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Overview of the Tenth Dialog System Technology Challenge: DSTC10

IEEE/ACM Transactions on Audio Speech and Language processing 2024年 32卷 765-778页

作者： Yoshino, Koichiro Chen, Yun-Nung Crook, Paul Kottur, Satwik Li, Jinchao Hedayatnia, Behnam Moon, Seungwhan Fei, Zhengcong Li, Zekang Zhang, Jinchao Feng, Yang Zhou, Jie Kim, Seokhwan Liu, Yang Jin, Di Papangelis, Alexandros Gopalakrishnan, Karthik Hakkani-Tur, Dilek Damavandi, Babak Geramifard, Alborz Hori, Chiori Shah, Ankit Zhang, Chen Li, Haizhou Sedoc, Joao D'haro, Luis F. Banchs, Rafael Rudnicky, Alexander Guardian Robot Project R-IH RIKEN 2-2-2 Hikaridai Seika Shoraku619-0288 Japan Information Science Nara Institute of Science and Technology Ikoma630-0101 Japan Computer Science and Information Engineering National Taiwan University Taipei10617 Taiwan Inc. Palo AltoCA95054 United States Alexa AI *** Inc. SunnyvaleCA94089 United States Meta Seattle RedmondWA98052 United States Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China Tencent AI Lab Beijing Beijing China Kexueyuan South Road Zhongguancun Beijing100190 China Beijing 100190 China Alexa AI *** Inc. SunnyvaleCA United States 1120 Enterprise way Sunnyvale94089 United States *** Inc. SeattleWA United States Menlo Park CA United States Audio and Speech Group Mitsubishi Electric Research Laboratories CambridgeMA02139-1955 United States Carnegie Mellon University Department of Language and Information Technologies or just Carnegie Mellon University Pittsburgh United States National University of Singapore Singapore Singapore Department of Electrical and Computer Engineering National University of Singapore Singapore Singapore Shenzhen Research Institute of Big Data School of Data Science Chinese University of Hong Kong Shenzhen518172 China New York University New YorkNY United States ETSI de Telecomunicacion - Speech Technology and Machine Learning Group Universidad Politecnica de Madrid Ciudad Universitaria Madrid28040 Spain Nanyang Technological University Singapore Singapore Carnegie Mellon University PittsburghPA United States

This article introduces the Tenth Dialog System Technology Challenge (DSTC-10). This edition of the DSTC focuses on applying end-to-end dialog technologies for five distinct tasks in dialog systems, namely 1. Incorporation of Meme images into open domain dialogs, 2. Knowledge-grounded Task-oriented Dialogue Modeling on Spoken Conversations, 3. Situated Interactive Multimodal dialogs, 4. Reasoning for Audio Visual Scene-Aware Dialog, and 5. Automatic Evaluation and Moderation of Open-domainDialogue Systems. This article describes the task definition, provided datasets, baselines, and evaluation setup for each track. We also summarize the results of the submitted systems to highlight the general trends of the state-of-the-art technologies for the tasks. © 2023 The Authors.

关键词： Job analysis

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High-Frequency Stereo Matching Network

High-Frequency Stereo Matching Network

引用

Conference on computer Vision and Pattern Recognition (CVPR)

作者： Haoliang Zhao Huizhou Zhou Yongjun Zhang Jie Chen Yitong Yang Yong Zhao Text Computing & Cognitive Intelligence Engineering Research Center of National Education Ministry State Key Laboratory of Public Big Data College of Computer Science and Technology Institute of Artificial Intelligence Guizhou University Guiyang Guizhou China Ghost-Valley AI Technology Shenzhen Guangdong China School of Physics and Optoelectronic Engineering Guangdong University of Technology Guangzhou China The Key Laboratory of Integrated Microsystems Shenzhen Graduate School Peking University China

