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Metadata Concepts for Advancing the Use of Digital Health Technologies in Clinical Research

Digital Biomarkers 2019年第3期3卷 116-132页

作者： Badawy, Reham Hameed, Farhan Bataille, Lauren Little, Max A. Claes, Kasper Saria, Suchi Cedarbaum, Jesse M. Stephenson, Diane Neville, Jon Maetzler, Walter Espay, Alberto J. Bloem, Bastiaan R. Simuni, Tanya Karlin, Daniel R. School of Computer Science University of Birmingham Birmingham United Kingdom Digital Medicine and Pfizer Innovation Research Lab Early Clinical Development Pfizer Inc. CambridgeMA United States College of Computer and Information Science Northeastern University BostonMA United States Analytics Informatics and Business Intelligence Chief Digital Office Pfizer Inc. New YorkNY United States Michael J. Fox Foundation for Parkinson's Research New YorkNY United States Media Lab Massachusetts Institute of Technology CambridgeMA United States UCB Biopharma Brussels Belgium Machine Learning and Healthcare Laboratory Departments of Computer Science Statistics and Health Policy Malone Center for Engineering in Healthcare Armstrong Institute for Patient Safety and Quality Johns Hopkins University BaltimoreMD United States Biogen CambridgeMA United States Critical Path Institute TucsonAZ United States Clinical Data Interchange Standards Consortium AustinTX United States Department of Neurology Christian Albrecht University Kiel Germany James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders University of Cincinnati CincinnatiOH United States Department of Neurology Donders Institute for Brain Cognition and Behavior Radboud University Medical Center Nijmegen Netherlands Department of Neurology Gardner Center for Parkinson's Disease and Movement Disorders UC Gardner Neuroscience Institute University of Cincinnati CincinnatiOH United States Tufts University School of Medicine BostonMA United States HealthMode New YorkNY United States School of Engineering and Applied Science Aston University BirminghamB47ET United Kingdom

Digital health technologies (smartphones, smartwatches, and other body-worn sensors) can act as novel tools to aid in the diagnosis and remote objective monitoring of an individual's disease symptoms, both in clinical care and in research. Nonetheless, such digital health technologies have yet to widely demonstrate value in clinical research due to insufficient data interpretability and lack of regulatory acceptance. Metadata, i.e., data that accompany and describe the primary data, can be utilized to better understand the context of the sensor data and can assist in data management, data sharing, and subsequent data analysis. The need for data and metadata standards for digital health technologies has been raised in academic and industry research communities and has also been noted by regulatory authorities. Therefore, to address this unmet need, we here propose a metadata set that reflects regulatory guidelines and that can serve as a conceptual map to (1) inform researchers on the metadata they should collect in digital health studies, aiming to increase the interpretability and exchangeability of their data, and (2) direct standard development organizations on how to extend their existing standards to incorporate digital health technologies. The proposed metadata set is informed by existing standards pertaining to clinical trials and medical devices, in addition to existing schemas that have supported digital health technology studies. We illustrate this specifically in the context of Parkinson's disease, as a model for a wide range of other chronic conditions for which remote monitoring would be useful in both care and science. We invite the scientific and clinical research communities to apply the proposed metadata set to ongoing and planned research. Where the proposed metadata fall short, we ask users to contribute to its ongoing revision so that an adequate degree of consensus can be maintained in a rapidly evolving technology landscape. © 2019 The Author(s

关键词： Metadata

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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Manifold-adaptive dimension estimation revisited

arXiv

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arXiv 2020年

作者： Benkő, Zsigmond Stippinger, Marcell Rehus, Roberta Bencze, Attila Fabó, Dániel Hajnal, Boglárka Erőss, Loránd Telcs, András Somogyvári, Zoltán Department of Computational Sciences Wigner Research Centre for Physics H-1121 Hungary János Szentágothai Doctoral School of Neurosciences Semmelweis University H-1085 Hungary Department of Computer Science and Information Theory Faculty of Electrical Engineering and Informatics Budapest University of Technology and Economics BudapestH-1111 Hungary Epilepsy Center Department of Neurology National Institute of Clinical Neurosciences BudapestH-1145 Hungary Department of Functional Neurosurgery National Institute of Clinical Neurosciences BudapestH-1145 Hungary Faculty of Information Technology and Bionics Péter Pázmány Catholic University BudapestH-1083 Hungary Department of Quantitative Methods University of Pannonia Faculty of Business and Economics VeszprémH-8200 Hungary Neuromicrosystems ltd. BudapestH-1113 Hungary

