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The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels (vol 400, pg 1619, 2022)

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LANCET 2022年第10365期400卷 1766-1766页

作者： Romanello, M. Di Napoli, C. Drummond, P. Institute for Global Health University College London London UK School of Agriculture Policy and Development University of Reading Reading UK Institute for Sustainable Resources University College London London UK Department of Global Health Centre for Health and the Global Environment University of Washington Seattle WA USA UCL Energy Institute University College London London UK Department of Health Sciences University of York York UK Department of Meteorology University of Reading Reading UK Institute for Risk and Disaster Reduction University College London London UK School of Earth and Environment University of Leeds Leeds UK Centre on Climate Change and Planetary Health London School of Hygiene & Tropical Medicine London UK School of Population Health University of Melbourne Melbourne VIC Australia Department of Earth System Science Tsinghua University Beijing China Mercator Research Institute on Global Commons and Climate Change Berlin Germany Department of Environment Climate Change and Health World Health Organization Geneva Switzerland Institute of Environmental Sciences University of Geneva Geneva Switzerland Cardiovascular Epidemiology Unit Department of Public Health & Primary Care University of Cambridge Cambridge UK School of Government University of Birmingham Birmingham UK Economic Analysis of Climate Impacts and Policy Division Centro Euro-Mediterraneo sui Cambiamenti Climatici Venice Italy Institute for Environmental Design and Engineering University College London London UK Natural Resources Institute University of Greenwich London UK Department of Environmental Health Sciences and Yale Center on Climate Change and Health Yale University New Haven CT USA Department of Civil and Environmental Engineering Northeastern University Boston MA USA Department of Fish and Wildlife Conservation Virginia Polytechnic Institute and State University Blacksburg VA USA Department of Geography University College London London UK NU

With advancements in the science of detection and attribution studies, the influence of climate change over many events has now been quantified. Because of the rapidly increasing temperatures, vulnerable populations (adults older than 65 years, and children younger than one year of age) were exposed to 3·7 billion more heatwave days in 2021 than annually in 1986–2005 (indicator 1.1.2), and heat-related deaths increased by 68% between 2000–04 and 2017–21 (indicator 1.1.5), a death toll that was significantly exacerbated by the confluence of the COVID-19 pandemic. Despite the local cooling and overall health benefits of urban greenspaces, only 277 (27%) of 1038 global urban centres were at least moderately green in 2021 (indicator 2.2.3), and the number of households with air conditioning increased by 66% from 2000 to 2020, a maladaptive response that worsens the energy crisis and further increases urban heat, air pollution, and greenhouse gas emissions. [...]millions of people do not have access to the energy needed to keep their homes at healthy temperatures, preserve food and medication, and meet the seventh Sustainable development Goal (to ensure access to affordable, reliable, sustainable, and modern energy for all). Aggravating this situation even further, governments continue to incentivise fossil fuel production and consumption: 69 (80%) of 86 countries reviewed had net-negative carbon prices (ie, provided a net subsidy to fossil fuels) for a net total of US$400 billion

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Erratum to “Implications of Implementing Promulgated and Prospective Emission Regulations on Air Quality and Health in India during 2030”

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Aerosol and Air Quality research 2023年第5期23卷 1-1页

作者： Debnath, Sreyashi Karumuri, Rama Krishna Govardhan, Gaurav Jat, Rajmal Saini, Himadri Vispute, Akash Kulkarni, Santosh H. Jena, Chinmay Kumar, Rajesh Chate, D. M. Ghude, Sachin D. Indian Institute of Tropical Meteorology (IITM) Ministry of Earth Sciences Pune India Department of Atmospheric and Space Sciences Savitribai Phule Pune University Pune India King Abdullah University of Science and Technology Thuwal Saudi Arabia National Center for Medium Range Weather Forecasting Ministry of Earth Sciences Noida India University of New South Wales (UNSW) Sydney Australia Centre for Development of Advanced Computing (C-DAC) Pune India India Meteorological Department New Delhi India National Center for Atmospheric Research Boulder USA

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Introduction to Deep Learning Business Applications for Developers 1st ed.

