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Multifaceted Disparities Associated with Translator Earnings: A Quantitative Study of Upwork Profiles

Journal of social Computing 2024年第1期5卷 88-100页

作者： Tyler Horan Data Analytics and Computational Social Science Program University of Massachusetts AmherstAmherstMA 01003USA

This study aims to quantitatively explore the multifaceted determinants that influence earnings in the translation *** a dataset comprising 45000 translator profiles,the study focusses on delineating disparities correlated with demographic variables such as age,gender,home country wealth,and language *** study uses a random forest regression model to delineate the complex interaction between gender,the economic standing of a translator’s domicile country,age,and linguistic proficiency,as they relate to *** findings substantiate and,in many ways,extend existing qualitative and anecdotal evidence that has shaped the discourse in this *** rigorous empirical framework employed here can be replicated or adapted to study other sectors within the gig economy,thus contributing to a more comprehensive understanding of labour dynamics in the digital age.

关键词： translation online employment gig economy intercultural communication

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Rural Sustainability 1

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丛书名： SpringerBriefs in Geography

1000年

作者： Qing Tian

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Multimodal AI predicts clinical outcomes of drug combinations from preclinical data

arXiv

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arXiv 2025年

作者： Huang, Yepeng Su, Xiaorui Ullanat, Varun Liang, Ivy Clegg, Lindsay Olabode, Damilola Ho, Nicholas John, Bino Gibbs, Megan Zitnik, Marinka Department of Biomedical Informatics Harvard Medical School BostonMA United States Program in Biological and Biomedical Sciences Harvard Medical School BostonMA United States Harvard College CambridgeMA United States Clinical Pharmacology and Quantitative Pharmacology Clinical Pharmacology & Safety Sciences R&D AstraZeneca GaithersburgMD United States Clinical Pharmacology and Quantitative Pharmacology Clinical Pharmacology & Safety Sciences R&D AstraZeneca WalthamMA United States Program in Computational Biology Carnegie Mellon University PittsburghPA United States Imaging and Data Analytics Clinical Pharmacology & Safety Sciences R&D AstraZeneca WalthamMA United States Kempner Institute for the Study of Natural and Artificial Intelligence Harvard University AllstonMA United States Broad Institute of MIT and Harvard CambridgeMA United States Harvard Data Science Initiative CambridgeMA United States

Predicting clinical outcomes from preclinical data is essential for identifying safe and effective drug combinations, reducing late-stage clinical failures, and accelerating the development of precision therapies. Current models rely on structural or target-based features to identify high-efficacy, low-toxicity drug combinations. However, these approaches fail to incorporate the multimodal data necessary for accurate, clinically-relevant predictions. Here, we introduce MADRIGAL, a multimodal AI model that learns from structural, pathway, cell viability, and transcriptomic data to predict drug combination effects across 953 clinical outcomes and 21,842 compounds, including combinations of approved drugs and novel compounds in development. MADRIGAL uses a transformer bottleneck module to unify preclinical drug data modalities while handling missing data during training and inference—a major challenge in multimodal learning. It outperforms single-modality methods and state-of-the-art models in predicting adverse drug interactions. MADRIGAL performs virtual screening of anticancer drug combinations and supports polypharmacy management for type II diabetes and metabolic dysfunction-associated steatohepatitis (MASH). It identifies transporter-mediated drug interactions. MADRIGAL predicts resmetirom, the first and only FDA-approved drug for MASH, among therapies with the most favorable safety profile. It supports personalized cancer therapy by integrating genomic profiles from cancer patients. Using primary acute myeloid leukemia samples and patient-derived xenograft models, it predicts the efficacy of personalized drug combinations. Integrating MADRIGAL with a large language model allows users to describe clinical outcomes in natural language, improving safety assessment by identifying potential adverse interactions and toxicity risks. MADRIGAL provides a multimodal approach for designing combination therapies with improved predictive accuracy and clinical relevance. Copy

关键词： Diseases

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The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms

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Developmental Cell 2025年第10期60卷 1467-1482.e8页