In the field of binocular stereo matching, remarkable progress has been made by iterative methods like RAFT-Stereo and CREStereo. However, most of these methods lose information during the iterative process, making it difficult to generate more detailed difference maps that take full advantage of high-frequency information. We propose the Decouple module to alleviate the problem of data coupling and allow features containing subtle details to transfer across the iterations which proves to alleviate the problem significantly in the ablations. To further capture high-frequency details, we propose a Normalization Refinement module that unifies the disparities as a proportion of the disparities over the width of the image, which address the problem of module failure in cross-domain scenarios. Further, with the above improvements, the ResNet-like feature extractor that has not been changed for years becomes a bottleneck. Towards this end, we proposed a multi-scale and multi-stage feature extractor that introduces the channel-wise self-attention mechanism which greatly addresses this bottleneck. Our method (DLNR) ranks 1st on the Middlebury leaderboard, significantly outperforming the next best method by 13.04%. Our method also achieves SOTA performance on the KITTI-2015 benchmark for D1-fg. Code and demos are available at: https://***/David-Zhao-1997/High-frequency-Stereo-Matching-Network.

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FABind: fast and accurate protein-ligand binding 23

FABind: fast and accurate protein-ligand binding

引用

Proceedings of the 37th International Conference on Neural Information processing Systems

作者： Qizhi Pei Kaiyuan Gao Lijun Wu Jinhua Zhu Yingce Xia Shufang Xie Tao Qin Kun He Tie-Yan Liu Rui Yan Gaoling School of Artificial Intelligence Renmin University of China and Engineering Research Center of Next-Generation Intelligent Search and Recommendation Ministry of Education School of Computer Science and Technology Huazhong University of Science and Technology Microsoft Research AI4Science School of Information Science and Technology University of Science and Technology of China Gaoling School of Artificial Intelligence Renmin University of China Gaoling School of Artificial Intelligence Renmin University of China and Beijing Key Laboratory of Big Data Management and Analysis Methods

Modeling the interaction between proteins and ligands and accurately predicting their binding structures is a critical yet challenging task in drug discovery. Recent advancements in deep learning have shown promise in addressing this challenge, with sampling-based and regression-based methods emerging as two prominent approaches. However, these methods have notable limitations. Sampling-based methods often suffer from low efficiency due to the need for generating multiple candidate structures for selection. On the other hand, regression-based methods offer fast predictions but may experience decreased accuracy. Additionally, the variation in protein sizes often requires external modules for selecting suitable binding pockets, further impacting efficiency. In this work, we propose FABind, an end-to-end model that combines pocket prediction and docking to achieve accurate and fast protein-ligand binding. FABind incorporates a unique ligand-informed pocket prediction module, which is also leveraged for docking pose estimation. The model further enhances the docking process by incrementally integrating the predicted pocket to optimize protein-ligand binding, reducing discrepancies between training and inference. Through extensive experiments on benchmark datasets, our proposed FABind demonstrates strong advantages in terms of effectiveness and efficiency compared to existing methods. Our code is available at Github https://***/QizhiPei/FABind.

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ImplantFormer: Vision Transformer based Implant Position Regression Using Dental CBCT data

arXiv

引用

arXiv 2022年

作者： Yang, Xinquan Li, Xuguang Li, Xuechen Wu, Peixi Shen, Linlin Deng, Yongqiang College of Computer Science and Software Engineering Shenzhen University Shenzhen China AI Research Center for Medical Image Analysis and Diagnosis Shenzhen University Shenzhen China National Engineering Laboratory for Big Data System Computing Technology Shenzhen University China Department of Stomatology Shenzhen University General Hospital Shenzhen China The School of Dentistry Shenzhen University Shenzhen China

Implant prosthesis is the most appropriate treatment for dentition defect or dentition loss, which usually involves a surgical guide design process to decide the implant position. However, such design heavily relies on the subjective experiences of dentists. In this paper, a transformer-based Implant Position Regression Network, ImplantFormer, is proposed to automatically predict the implant position based on the oral CBCT data. We creatively propose to predict the implant position using the 2D axial view of the tooth crown area and fit a centerline of the implant to obtain the actual implant position at the tooth root. Convolutional stem and decoder are designed to coarsely extract image features before the operation of patch embedding and integrate multi-level feature maps for robust prediction, respectively. As both long-range relationship and local features are involved, our approach can better represent global information and achieves better location performance. Extensive experiments on a dental implant dataset through five-fold cross-validation demonstrated that the proposed ImplantFormer achieves superior performance than existing methods. Copyright © 2022, The Authors. All rights reserved.