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丛书名： For professionals by professionals

2018年

作者： Armando Vieira Bernardete Ribeiro

ISBN: (数字)9781484234532

ISBN: (纸本)9781484234525

Discover the potential applications, challenges, and opportunities of deep learning from a business perspective with technical examples. These applications include image recognition, segmentation and annotation, video processing and annotation, voice recognition, intelligent personal assistants, automated translation, and autonomous vehicles. An Introduction to Deep Learning Business Applications for Developers covers some common DL algorithms such as content-based recommendation algorithms and natural language processing. Youll explore examples, such as video prediction with fully convolutional neural networks (FCNN) and residual neural networks (ResNets). You will also see applications of DL for controlling robotics, exploring the DeepQ learning algorithm with Monte Carlo Tree search (used to beat humans in the game of Go), and modeling for financial risk assessment. There will also be mention of the powerful set of algorithms called Generative Adversarial Neural networks (GANs) that can be applied for image colorization, image completion, and style transfer. After reading this book you will have an overview of the exciting field of deep neural networks and an understanding of most of the major applications of deep learning. The book contains some coding examples, tricks, and insights on how to train deep learning models using the Keras framework. What You Will Learn Find out about deep learning and why it is so powerful Work with the major algorithms available to train deep learning models See the major breakthroughs in terms of applications of deep learning Run simple examples with a selection of deep learning libraries Discover the areas of impact of deep learning in business Who This Book Is ForData scientists, entrepreneurs, and business developers.

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Targeting druggable proteins hisB, aroC, and trpD in the co-diphtheria infection caused by Corynebacterium ulcerans with Traditional Chinese Medicine

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Heliyon 2025年

作者： Sania Kanwal Ayesha Wisal Saman Sohail Paulo VS. Daltron Muhammad Shafique Muhammad Imran Ihosvany Camps Syed S. Hassan Department of Chemistry Islamia College Peshawar Peshawar-KP Pakistan 25000 Centre for Technological Development in Health (CDTS) Fiocruz Rio de Janeiro RJ 21040-361 Brazil Department of Pharmaceutical Sciences College of Pharmacy Shaqra University Shaqra Saudi Arabia Research Center for Advanced Materials Science (RCAMS) Department of Chemistry Faculty of Science King Khalid University Abha Aseer 61413 P.O. Box 9004 Saudi Arabia High Performance & Quantum Computing Labs Waterloo Canada Laboratório de Modelagem Computacional—LaModel Instituto de Ciências Exatas—ICEx. Universidade Federal de Alfenas—UNIFAL-MG Alfenas Minas Gerais Brazil JRC Genome Research International Center for Chemical and Biological Sciences (PCMD-ICCBS) University of Karachi Pakistan 75270

Corynebacterium ulcerans is a rod-shaped emerging zoonotic pathogen responsible for diphtheria-like infections in humans, posing a significant health threat to public due to its toxigenic potential and ability to affect multiple hosts. This study employed a subtractive genomics / proteomics approach to identify novel therapeutic targets. A total of 900 conserved non-host homologous proteins were identified across 20 C. ulcerans strains, of which 49 essential proteins were shortlisted based on their essential role in bacterial survival. Among these, hisB , aroC , and trpD were prioritized as potential drug targets due to their gene essentiality, PPI, critical roles in metabolic pathways, virulence, cellular localization, and druggability. These targets were subjected to molecular docking studies against a Traditional Chinese Medicine (TCM) compound library of 36,043 molecules. Lead compounds displayed strong binding affinities and favorable interactions with the active sites of the target proteins. Molecular dynamics simulations validated the stability of the protein-ligand complexes over 200 ns, further confirming the favorable interaction of the therapeutic targets. Functional pathways analysis highlighted the essential role in histidine, aromatic amino acid, and tryptophan biosynthesis, critical for bacterial viability. These findings provide valuable insights into the design of novel antimicrobial agents targeting C. ulcerans and pave the way for experimental validation of the identified drug candidates.

关键词： Corynebacterium ulcerans Diphtheria co-infection Subtractive proteomics Drug Discovery MD simulations

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Corrigendum to “Hybridizing flower pollination algorithm with particle swarm optimization for enhancing the performance of IPv6 intrusion detection system” [Alex. Eng. J. 104 (2024) 504–514]

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Alexandria Engineering Journal 2025年 110卷 376-376页