Data dimensionality informs us about data complexity and sets limit on the structure of successful signal processing pipelines. In this work we revisit and improve the manifold adaptive Farahmand-Szepesvári-Audibert (FSA) dimension estimator, making it one of the best nearest neighbor-based dimension estimators available. We compute the probability density function of local FSA estimates, if the local manifold density is uniform. Based on the probability density function, we propose to use the median of local estimates as a basic global measure of intrinsic dimensionality, and we demonstrate the advantages of this asymptotically unbiased estimator over the previously proposed statistics: the mode and the mean. Additionally, from the probability density function, we derive the maximum likelihood formula for global intrinsic dimensionality, if i.i.d. holds. We tackle edge and finite-sample effects with an exponential correction formula, calibrated on hypercube datasets. We compare the performance of the corrected-median-FSA estimator with kNN estimators: maximum likelihood (ML, Levina-Bickel) and two implementations of DANCo (R and matlab). We show that corrected-median-FSA estimator beats the ML estimator and it is on equal footing with DANCo for standard synthetic benchmarks according to mean percentage error and error rate metrics. With the median-FSA algorithm, we reveal diverse changes in the neural dynamics while resting state and during epileptic seizures. We identify brain areas with lower-dimensional dynamics that are possible causal sources and candidates for being seizure onset zones. Copyright © 2020, The Authors. All rights reserved.

关键词： Maximum likelihood estimation

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Size effects in LiNbO3 thin films fabricated by pulsed laser deposition 5

Size effects in LiNbO3 thin films fabricated by pulsed laser...

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5th International School and Conference on Optoelectronics, Photonics, engineering and Nanostructures, Saint Petersburg OPEN 2018

作者： Vakulov, Z. Ivonin, M. Zamburg, E.G. Klimin, V.S. Volik, D.P. Golosov, D.A. Zavadskiy, S.M. Dostanko, A.P. Miakonkikh, A.V. Clemente, I.E. Rudenko, K.V. Ageev, O.A. Research and Education Centre Nanotechnology Southern Federal University Taganrog347922 Russia Department of Electrical and Computer Engineering National University of Singapore Singapore119077 Singapore Department of Radio Engineering Electronics Southern Federal University Taganrog347922 Russia Department of Research and Development Belarusian State University of Informatics and Radioelectronics Minsk220013 Belarus Institute of Physics and Technology RAS Moscow117218 Russia

This paper shows the results of the study of size effects of electro-physical parameters in nanostructured LiNbO3 thin films fabricated by pulsed laser deposition. Obtained results shown that with an increase in the number of laser pulses from 50 000 to 150 000, the maximum value of the amplitudes (psi) increases from 36 to 47, and phase shift (delta) varies from 160 to 175. It was found that with increasing of the film thickness from 45.3 to 192.9 nm, charge carrier concentration in the films increasing from 4.1•1012 to 8.75•1012 cm-3. An increase in the grain diameter from 118 to 172 nm causes a gradual increase in charge carriers mobility from 125.714 to 505.841 cm2/V•s. © Published under licence by IOP Publishing Ltd.

关键词： Thin films

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Observation of large scale precursor correlations between cosmic rays and earthquakes