关键词： Forecasting

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Unsupervised Domain Adaptive Person Re-Identification via Human Learning Imitation

arXiv

引用

arXiv 2021年

作者： Peng, Yang Liu, Ping Luo, Yawei Zhou, Pan Xu, Zichuan Liu, Jingen Center for Frontier AI Research Agency for Science Technology and Research Singapore Hubei Engineering Research Center on Big Data Security School of Cyber Science and Engineering Huazhong University of Science and Technology Hubei Wuhan China College of Computer Science and Technology Zhejiang University Zhejiang Hangzhou China Key Laboratory for Ubiquitous Network and Service Software of Liaoning Province School of Software Dalian University of Technology Liaoning Dalian China

Unsupervised domain adaptive person re-identification has received significant attention due to its high practical value. In past years, by following the clustering and finetuning paradigm, researchers propose to utilize the teacher-student framework in their methods to decrease the domain gap between different person re-identification datasets. Inspired by recent teacher-student framework based methods, which try to mimic the human learning process either by making the student directly copy behavior from the teacher or selecting reliable learning materials, we propose to conduct further exploration to imitate the human learning process from different aspects, i.e., adaptively updating learning materials, selectively imitating teacher behaviors, and analyzing learning materials structures. The explored three components, collaborate together to constitute a new method for unsupervised domain adaptive person re-identification, which is called Human Learning Imitation framework. The experimental results on three benchmark datasets demonstrate the efficacy of our proposed method. Copyright © 2021, The Authors. All rights reserved.

关键词： Students

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DeePMD-kit v2: A software package for Deep Potential models

arXiv

引用

arXiv 2023年

作者： Zeng, Jinzhe Zhang, Duo Lu, Denghui Mo, Pinghui Li, Zeyu Chen, Yixiao Rynik, Marián Huang, Li'ang Li, Ziyao Shi, Shaochen Wang, Yingze Ye, Haotian Tuo, Ping Yang, Jiabin Ding, Ye Li, Yifan Tisi, Davide Zeng, Qiyu Bao, Han Xia, Yu Huang, Jiameng Muraoka, Koki Wang, Yibo Chang, Junhan Yuan, Fengbo Bore, Sigbjørn Løland Cai, Chun Lin, Yinnian Wang, Bo Xu, Jiayan Zhu, Jia-Xin Luo, Chenxing Zhang, Yuzhi Goodall, Rhys E.A. Liang, Wenshuo Singh, Anurag Kumar Yao, Sikai Zhang, Jingchao Wentzcovitch, Renata Han, Jiequn Liu, Jie Jia, Weile York, Darrin M. Weinan, E. Car, Roberto Zhang, Linfeng Wang, Han Laboratory for Biomolecular Simulation Research Institute for Quantitative Biomedicine Department of Chemistry and Chemical Biology Rutgers University PiscatawayNJ08854 United States AI for Science Institute Beijing100080 China DP Technology Beijing100080 China Academy for Advanced Interdisciplinary Studies Peking University Beijing100871 China HEDPS CAPT College of Engineering Peking University Beijing100871 China College of Electrical and Information Engineering Hunan University Changsha China Yuanpei College Peking University Beijing100871 China Program in Applied and Computational Mathematics Princeton University PrincetonNJ08540 United States Department of Experimental Physics Comenius University Mlynská Dolina F2 Bratislava842 48 Slovakia Center for Quantum Information Institute for Interdisciplinary Information Sciences Tsinghua University Beijing100084 China Center for Data Science Peking University Beijing100871 China ByteDance Research Zhonghang Plaza No. 43 North 3rd Ring West Road Haidian District Beijing China College of Chemistry and Molecular Engineering Peking University Beijing100871 China Baidu Inc. Beijing China Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University Zhejiang Hangzhou China Westlake AI Therapeutics Lab Westlake Laboratory of Life Sciences and Biomedicine Zhejiang Hangzhou China Department of Chemistry Princeton University PrincetonNJ08544 United States SISSA Scuola Internazionale Superiore di Studi Avanzati Trieste34136 Italy Laboratory of Computational Science and Modeling Institute of Materials École Polytechnique Fédérale de Lausanne Lausanne1015 Switzerland Department of Physics National University of Defense Technology Hunan Changsha410073 China State Key Lab of Processors Institute of Computing Technology Chinese Academy of Sciences Beijing China University of Chinese Academy of Sciences Beijing China School of Electronics Engineerin