作者： Adnan Hasan Bdair AIghuraibawi Selvakumar Manickam Zaid Abdi Alkareem Alyasseri Rosni Abdullah Ayman Khallel Riyadh Rahef Nuiaa Al Ogaili Fahd N. Al-Wesabi Abdulsamad Ebrahim Yahya National Advanced IPv6 Centre (NAv6) Universiti Sains Malaysia Penang 11800 Malaysia Baghdad College of Economic Sciences University Baghdad Iraq Information Technology Research and Development Center University of Kufa Najaf Iraq College of Engineering University of Warith Al-Anbiyaa Karbala Iraq School of Computer Sciences Universiti Sains Malays Penang 11800 Malaysia Faculty of Computing and Informatics Universiti Malaysia Sabah Sabah Malaysia Department of Cybersecurity Engineering Technology Al Hikma University College Baghdad Iraq Department of Computer Science/ College of Computer Science and Information Technology Wasit University Kut Wasit 52001 Iraq Department of Computer Science College of Science & Art at Mahayil King Khalid University Saudi Arabia Department of Information Technology College of Computing and Information Technology Northern Border University Arar Saudi Arabia

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Overcoming the disconnect between energy system and climate modelling

arXiv

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arXiv 2022年

作者： Craig, Michael T. Wohland, Jan Stoop, Laurens P. Kies, Alexander Pickering, Bryn Bloomfield, Hannah C. Browell, Jethro De Felice, Matteo Dent, Chris J. Deroubaix, Adrien Frischmuth, Felix Gonzalez, Paula L.M. Grochowicz, Aleksander Gruber, Katharina Härtel, Philipp Kittel, Martin Kotzur, Leander Labuhn, Inga Lundquist, Julie K. Pflugradt, Noah van der Wiel, Karin Zeyringer, Marianne Brayshaw, David J. School for Environment and Sustainability University of Michigan United States Institute for Environmental Decisions ETH Zurich Switzerland Helmholtz-Zentrum Hereon Germany Information and Computing Science Copernicus Institute of Sustainable Development Utrecht University Netherlands TenneT TSO B.V. Arnhem Netherlands Royal Netherlands Meteorological Institute Netherlands Frankfurt Institute for Advanced Studies Germany Department of Electrical and Computer Engineering Aarhus University Denmark ETH Zürich Switzerland School of Geographical Sciences University of Bristol United Kingdom Department of Meteorology University of Reading United Kingdom University of Glasgow United Kingdom European Commission Joint Research Centre Netherlands School of Mathematics University of Edinburg United Kingdom The Alan Turing Institute United Kingdom Max Planck Institute Germany Fraunhofer Institute for Energy Economics and Energy System Technology Germany Department of Mathematics University of Oslo Norway University of Natural Resources and Life Sciences Austria German Institute for Economic Research Germany Institute of Energy and Climate Research Techno-economic Systems Analysis Germany University of Bremen Institute of Geography Germany Dept. of Atmospheric and Oceanic Science University of Colorado Boulder United States National Renewable Energy Laboratory United States Renewable and Sustainable Energy Institute United States Forschungszentrum Jülich Germany Department of Technology Systems University of Oslo Norway

Energy system models underpin decisions by energy system planners and operators. Energy system modelling faces a transformation: accounting for changing meteorological conditions imposed by climate change. To enable that transformation, a community of practice in energy-climate modelling has started to form that aims to better integrate energy system models with weather and climate models. Here, we evaluate the disconnects between the energy system and climate modelling communities, then lay out a research agenda to bridge those disconnects. In the near-term, we propose interdisciplinary activities for expediting uptake of future climate data in energy system modelling. In the long-term, we propose a transdisciplinary approach to enable development of (1) energy-system-tailored climate datasets for historical and future meteorological conditions and (2) energy system models that can effectively leverage those datasets. This agenda increases the odds of meeting ambitious climate mitigation goals by systematically capturing and mitigating climate risk in energy sector decision making. © 2022, CC BY-NC-ND.

关键词： Decision making

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FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare

arXiv

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arXiv 2023年

作者： Lekadir, Karim Feragen, Aasa Fofanah, Abdul Joseph Frangi, Alejandro F. Buyx, Alena Emelie, Anais Lara, Andrea Porras, Antonio R. Chan, An-Wen Navarro, Arcadi Glocker, Ben Botwe, Benard O. Khanal, Bishesh Beger, Brigit Wu, Carol C. Cintas, Celia Langlotz, Curtis P. Rueckert, Daniel Mzurikwao, Deogratias Fotiadis, Dimitrios I. Zhussupov, Doszhan Ferrante, Enzo Meijering, Erik Weicken, Eva González, Fabio A. Asselbergs, Folkert W. Prior, Fred Krestin, Gabriel P. Collins, Gary S. Tegenaw, Geletaw S. Kaissis, Georgios Misuraca, Gianluca Tsakou, Gianna Dwivedi, Girish Kondylakis, Haridimos Jayakody, Harsha Woodruf, Henry C. Mayer, Horst Joachim Aerts, Hugo JWL Walsh, Ian Chouvarda, Ioanna Buvat, Irène Tributsch, Isabell Rekik, Islem Duncan, James Kalpathy-Cramer, Jayashree Zahir, Jihad Park, Jinah Mongan, John Gichoya, Judy W. Schnabel, Julia A. Kushibar, Kaisar Riklund, Katrine Mori, Kensaku Marias, Kostas Amugongo, Lameck M. Fromont, Lauren A. Maier-Hein, Lena Alberich, Leonor Cerdá Rittner, Leticia Phiri, Lighton Marrakchi-Kacem, Linda Donoso-Bach, Lluís Martí-Bonmatí, Luis Cardoso, M. Jorge Bobowicz, Maciej Shabani, Mahsa Tsiknakis, Manolis Zuluaga, Maria A. Bielikova, Maria Fritzsche, Marie-Christine Camacho, Marina Linguraru, Marius George Wenzel, Markus De Bruijne, Marleen Tolsgaard, Martin G. Ghassemi, Marzyeh Ashrafuzzaman, Md Goisauf, Melanie Yaqub, Mohammad Abadía, Mónica Cano Mahmoud, Mukhtar M.E. Elattar, Mustafa Rieke, Nicola Papanikolaou, Nikolaos Lazrak, Noussair Díaz, Oliver Salvado, Olivier Pujol, Oriol Sall, Ousmane Guevara, Pamela Gordebeke, Peter Lambin, Philippe Brown, Pieta Abolmaesumi, Purang Dou, Qi Lu, Qinghua Osuala, Richard Nakasi, Rose Zhou, S. Kevin Napel, Sandy Colantonio, Sara Albarqouni, Shadi Joshi, Smriti Carter, Stacy Klein, Stefan Petersen, Steffen E. Aussó, Susanna Awate, Suyash Raviv, Tammy Riklin Cook, Tessa Mutsvangwa, Tinashe E.M. Rogers, Wendy A. Niessen, Wiro J. Puig-Bosch, Xènia Zeng, Yi Mohammed, Yunusa G. Aquino, Yves Saint James Salahuddin, Zohaib Starmans, Martijn P.A. Department de Matemàtiques i Informàtica Universitat de Barcelona Barcelona Spain Barcelona Spain DTU Compute Technical University of Denmark Kgs Lyngby Denmark Department of Mathematics and Computer Science Faculty of Science and Technology Milton Margai Technical University Freetown Sierra Leone Center for Computational Imaging & Simulation Technologies in Biomedicine Schools of Computing and Medicine University of Leeds Leeds United Kingdom Cardiovascular Science and Electronic Engineering Departments KU Leuven Leuven Belgium Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Faculty of Engineering of Systems Informatics and Sciences of Computing Galileo University Guatemala City Guatemala Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Department of Medicine Women’s College Research Institute University of Toronto Toronto Canada Universitat Pompeu Fabra BarcelonaBeta Brain Research Center Barcelona Spain Department of Computing Imperial College London London United Kingdom School of Biomedical & Allied Health Sciences University of Ghana Accra Ghana Department of Midwifery & Radiography School of Health & Psychological Sciences City University of London United Kingdom Kathmandu Nepal European Heart Network Brussels Belgium Department of Thoracic Imaging University of Texas MD Anderson Cancer Center Houston United States IBM Research Africa Nairobi Kenya Departments of Radiology Medicine and Biomedical Data Science Stanford University School of Medicine Stanford United States Institute for AI and Informatics in Medicine Klinikum rechts der Isar Technical University Munich Munich Germany Department of Computing Imperial College London London United Kingdom Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania United Republic of Ioannina Greece Almaty AI Lab Almaty Kazakhstan

Background: Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. In recent years, concerns have been raised about the clinical, technical, ethical and legal risks associated with healthcare AI. To increase adoption in the real world, it is essential that AI technologies are trusted and accepted by patients, clinicians, health organisations and authorities. This paper describes the FUTURE-AI framework as the first international consensus guideline for trustworthy AI in healthcare. Methods: The FUTURE-AI consortium was founded in 2021 and now comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two-year period, the consortium established guiding principles and best practices for trustworthy and deployable AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. Findings: The FUTURE-AI framework was established based on six guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 30 best practices were defined, addressing technical, clinical, socio-ethical and legal dimensions of trustworthy AI. The recommendations cover the entire lifecycle of healthcare AI, from design, development and validation to regulation, deployment, and monitoring. Interpretation: FUTURE-AI is a structured, risk-informed framework which provides guidance for constructing healthcare AI tools that will be trusted, deployed and adopted in real-world clinical practice. researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of healthcare AI. Copyright © 2023, The Authors. All rights

关键词： Clinical research

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ShenTu: Processing Multi-Trillion Edge Graphs on Millions of Cores in Seconds 18

ShenTu: Processing Multi-Trillion Edge Graphs on Millions of...

