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12th IEEE/ACM International Symposium on Cluster, Cloud and Grid Computing, CCGrid 2012

作者： Tanaka, Masahiro Tatebe, Osamu Center for Computational Sciences University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki Japan Faculty of Engineering Information and Systems University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki Japan Core Research for Evolutional Science and Technology Japan Science and Technology Agency Kawaguchi Saitama Japan

ISBN: (纸本)9780769546919

Among scheduling algorithms of scientific workflows, the graph partitioning is a technique to minimize data transfer between nodes or clusters. However, when the graph partitioning is simply applied to a complex workflow DAG, tasks in each parallel phase are not always evenly assigned to computation nodes since the graph partitioning algorithm is not aware of edge directions that represent task dependencies. Thus, we propose a new method of task assignment based on Multi-Constraint Graph Partitioning. This method relates the dimension of weight vectors to the rank of a task phase defined by traversing the task graph. Our algorithm is implemented in the Pwrake workflow system and evaluated the performance of the Montage workflow using a computer cluster. The result shows that the file size accessed from remote nodes is reduced from 88% to 14% of the total file size accessed during the workflow and that the elapsed time is reduced by 31%. © 2012 IEEE.

关键词： Scheduling algorithms

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Cytokine 2013年第3期63卷 303-303页

作者： Ce Tang Tomonori Kamiya Motohiko Kadoki Yoichiro Iwakura Research Institute for Biomedical Sciences Tokyo University of Science Noda-shi Chiba Japan Center for Experimental Medicine and Systems Biology Institute of Medical Science University of Tokyo Minato-ku Tokyo Japan Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) Saitama Japan Graduate School of Science The University of Tokyo Minato-ku Tokyo Japan

The intestinal immune system has to take dual tasks; the system should fight against invading pathogens and, at the same time, the system should be tolerant toward commensal microbiota or food components. Dectin-1 is the receptor for beta-glucans expressed in fungal cell walls and activates the immune system to prevent infection. Because beta-glucans are contained in wide variety of foods and commensal microbiota, we investigated the effects of Dectin-1 signaling on the intestinal immunity. We found that Dectin-1-deficient mice were refractory to dextran sodium sulfate-induced colitis , a model for inflammatory bowel diseases , due to expansion of one genus of Gram-positive commensal bacteria in the colon associated with remodification of T cell subpopulations . Furthermore, oral administration of a seaweed-derived Dectin-1 antagonist, inhibited the proinflammatory cytokine production in colonic lamina propria cells and suppressed the development of colitis. These observations suggest that inhibition of Dectin-1 signaling in the colon regulates the balance of intestinal microbiota and cellular immunity , and further suppresses the development of inflammatory bowel diseases.

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Hydrogels: Preorganized Hydrogel: Self‐Healing Properties of Supramolecular Hydrogels Formed by Polymerization of Host–Guest‐Monomers that Contain Cyclodextrins and Hydrophobic Guest Groups (Adv. Mater. 20/2013)

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Advanced Materials 2013年第20期25卷

作者： Takahiro Kakuta Yoshinori Takashima Masaki Nakahata Miyuki Otsubo Hiroyasu Yamaguchi Akira Harada Department of Macromolecular Science Graduate School of Science Osaka University Toyonaka Osaka 560‐0043 Japan Core Research for Evolutional Materials Science and Technology (CREST) Japan Science and Technology Agency (JST) Sanban‐cho Building 4F 5 Sanban‐cho Chiyoda‐ku Tokyo 102‐0075 Japan

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Photoinduced magnetic bound state in an itinerant correlated electron system with a spin-state degree of freedom

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Physical Review B 2012年第4期86卷 045137-045137页

作者： Yu Kanamori Jun Ohara Sumio Ishihara Department of Physics Tohoku University Sendai 980-8578 Japan Core Research for Evolutional Science and Technology (CREST) Sendai 980-8578 Japan

The photoexcited state in a correlated electron system with a spin-state degree of freedom is studied. We start from the two-orbital extended Hubbard model where the energy difference between the two orbitals is introduced. The photoexcited metastable state is examined based on the effective model Hamiltonian derived using the two-orbital Hubbard model. Spin-state change is induced by photoirradiation in the low-spin band insulator near the phase boundary, and it is found that a high-spin state is stabilized by creating a ferromagnetic bound state with photodoped hole carriers. An optical absorption occurs between the bonding and antibonding orbitals inside the bound state. The time evolution of photoexcited states is simulated in the time-dependent mean-field scheme. It is found that pair annihilations of photodoped electrons and holes generate the high-spin state in a low-spin band insulator. We propose that this process is directly observed by the time-resolved photoemission experiments.

