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The 9th Asia-Pacific Conference on Vision(第九届亚太视觉会议)

作者： Yu Fang Masaki Emoto Ryoichi Nakashima Kazumichi Matsumiya Ichiro Kuriki Satoshi Shioiri Japan Science and Technology Agency Core Research for Evolutional Science & Technology Research Institute of Electrical CommunicationTohoku University Graduate School of Information Sciences Tohoku University NHK Science & Technology Research Laboratories Research Institute of Electrical CommunicationTohoku University

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Development of novel two-photon microscopy for living brain and neuron

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Microscopy (Oxford, England) 2014年第SUPPL_1期63 Suppl 1卷 i7-i8页

作者： Tomomi Nemoto Research Institute for Electronic Science Hokkaido University Kita 21 Nishi 10 Kita-ku Sapporo 001-0021 Japan Graduate School of Information Science and Technology Hokkaido University Kita 21 Nishi 10 Kita-ku Sapporo 001-0021 Japan Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) Japan tn@es.hokudai.ac.jp.

"In vivo" two-photon microscopy (TPLSM) has revealed vital information on neural activity for brain function, even in light of its limitation in imaging events at depths greater than a several hundred micrometers from the brain surface. To break the limit of this penetration depth, we introduced a novel light source based on a semiconductor laser [1]. The light source successfully visualized not only cortex layer V pyramidal neurons spreading to all cortex layers at a superior S/N ratio, but visualize hippocampal CA1 neurons in young adult mice [2]. These results indicate that the penetration depth of this laser was ∼1.4 mm. In vivo TPLSM with a laser emitting a longer wavelength might give us insights on activities of neurons in the cortex or the hippocampus. This deep imaging method could be applicable to other living organs including tumor tissues. In addition, we developed liquid crystal devices to convert linearly polarized beams (LP) to vector beams [3]. A liquid device generated a vector beam called higher-order radially polarized (HRP) beam, which enabled that each of the aggregated 0.17 m beads was distinguished individually, whereas in conventional confocal microscopy or TPLSM they could not. We also visualized the finer structures of networks of filamentous cytoskeleton microtubule fluorescently-labeled in the COS-7, and primary culture of mouse neurons. Moreover, by taking an advantage of the LCDs that can utilize various wavelengths including near-infrared, we could employ an HRP beam for improving TPLSM. An HRP beam visualized fine intracellular structures not only in fixed cells stained with various dyes, but also in living cells expressing a fluorescent protein [4]. HRP beam also visualized finer structures of microtubules in fixed cells. Here, we will discuss these improvements and future application on the basis of our recent ***;63/suppl_1/i7/DFU087F1F1DFU087F1Fig. 1."in vivo" imaging of living mouse brain (H-line).

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Thermal Activiation of Sr3Fe2O7 Electrocatalysts for Water Oxidation at Neutral pH

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ECS Transactions 2014年第22期61卷

作者： Toshihiro Takashima Koki Ishikawa Hiroshi Irie Clean Energy Reseach Center University of Yamanashi Special Doctoral Program for Green Energy Conversion Science and Technology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Japan Science and Technology Agency (JST) Core Research for Evolutionary Science and Technology (CREST Clean Energy Research Center University of Yamanashi

The Ruddlesden-Popper-type layered perovskite strontium ferrite (Sr3Fe2O7) was studied as an electrocatalyst for water oxidation to molecular oxygen (O2). The electrocatalytic activity of Sr3Fe2O7 was found to be dependent on the temperature, and the overpotential for water oxidation was markedly lower at 70 oC than at 30 oC. Namely, at pH 7, O2 evolution initiated with overpotentials of approximately 100 and 300 mV at 70 and 30 oC, respectively. When lanthanum-substituted Sr3Fe2O7, Sr2.6La0.4Fe2O7, was used to catalyze O2 evolution, the distinctive temperature dependence disappeared and O2 evolution was driven with a low overpotential even at 30 oC. These results suggest that the formation of Fe4+ is important for decreasing the overpotential for water oxidation to produce O2.