arXiv

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arXiv 2022年

作者： Homola, Piotr Marchenko, V. Napolitano, A. Damian, R. Guzik, R. Alvarez-Castillo, D. Stuglik, S. Ruimi, O. Skorenok, O. Zamora-Saa, J. Vaquero, J.M. Wibig, T. Knap, M. Dziadkowiec, K. Karpiel, M. Sushchov, O. Mietelski, J.W. Gorzkiewicz, K. Zabari, N. Almeida Cheminant, K. Idźkowski, B. Bulik, T. Bhatta, G. Budnev, N. Kamiński, R. Medvedev, M.V. Kozak, K. Bar, O. Bibrzycki, L. Bielewicz, M. Frontczak, M. Kovács, P. Lozowski, B. Miszczyk, J. Niedźwiecki, M. del Peral, L. Piekarczyk, M. Rodriguez Frias, M.D. Rzecki, K. Smelcerz, K. Sośnicki, T. Stasielak, J. Tursunov, A.A. Institute of Nuclear Physics Polish Academy of Sciences Kraków31-342 Poland Racah Institute of Physics Hebrew University of Jerusalem IL Jerusalem91904 Israel Departamento de Ciencias Físicas Universidad Andres Bello Fernández Concha 700 Las Condes Santiago Chile Millennium Institute for Subatomic Physics at High Energy Frontier - SAPHIR Fernández Concha 700 Las Condes Santiago Chile Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences Kraków30-239 Poland Astroparticle Physics Amateur Zakopane34-500 Poland Departamento de Física Centro Universitario de Mérida Universidad de Extremadura Avda. Santa Teresa de Jornet 38 Mérida BadajozE-06800 Spain Astronomical Observatory University of Warsaw Al. Ujazdowskie 4 Warsaw00-478 Poland Taras Shevchenko National University of Kyiv Kyiv01601 Ukraine AGH University of Science and Technology ul. Mickiewicza 30 Kraków30-059 Poland Astrocent Nicolaus Copernicus Astronomical Center Rektorska 4 Warsaw00-614 Poland Pedagogical University of Krakow Podchorążych 2 Kraków30-084 Poland Institute of Physics Silesian University in Opava Bezručovo nám. 13 OpavaCZ-74601 Czech Republic Space and Astroparticle Group University of Alcalá Ctra. Madrid-Barcelona Km. 33.7 MadridE-28871 Spain Wigner Research Centre for Physics Konkoly-Thege Miklós út 29-33 BudapestH-1121 Hungary Department of Theoretical Physics Faculty of Physics and Applied Informatics University of Lodz Pomorska 149/153 LodzPL-90-236 Poland University of Napoli Parthenope Department of Engineering Centro Direzionale Isola C4 Napoli80143 Italy Irkutsk State University Physical Department K.Marx str. 1 Irkutsk664003 Russia Astroparticle Physics Amateur Dobromierz58-170 Poland Department of Physics and Astronomy University of Kansas LawrenceKS66045 United States Laboratory for Nuclear Science Massachusetts Institute of Technology CambridgeMA02139 United States Faculty of Natural Sciences University of S

The search for correlations between secondary cosmic ray detection rates and seismic effects has long been a subject of investigation motivated by the hope of identifying a new precursor type that could feed a global early warning system against earthquakes. Here we show for the first time that the average variation of the cosmic ray detection rates correlates with the global seismic activity to be observed with a time lag of approximately two weeks, and that the significance of the effect varies with a periodicity resembling the undecenal solar cycle, with a shift in phase of around three years, exceeding 6 σ at local maxima. The precursor characteristics of the observed correlations point to a pioneer perspective of an early warning system against earthquakes. © 2022, CC BY.

关键词： Cosmic rays

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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W-band radio-over-fiber link based on self-oscillating optical frequency comb generator

W-band radio-over-fiber link based on self-oscillating optic...

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Optical Fiber Communication Conference, OFC 2018

作者： Hasanuzzaman, G.K.M. Kanno, Atsushi Dat, Pham Tien Iezekiel, Stavros Microwave Photonics Research Laboratory Department of Electrical and Computer Engineering University of Cyprus Nicosia1678 Cyprus Network System Research Institute National Institute of Information and Communication Technology Tokyo184-8795 Japan

A 94.8 GHz radio-over-fiber link was implemented with a self-oscillating frequency comb. An LTE Advanced OFDM FDD 64-QAM signal of 20 MHz bandwidth was transmitted over 1.3 m wireless distance with an EVM of 2.23%. &#... 详细信息

ISBN: (纸本)9781943580385

关键词： Radio-over-fiber

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Observation of Large Scale Precursor Correlations between Cosmic Rays and Earthquakes with a Periodicity Similar to the Solar Cycle