DeePMD-kit is a powerful open-source software package that facilitates molecular dynamics simulations using machine learning potentials (MLP) known as Deep Potential (DP) models. This package, which was released in 2017, has been widely used in the fields of physics, chemistry, biology, and material science for studying atomistic systems. The current version of DeePMD-kit offers numerous advanced features such as DeepPot-SE, attention-based and hybrid descriptors, the ability to fit tensile properties, type embedding, model deviation, Deep Potential - Range Correction (DPRc), Deep Potential Long Range (DPLR), GPU support for customized operators, model compression, non-von Neumann molecular dynamics (NVNMD), and improved usability, including documentation, compiled binary packages, graphical user interfaces (GUI), and application programming interfaces (API). This article presents an overview of the current major version of the DeePMD-kit package, highlighting its features and technical details. Additionally, the article benchmarks the accuracy and efficiency of different models and discusses ongoing developments. © 2023, CC BY-NC-ND.

关键词： Molecular dynamics

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Foundation models and intelligent decision-making: Progress, challenges, and perspectives

引用

The Innovation 2025年第6期6卷

作者： Jincai Huang Yongjun Xu Qi Wang Qi (Cheems) Wang Xingxing Liang Fei Wang Zhao Zhang Wei Wei Boxuan Zhang Libo Huang Jingru Chang Liantao Ma Ting Ma Yuxuan Liang Jie Zhang Jian Guo Xuhui Jiang Xinxin Fan Zhulin An Tingting Li aiguo Fei Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China National Engineering Research Center for Software Engineering Peking University Beijing 100871 China College of Systems Engineering National University of Defense Technology Changsha 410073 China Department of Oral Implantology Peking University School and Hospital of Stomatology Beijing 100081 China Laboratory for Big Data and Decision National University of Defense Technology Changsha 410073 China School of Automation Beijing Institute of Technology Beijing 100081 China Huazhong University of Science and Technology Wuhan 430074 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of AI Safety Beijing 100190 China Department of Automation Tsinghua University Beijing 100084 China School of Information Science and Engineering Dalian Polytechnic University Dalian 116034 China The Hong Kong University of Science and Technology (Guangzhou) Guangzhou 511453 China College of Information and Electrical Engineering China Agricultural University Beijing 100083 China State Key Laboratory of Efficient Utilization of Agricultural Water Resources Beijing 100083 China IDEA Research International Digital Economy Academy Shenzhen 518057 China School of Computer Science National Pilot Software Engineering School Beijing University of Posts and Telecommunications Beijing 100876 China

Intelligent decision-making (IDM) is a cornerstone of artificial intelligence (ai) designed to automate or augment decision processes. Modern IDM paradigms integrate advanced frameworks to enable intelligent agents to make effective and adaptive choices and decompose complex tasks into manageable steps, such as ai agents and high-level reinforcement learning. Recent advances in multimodal foundation-based approaches unify diverse input modalities—such as vision, language, and sensory data—into a cohesive decision-making process. Foundation models (FMs) have become pivotal in science and industry, transforming decision-making and research capabilities. Their large-scale, multimodal data-processing abilities foster adaptability and interdisciplinary breakthroughs across fields such as healthcare, life sciences, and education. This survey examines IDM’s evolution, advanced paradigms with FMs and their transformative impact on decision-making across diverse scientific and industrial domains, highlighting the challenges and opportunities in building efficient, adaptive, and ethical decision systems.

