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9th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2005

作者： Tamaki, E. Hibara, A. Tsukahara, T. Kim, H.B. Kitamori, T. Core Research for Evolutional Science and Technology Japan Science and Technology Agency Japan Department of Applied Chemistry School of Engineering University of Tokyo Tokyo Japan Kanagawa Academy of Science and Technology Kawasaki Japan

ISBN: (纸本)0974361119

We developed a pressure-driven flow control system for chemical reaction in nanochannel. In this system, back pressure regulating was utilized to prevent the high pressure loss, which is usually occured in nanochannel. We evaluated the back pressure regulating system by investigating the flow rate in nanochannel. By utilizing the flow control system, chemical reaction in nanochannel was demonstrated. Two different solution for chemical reaction were simultaneously introduced into Y-shaped nanochannel and chemical reaction in nanochannel was performed. Copyright © 2005 by the Transducer research Foundation, Inc.

关键词： Chemical reactions

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Fine Size Control of Platinum on Carbon Nanotubes: From Single Atoms to Clusters†

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Angewandte Chemie 2006年第3期118卷

作者： Yong‐Tae Kim Kazuyoshi Ohshima Koichi Higashimine Tomoya Uruga Masaki Takata Hiroyoshi Suematsu Tadaoki Mitani Department of Physical Materials Science School of Materials Science Japan Advanced Institute of Science and Technology (JAIST) 1‐1 Asahidai Nomi Ishikawa 923‐1292 Japan Fax: (+81) 761‐51‐1149 Center for Nano Materials and Technology Japan Advanced Institute of Science and Technology (JAIST) 1‐1 Asahidai Nomi Ishikawa 923‐1292 Japan Japan Synchrotron Radiation Research Institute (JASRI)/SPring‐8 1‐1‐1 Kouto Mikazuki Hyogo 679‐5198 Japan Core Research for Evolutional Science and Technology Japan Science Technology Cooperation (CREST/JST) 4‐1‐8 Honcho Kawaguchi Saitama 332‐0012 Japan

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Fabrication of porous polyimide nanoparticles with controllable morphology

Fabrication of porous polyimide nanoparticles with controlla...

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54th SPSJ Symposium on Macromolecules

作者： Zhao, Gufan Ishizaka, Takayuki Kasai, Hitoshi Oikawa, Hidetoshi Nakanishi, Hachiro Institute of Multidisciplinary Research for Advanced Materials Tohoku University 2-1-1 Katahira Aobaku Sendai 980-8577 Japan Core Research for Evolutional Science and Technology Japan Science and Technology Agency

Porous polyimide (PI) nanoparticles with pores in the form of spherical void were fabricated by adding a second polymer (e.g., poly(acrylic acid)) as a template, which acted as the source of porosity, via the reprecipitation method. The morphology of porous particles was mainly affected by the miscibility of poly(amic acid) (PAA, precursor of PI) and the template. And the diameter of pores varied in the range of 30-100 nm simply by changing the content of proper template. It provides a unique approach for dielectric applications with extendibility to the ultra-low dielectric constant regime (k <2.0).

关键词： Nanostructured materials

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Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

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European Journal of Immunology 2006年第4期29卷

作者： Tomohiro Kodama Kazuyoshi Takeda Osamu Shimozato Yoshihiro Hayakawa Machiko Atsuta Kimio Kobayashi Mamoru Ito Hideo Yagita Ko Okumura Department of Immunology Juntendo University School of Medicine Bunkyo-ku Tokyo Japan First Department of Surgery Tohoku University School of Medicine Sendai Japan Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation Chiyoda-ku Tokyo Japan Department of Pathogenic Biochemistry Reserach Institute of Wakan-yaku Toyama Medical and Pharmaceutical University Toyama Japan Central Institute for Experimental Animals Nogawa Miyamae Kawasaki Japan

IL-12 exerts a potent anti-tumor effect, which is possibly mediated by multiple mechanisms including activation of NK and NKT cells, induction of cytotoxic T lymphocytes, and inhibition of angiogenesis. In the present study, we characterized the cytotoxic effector cells and mechanisms responsible for the anti-metastatic effect of IL-12. Administration of IL-12 had a comparable inhibitory effect on experimental lung metastasis of B16 melanoma cells in wild-type C57BL / 6 mice and RAG-2 − / − mice that lack T and NKT cells, which was abolished by depletion of NK cells. Cytotoxic activity of liver and splenic mononuclear cells against B16 was induced by IL-12 administration in RAG-2 − / − mice at a level comparable to that in wild-type mice, which was also abolished by depletion of NK cells. Moreover, the anti-metastatic effect of IL-12 was abrogated by perforin deficiency, but not by Fas ligand deficiency, in association with a lack of IL-12-induced cytotoxic activity of liver and splenic mononuclear cells against B16. These results suggest that perforin-dependent cytotoxicity of IL-12-activated NK cells is sufficient for the anti-metastatic effect of IL-12.