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ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response

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BMC research Notes 2013年第1期6卷 1-23页

作者： Umemori, Juzoh Takao, Keizo Koshimizu, Hisatsugu Hattori, Satoko Furuse, Tamio Wakana, Shigeharu Miyakawa, Tsuyoshi Division of Systems Medical Science Institute for Comprehensive Medical Science Fujita Health University Toyoake 470-1192 1-98 Dengakugakubo Kutsukake-cho Japan Japan Science and Technology Agency (JST) Core Research for Evolutional Science and Technology (CREST) Kawaguchi Japan Section of Behavior Analysis Center for Genetic Analysis of Behavior National Institute for Physiological Sciences Okazaki Japan Genetic Engineering and Functional Genomics Group Frontier Technology Center Kyoto University Graduate School of Medicine Kyoto Japan Technology and Development Team for Mouse Phenotype Analysis Japan Mouse Clinic RIKEN BioResource Center Tsukuba Japan

Background: The Grin1 (glutamate receptor, ionotropic, NMDA1) gene expresses a subunit of N-methyl-D-aspartate (NMDA) receptors that is considered to play an important role in excitatory neurotransmission, synaptic plasticity, and brain development. Grin1 is a candidate susceptibility gene for neuropsychiatric disorders, including schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD). In our previous study, we examined an N-ethyl-N-nitrosourea (ENU)-generated mutant mouse strain (Grin1 ^Rgsc174/Grin1 ⁺) that has a non-synonymous mutation in Grin1. These mutant mice showed hyperactivity, increased novelty-seeking to objects, and abnormal social interactions. Therefore, Grin1 ^Rgsc174/ Grin1 ⁺ mice may serve as a potential animal model of neuropsychiatric disorders. However, other behavioral characteristics related to these disorders, such as working memory function and sensorimotor gating, have not been fully explored in these mutant mice. In this study, to further investigate the behavioral phenotypes of Grin1 ^Rgsc174/Grin1 ⁺ mice, we subjected them to a comprehensive battery of behavioral tests. Results: There was no significant difference in nociception between Grin1 ^Rgsc174/Grin1 ⁺ and wild-type mice. The mutants did not display any abnormalities in the Porsolt forced swim and tail suspension tests. We confirmed the previous observations that the locomotor activity of these mutant mice increased in the open field and home cage activity tests. They displayed abnormal anxiety-like behaviors in the light/dark transition and the elevated plus maze tests. Both contextual and cued fear memory were severely deficient in the fear conditioning test. The mutant mice exhibited slightly impaired working memory in the eight-arm radial maze test. The startle amplitude was markedly decreased in Grin1 ^Rgsc174/Grin1 ⁺ mice, whereas no signific

关键词： ADHD Comprehensive behavioral test battery ENU-mutagenesis Grin1 NMDA receptor Psychiatric disorder Schizophrenia

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Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015

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BMC genomics 2016年第6期17 Suppl 6卷 487页