关键词： ELECTRON spin DEGREES of freedom BOUND states (Quantum mechanics) HIGH spin physics MEAN field theory ENERGY gaps (Physics) PHYSICS experiments

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Impacts of Temperature and Moisture on the Resistive Switching Characteristics of a Cu-Ta2O5-Based Atomic Switch

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MRS Online Proceedings Library 2012年第1期1430卷 25-30页

作者： Tsuruoka, Tohru Hasegawa, Tsuyoshi Terabe, Kazuya Aono, Masakazu International Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science (NIMS) Tsukuba Japan Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) Chiyoda-ku Japan

The effects of temperature and moisture on the resistive switching characteristics of oxide-based atomic switches were investigated to reveal their switching mechanism. The observed temperature variations of the SET voltages can be qualitatively explained by the classical nucleation theory. The moisture absorption in oxides results in the formation of a hydrogen-bond network at grain boundaries, and metal ions are likely to migrate along the grain boundaries. Depending on the strength of hydrogen bonds in oxides, the atomic switches exhibit a different switching behavior to ambient conditions.

关键词： memory oxide ionic conductor

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Tactic direction determined by the interaction between oscillatory chemical waves and rheological deformation in an amoeba

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Physical Review E 2012年第1期86卷 011927-011927页

作者： Kei-Ichi Ueda Seiji Takagi Toshiyuki Nakagaki Department of Complex and Intelligent Systems Faculty of Systems Information Science Future University Hakodate Hakodate 041-8655 Japan and Japan Science and Technology Agency Core Research for Evolutional Science and Technology Chiyoda-ku Tokyo 102-0075 Japan

The survival of an organism can depend upon the direction in which it decides to move in response to changes in external conditions. Here we propose a physicochemical mechanism of the decision process for migration direction in the case of a giant amoebalike Physarum plasmodium. The tactical movement response could be changed by reversal of the phase wave of the rhythmic contractions that occur in any part of the plasmodium body when local stimulation is applied and the frequency of the rhythmic contractions is locally modulated in the stimulated region. The proposed model describes a physicochemical mechanism of coupling between the local modulation of frequency and the global transport of protoplasmic mass. The decision process is clarified from a rheological point of view.

关键词： PHYSARUM MUSCLE contraction PLASMODIUM NEURAL stimulation OSCILLATIONS

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A polarization analyzing CMOS image sensor with metal wire grid in 65-nm standard CMOS technology

A polarization analyzing CMOS image sensor with metal wire g...

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International Meeting for Future of Electron Devices

作者： Norimitsu Wakama Hitoshi Matsuoka Keisuke Ando Toshihiko Noda Kiyotaka Sasagawa Takashi Tokuda Jun Ohta Graduate School of Materials Science Nara Institute of Science and Technology Ikoma Nara Japan Core Research for Evolutional Science and Technology CREST Japan Science and Technology Agency Kawaguchi Saitama Japan

In this paper, we demonstrate a CMOS image sensor with high extinction ratio on-chip polarizers with 65-nm standard CMOS technology. The polarizer is based on a metal wire grid fabricated with the metal wiring layers. The extinction ratio of 11.0 dB is achieved by a pixel with on-chip polarizer where the line / space widths are 90 nm / 90 nm.

关键词： Extinction ratio CMOS image sensors Metals CMOS integrated circuits Wires System-on-a-chip

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Development of a CMOS-based implantable device for wide-area brain functional imaging

Development of a CMOS-based implantable device for wide-area...

