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Publisher Correction: Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance

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Nature genetics 2024年第10期56卷 2281页

作者： Qingbo S Wang Takanori Hasegawa Ho Namkoong Ryunosuke Saiki Ryuya Edahiro Kyuto Sonehara Hiromu Tanaka Shuhei Azekawa Shotaro Chubachi Yugo Takahashi Saori Sakaue Shinichi Namba Kenichi Yamamoto Yuichi Shiraishi Kenichi Chiba Hiroko Tanaka Hideki Makishima Yasuhito Nannya Zicong Zhang Rika Tsujikawa Ryuji Koike Tomomi Takano Makoto Ishii Akinori Kimura Fumitaka Inoue Takanori Kanai Koichi Fukunaga Seishi Ogawa Seiya Imoto Satoru Miyano Yukinori Okada Department of Genome Informatics Graduate School of Medicine University of Tokyo Tokyo Japan. qingbow@m.u-tokyo.ac.jp. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. qingbow@m.u-tokyo.ac.jp. M&D Data Science Center Tokyo Medical and Dental University Tokyo Japan. Department of Infectious Diseases Keio University School of Medicine Tokyo Japan. hounamugun@keio.jp. Department of Pathology and Tumor Biology Kyoto University Kyoto Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine Suita Japan. Department of Genome Informatics Graduate School of Medicine University of Tokyo Tokyo Japan. Division of Pulmonary Medicine Department of Medicine Keio University School of Medicine Tokyo Japan. Faculty of Medicine Osaka University Suita Japan. Center for Data Sciences Brigham and Women's Hospital Harvard Medical School Boston MA USA. Divisions of Genetics and Rheumatology Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA. Laboratory of Children's Health and Genetics Division of Health Science Osaka University Graduate School of Medicine Suita Japan. Department of Pediatrics Osaka University Graduate School of Medicine Suita Japan. Division of Genome Analysis Platform Development National Cancer Center Research Institute Tokyo Japan. Institute for the Advanced Study of Human Biology (WPI-ASHBi) Kyoto University Kyoto Japan. Health Science Research and Development Center (HeRD) Tokyo Medical and Dental University Tokyo Japan. Laboratory of Veterinary Infectious Disease Department of Veterinary Medicine Kitasato University Tokyo Japan. Department of Respiratory Medicine Nagoya University Graduate School of Medicine Nagoya Japan. In

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Jet modification via π0-hadron correlations in Au+Au collisions at sNN=200 GeV

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Physical Review C 2024年第4期110卷 044901页

