On the Chirp of Narrowband Terahertz Pulses Generated by Photomixing with Nonlinearly Chirped Laser Pulse Pairs'

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Applied Physics Express 2014年第2期7卷

作者： Shohei Kamada Shuhei Murata Takao Aoki School of Advanced Science and Technology Waseda University Shinjuku Tokyo 169-8555 Japan Core Research for Evolutional Science and Technology Japan Science and Technology Agency Kawaguchi Saitama 332-0012 Japan

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Phase imaging of extreme-ultraviolet mask using coherent extreme-ultraviolet scatterometry microscope

Phase imaging of extreme-ultraviolet mask using coherent ext...

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作者： Harada, Tetsuo Nakasuji, Masato Nagata, Yutaka Watanabe, Takeo Kinoshita, Hiroo Center for EUV Lithography Laboratory of Advanced Science and Technology for Industry University of Hyogo Kamigori Hyogo 678-1205 Japan Laser Technology Laboratory RIKEN Wako Saitama 351-0198 Japan Core Research for Evolutional Science and Technology Japan Science and Technology Agency Kawaguchi Saitama 332-0012 Japan

Phase-shifting masks were developed for extreme ultraviolet (EUV) lithography to enlarge the process window, and some researchers developed mask phase defect compensation methods adopting absorber pattern modification. To evaluate these small phase structures, a phase-imaging microscope is required. For actinic phase imaging, we have developed a coherent EUV scatterometry microscope (CSM) based on a coherent diffraction imaging method. The image-forming optics are replaced by an inverse computation, where the frequency space phase data are retrieved. Therefore, the aerial image phase data are also reconstructed. The CSM thus observes the intensity and phase image. We improved the reconstruction algorithm by which the illumination probe was simultaneously reconstructed;phase images of a crossed line pattern, an 88nm line-and-space pattern, and a phase defect were reconstructed quantitatively. The CSM will be helpful for phase-shift mask development and phase defect compensation. © 2013 The Japan Society of Applied Physics.

关键词： Antennas

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Mechanism of strain relaxation in BaSi2 epitaxial films on Si(111) substrates during post-growth annealing and application for film exfoliation

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Physica Status Solidi (C) Current Topics in Solid State Physics 2013年第12期10卷 1677-1680页

作者： Hara, Kosuke O. Usami, Noritaka Nakamura, Kotaro Takabe, Ryouta Baba, Masakazu Toko, Kaoru Suemasu, Takashi Graduate School of Engineering Nagoya University Furo-cho. Chikusa-ku Nagoya 464-8603 Japan Core Research for Evolutional Science and Technology Japan Science and Technology Agency Gobancho Chiyoda Tokyo 102-0076 Japan Institute of Applied Physics University of Tsukuba 1-1-1 Tennohdai Tsukuba Ibaraki 305-8573 Japan

Strain accumulation and relaxation in BaSi2 epitaxial films on Si(111) substrates during thermal treatments have been studied. The 2θ -ω X-ray diffraction analysis shows that the film-normal lattice parameters (a) in epitaxial films are smaller than that in the bulk, indicating in-plane tensile stress is accumulated in the asgrown films. Resultant curvature of the substrate has been observed by spatially-resolved X-ray rocking curve analysis. This strain is relaxed by post-growth annealing through cracking. The conditions of cracking are revealed in terms of the film thickness and annealing temperature, from which the mechanism of strain relaxation is discussed. It is found from the tape test that the films with cracks can be exfoliated with an adhesive tape. The free-standing annealed films are subjected to the microwave-detected photoconductivity decay measurement, which reveals a long minority-carrier lifetime of 5 μs. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

关键词： Cracks

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31st Annual Meeting and Associated programs of the Society for Immunotherapy of Cancer (SITC 2016): part two Abstracts

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JOURNAL FOR IMMUNOTHERAPY OF CANCER 2016年第SUPPL 1期4卷 107-221页