关键词： artificial intelligence intelligent decision-making foundation models agent large language model

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FUTURE-ai: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare

arXiv

引用

arXiv 2023年

作者： Lekadir, Karim Feragen, Aasa Fofanah, Abdul Joseph Frangi, Alejandro F. Buyx, Alena Emelie, Anais Lara, Andrea Porras, Antonio R. Chan, An-Wen Navarro, Arcadi Glocker, Ben Botwe, Benard O. Khanal, Bishesh Beger, Brigit Wu, Carol C. Cintas, Celia Langlotz, Curtis P. Rueckert, Daniel Mzurikwao, Deogratias Fotiadis, Dimitrios I. Zhussupov, Doszhan Ferrante, Enzo Meijering, Erik Weicken, Eva González, Fabio A. Asselbergs, Folkert W. Prior, Fred Krestin, Gabriel P. Collins, Gary S. Tegenaw, Geletaw S. Kaissis, Georgios Misuraca, Gianluca Tsakou, Gianna Dwivedi, Girish Kondylakis, Haridimos Jayakody, Harsha Woodruf, Henry C. Mayer, Horst Joachim Aerts, Hugo JWL Walsh, Ian Chouvarda, Ioanna Buvat, Irène Tributsch, Isabell Rekik, Islem Duncan, James Kalpathy-Cramer, Jayashree Zahir, Jihad Park, Jinah Mongan, John Gichoya, Judy W. Schnabel, Julia A. Kushibar, Kaisar Riklund, Katrine Mori, Kensaku Marias, Kostas Amugongo, Lameck M. Fromont, Lauren A. Maier-Hein, Lena Alberich, Leonor Cerdá Rittner, Leticia Phiri, Lighton Marrakchi-Kacem, Linda Donoso-Bach, Lluís Martí-Bonmatí, Luis Cardoso, M. Jorge Bobowicz, Maciej Shabani, Mahsa Tsiknakis, Manolis Zuluaga, Maria A. Bielikova, Maria Fritzsche, Marie-Christine Camacho, Marina Linguraru, Marius George Wenzel, Markus De Bruijne, Marleen Tolsgaard, Martin G. Ghassemi, Marzyeh Ashrafuzzaman, Md Goisauf, Melanie Yaqub, Mohammad Abadía, Mónica Cano Mahmoud, Mukhtar M.E. Elattar, Mustafa Rieke, Nicola Papanikolaou, Nikolaos Lazrak, Noussair Díaz, Oliver Salvado, Olivier Pujol, Oriol Sall, Ousmane Guevara, Pamela Gordebeke, Peter Lambin, Philippe Brown, Pieta Abolmaesumi, Purang Dou, Qi Lu, Qinghua Osuala, Richard Nakasi, Rose Zhou, S. Kevin Napel, Sandy Colantonio, Sara Albarqouni, Shadi Joshi, Smriti Carter, Stacy Klein, Stefan Petersen, Steffen E. Aussó, Susanna Awate, Suyash Raviv, Tammy Riklin Cook, Tessa Mutsvangwa, Tinashe E.M. Rogers, Wendy A. Niessen, Wiro J. Puig-Bosch, Xènia Zeng, Yi Mohammed, Yunusa G. Aquino, Yves Saint James Salahuddin, Zohaib Starmans, Martijn P.A. Department de Matemàtiques i Informàtica Universitat de Barcelona Barcelona Spain Barcelona Spain DTU Compute Technical University of Denmark Kgs Lyngby Denmark Department of Mathematics and Computer Science Faculty of Science and Technology Milton Margai Technical University Freetown Sierra Leone Center for Computational Imaging & Simulation Technologies in Biomedicine Schools of Computing and Medicine University of Leeds Leeds United Kingdom Cardiovascular Science and Electronic Engineering Departments KU Leuven Leuven Belgium Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Faculty of Engineering of Systems Informatics and Sciences of Computing Galileo University Guatemala City Guatemala Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Department of Medicine Women’s College Research Institute University of Toronto Toronto Canada Universitat Pompeu Fabra BarcelonaBeta Brain Research Center Barcelona Spain Department of Computing Imperial College London London United Kingdom School of Biomedical & Allied Health Sciences University of Ghana Accra Ghana Department of Midwifery & Radiography School of Health & Psychological Sciences City University of London United Kingdom Kathmandu Nepal European Heart Network Brussels Belgium Department of Thoracic Imaging University of Texas MD Anderson Cancer Center Houston United States IBM Research Africa Nairobi Kenya Departments of Radiology Medicine and Biomedical Data Science Stanford University School of Medicine Stanford United States Institute for AI and Informatics in Medicine Klinikum rechts der Isar Technical University Munich Munich Germany Department of Computing Imperial College London London United Kingdom Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania United Republic of Ioannina Greece Almaty AI Lab Almaty Kazakhstan