作者： Jerry W. Shay Noriko Homma Ruyun Zhou Muhammad Imran Naseer Adeel G. Chaudhary Mohammed Al-Qahtani Nobutaka Hirokawa Maryam Goudarzi Albert J. Fornace Saleh Baeesa Deema Hussain Mohammed Bangash Fahad Alghamdi Hans-Juergen Schulten Angel Carracedo Ishaq Khan Hanadi Qashqari Nawal Madkhali Mohamad Saka Kulvinder S. Saini Awatif Jamal Jaudah Al-Maghrabi Adel Abuzenadah Adeel Chaudhary Mohammed Al Qahtani Ghazi Damanhouri Heba Alkhatabi Anne Goodeve Laura Crookes Nikolas Niksic Nicholas Beauchamp Adel M. Abuzenadah Jim Vaught Bruce Budowle Mourad Assidi Abdelbaset Buhmeida Leena Merdad Sudhir Kumar Sayaka Miura Karen Gomez Mahmood Rasool Ahmed Rebai Sajjad Karim Hend F. Nour Eldin Heba Abusamra Elham M. Alhathli Nada Salem Mohammed H. Al-Qahtani Hossam Faheem Ashok Agarwa Eberhard Nieschlag Joachim Wistuba Oliver S. Damm Mohd A. Beg Taha A. Abdel-Meguid Hisham A. Mosli Osama S. Bajouh Serdar Coskun Muhammad Abu-Elmagd Ashraf Dallol Sahar Hakamy Wejdan Al-Qahtani Asia Al-Harbi Shireen Hussain Burak Ozkosem Rick DuBois Safia S. Messaoudi Maryam T. Dandana Touhami Mahjoub Wassim Y. Almawi S. Abdalla M. Nabil Al-Aama Asmaa Elzawahry Tsuyoshi Takahashi Sachiyo Mimaki Eisaku Furukawa Rie Nakatsuka Isao Kurosaka Takahiko Nishigaki Hiromi Nakamura Satoshi Serada Tetsuji Naka Seiichi Hirota Tatsuhiro Shibata Katsuya Tsuchihara Toshirou Nishida Mamoru Kato Sajid Mehmood Naeem Mahmood Ashraf Awais Asif Muhammad Bilal Malik Siddique Mehmood Aadil Hussain Qazi Mohammad Sajid Jamal Mughees Uddin Siddiqui Mohammad A. Alzohairy Mohammad A. Al Karaawi Taoufik Nedjadi Heba Al-Khattabi Adel Al-Ammari Ahmed Al-Sayyad Hédia Zitouni Nozha Raguema Marwa Ben Ali Wided Malah Raja Lfalah Wassim Almawi Mohammed Elanbari Andrey Ptitsyn Sana Mahjoub Rabeb El Ghali Bechir Achour Nidhal Ben Amor Brahim N’siri Hamid Morjani Esam Azhar Vera Chayeb Maryam Dendena Hedia Zitouni Khedija Zouari-Limayem Bassem Refaat Ahmed M. Ashshi Sarah A. Batwa Hazem Ramadan Amal Awad Ahmed Ateya Adel Galal Ahmed El-Shemi Ahmad Ashshi Mohammed Basalamah Youjin Na Cha University of Texas Southwestern Medical Center Dallas USA Department of Cell Biology and Anatomy Graduate School of Medicine the University of Tokyo Tokyo Japan Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Department of Biochemistry and Molecular & Cellular Biology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Radiation Medicine Lombardi Comprehensive Cancer Center Georgetown University Washington USA Center of Excellence in Genomic Medicine Research (CEGMR) King Abdulaziz University Jeddah Kingdom of Saudi Arabia King Fahd Medical Research Centre King Abdulaziz University Jeddah Saudi Arabia Centre of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Sheffield Diagnostic Genetic Service Sheffield Children’s NHS Foundation Trust Western Bank Sheffield UK Center of Innovations in Personalized Medicine King Abdulaziz University Jeddah Saudi Arabia President ISBER Editor-in-Chief Biopreservation & Biobanking ᅟ USA Institute of Applied Genetics Department of Molecular and Medical Genetics University of North Texas Health Science Center Fort Worth USA Department of Dental Public Health Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia Institute for Genomics and Evolutionary Medicine Temple University Philadelphia USA Center of Excellence in Genomic Medicine King Abdulaziz University Jeddah Kingdom of Saudi Arabia Laboratory of Molecular and Cellular Screening Processes (Bioinformatics Group) Centre of Biotechnology of Sfax Sfax Tunisia Fujitsu Technology Solutions International ᅟ ᅟ Case Western Reserve University School of Medicine and Lerner College of Medicine Cleveland Clinic Foundation Cleveland USA American Center for Reproductive Medicine Andrology Center Cleveland USA Center for Reproductive Medicine and

O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J. Fornace Jr. O4 A unique integrated system to discern pathogenesis of central nervous system tumors Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S. Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri O5 RPL27A is a target of miR-595 and deficiency contributes to ribosomal dysgenesis Heba Alkhatabi O6 Next generation DNA sequencing panels for haemostatic and platelet disorders and for Fanconi anaemia in routine diagnostic service Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp O7 Targeted sequencing panels and their utilization in personalized medicine Adel M. Abuzenadah O8 International biobanking in the era of precision medicine Jim Vaught O9 Biobank and biodata for clinical and forensic applications Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida O10 Tissue microarray technique: a powerful adjunct tool for molecular profiling of solid tumors Jaudah Al-Maghrabi O11 The CEGMR biobanking unit: achievements, challenges and future plans Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad O12 Phylomedicine of tumors Sudhir Kumar, Sayaka Miura, Karen Gomez O13 Clinical implementation of pharmacogenomics for colorectal cancer treatment Angel Carracedo, Mahmood Rasool O14 From association to causality: translation of GWAS findings for genomic me

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Cover Picture: Hydrogen‐Bonding Effect on Spin‐Center Transfer of Tetrathiafulvalene‐Linked 6‐Oxophenalenoxyl Evaluated Using Temperature‐Dependent Cyclic Voltammetry and Theoretical Calculations (Chem. Asian J. 2/2014)