作者： N. J. Abdulameer U. Acharya A. Adare S. Afanasiev C. Aidala N. N. Ajitanand Y. Akiba H. Al-Bataineh J. Alexander M. Alfred K. Aoki N. Apadula L. Aphecetche J. Asai H. Asano E. T. Atomssa R. Averbeck T. C. Awes B. Azmoun V. Babintsev M. Bai G. Baksay L. Baksay A. Baldisseri N. S. Bandara B. Bannier K. N. Barish P. D. Barnes B. Bassalleck A. T. Basye S. Bathe S. Batsouli V. Baublis C. Baumann A. Bazilevsky M. Beaumier S. Beckman S. Belikov R. Belmont R. Bennett A. Berdnikov Y. Berdnikov L. Bichon A. A. Bickley B. Blankenship D. S. Blau J. G. Boissevain J. S. Bok H. Borel V. Borisov K. Boyle M. L. Brooks J. Bryslawskyj H. Buesching V. Bumazhnov G. Bunce S. Butsyk C. M. Camacho S. Campbell B. S. Chang W. C. Chang J. L. Charvet C.-H. Chen D. Chen S. Chernichenko M. Chiu C. Y. Chi I. J. Choi J. B. Choi R. K. Choudhury T. Chujo P. Chung A. Churyn V. Cianciolo Z. Citron B. A. Cole M. Connors P. Constantin R. Corliss M. Csanád T. Csörgő D. d'Enterria T. Dahms S. Dairaku T. W. Danley K. Das A. Datta M. S. Daugherity G. David K. DeBlasio K. Dehmelt A. Denisov A. Deshpande E. J. Desmond O. Dietzsch A. Dion P. B. Diss M. Donadelli V. Doomra J. H. Do O. Drapier A. Drees K. A. Drees A. K. Dubey J. M. Durham A. Durum D. Dutta V. Dzhordzhadze Y. V. Efremenko F. Ellinghaus H. En'yo T. Engelmore A. Enokizono R. Esha K. O. Eyser B. Fadem N. Feege D. E. Fields M. Finger, Jr. M. Finger D. Firak D. Fitzgerald F. Fleuret S. L. Fokin Z. Fraenkel J. E. Frantz A. Franz A. D. Frawley K. Fujiwara Y. Fukao T. Fusayasu P. Gallus C. Gal P. Garg I. Garishvili H. Ge F. Giordano A. Glenn H. Gong M. Gonin J. Gosset Y. Goto R. Granier de Cassagnac N. Grau S. V. Greene M. Grosse Perdekamp T. Gunji T. Guo H.-Å. Gustafsson T. Hachiya A. Hadj Henni J. S. Haggerty K. I. Hahn H. Hamagaki H. F. Hamilton J. Hanks R. Han S. Y. Han E. P. Hartouni K. Haruna S. Hasegawa T. O. S. Haseler K. Hashimoto E. Haslum R. Hayano M. Heffner T. K. Hemmick T. Hester X. He J. C. Hill A. Hodges M. Hohlmann R. S. Hollis W. Holzmann K. Homma B. Hong T. Horaguchi D. Hornback T. Debrecen University H-4010 Debrecen Egyetem tér 1 Hungary HUN-REN ATOMKI H-4026 Debrecen Bem tér 18/c Hungary Atlanta Georgia 30303 USA University of Colorado Boulder Colorado 80309 USA Joint Institute for Nuclear Research 141980 Dubna Moscow Region Russia Department of Physics University of Massachusetts Amherst Massachusetts 01003-9337 USA Department of Physics University of Michigan Ann Arbor Michigan 48109-1040 USA Chemistry Department Stony Brook University SUNY Stony Brook New York 11794-3400 USA RIKEN Nishina Center for Accelerator-Based Science Wako Saitama 351-0198 Japan RIKEN BNL Research Center New Mexico State University Las Cruces New Mexico 88003 USA Department of Physics and Astronomy Howard University Washington DC 20059 USA KEK High Energy Accelerator Research Organization Tsukuba Ibaraki 305-0801 Japan Kyoto University Kyoto 606-8502 Japan Iowa State University Ames Iowa 50011 USA Department of Physics and Astronomy Stony Brook University SUNY Stony Brook New York 11794-3800 USA SUBATECH (Ecole des Mines de Nantes CNRS-IN2P3 Université de Nantes) BP 20722-44307 Nantes France Laboratoire Leprince-Ringuet Ecole Polytechnique CNRS-IN2P3 Route de Saclay F-91128 Palaiseau France Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA Physics Department IHEP Protvino State Research Center of Russian Federation Institute for High Energy Physics Protvino 142281 Russia Collider-Accelerator Department Florida Institute of Technology Melbourne Florida 32901 USA Dapnia CEA Saclay F-91191 Gif-sur-Yvette France University of California-Riverside Riverside California 92521 USA Los Alamos National Laboratory Los Alamos New Mexico 87545 USA University of New Mexico Albuquerque New Mexico 87131 USA Abilene Christian University Abilene Texas 79699 USA Baruch College City University of New York New York New York 10010 USA PNPI Petersburg Nuclear Physics Institute Gatchina Leningrad region 188300 Russia Institut für

High-momentum two-particle correlations are a useful tool for studying jet-quenching effects in the quark-gluon plasma. Angular correlations between neutral-pion triggers and charged hadrons with transverse momenta in the range 4–12 GeV/c and 0.5–7 GeV/c, respectively, have been measured by the PHENIX experiment in 2014 for Au+Au collisions at sNN=200 GeV. Suppression is observed in the yield of high-momentum jet fragments opposite the trigger particle, which indicates jet suppression stemming from in-medium partonic energy loss, while enhancement is observed for low-momentum particles. The ratio and differences between the yield in Au+Au collisions and p+p collisions, IAA and ΔAA, as a function of the trigger-hadron azimuthal separation, Δϕ, are measured for the first time at the BNL Relativistic Heavy Ion Collider. These results better quantify how the yield of low-pT associated hadrons is enhanced at wide angle, which is crucial for studying energy loss as well as medium-response effects.