作者： Gehrs, Stephanie Jakab, Moritz Gutjahr, Ewgenija Gu, Zuguang Weichenhan, Dieter Mallm, Jan-Philipp Mogler, Carolin Schlesner, Matthias Plass, Christoph Schlereth, Katharina Augustin, Hellmut G. Division of Vascular Oncology and Metastasis German Cancer Research Center (DKFZ) Heidelberg 69120 Germany European Center for Angioscience (ECAS) Medical Faculty Mannheim Heidelberg University Mannheim 68167 Germany Faculty of Biosciences Heidelberg University Heidelberg 69120 Germany Institute of Pathology University Clinic Heidelberg Heidelberg 69120 Germany Computational Oncology Group Molecular Precision Oncology Program National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ) Heidelberg 69120 Germany Division of Cancer Epigenomics German Cancer Research Center (DKFZ) Heidelberg 69120 Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and Bioquant Heidelberg 69120 Germany Institute of Pathology TUM School of Medicine Technical University of Munich Munich 80333 Germany Biomedical Informatics Data Mining and Data Analytics Faculty of Applied Computer Science and Medical Faculty University of Augsburg Augsburg 86159 Germany

The labyrinthian fetoplacental capillary network is vital for proper nourishment of the developing embryo. Dysfunction of the maternal-fetal circulation is a primary cause of placental insufficiency. Here, we show that the spatial zonation of the murine placental labyrinth vasculature is controlled by flow-regulated epigenetic mechanisms. Spatiotemporal transcriptomic profiling identified a gradual change in the expression of epigenetic enzymes, including the de novo DNA methyltransferase 3a (DNMT3A). Loss of Dnmt3a resulted in DNA hypomethylation and perturbation of zonated placental gene expression. The resulting global DNA hypomethylation impaired the angiogenic capacity of endothelial cells. Global or endothelium-predominant deletion of Dnmt3a resulted in impaired placental vascularization and fetal growth retardation (FGR). Human placental endothelial gene expression profiling associated preeclampsia with reduced DNMT3A expression. Collectively, our study identified DMNT3A as critical methylome-regulator of placental endothelial gene expression and function with clinical implications for placental dysfunction, as it occurs during preeclampsia or FGR. © 2024 The Authors

关键词： angiogenesis DNA methylation DNMT3A epigenetic regulation growth retardation placental endothelium spatial zonation

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BIM: Improving Graph Neural Networks with Balanced Influence Maximization 40

BIM: Improving Graph Neural Networks with Balanced Influence...

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40th IEEE International Conference on data Engineering, ICDE 2024

作者： Zhang, Wentao Gao, Xinyi Yang, Ling Cao, Meng Huang, Ping Shan, Jiulong Yin, Hongzhi Cui, Bin Peking University Center for Machine Learning Research China Institute of Advanced Algorithms Research Shanghai China National Engineering Labratory for Big Data Analytics and Applications The University of Queensland Australia Peking University Key Lab of High Confidence Software Technologies China Apple Inc. Institute of Computational Social Science Peking University Qingdao China

ISBN: (纸本)9798350317152

The imbalanced data classification problem has aroused lots of concerns from both academia and industry since data imbalance is a widespread phenomenon in many real-world scenarios. Although this problem has been well researched from the view of imbalanced class samples, we further argue that graph neural networks (GNNs) expose a unique source of imbalance from the influenced nodes of different classes of labeled nodes, i.e., labeled nodes are imbalanced in terms of the number of nodes they influenced during the influence propagation in GNNs. To tackle this previously unexplored influence-imbalance issue, we connect social influence maximization with the imbalanced node classification problem and propose balanced influence maximization (BIM). Specifically, BIM greedily assigns the pseudo label to the node which can maximize the number of influenced nodes in GNN training while making the influence of each class more balance. Experimental results on five public datasets demonstrate the effectiveness of our method in relieving the influence-imbalance issue. For example, when training a GCN with an imbalance ratio of 0.1, BIM significantly outperforms the most competitive baseline by 0.6% -9.8% in five public datasets in terms of the F1 score. © 2024 IEEE.