关键词： IL-12 Perforin NK cell

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Synthesis and template effects of resorcinol-based polymer nanostructures

Synthesis and template effects of resorcinol-based polymer n...

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54th SPSJ Annual Meeting 2005

作者： Fujikawa, Daisuke Uota, Masafumi Yoshimura, Takumi Sakai, Go Kijima, Tsuyoshi Department of Applied Chemistry Miyazaki University Core Research for Evolutional Science and Technology 1-1 Nishi Gakuenkibanadai Miyazaki-shi 889-2192 Japan

Recently, we have reported the synthesis of phenol-furfural (or formaldehyde) polymer nanotubes in the presence of cationic surfactant as the template. But it was unsuccessful to apply these nanotubes to proton conductors and carbon precursors, due to chemical and thermal instability of their frameworks. Here we report the synthesis of nanostructural polymer materials through resorcinol-formaldehyde copolymerization in the presence of CnTAB (n=16, 18).

关键词： Nanostructured materials

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Nano-phase separation structure of monolayer of triblock copolymer having azobenzene moiety

Nano-phase separation structure of monolayer of triblock cop...

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54th SPSJ Annual Meeting 2005

作者： Kadota, Souhei Aoki, Kenji Nagano, Shusaku Seki, Takahiro Graduate School of Engineering Nagoya Univ Chikusa-ku Nagoya 464-8603 Japan Core Research for Evolutional Science and Technology Japan Science and Technology Chikusa-ku Nagoya 464-8603 Japan

We studied the 2D microphase separation behavior a novel azobenzne-containing ABA triblock copolymer on a substrate. The target polymers with narrow polydispersity were synthesized from polyethylene glycol and azobenzene methacrylate via ATRP method. The micro-phase separation in the monolayer of trans-Az gave a mixture of dod and rod. The cis-Az monolayer gave elongated flat stripes. In the cis-Az, stripe morphology was converted to dot by thermal reversion for 6 days. This fact suggests that the PEO block preferentially adopts loop conformations.

关键词： Block copolymers

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Conformation of triblock copolymer having azobenzene moiety in 2D state

Conformation of triblock copolymer having azobenzene moiety ...

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54th SPSJ Symposium on Macromolecules

作者： Kadota, Souhei Aoki, Kenji Nagano, Shusaku Seki, Takahiro Graduate School of Engineering Nagoya Univ. Chikusa-ku Nagoya 464-8603 Japan Core Research for Evolutional Science and Technology Japan Science and Technology Chikusa-ku Nagoya 464-8603 Japan

We studied the monolayer nano-phase separation structure of an ABA triblock copolymer comprising of azobenzene-containing methacrylate and poly(ethylene oxide) as A and B block, respectively. The micro-phase separation in the monolayer of trans-Az gave a mixture of dod and rod. The cis-Az monolayer gave elongated flat stripes. We observed the morphological change of the monolayer on mica induced by photoisomerization of azobenzene under high humidity. In the cis-Az, stripe morphology was converted to dot by thermal reversion for 6 days. This fact suggests that the PEO block preferentially adopts loop conformations.

关键词： Block copolymers

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Linkage between innate and acquired immunities at the mucosa

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International Congress Series 2005年第0期1285卷 84-93页

作者： Igarashi, Osamu Nochi, Tomonori Terahara, Kazutaka Kiyono, Hiroshi Division of Mucosal Immunology Institute of Medical Science The University of Tokyo Minato-ku 108-8639 Tokyo 4-6-1 Shirokanedai Japan Core Research for Evolutional Science and Technology Agency (CREST) Japan Science and Technology Corporation (JST) Saitama Japan

The epithelium covering mucosal tissues consists of epithelial cells (ECs) and intraepithelial lymphocytes (IELs), which constitutes the first line of defense against infection by microorganisms, through mucosal innate and acquired immunity. One of the principal roles of the mucosal epithelium is to form a strong physical barrier such as tight junction to prevent microbial penetration. While adhesion mechanisms between ECs have been extensively studied, there are few investigations on the mechanisms between ECs and IELs. Our findings indicate that a homophylic adhesion molecule termed epithelial cell adhesion molecule (Ep-CAM) is also expressed in IELs in addition to ECs, thus forming a physical interaction between ECs and IELs. In addition, we also characterized the expression and function of Toll-like receptors (TLRs) in mucosal epithelium using human corneal epithelial cells (HCEs). TLRs are mainly expressed by antigen presenting cells (APCs) and recognize pathogen-associated molecular patterns (PAMPs). However, responsiveness via TLR2 and TLR4 in HCEs was impaired, presumably due to restricted expression of the TLRs in the cytoplasm. These findings suggest that mucosal epithelium may create a state of tolerance in order to avoid unnecessary response to environmental and commensal antigens via TLRs. However, the mucosal surfaces that cover gut and respiratory lymphoid tissues such as Peyer's patch and nasopharynx-associated lymphoid tissue (NALT) are equipped with the gateway system which effectively uptake the outside antigens via M cells to initiate both the positive and negative immune responses. We recently identified M cell-like cells that are located within the villous epithelium and involved in antigen-transport into the lamina propria. Therefore, we designated them as villous M cells. These findings suggest that mucosal immune system is equipped with multiple layers of induction/suppression mechanisms for the regulation of mucosal innate and acquired immu

