Essential ncRNA is a type of ncRNAwhich is indispensable for the sur-vival of *** essential ncRNAs cannot encode proteins,they are as important as essential coding genes in *** have got wide variety of applications su...
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Essential ncRNA is a type of ncRNAwhich is indispensable for the sur-vival of *** essential ncRNAs cannot encode proteins,they are as important as essential coding genes in *** have got wide variety of applications such as antimicrobial target discovery,minimal genome construction and evolution *** present,the number of species required for the deter-mination of essential ncRNAs in the whole genome scale is still very few due to the traditional methods are time-consuming,laborious and *** addition,tra-ditional experimental methods are limited by the organisms as less than 1%of bacteria can be cultured in the ***,it is important and necessary to develop theories and methods for the recognition of essential non-coding *** this paper,we present a novel method for predicting essential ncRNA by using both compositional and derivative features calculated by information theory of ncRNA *** method was developed with Support Vector Machine(SVM).The accuracy of the method was evaluated through cross-species cross-vali-dation and found to be between 0.69 and *** shows that the features we selected have good performance for the prediction of essential ncRNA using ***,the method can be applied for discovering essential ncRNAs in bacteria.
Much of commonsense knowledge in real world is in the form of procudures or sequences of steps to achieve particular goals. In recent years, knowledge extraction on procedural documents has attracted considerable atte...
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This paper aims to address the difficulties faced by novice programmers in grasping code structure and execution flow, improving programming thinking, and pinpointing code errors with accuracy. It proposes providing s...
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As a subversive concept,the metaverse has recently attracted widespread attention around the world and has set off a wave of enthusiasm in academic,industrial,and investment ***,while the metaverse brings unprecedente...
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As a subversive concept,the metaverse has recently attracted widespread attention around the world and has set off a wave of enthusiasm in academic,industrial,and investment ***,while the metaverse brings unprecedented opportunities for transformation to human society,it also contains related *** is a digital living space with information infrastructure,interoperability system,content production system,and value settlement system as the underlying structure in which the inner core is to connect real residents through applications and *** social incentives and governance rules,the metaverse reflects the digital migration of human *** article will conduct an in-depth analysis of the metaverse from the perspective of electronic data ***,from the perspective of Internet development,the background and development process of the metaverse is *** systematically elaborating on the concept and connotation of the metaverse,this paper summarizes the different views of current practitioners,experts,and scholars on the ***,from the perspective of metaverse security,the social risk and crime risks of the metaverse are *** the importance of metaverse forensics is ***,from the perspective of blockchain,smart wearable devices,and virtual reality devices,the objects and characteristics of metaverse forensics have been studied in *** smart wearable devices as an example,this paper gives the relevant experimental process of smart bracelet ***,many challenges faced by metaverse forensics are summarized by us which provide readers with some exploratory guidance.
In the modern digital landscape, integrating geographic locations and textual descriptions within a geo-textual dataset enhances location-based services (LBS) via spatial keyword queries, as these queries combine spat...
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Deep learning provides more advanced solutions for Unmanned Aerial Vehicle (UAV) fault diagnosis, but most existing deep learning methods are designed for a single fault diagnosis task. A UAV is a complex system with ...
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High dimension data increasingly emerged in many application areas. Feature selection methods are widely studied to solve the issues, playing a crucial role in eliminating redundant or irrelevant feature. Previous fea...
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This study proposes a laboratory intelligent facial recognition system based on improved CNN, which significantly improves the accuracy of facial recognition by optimising the portrait recognition algorithm, improving...
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Adenosine triphosphate(ATP)is closely related to the pathogenesis of certain diseases,so the detection of trace ATP is of great significance to disease diagnosis and drug *** field-effect transistors(GFETs)have been p...
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Adenosine triphosphate(ATP)is closely related to the pathogenesis of certain diseases,so the detection of trace ATP is of great significance to disease diagnosis and drug *** field-effect transistors(GFETs)have been proven to be a promising platform for the rapid and accurate detection of small molecules,while the Debye shielding limits the sensitive detection in real ***,a three-dimensional wrinkled graphene field-effect transistor(3D WG-FET)biosensor for ultra-sensitive detection of ATP is *** lowest detection limit of 3D WG-FET for analyzing ATP is down to 3.01 aM,which is much lower than the reported *** addition,the 3D WG-FET biosensor shows a good linear electrical response to ATP concentrations in a broad range of detection from 10 aM to 10 ***,we achieved ultra-sensitive(LOD:10 aM)and quantitative(range from 10 aM to 100 fM)measurements of ATP in human *** 3D WG-FET also exhibits high *** work may provide a novel approach to improve the sensitivity for the detection of ATP in complex biological matrix,showing a broad application value for early clinical diagnosis and food health monitoring.
Developing novel nanoparticle-based bioprobes utilized in clinical settings with imaging resolutions ranging from cell to tissue levels is a major challenge for tumor diagnosis and ***,an optimized strategy for design...
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Developing novel nanoparticle-based bioprobes utilized in clinical settings with imaging resolutions ranging from cell to tissue levels is a major challenge for tumor diagnosis and ***,an optimized strategy for designing a Fe_(3)O_(4)-based bioprobe for dual-modal cancer imaging based on surface-enhanced Raman scattering(SERS)and magnetic resonance imaging(MRI)is *** SERS activity of ultrasmall Fe_(3)O_(4) nanoparticles(NPs)was discovered,and a 5×10^(-9)M limit of detection for crystal violet molecules was successfully *** high-efficiency interfacial photon-induced charge transfer in Fe_(3)O_(4) NPs was promoted by multiple electronic energy levels ascribed to the multiple valence states of Fe,which was observed using ultraviolet-visible diffuse reflectance *** functional theory calculations were utilized to reveal that the narrow band gap and high electron density of states of ultrasmall Fe_(3)O_(4) NPs significantly boosted the vibronic coupling resonances in the SERS system upon *** subtypes of cancer cells were accurately recognized via high-resolution SERS imaging in vitro using the prepared Feg Og-based bioprobe with high sensitivity and good ***,Fe_(3)O_(4)-based bioprobes simultaneously exhibited T,-weighted MRI contrast enhancement with an active targeting capability for tumors in *** the best of our knowledge,this is the first report on the use of pure semiconductor-based SERS-MRI dual-modal nanoprobes in tumor imaging in vivo and in vitro,which has been previously realized only using semiconductor-metal complex *** non-metallic materials with SERS-MRI dual-modal imaging established in this report are a promising cancer diagnostic platform,which not only showed excellent performance in early tumor diagnosis but also possesses great potential for image-guided tumor treatment.
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