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International Meeting for Future of Electron Devices

作者： Makito Haruta Takuma Kobayashi Chikara Kitsumoto Toshihiko Noda Kiyotaka Sasagawa Takashi Tokuda Jun Ohta Graduate School of Materials Science Nara Institute of Science and Technology Ikoma Nara Japan Core Research for Evolutional Science and Technology CREST Japan Science and Technology Agency Kawaguchi Saitama Japan

We have developed a CMOS image sensor with hexagonally shaped outline for wide-area brain functional imaging. The hexagonal shape of the sensor chip allows covering wide area on curved surface of the brain by placing multiple chips. In this paper, we report two results for wide-area brain functional imaging. First, we designed a hexagonally shaped CMOS-based imaging device which has highly sensitive pixels and evaluated the characteristics of the sensor. Second, we successfully demonstrated fluorescent imaging using the sensor.

关键词： Fluorescence CMOS image sensors Sensitivity CMOS integrated circuits Brain Mice

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Biofuel Cells: Molecularly Ordered Bioelectrocatalytic Composite Inside a Film of Aligned Carbon Nanotubes (Adv. Energy Mater. 1/2013)

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Advanced Energy Materials 2013年第1期3卷

作者： Syuhei Yoshino Takeo Miyake Takeo Yamada Kenji Hata Matsuhiko Nishizawa Department of Bioengineering and Robotics Tohoku University 6‐6‐1 Aoba Sendai 980‐8579 Japan Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) Tokyo 102‐0075 Japan National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 5 1‐1‐1 Higashi Tsukuba Ibaraki 308‐8565 Japan

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Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice

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BMC research Notes 2012年第1期5卷 1-15页

作者： Shoji, Hirotaka Toyama, Keiko Takamiya, Yoshihiro Wakana, Shigeharu Gondo, Yoichi Miyakawa, Tsuyoshi Division of Systems Medical Science Institute for Comprehensive Medical Science Fujita Health University Toyoake Aichi Japan Japan Science and Technology Agency (JST) Core Research for Evolutional Science and Technology (CREST) Kawaguchi Saitama Japan National Museum of Emerging Science and Innovation Koto-ku Tokyo Japan Technology and Development Team for Mouse Phenotype Analysis Riken BioResource Center Tsukuba Ibaraki Japan Mutagenesis and Genomics Team Riken BioResource Center Tsukuba Ibaraki Japan Center for Genetic Analysis of Behavior National Institute for Physiological Sciences Okazaki Aichi Japan

Background: Disrupted-in-Schizophrenia 1 (DISC1) is considered to be a candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder, and major depression. A recent study reported that N-ethyl-N-nitrosourea (ENU)-induced mutations in exon 2 of the mouse Disc1 gene, which resulted in the amino acid exchange of Q31L and L100P, caused an increase in depression-like behavior in 31 L mutant mice and schizophrenia-like behavior in 100P mutant mice;thus, these are potential animal models of psychiatric disorders. However, remaining heterozygous mutations that possibly occur in flanking genes other than Disc1 itself might induce behavioral abnormalities in the mutant mice. Here, to confirm the effects of Disc1-Q31L and Disc1-L100P mutations on behavioral phenotypes and to investigate the behaviors of the mutant mice in more detail, the mutant lines were backcrossed to C57BL/6JJcl through an additional two generations and the behaviors were analyzed using a comprehensive behavioral test battery. Results: Contrary to expectations, 31 L mutant mice showed no significant behavioral differences when compared with wild-type control mice in any of the behavioral tests, including the Porsolt forced swim and tail suspension tests, commonly used tests for depression-like behavior. Also, 100P mutant mice exhibited no differences in almost all of the behavioral tests, including the prepulse inhibition test for measuring sensorimotor gating, which is known to be impaired in schizophrenia patients;however, 100P mutant mice showed higher locomotor activity compared with wild-type control mice in the light/dark transition test. Conclusions: Although these results are partially consistent with the previous study in that there was hyperactivity in 100P mutant mice, the vast majority of the results are inconsistent with those of the previous study;this discrepancy may be explained by differences in the genetic background of the mice, the laboratory environ

关键词： Mutant Mouse Behavioral Phenotype Prepulse Inhibition Tail Suspension Test Startle Stimulus

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