关键词： (Ep-CAM) Epithelial cell adhesion molecule IEL M cell TLR

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Cover Picture: A PEG-Based Biocompatible Block Catiomer with High Buffering Capacity for the Construction of Polyplex Micelles Showing Efficient Gene Transfer toward Primary Cells (ChemMedChem 4/2006)

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ChemMedChem 2006年第4期1卷 389-389页

作者： Naoki Kanayama Dr. Shigeto Fukushima Nobuhiro Nishiyama Dr. Keiji Itaka Dr. Woo-Dong Jang Dr. Kanjiro Miyata Yuichi Yamasaki Dr. Ung-il Chung Prof. Dr. Kazunori Kataoka Prof. Dr. Department of Materials Engineering Graduate School of Engineering The University of Tokyo Tokyo 113-8656 Japan Fax: (+81) 3-5841-7139 Core Research for Evolutional Science and Technology (CREST) Japan Science and Technology Agency (JST) Japan R & D Division Pharmaceuticals Group Nippon Kayaku Co. Ltd. Japan Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo Tokyo 113-0033 Japan Fax: (+81) 3-5841-7139

The cover picture shows highly transfection-efficient and less toxic polyplex micelles formed by the electrostatic interaction between DNA and block catiomers equipped with an ethylenediamine unit at the side chain. The catiomers undergo a conformational transition of the ethylenediamine unit from the gauche (mono-protonated) to the anti (di-protonated) form as the pH decreases from physiological to acidic conditions, providing a high buffering capacity for efficient transfection. The polyplex micelles showed effective and non-cytotoxic transfection of a green fluorescent protein (GFP) gene into mouse primary osteoblast cells (background). For more details, see the full paper by N. Kanayama et al. on p. 439 ff.

关键词： aminolysis block copolymers gene delivery polycations polymeric micelles

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Peptide nucleic acid-modified carbon nanotube field-effect transistor for ultra-sensitive real-time detection of DNA hybridization

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Nanobiotechnology 2005年第1期1卷 65-70页

作者： Kerman, Kagan Morita, Yasutaka Takamura, Yuzuru Tamiya, Eiichi Maehashi, Kenzo Matsumoto, Kazuhiko School of Materials Science Japan Advanced Institute of Science and Technology Ishikawa 923-1211 1-1 Asahidai Tatsunokuchi Japan Institute of Scientific and Industrial Research Osaka University Ibaraki Osaka 567-0047 8-1 Mihogaoka Japan Core Research for Evolutional Science and Technology Japan Science and Technology Corporation Saitama 312-0012 4-1-8 Honmachi Kawaguchi Japan

We have developed a nanosensor array composed of carbon nanotube field-effect transistors (CNTFETs) on SiO2/Si substrates. Unlike previously reported CNTFETs where the recognition event occurred directly on the CNT, in this case, the reverse surface of the substrate was utilized for the biomolecular functionalization. A self-assembled monolayer (SAM) of peptide nucleic acid (PNA) probes associated with the tumor necrosis factor-α gene (TNF-α) was attached onto the gold electrode on the reverse side of the CNTFET device. A time-dependent conductance increase was monitored upon sequential introduction of wild-type (WT) DNA samples through a microfluidic channel of the poly(dimethylsiloxane) (PDMS) chip. High selectivity of PNA probes only toward the full-complementary WT DNA samples enabled rapid and simple discrimination against single-nucleotide polymorphism (SNP) or non-complementary (NC) DNA. Concentration-dependent measurements indicated a limit-of-detection (LOD) of 6.8 fM WT DNA. Our CNTFET-based biochip is a promising candidate for the development of an integrated, high-throughput, portable device for nucleic acid-based diagnostics. Copyright © 2005 Humana Press Inc. All rights of any nature whatsoever are reserved.

关键词： Biosensor Carbon nanotube field-effect transistor DNA hybridization Nanosensor PNA

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