关键词： Graph neural networks

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NC-ALG: Graph-Based Active Learning under Noisy Crowd 40

NC-ALG: Graph-Based Active Learning under Noisy Crowd

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40th IEEE International Conference on data Engineering, ICDE 2024

作者： Zhang, Wentao Wang, Yexin You, Zhenbang Li, Yang Cao, Gang Yang, Zhi Cui, Bin Center for Machine Learning Research Peking University China Key Lab of High Confidence Software Technologies Peking University China Institute of Advanced Algorithms Research Shanghai China Institute of Computational Social Science Peking University Qingdao China National Engineering Labratory for Big Data Analytics and Applications China TEG Tencent Inc. Department of Data Platform China Beijing Academy of Artificial Intelligence China

ISBN: (纸本)9798350317152

Graph Neural Networks (GNNs) have achieved great success in various data mining tasks but they heavily rely on a large number of annotated nodes, requiring considerable human efforts. Despite the effectiveness of existing GNN-based Active Learning (AL) methods, they assume that the annotated labels are always correct, which is contradictory to the error-prone labeling process in a practical crowdsourcing environment. Besides, due to this impractical assumption, existing works only focus on optimizing the node selection in AL but neglect optimizing the labeling process. Therefore, we present NC-ALG, the first GNN-based AL framework that optimizes both the node selection and node labeling process under a noisy crowd. For node selection, NC-ALG introduces a new measurement to model influence reliability and an effective influence maximization objective to select nodes. For node labeling, NC-ALG significantly reduces the labeling cost by considering the model-predicted labels and the labels of mirror nodes. To the best of our knowledge, this is the first attempt to consider GNN-based AL under the practical noisy crowd. Empirical studies on public datasets demonstrate that NC-ALG significantly outperforms existing methods in terms labeling efficiency. Notably, it only takes NC-ALG one-third of the labeling budget that the competitive baseline GRAIN needs to achieve an accuracy of 70.7 % on PubMed. © 2024 IEEE.

关键词： Crowdsourcing

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Between Local and Global Strategy Updating in Public Goods Game

SSRN

引用

SSRN 2022年

作者： Wang, Chaoqian Huang, Chaochao Program for Computational Social Science Department of Computational and Data Sciences George Mason University FairfaxVA22030 United States International Institute of Finance School of Management University of Science and Technology of China Hefei230026 China

In the spatial public goods game (PGG), agents interact with local neighbors. In a well-mixed population, agents globally interact with the whole population. In this work, we explore the middle ground between the two from the perspective of strategy imitation. First, we assume each agent can select the reference agent for imitation by global interactions with a probability and otherwise local interactions. The results show that local interactions can maintain cooperation better under a strong dilemma, because cooperators can aggregate to defend against the invasion of defection. For a weak dilemma, both local and global interactions are beneficial to cooperation, because the dilemma is weak;however, the combination of the two is harmful to cooperation. Secondly, we consider different possibilities for cooperative and defective agents to select global references. The results show that when global interactions are frequently accessed by defectors but hardly accessed by cooperators, the system is most unfavorable for cooperation: defectors near the cooperation aggregation are hard to affect by cooperators around, while cooperators interact locally and are invaded by defectors around. However, when global interactions are moderately accessed by defectors and hardly accessed by cooperators, the system is most favorable for the cooperation domain: defectors near the cooperation aggregation have chances to imitate the strategy of cooperation, defectors far away from the aggregation also have chances to imitate the strategy of aggregated cooperators. Meanwhile, the aggregated cooperators hardly imitate defection and can avoid being invaded remotely. The present work unveils the evolutionary behavior of cooperation in the middle of structured and well-mixed pairwise imitation dynamics. © 2022, The Authors. All rights reserved.