关键词： Particle correlations & fluctuations Relativistic heavy-ion collisions Hadrons Pions Hadron colliders

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Identified charged-hadron production in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and in U+U collisions at sNN=193GeV

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Physical Review C 2024年第5期109卷 054910-054910页

作者： N. J. Abdulameer U. Acharya A. Adare C. Aidala N. N. Ajitanand Y. Akiba R. Akimoto J. Alexander M. Alfred V. Andrieux K. Aoki N. Apadula H. Asano E. T. Atomssa T. C. Awes B. Azmoun V. Babintsev M. Bai X. Bai N. S. Bandara B. Bannier K. N. Barish S. Bathe V. Baublis C. Baumann S. Baumgart A. Bazilevsky M. Beaumier S. Beckman R. Belmont A. Berdnikov Y. Berdnikov L. Bichon D. Black B. Blankenship D. S. Blau J. S. Bok V. Borisov K. Boyle M. L. Brooks J. Bryslawskyj H. Buesching V. Bumazhnov S. Butsyk S. Campbell V. Canoa Roman R. Cervantes C.-H. Chen D. Chen M. Chiu C. Y. Chi I. J. Choi J. B. Choi S. Choi P. Christiansen T. Chujo V. Cianciolo Z. Citron B. A. Cole M. Connors R. Corliss Y. Corrales Morales N. Cronin N. Crossette M. Csanád T. Csörgő L. D'Orazio T. W. Danley A. Datta M. S. Daugherity G. David C. T. Dean K. DeBlasio K. Dehmelt A. Denisov A. Deshpande E. J. Desmond L. Ding A. Dion P. B. Diss D. Dixit V. Doomra J. H. Do O. Drapier A. Drees K. A. Drees J. M. Durham A. Durum H. En'yo T. Engelmore A. Enokizono R. Esha K. O. Eyser B. Fadem W. Fan N. Feege D. E. Fields M. Finger, Jr. M. Finger D. Firak D. Fitzgerald F. Fleuret S. L. Fokin J. E. Frantz A. Franz A. D. Frawley Y. Fukao Y. Fukuda T. Fusayasu K. Gainey P. Gallus C. Gal P. Garg A. Garishvili I. Garishvili H. Ge M. Giles F. Giordano A. Glenn X. Gong M. Gonin Y. Goto R. Granier de Cassagnac N. Grau S. V. Greene M. Grosse Perdekamp Y. Gu T. Gunji T. Guo H. Guragain T. Hachiya J. S. Haggerty K. I. Hahn H. Hamagaki H. F. Hamilton J. Hanks S. Y. Han M. Harvey S. Hasegawa T. O. S. Haseler K. Hashimoto R. Hayano T. K. Hemmick T. Hester X. He J. C. Hill K. Hill A. Hodges R. S. Hollis K. Homma B. Hong T. Hoshino N. Hotvedt J. Huang T. Ichihara Y. Ikeda K. Imai Y. Imazu M. Inaba A. Iordanova D. Isenhower A. Isinhue D. Ivanishchev B. V. Jacak S. J. Jeon M. Jezghani X. Jiang Z. Ji B. M. Johnson K. S. Joo D. Jouan D. S. Jumper J. Kamin S. Kanda B. H. Kang J. H. Kang J. S. Kang D. Kapukchyan J. Kapustinsky S. Karthas D. Kawall A. V. Kazantsev J. A. Key V. Khachatrya Debrecen University H-4010 Debrecen Egyetem tér 1 Hungary Georgia State University Atlanta Georgia 30303 USA University of Colorado Boulder Colorado 80309 USA Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Department of Physics University of Michigan Ann Arbor Michigan 48109 USA Chemistry Department State University of New York at Stony Brook Stony Brook New York 11794 USA RIKEN Nishina Center for Accelerator-Based Science Wako Saitama 351-0198 Japan RIKEN BNL Research Center Brookhaven National Laboratory Upton New York 11973 USA Center for Nuclear Study Graduate School of Science University of Tokyo 7-3-1 Hongo Bunkyo Tokyo 113-0033 Japan Department of Physics and Astronomy Howard University Washington DC 20059 USA KEK High Energy Accelerator Research Organization Tsukuba Ibaraki 305-0801 Japan Iowa State University Ames Iowa 50011 USA Department of Physics and Astronomy State University of New York at Stony Brook Stony Brook New York 11794 USA Kyoto University Kyoto 606-8502 Japan Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA Physics Department Brookhaven National Laboratory Upton New York 11973 USA IHEP Protvino State Research Center of Russian Federation Institute for High Energy Physics Protvino 142281 Russia Collider-Accelerator Department Brookhaven National Laboratory Upton New York 11973 USA Science and Technology on Nuclear Data Laboratory China Institute of Atomic Energy Beijing 102413 People's Republic of China Department of Physics University of Massachusetts Amherst Massachusetts 01003 USA University of California-Riverside Riverside California 92521 USA Baruch College City University of New York New York New York 10010 USA Petersburg Nuclear Physics Institute Gatchina Leningrad Region 188300 Russia Physics and Astronomy Department University of North Carolina at Greensboro Greensboro North Carolina 27412 USA Vanderbilt University Nashville Tennessee 37235 USA Saint Petersburg Stat