Background: Despite major advances in artificial intelligence (ai) research for healthcare, the deployment and adoption of ai technologies remain limited in clinical practice. In recent years, concerns have been raised about the clinical, technical, ethical and legal risks associated with healthcare ai. To increase adoption in the real world, it is essential that ai technologies are trusted and accepted by patients, clinicians, health organisations and authorities. This paper describes the FUTURE-ai framework as the first international consensus guideline for trustworthy ai in healthcare. Methods: The FUTURE-ai consortium was founded in 2021 and now comprises 117 interdisciplinary experts from 50 countries representing all continents, including ai scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two-year period, the consortium established guiding principles and best practices for trustworthy and deployable ai through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. Findings: The FUTURE-ai framework was established based on six guiding principles for trustworthy ai in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 30 best practices were defined, addressing technical, clinical, socio-ethical and legal dimensions of trustworthy ai. The recommendations cover the entire lifecycle of healthcare ai, from design, development and validation to regulation, deployment, and monitoring. Interpretation: FUTURE-ai is a structured, risk-informed framework which provides guidance for constructing healthcare ai tools that will be trusted, deployed and adopted in real-world clinical practice. researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of healthcare ai. Copyright © 2023, The Authors. All rights

关键词： Clinical research

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Unleashing the Strengths of Unlabeled data in Pan-cancer Abdominal Organ Quantification: The FLARE22 Challenge

arXiv

引用

arXiv 2023年

作者： Ma, Jun Zhang, Yao Gu, Song Ge, Cheng Ma, Shihao Young, Adamo Zhu, Cheng Meng, Kangkang Yang, Xin Huang, Ziyan Zhang, Fan Liu, Wentao Pan, YuanKe Huang, Shoujin Wang, Jiacheng Sun, Mingze Xu, Weixin Jia, Dengqiang Choi, Jae Won Alves, Natália de Wilde, Bram Koehler, Gregor Wu, Yajun Wiesenfarth, Manuel Zhu, Qiongjie Dong, Guoqiang He, Jian Wang, Bo He, Junjun Yang, Hua Yang, Huihua Huang, Bingding Lyu, Mengye Ma, Yongkang Guo, Heng Zhang, Rongguo Maier-Hein, Klaus The Department of Laboratory Medicine and Pathobiology University of Toronto Peter Munk Cardiac Centre University Health Network Vector Institute Toronto Canada Shanghai AI Laboratory Shanghai200232 China The Department of Image Reconstruction Nanjing Anke Medical Technology Co. Ltd. Nanjing211113 China Ocean University of China Qingdao266100 China The Department of Computer Science University of Toronto Peter Munk Cardiac Centre University Health Network Vector Institute Toronto Canada Tinavi Medical Technologies Co. Ltd. Beijing100192 China University of Science and Technology Beijing Beijing100083 China The School of Biomedical Engineering Health Science Center Shenzhen University Shenzhen518055 China The Department of Radiological Algorithm Fosun Aitrox Information Technology Co. Ltd. Shanghai200033 China The School of Artificial Intelligence Beijing University of Posts and Telecommunications Beijing100876 China Shenzhen Technology University Shenzhen518000 China Xiamen University Xiamen361005 China Alibaba Beijing100084 China Infervision Medical Technology Co. Ltd. Beijing100025 China Hong Kong Centre for Cerebro-cardiovascular Health Engineering 000000 Hong Kong The Department of Radiology Armed Forces Yangju Hospital Yangju11429 Korea Republic of The Department of Radiology Radboudumc Nijmegen6525XZ Netherlands The Department of Medical Image Computing German Cancer Research Center Heidelberg69120 Germany ShenZhen Yorktal DMIT LLC Shenzhen518100 China Heidelberg69120 Germany The Department of Nuclear Medicine Nanjing Drum Tower Hospital Nanjing210008 China The College of Big Data and Internet Shenzhen Technology University Shenzhen518188 China The College of Health Science and Environmental Engineering Shenzhen Technology University Shenzhen China The Manteia Technologies Co. Ltd Xiamen China The Alibaba DAMO Academy Beijing China The Peter Munk Cardiac Centre University Health Network Department of Laboratory M