关键词： Behavioral research

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Involution game with spatio-temporal heterogeneity of social resources

arXiv

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arXiv 2022年

作者： Wang, Chaoqian Szolnoki, Attila Program for Computational Social Science Department of Computational and Data Sciences George Mason University FairfaxVA22030 United States Institute of Technical Physics and Materials Science Centre for Energy Research P.O. Box 49 BudapestH-1525 Hungary

When group members claim a portion of limited resources, it is tempting to invest more effort to get a larger share. However, if everyone acts similarly, they all get the same piece they would obtain without extra effort. This is the involution game dilemma that can be detected in several real-life situations. It is also a realistic assumption that resources are not uniform in space and time, which may influence the system's resulting involution level. We here introduce spatio-temporal heterogeneity of social resources and explore their consequences on involution. When spatial heterogeneity is applied, network reciprocity can mitigate the involution for rich resources, which would be critical otherwise in a homogeneous population. Interestingly, when the resource level is modest, spatial heterogeneity causes more intensive involution in a system where most cooperator agents, who want to keep investment at a low level, are present. This picture is partly the opposite in the extreme case when more investment is less effective. Spatial heterogeneity can also produce a counterintuitive effect when the presence of alternative resource levels cannot explain the emergence of involution. If we apply temporal heterogeneity additionally, then the impact of spatial heterogeneity practically vanishes, and we turn back to the behavior observed in a homogeneous population earlier. Our observations are also supported by solving the corresponding replicator equations numerically. © 2022, CC BY.

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ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices

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Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2025年第4期10卷 425-436页

作者： Ganesan, Saampras Barrios, Fernando A. Batta, Ishaan Bauer, Clemens C.C. Braver, Todd S. Brewer, Judson A. Brown, Kirk Warren Cahn, Rael Cain, Joshua A. Calhoun, Vince D. Cao, Lei Chetelat, Gaël Ching, Christopher R.K. Creswell, J. David Dagnino, Paulina Clara Davanger, Svend Davidson, Richard J. Deco, Gustavo Dutcher, Janine M. Escrichs, Anira Eyler, Lisa T. Fani, Negar Farb, Norman A.S. Fialoke, Suruchi Fresco, David M. Garg, Rahul Garland, Eric L. Goldin, Philippe Hafeman, Danella M. Jahanshad, Neda Kang, Yoona Khalsa, Sahib S. Kirlic, Namik Lazar, Sara W. Lutz, Antoine McDermott, Timothy J. Pagnoni, Giuseppe Piguet, Camille Prakash, Ruchika S. Rahrig, Hadley Reggente, Nicco Saccaro, Luigi F. Sacchet, Matthew D. Siegle, Greg J. Tang, Yi-Yuan Thomopoulos, Sophia I. Thompson, Paul M. Torske, Alyssa Treves, Isaac N. Tripathi, Vaibhav Tsuchiyagaito, Aki Turner, Matthew D. Vago, David R. Valk, Sofie Zeidan, Fadel Zalesky, Andrew Turner, Jessica A. King, Anthony P. Department of Biomedical Engineering The University of Melbourne Carlton VIC Australia Contemplative Studies Centre Melbourne School of Psychological Sciences The University of Melbourne Melbourne VIC Australia Systems Lab of Neuroscience Neuropsychiatry and Neuroengineering The University of Melbourne Parkville VIC Australia Universidad Nacional Autónoma de México Instituto de Neurobiolgía México Querétaro Mexico Center for Translational Research in Neuroimaging and Data Science: Georgia State University Georgia Institute of Technology and Emory University Atlanta GA United States Department of Psychology Northeastern University Boston Massachusetts Brain and Cognitive Science McGovern Institute for Brain Research Massachusetts Institute of Technology Cambridge Massachusetts Department of Psychological and Brain Sciences Washington University St. Louis Missouri Department of Behavioral and Social Sciences Brown University School of Public Health Providence Rhode Island Department of Psychology Carnegie Mellon University Pittsburgh PA United States University of Southern California Department of Psychiatry & Behavioral Sciences Los Angeles California University of Southern California Center for Mindfulness Science Los Angeles California Institute for Advanced Consciousness Studies Santa Monica California Department of Psychiatry and Behavioral Health The Ohio State University College of Medicine Columbus OH United States Normandie University Université de Caen Normandie INSERM U1237 Neuropresage Team Cyceron Caen France Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine of the University of Southern California Los Angeles California Desert-Pacific Mental Illness Research Education and Clinical Center VA San Diego Healthcare System San Diego California Computational Neuroscience Group Center for Brain and Cognition Department of Information and Communication Technologies Universitat Pompeu Fa

Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past decade, neuroimaging has been used to examine the neuroscientific basis of meditation practices, effects, states, and outcomes for clinical and nonclinical populations. However, the generalizability and replicability of current neuroscientific models of meditation have not yet been established, because they are largely based on small datasets entrenched with heterogeneity along several domains of meditation (e.g., practice types, meditation experience, clinical disorder targeted), experimental design, and neuroimaging methods (e.g., preprocessing, analysis, task-based, resting-state, structural magnetic resonance imaging). These limitations have precluded a nuanced and rigorous neuroscientific phenotyping of meditation practices and their potential benefits. Here, we present ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)–Meditation, the first worldwide collaborative consortium for neuroscientific investigations of meditation practices. ENIGMA-Meditation will enable systematic meta- and mega-analyses of globally distributed neuroimaging datasets of meditation using shared, standardized neuroimaging methods and tools to improve statistical power and generalizability. Through this powerful collaborative framework, existing neuroscientific accounts of meditation practices can be extended to generate novel and rigorous neuroscientific insights that account for multidomain heterogeneity. ENIGMA-Meditation will inform neuroscientific mechanisms that underlie therapeutic action of meditation practices on psychological and cognitive attributes, thereby advancing the f

关键词： Consortium ENIGMA Magnetic resonance imaging (MRI) Meditation Mindfulness Neuroimaging

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Relative magnetic field and slipping effect on Casson dusty fluid of two phase fluctuating flow over inclined parallel plate

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South African Journal of Chemical Engineering 2023年 44卷 135-146页

作者： khan, Dolat Kumam, Poom Kumam, Wiyada Suttiarporn, Panawan Rehman, Ali Fixed Point Research Laboratory Fixed Point Theory and Applications Research Group Center of Excellence in Theoretical and Computational Science (TaCS-CoE) Faculty of Science King Mongkut's University of Technology Thonburi (KMUTT) 126 Pracha Uthit Rd. Bang Mod Bangkok Thung Khru 10140 Thailand Center of Excellence in Theoretical and Computational Science (TaCS-CoE) Faculty of Science King Mongkut's University of Technology Thonburi (KMUTT) 126 Pracha Uthit Rd. Bang Mod Bangkok Thung Khru 10140 Thailand Applied Mathematics for Science and Engineering Research Unit (AMSERU) Program in Applied Statistics Department of Mathematics and Computer Science Faculty of Science and Technology Rajamangala University of Technology Thanyaburi (RMUTT) Pathum Thani 12110 Thailand Faculty of Science Energy and Environment King Mongkut's University of Technology North Bangkok Rayong Campus Rayong 21120 Thailand Special Interest Group for Modelling and Data Analytics Faculty of Ocean Engineering Technology and Informatics Universiti Malaysia Terengganu Terengganu Kuala Nerus 21030 Malaysia

Due to its significant applications in magnetic devices for cell separation, magnetic drugs for cancer tumor treatment, blood flow adjustment during surgery, magnetic endoscopy, and fluid pumping in industrial and engineering processes, magnetohydrodynamics (MHD) has a wide range of applications. Therefore, the aim of this study to investigate the Relative Magnetic Field and slipping effect on Casson dusty fluid of two-phase fluctuating flow over inclined parallel plate. More exactly, the relative magnetic phenomena are fixed relatively to the plate (MFFRP) or fixed relatively to the fluid (MFFRF). The mathematical modeling was established as the set of partial differential equations for dusty Casson fluid. Buckingham's pi theorem is used to find out the dimensionless variables, to make our system dimensionless. The solution in perturb form is to find out by incorporating Poincare–Lighthill perturbation technique (PLPT). To know in-depth different parameters the graphical results for both velocities are plotted with the help of software Mathcad- 15. It is clearly detected that the relative magnetic field performs a vital part in the fluid as well as particle motion. Moreover, the relative magnetic field play a vital role in the decreasing of skin friction of both plates. © 2023

关键词： Brinkman fluid Dust particles Fluctuating vertical plate Inclined relative magnetic field PLPT

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