The PHENIX experiment has performed a systematic study of identified charged-hadron (π±, K±, p, p¯) production at midrapidity in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and U+U collisions at sNN=193GeV. Identified charged-hadron invariant transverse-momentum (pT) and transverse-mass (mT) spectra are presented and interpreted in terms of radially expanding thermalized systems. The particle ratios of K/π and p/π have been measured in different centrality ranges of large (Cu+Au and U+U) and small (p+Al and He3+Au) collision systems. The values of K/π ratios measured in all considered collision systems were found to be consistent with those measured in p+p collisions. However, the values of p/π ratios measured in large collision systems reach the values of ≈0.6, which is a factor of ≈2 larger than in p+p collisions. These results can be qualitatively understood in terms of the baryon enhancement expected from hadronization by recombination. Identified charged-hadron nuclear-modification factors (RAB) are also presented. Enhancement of proton RAB values over meson RAB values was observed in central He3+Au, Cu+Au, and U+U collisions. The proton RAB values measured in the p+Al collision system were found to be consistent with RAB values of ϕ, π±, K±, and π0 mesons, which may indicate that the size of the system produced in p+Al collisions is too small for recombination to cause a noticeable increase in proton production.

关键词： Hadron production Relativistic heavy-ion collisions Hadrons Kaons Pions Protons

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Charm- and bottom-quark production in Au+Au collisions at sNN=200 GeV

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Physical Review C 2024年第4期109卷 044907-044907页

作者： N. J. Abdulameer U. Acharya A. Adare C. Aidala N. N. Ajitanand Y. Akiba M. Alfred N. Apadula H. Asano B. Azmoun V. Babintsev M. Bai N. S. Bandara B. Bannier K. N. Barish S. Bathe A. Bazilevsky M. Beaumier S. Beckman R. Belmont A. Berdnikov Y. Berdnikov L. Bichon B. Blankenship D. S. Blau J. S. Bok V. Borisov K. Boyle M. L. Brooks J. Bryslawskyj V. Bumazhnov S. Campbell V. Canoa Roman C.-H. Chen M. Chiu C. Y. Chi I. J. Choi J. B. Choi T. Chujo Z. Citron M. Connors R. Corliss Y. Corrales Morales M. Csanád T. Csörgő T. W. Danley A. Datta M. S. Daugherity G. David C. T. Dean K. DeBlasio K. Dehmelt A. Denisov A. Deshpande E. J. Desmond A. Dion P. B. Diss J. H. Do V. Doomra A. Drees K. A. Drees J. M. Durham A. Durum A. Enokizono R. Esha B. Fadem W. Fan N. Feege D. E. Fields M. Finger, Jr. M. Finger D. Firak D. Fitzgerald S. L. Fokin J. E. Frantz A. Franz A. D. Frawley P. Gallus C. Gal P. Garg H. Ge M. Giles F. Giordano A. Glenn Y. Goto N. Grau S. V. Greene M. Grosse Perdekamp T. Gunji T. Hachiya J. S. Haggerty K. I. Hahn H. Hamagaki H. F. Hamilton J. Hanks S. Y. Han M. Harvey S. Hasegawa T. O. S. Haseler K. Hashimoto T. K. Hemmick X. He J. C. Hill A. Hodges R. S. Hollis K. Homma B. Hong T. Hoshino N. Hotvedt J. Huang K. Imai M. Inaba A. Iordanova D. Isenhower D. Ivanishchev B. V. Jacak M. Jezghani X. Jiang Z. Ji B. M. Johnson D. Jouan D. S. Jumper S. Kanda J. H. Kang D. Kawall A. V. Kazantsev J. A. Key V. Khachatryan A. Khanzadeev A. Khatiwada B. Kimelman C. Kim D. J. Kim E.-J. Kim G. W. Kim M. Kim T. Kim D. Kincses A. Kingan E. Kistenev R. Kitamura J. Klatsky D. Kleinjan P. Kline T. Koblesky B. Komkov D. Kotov L. Kovacs B. Kurgyis K. Kurita M. Kurosawa Y. Kwon J. G. Lajoie D. Larionova A. Lebedev S. Lee S. H. Lee M. J. Leitch N. A. Lewis S. H. Lim M. X. Liu X. Li D. A. Loomis D. Lynch S. Lökös T. Majoros Y. I. Makdisi M. Makek A. Manion V. I. Manko E. Mannel M. McCumber P. L. McGaughey D. McGlinchey C. McKinney A. Meles M. Mendoza A. C. Mignerey A. Milov D. K. Mishra J. T. Mitchell M. Mitrankova Iu. Mitrankov S. Miyas Debrecen University H-4010 Debrecen Egyetem tér 1 Hungary Georgia State University Atlanta Georgia 30303 USA University of Colorado Boulder Colorado 80309 USA Department of Physics University of Michigan Ann Arbor Michigan 48109-1040 USA Chemistry Department Stony Brook University SUNY Stony Brook New York 11794-3400 USA RIKEN Nishina Center for Accelerator-Based Science Wako Saitama 351-0198 Japan RIKEN BNL Research Center Brookhaven National Laboratory Upton New York 11973-5000 USA Department of Physics and Astronomy Howard University Washington DC 20059 USA Iowa State University Ames Iowa 50011 USA Department of Physics and Astronomy Stony Brook University SUNY Stony Brook New York 11794-3800 USA Kyoto University Kyoto 606-8502 Japan Physics Department Brookhaven National Laboratory Upton New York 11973-5000 USA IHEP Protvino State Research Center of Russian Federation Institute for High Energy Physics Protvino 142281 Russia Collider-Accelerator Department Brookhaven National Laboratory Upton New York 11973-5000 USA Department of Physics University of Massachusetts Amherst Massachusetts 01003-9337 USA University of California-Riverside Riverside California 92521 USA Baruch College City University of New York New York New York 10010 USA Physics and Astronomy Department University of North Carolina at Greensboro Greensboro North Carolina 27412 USA Saint Petersburg State Polytechnic University St. Petersburg 195251 Russia Vanderbilt University Nashville Tennessee 37235 USA National Research Center “Kurchatov Institute” Moscow 123098 Russia National Research Nuclear University MEPhI Moscow Engineering Physics Institute Moscow 115409 Russia New Mexico State University Las Cruces New Mexico 88003 USA Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Columbia University New York New York 10027 and Nevis Laboratories Irvington New York 10533 USA University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA Je

