GenAI has revolutionized the generation of realistic and imaginative data in ways that were previously beyond the capabilities of other machine learning algorithms. This area is rapidly gaining traction, with extensiv...
详细信息
A variety of network deployments in disaster recovery, fire fighting and military scenarios create networks that do not form a connected network all the time. In such scenarios, paths between a source and destination ...
详细信息
Perceptual hashing has proven its robustness in securing biometric templates, where several methods have been proposed in order to have a robust and discriminating hash code against acceptable attacks. This paper prop...
详细信息
This study investigated the predictive ability of ten different machine learning (ML) models for diabetes using a dataset that was not evenly distributed. Additionally, the study evaluated the effectiveness of two ove...
详细信息
We consider the problem of instance-optimal statistical estimation under the constraint of differential privacy where mechanisms must adapt to the difficulty of the input dataset. We prove a new instance specific lowe...
Antibody-drug conjugates (ADCs) represent a transformative approach in cancer therapy, combining the specificity of monoclonal antibodies with targeted delivery of potent cytotoxic drugs to tumors. Discovery of novel ...
Antibody-drug conjugates (ADCs) represent a transformative approach in cancer therapy, combining the specificity of monoclonal antibodies with targeted delivery of potent cytotoxic drugs to tumors. Discovery of novel antigens has been the hallmark for development of ADC therapeutics and MUC1 is one such oncoprotein, which has garnered renewed interest recently. The 3D1 antibody, engineered to bind specifically to the alpha 3 (α3) helix of the MUC1-C/extracellular domain, is being actively developed towards clinical translation. The study examined the conformational coupling in the residues spanning the MUC1 sea urchin sperm protein, enterokinase, and agrin domain (SEA), which incorporates MUC1-C. 3D1 has been shown to be sensitive to three specific point mutations—D85E, V86A, and T88A— at the interaction surface between MUC1-C and the 3D1 antibody. Our findings reveal that D85E and T88A mutations cause significant conformational shifts and reduced binding affinity due to altered electrostatic interactions and hydrogen bonding. The V86A mutation, while maintaining the overall conformation, disrupts local hydrophobic interactions, leading to decreased binding efficiency. Further, residue 85 in the wild-type (WT) MUC1 SEA domain interacts with other residues, contributing to local frustration and destabilization. Mutants D85E, V86A, and T88A exhibited similar frustration patterns but with increased local energy, indicating reduced stability. Frustration calculations highlighted the crucial role of the α3 helix in protein stability and antibody interaction. Collectively, these data highlight the importance of specific residues contributing to the local frustration in maintaining effective antibody binding and suggest that mutations impacting these residues can significantly alter antigen binding dynamics.
Efficiently managing the use of water and fertilizers has always been a major concern in agricultural practices. The scarcity of fresh water has been one of the motivating factors in developing efficient irrigation sy...
详细信息
ISBN:
(纸本)1424403707
Efficiently managing the use of water and fertilizers has always been a major concern in agricultural practices. The scarcity of fresh water has been one of the motivating factors in developing efficient irrigation systems. Apart from the environmental concern in water management, it facilitates better growth of the crops. Fertilizers in low quantities can considerably retard crop growth and hence affect production. Synthetic fertilizers in high quantities pollute the soil and render ground water unsuitable for consumption. Measuring the nutrient availability in real time and properly delivering the right amount of the nutrients at the appropriate time can be immensely useful. The primary objective of SWARM is to remotely monitor the water and nutrient availability and deliver the corresponding resources dynamically in accordance with the data collected. The SWARM system was implemented at a farm measuring 250 ft × 80 ft in Kuppam, Andhra Pradesh, India. Groundnut is being cultivated in the farm. It was tested for a period of around one and a half months and results have been provided. The system has shown promising results when compared to manually supplying water and fertilizers. The SWARM software was written in the JAVA programming language. @w006 IEEE.
With regard to pulmonary nodule detection, due to the similar texture and shape as particular tissues, it is difficult for computer-Aided Detection (CAD) system in detecting pulmonary nodule with both high accuracy an...
详细信息
Similarity estimation can be used in many applications such as recommender system, cluster analysis, information retrieval and link prediction. SimRank is a famous algorithm to measure objects' similarities based ...
详细信息
Deep neural network adversarial attacks have extended to the domain of interpretability, resulting in interpretation manipulation. Therefore, we propose a novel approach for detecting explanatory adversarial examples ...
详细信息
暂无评论