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ACM/IEEE International Conference for High Performance computing, Networking, Storage, and Analysis

作者： Heng Lin Xiaowei Zhu Bowen Yu Xiongchao Tang Wei Xue Wenguang Chen Lufei Zhang Torsten Hoefler Xiaosong Ma Xin Liu Weimin Zheng Jingfang Xu Tsinghua University and Fma Technology Tsinghua University and Qatar Computing Research Institute Tsinghua University State Key Laboratory of Mathematical Engineering and Advanced Computing ETH Zurich Qatar Computing Research Institute National Research Centre of Parallel Computer Engineering and Technology Beijing Sogou Technology Development Co. Ltd

ISBN: (纸本)9781538683859

Graphs are an important abstraction used in many scientific fields. With the magnitude of graph-structured data constantly increasing, effective data analytics requires efficient and scalable graph processing systems. Although HPC systems have long been used for scientific computing, people have only recently started to assess their potential for graph processing, a workload with inherent load imbalance, lack of locality, and access irregularity. We propose ShenTu ⁸ the first general-purpose graph processing framework that can efficiently utilize an entire Petascale system to process multi-trillion edge graphs in seconds. ShenTu embodies four key innovations: hardware specialization, supernode routing, on-chip sorting, and degree-aware messaging, which together enable its unprecedented performance and scalability. It can traverse a record-size 70-trillion-edge graph in seconds. Furthermore, ShenTu enables the processing of a spam detection problem on a 12-trillion edge Internet graph, making it possible to identify trustworthy and spam webpages directly at the fine-grained page level.

关键词： Random access memory Servers Data analysis Supercomputers Task analysis Computer architecture Optimization supercomputer task analysis random access machine Computer Architecture Servers Data analysis core Core samples Scalability Edge of a figure or solid Unsolicited electronic mail

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Smart city: A GECAD-BISITE energy management case study 15th

Smart city: A GECAD-BISITE energy management case study

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15th International Conference on Practical Applications of Agents and Multi-Agent Systems, PAAMS 2017

作者： Canizes, Bruno Pinto, Tiago Soares, João Vale, Zita Chamoso, Pablo Santos, Daniel GECAD – Research Group on Intelligent Engineering and Computing for Advanced Innovation and Development Institute of Engineering Polytechnic of Porto Porto Portugal BISITE Research Centre University of Salamanca Salamanca Spain

ISBN: (纸本)9783319615776

This paper presents the demonstration of an energy resources management approach using a physical smart city model environment. Several factors from the industry, governments and society are creating the demand for smart cities. In this scope, smart grids focus on the intelligent management of energy resources in a way that the use of energy from renewable sources can be maximized, and that the final consumers can feel the positive effects of less expensive (and pollutant) energy sources, namely in their energy bills. A large amount of work is being developed in the energy resources management domain, but an effective and realistic experimentation are still missing. This work thus presents an innovative means to enable a realistic, physical, experimentation of the impacts of novel energy resource management models, without affecting consumers. This is done by using a physical smart city model, which includes several consumers, generation units, and electric vehicles. © Springer International Publishing AG 2018.

关键词： Smart power grids

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Tools control center to enable the joint simulation of multi-agent systems 15th

Tools control center to enable the joint simulation of multi...

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15th International Conference on Practical Applications of Agents and Multi-Agent Systems, PAAMS 2017

作者： Teixeira, Brígida Pinto, Tiago Santos, Gabriel Praça, Isabel Vale, Zita GECAD – Research Group on Intelligent Engineering and Computing for Advanced Innovation and Development Institute of Engineering – Polytechnic of Porto Porto Portugal BISITE – Research Centre University of Salamanca Salamanca Spain

ISBN: (纸本)9783319615776

The penetration of micro-generation brings complex problems to the energy field. In this way, various simulators were designed to give decision support for the stakeholders, however, they intent to solve very specific problems. The proposed tool enables the interoperability between heterogeneous simulators, to simulate more complex problems. © Springer International Publishing AG 2018.

关键词： Multi agent systems

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