Quantitative organ assessment is an essential step in automated abdominal disease diagnosis and treatment planning. Artificial intelligence (ai) has shown great potential to automatize this process. However, most existing ai algorithms rely on many expert annotations and lack a comprehensive evaluation of accuracy and efficiency in real-world multinational settings. To overcome these limitations, we organized the FLARE 2022 Challenge, the largest abdominal organ analysis challenge to date, to benchmark fast, low-resource, accurate, annotation-efficient, and generalized ai algorithms. We constructed an intercontinental and multinational dataset from more than 50 medical groups, including Computed Tomography (CT) scans with different races, diseases, phases, and manufacturers. We independently validated that a set of ai algorithms achieved a median Dice Similarity Coefficient (DSC) of 90.0% by using 50 labeled scans and 2000 unlabeled scans, which can significantly reduce annotation requirements. The best-performing algorithms successfully generalized to holdout external validation sets, achieving a median DSC of 89.5%, 90.9%, and 88.3% on North American, European, and Asian cohorts, respectively. They also enabled automatic extraction of key organ biology features, which was labor-intensive with traditional manual measurements. This opens the potential to use unlabeled data to boost performance and alleviate annotation shortages for modern ai models. © 2023, CC BY-NC-ND.

关键词： Diseases

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Deep Learning in Digital Breast Tomosynthesis: Current Status, Challenges, and Future Trends

MedComm

引用

MedComm 2025年第6期6卷

作者： Ruoyun Wang Fanxuan Chen Haoman Chen Chenxing Lin Jincen Shuai Yutong Wu Lixiang Ma Xiaoqu Hu Min Wu Jin Wang Qi Zhao Jianwei Shuai Jingye Pan Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine Vision and Brain Health) Wenzhou Institute University of Chinese Academy of Sciences Wenzhou China Wenzhou Medical University Wenzhou China UCSC Baskin School of Engineering University of California Santa Cruz California USA Department of Anatomy Histology & Embryology School of Basic Medical Sciences Fudan University Shanghai China Department of Medicine Harvard Medical School and Brigham and Women's Hospital Boston Massachusetts USA Joint Research Centre on Medicine The Affiliated Xiangshan Hospital of Wenzhou Medical University Ningbo China Stony Brook University Stony Brook New York USA School of Computer Science and Software Engineering University of Science and Technology Liaoning Anshan China Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Province Wenzhou China Department of Big Data in Health Science The First Affiliated Hospital of Wenzhou Medical University Wenzhou China Zhejiang Engineering Research Center for Hospital Emergency and Process Digitization Wenzhou China

The high-resolution three-dimensional (3D) images generated with digital breast tomosynthesis (DBT) in the screening of breast cancer offer new possibilities for early disease diagnosis. Early detection is especially important as the incidence of breast cancer increases. However, DBT also presents challenges in terms of poorer results for dense breasts, increased false positive rates, slightly higher radiation doses, and increased reading times. Deep learning (DL) has been shown to effectively increase the processing efficiency and diagnostic accuracy of DBT images. This article reviews the application and outlook of DL in DBT-based breast cancer screening. First, the fundamentals and challenges of DBT technology are introduced. The applications of DL in DBT are then grouped into three categories: diagnostic classification of breast diseases, lesion segmentation and detection, and medical image generation. Additionally, the current public databases for mammography are summarized in detail. Finally, this paper analyzes the main challenges in the application of DL techniques in DBT, such as the lack of public datasets and model training issues, and proposes possible directions for future research, including large language models, multisource domain transfer, and data augmentation, to encourage innovative applications of DL in medical imaging.

关键词： early breast cancer screening digital breast tomosynthesis deep learning public database medical image analysis

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