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Chemistry – An Asian Journal 2014年第2期9卷

作者： Shinsuke Nishida Kozo Fukui Yasushi Morita Department of Chemistry Graduate School of Science Osaka University Toyonaka Osaka 560‐0043 (Japan) Fax: (+81) 6‐6850‐5393 http://www.chem.sci.osaka‐u.ac.jp/lab/nakasuji/morita/index.html Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) 5 Sanban‐cho Chiyoda‐ku Tokyo 102‐0075 (Japan)

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31st Annual Meeting and Associated programs of the Society for Immunotherapy of Cancer (SITC 2016): part one: National Harbor, MD, USA. 9-13 November 2016

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J Immunother Cancer 2016年第SUPPL 1期4卷 1-1页

作者： Andreas Lundqvist Vincent van Hoef Xiaonan Zhang Erik Wennerberg Julie Lorent Kristina Witt Laia Masvidal Sanz Shuo Liang Shannon Murray Ola Larsson Rolf Kiessling Yumeng Mao John-William Sidhom Catherine A. Bessell Jonathan Havel Jonathan Schneck Timothy A. Chan Eliot Sachsenmeier David Woods Anders Berglund Rupal Ramakrishnan Andressa Sodre Jeffrey Weber Roberta Zappasodi Yanyun Li Jingjing Qi Philip Wong Cynthia Sirard Michael Postow Walter Newman Henry Koon Vamsidhar Velcheti Margaret K. Callahan Jedd D. Wolchok Taha Merghoub Lawrence G. Lum Minsig Choi Archana Thakur Abhinav Deol Gregory Dyson Anthony Shields Cara Haymaker Marc Uemura Ravi Murthy Marihella James Daqing Wang Julie Brevard Catherine Monaghan Suzanne Swann James Geib Mark Cornfeld Srinivas Chunduru Sudhir Agrawal Cassian Yee Jennifer Wargo Sapna P. Patel Rodabe Amaria Hussein Tawbi Isabella Glitza Scott Woodman Wen-Jen Hwu Michael A. Davies Patrick Hwu Willem W. Overwijk Chantale Bernatchez Adi Diab Erminia Massarelli Neil H. Segal Vincent Ribrag Ignacio Melero Tara C. Gangadhar Walter Urba Dirk Schadendorf Robert L. Ferris Roch Houot Franck Morschhauser Theodore Logan Jason J. Luke William Sharfman Fabrice Barlesi Patrick A. Ott Laura Mansi Shivaani Kummar Gilles Salles Cecilia Carpio Roland Meier Suba Krishnan Dan McDonald Matthew Maurer Xuemin Gu Jaclyn Neely Satyendra Suryawanshi Ronald Levy Nikhil Khushalani Jennifer Wu Jinyu Zhang Fahmin Basher Mark Rubinstein Mark Bucsek Guanxi Qiao Cameron MacDonald Bonnie Hylander Elizabeth Repasky Shilpak Chatterjee Anusara Daenthanasanmak Paramita Chakraborty Kyle Toth Megan Meek Elizabeth Garrett-Mayer Michael Nishimura Chrystal Paulos Craig Beeson Xuezhong Yu Shikhar Mehrotra Fei Zhao Kathy Evans Christine Xiao Alisha Holtzhausen Brent A. Hanks Nicole Scharping Ashley V. Menk Rebecca Moreci Ryan Whetstone Rebekah Dadey Simon Watkins Robert Ferris Greg M. Delgoffe Jonathan Peled Sean Devlin Anna Staffas Melissa Lumish Kori Porosnicu Rodriguez Katya Ahr Miguel Perales Sergio Giralt Ying Taur Eric Pam Karolinska Institutet Stockholm Stockholms Lan Sweden Weill Cornell Medical College New York NY USA Nova Southeastern University Cell Therapy Institute Fort Lauderdale FL USA Johns Hopkins University School of Medicine Baltimore MD USA Immunology Program Johns Hopkins University School of Medicine Columbia MD USA Memorial Sloan Kettering Cancer Center New York NY USA Johns Hopkins Medical Institute Baltimore MD USA University of Rochester Monrovia MD USA NYU Langone Medical Center New York NY USA H. Lee Moffitt Cancer Center Tampa FL USA Ludwig Collaborative Laboratory Memorial Sloan Kettering Cancer Center New York NY USA Immune Monitoring Core Facility Memorial Sloan Kettering Cancer Center New York NY USA Leap Therapeutics Cambridge MA USA Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA Case Western Reserve University Cleveland OH USA Cleveland Clinic Main Campus Cleveland OH USA University of Virginia Cancer Center Charlottesville VA USA Stony Brook University Medical Center Stony Brook NY USA Karmanos Cancer Institute Detroit MI USA University of Texas MD Anderson Cancer Center Houston TX USA Idera Pharmaceuticals Inc. Cambridge MA USA Institut Gustave Roussy Villejuif Ile-de-France France Center for Applied Medical Research (CIMA) University of Navarra Pamplona Navarra Spain University of Pennsylvania Philadelphia PA USA Earle A. Chiles Research Institute Providence Cancer Center Portland OR USA Universitätsklinikum Essen Essen Nordrhein-Westfalen Germany University of Pittsburgh Pittsburgh PA USA CHU Rennes Service Hématologie Clinique and INSERM 0203 Unité d’Investigation Clinique Rennes Bretagne France Centre Hospitalier Régional Universitaire de Lille Lille Nord-Pas-de-Calais France Simon Cancer Center Indiana University Indianapolis IN USA University of Chicago School of Medicine Chicago IL USA Johns Hopkins University School of Medicine Lutherville MD USA Multidisciplinary Oncology and Therapeuti