作者： [Anonymous] Department of Immunology University of Texas MD Anderson Cancer Center Houston TX USA Department of Cancer Medicine University of Texas MD Anderson Cancer Center Houston TX USA Immune Design Seattle WA USA Innate Pharma Marseille Provence-Alpes-Cote d’Azur France MedImmune Cambridge England UK Georgetown-Lombardi Comprehensive Cancer Center Washington DC USA Westmead and Blacktown Hospitals Melanoma Institute Australia and the University of Sydney Westmead New South Wales Australia University of California Los Angeles CA USA University of Washington Seattle WA USA Dana-Farber Cancer Institute/Brigham and Women’s Hospital Harvard University Boston MA USA University of Texas MD Anderson Cancer Center Houston TX USA Beth Israel Deaconess Medical Center Boston MA USA Gallipoli Medical Research Foundation Greenslopes Private Hospital and the University of Queensland Greenslopes Queensland Australia Olivia Newton-John Cancer Research Institute Heidelberg Victoria Australia Canterbury District Health Board Christchurch Hospital Christchurch New Zealand Waikato Hospital Regional Cancer Centre Hamilton New Zealand Royal Prince Alfred Hospital Melanoma Institute Australia the University of Sydney and Chris O’Brien Lifehouse Camperdown New South Wales Australia Tasman Oncology Research Southport Gold Coast Queensland Australia Merck & Co. Inc. Kenilworth NJ USA Quantitative Solutions A Certara Company Oss Netherlands Melanoma Institute Australia the University of Sydney Mater Hospital and Royal North Shore Hospital Wollstonecraft New South Wales Australia Columbia University Medical Center New York NY USA Institut d’Investigacions Biomediques August Pi i Sunyer Barcelona Catalonia Spain Icahn School of Medicine at Mount Sinai New York NY USA New York Presbyterian/Columbia University Medical Center New York NY USA Memorial Sloan Kettering Cancer Center New York NY USA Peregrine Pharmaceuticals Inc. Tustin CA USA Regeneron Tarrytown NY USA University of

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Disease-Specific Induced Pluripotent Stem Cells Recapitulate The Pathophysiology Of Familial Platelet Disorder With Predisposition To Acute Myelogenous Leukemia

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BLOOD 2013年第21期122卷 1188-1188页

作者： Arai, Shunya Iiduka, Hiromitsu Takayama, Naoya Masashi, Miyauchi Taoka, Kazuki Kataoka, Keisuke Hosoi, Masataka Kumano, Keiki Eto, Koji Kurokawa, Mineo Department of Hematology and Oncology The University of Tokyo Hospital Tokyo Japan Department of Hematology & Oncology Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Clinical Application Center for iPS Cell Research and Application (CiRA) Kyoto University Kyoto Japan Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) Tokyo Japan

Familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) is an autosomal dominant disorder and is characterized by inherited thrombocytopenia and a lifelong risk of development of hematological malignancies. About 30 pedigrees of FPD/AML have been reported in the literature, when the first FPD/AML pedigree was reported. Heterozygous inherited RUNX1 mutations as the cause of this disorder was confirmed. Mutations of RUNX1 observed in FPD/AML are heterogeneous and tend to be specific to individual families. An individual mutation is thought to cause a functional loss of the RUNX1 protein with an individual severity, accounting for the variable phenotypes of FPD/AML among pedigrees. Mutations that cause haploinsufficiency are most frequent, though some mutations are predicted to result in dominant-negative effects. Indeed, the ability to gain more insight into the pathogenesis of FPD itself or leukemia progression of FPD/AML has been hampered by small patient numbers and the heterogeneity of the disease. Human induced pluripotent stem cells (iPSCs) derived from somatic cells hold promise to develop research models, especially for rare inherited and acquired diseases. Therefore, we obtained samples from a 45-year old female FPD/AML patient, who had inherited RUNX1 R174X mutation. She was diagnosed as acute myeloid leukemia at the age of 41 and received matched unrelated bone marrow transplantation, and was in remission for three years. Using primary dermal fibroblasts, we established induced pluripotent stem cells with heterozygous RUNX1 R174X mutation (FPD-iPSCs), by two-rounds of infection with pMX retrovirus encoding Oct4, Sox2, Klf4 and c-Myc. The morphology of FPD-iPSCs looked like embryonic stem cells. The endogenous stem cell genes were expressed. And the RUNX1 mutation derived from the primary patient cells was confirmed in the FPD-iPSCs. If iPSCs which harbor genomic abnormalities specific for the diseases are established, we can d

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