SSRN

引用

SSRN 2022年

作者： Homola, Piotr Marchenko, Volodymyr Napolitano, Antonio Damian, Rafal Guzik, Rafal Alvarez-Castillo, David Stuglik, Slawomir Ruimi, Ophir Skorenok, Oleksandr Zamora-Saa, Jilberto Vaquero, José M. Wibig, Tadeusz Knap, Marek Dziadkowiec, Krzysztof Karpiel, Magdalena Sushchov, Oleksandr Mietelski, Jerzy W. Gorzkiewicz, Krzysztof Zabari, Noemi Cheminant, Kevin Almeida Idźkowski, Bartosz Bulik, Tomasz Bhatta, Gopal Budnev, Nikolay Kamiński, Robert Medvedev, Mikhail V. Kozak, Krzysztof Bar, Olaf Bibrzycki, Lukasz Bielewicz, Marcin Frontczak, Michal Kovács, Péter Lozowski, Bartosz Miszczyk, Justyna Niedźwiecki, Michal del Peral, Luis Piekarczyk, Marcin Rodriguez Frias, María D. Rzecki, Krzysztof Smelcerz, Katarzyna Sośnicki, Tomasz Stasielak, Jaroslaw Tursunov, Arman A. Institute of Nuclear Physics Polish Academy of Sciences Kraków31-342 Poland Racah Institute of Physics Hebrew University of Jerusalem IL Jerusalem91904 Israel Departamento de Ciencias Físicas Universidad Andres Bello Fernández Concha 700 Las Condes Santiago Chile Millennium Institute for Subatomic Physics at High Energy Frontier - SAPHIR Fernández Concha 700 Las Condes Santiago Chile Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences Kraków30-239 Poland Astroparticle Physics Amateur Zakopane34-500 Poland Departamento de Física Centro Universitario de Mérida Universidad de Extremadura Avda. Santa Teresa de Jornet 38 Mérida BadajozE-06800 Spain Astronomical Observatory University of Warsaw Al. Ujazdowskie 4 Warsaw00-478 Poland Taras Shevchenko National University of Kyiv Kyiv01601 Ukraine AGH University of Science and Technology ul. Mickiewicza 30 Kraków30-059 Poland Astrocent Nicolaus Copernicus Astronomical Center Rektorska 4 Warsaw00-614 Poland Pedagogical University of Krakow Podchorążych 2 Kraków30-084 Poland Institute of Physics Silesian University in Opava Bezručovo nám. 13 OpavaCZ-74601 Czech Republic Space and Astroparticle Group University of Alcalá Ctra. Madrid-Barcelona Km. 33.7 MadridE-28871 Spain Wigner Research Centre for Physics Konkoly-Thege Miklós út 29-33. BudapestH-1121 Hungary Department of Theoretical Physics Faculty of Physics and Applied Informatics University of Lodz Pomorska 149/153 LodzPL-90-236 Poland University of Napoli "Parthenope" Department of Engineering Centro Direzionale Isola C4 Napoli80143 Italy Irkutsk State University Physical Department K.Marx str. 1 Irkutsk664003 Russia Astroparticle Physics Amateur Dobromierz58-170 Poland Department of Physics and Astronomy University of Kansas LawrenceKS66045 United States Laboratory for Nuclear Science Massachusetts Institute of Technology CambridgeMA02139 United States Faculty of Natural Sciences University o

The search for correlations between secondary cosmic ray detection rates and seismic effects has long been a subject of investigation motivated by the hope of identifying a new precursor type that could feed a global early warning system against earthquakes. Here we show for the first time that the average variation of the cosmic ray detection rates correlates with the global seismic activity to be observed with a time lag of approximately two weeks, and that the significance of the effect varies with a periodicity resembling the undecenal solar cycle, with a shift in phase of around three years, exceeding 6 o at local maxima. The precursor characteristics of the observed correlations point to a pioneer perspective of an early warning system against earthquakes. © 2022, The Authors. All rights reserved.

关键词： Cosmic rays

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Fs laser inscription of FBGs in silicon core silica clad optical fibres 5

Fs laser inscription of FBGs in silicon core silica clad opt...

引用

5th Workshop on Specialty Optical Fibers and Their Applications, WSOF 2017

作者： Theodosiou, Antreas Fokine, Michael Song, Seunghan Hawkins, Thomas Ballato, John Gibson, Ursula J. Kalli, Kyriacos Cyprus University of Technology Department of Electrical Engineering Computer Engineering and Informatics Limassol3036 Cyprus Department of Applied Physics KTH Royal Institute of Technology Stockholm100-44 Sweden Department of Physics Norwegian University of Science and Technology TrondheimN-7491 Norway Center for Optical Materials Science and Engineering Technologies COMSET Clemson University ClemsonSC29634 United States

We present results on fs laser inscription of Bragg gratings in Si-core fibres throughmodification of the silicon-glass interface;this results in stress modulation with indications ofquasi-periodic stress relief in th... 详细信息

关键词： Stress relief

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