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VUV generation below 200 nm with borate crystals

VUV generation below 200 nm with borate crystals

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第6届国际激光/闪烁和非线性光学材料研讨会(The 6th International Symposium on Lasers,Scintillators and Non-Linear Optical Materials)

作者： C.Qu M.Yoshimura J.Tsunoda Y.Kaneda M.Imade T.Sasaki Y.Mori Core Research for Evolutional Science and Technology(CREST) Japan Science and Technology Agency(JST) Japan Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan Core Research for Evolutional Science and Technology(CREST) Japan Science and Technology Agency(JST) Japan Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan College of Optical Sciences The University of Arizona USA Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan

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Cover Picture: [NiFe]Hydrogenase fromCitrobactersp. S-77 Surpasses Platinum as an Electrode for H2Oxidation Reaction (Angew. Chem. Int. Ed. 34/2014)

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Angewandte Chemie International Edition 2014年第34期53卷

作者： Dr. Takahiro Matsumoto Shigenobu Eguchi Dr. Hidetaka Nakai Prof. Takashi Hibino Dr. Ki-Seok Yoon Prof. Seiji Ogo Department of Chemistry and Biochemistry Graduate School of Engineering Kyushu University 744 Moto-oka Nishi-ku Fukuoka 819-0395 (Japan) Graduate School of Environmental Studies Nagoya University Furo-cho Chikusa-ku Nagoya 464-8601 (Japan) Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) Kawaguchi Center Building 4-1-8 Honcho Kawaguchi Saitama 332-0012 (Japan)

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Nanocycles of Materials' Transport studied by in-situ Electron Microscopy and Diffraction

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Journal of Physics: Conference Series 2014年第1期522卷

作者： K Takayanagi Y Oshima S Lee T Tanaka Y Tanishiro Department of Physics Tokyo Institute of Technology 2-12-1-H-51 Oh-okayama Meguro-ku Tokyo 152-8551 Japan Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) K's Gobancho 7 Gobancho Chiyoda-ku Tokyo 102-0076 Japan Research center for ultra HVEM Osaka University 7-1 Mihokaoka Ibaraki 5670047 Japan Department of Materials Science & Engineering Tokyo Institute of Technology 2-12-1-H-51 Oh-okayama Meguro-ku Tokyo 152-8551 Japan

A sub-50pm resolution electron microscope was applied for in-situ studies of ion transport in lithium ion battery and CO-oxidation catalyst. Lithium ions in LiM2O4 electrodes (M: transition metals) and titanium ions in Au/TiO2 catalyst were enabled us to observe individually by ABF-STEM and TEM. Transport of lithium ions was seen, after in-situ observations, to induce structural transformation of the electrode materials that causes irreversible cycle of the battery reaction. Transport of the interstitial titanium ions results, due to oxygen gas for CO-oxidation, in modification of Au/TiO2 interface structure. In-situ studies, thus, revealed materials' transformation induced locally by ion/electron transport of the battery/catalyst system at high resolution and high contrast.

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