The invariant yield of electrons from open-heavy-flavor decays for 1<pT<8 GeV/c at midrapidity |y|<0.35 in Au+Au collisions at sNN = 200 GeV has been measured by the PHENIX experiment at the BNL Relativistic ... 详细信息

The invariant yield of electrons from open-heavy-flavor decays for 1

关键词： Hadronic decays Jets & heavy flavor physics Particle & resonance production Bottom quark Charm quark Hadron colliders

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STATE OF THE CLIMATE IN 2021

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BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY 2022年第8期103卷 S1-S1页

作者： Blunden, Jessica NOAA/NESDIS National Centers for Environmental Information Asheville NC United States NOAA NESDIS National Centers for Environmental Information Silver Spring MD United States Met Office Hadley Centre Exeter United Kingdom Cooperative Institute for Satellite Earth System Studies North Carolina State University Asheville NC United States Communications and Outreach NOAA/NESDIS National Centers for Environmental Information Asheville NC United States Innovative Consulting and Management Services LLC NOAA/NESDIS National Centers for Environmental Information Asheville NC United States European Centre for Medium-Range Weather Forecasts Reading United Kingdom CMNS-Earth System Science Interdisciplinary Center University of Maryland College Park MD United States Department of Meteorology National Centre for Earth Observation University of Reading Reading United Kingdom Department of Atmospheric and Planetary Science Hampton University Hampton VA United States National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Life and Environmental Sciences Osaka Prefecture University Osaka Sakai Japan University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder CO United States Centro de Investigaciones sobre Desertificación Spanish National Research Council (CIDE CSIC-UV-Generalitat Valenciana) Climate Atmosphere and Ocean Laboratory (Climatoc-Lab) Moncada Valencia Spain Instituto de Geografía Pontificia Universidad Católica de Valparaíso Valparaíso Chile Climatic Research Unit School of Environmental Sciences University of East Anglia Norwich United Kingdom Joint Research Centre of the European Commission Ispra Italy GloH2O Almere Netherlands University of Reading Reading United Kingdom School of Engineering Newcastle University Newcastle-upon-Tyne United Kingdom Université de Paris Cité Institut de physique du globe de Paris CNRS IGN Paris

Editors note: For easy download the posted pdf of the State of the Climate in 2021 is a low-resolution file. A high-resolution copy of the report is available by clickinghere. Please be patient as it may take a few mi... 详细信息

关键词： Greenhouse gases

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Comparison of Polarized Radiative Transfer Codes used by the EHT Collaboration

arXiv

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arXiv 2023年

作者： Prather, Ben S. Dexter, Jason Moscibrodzka, Monika Pu, Hung-Yi Bronzwaer, Thomas Davelaar, Jordy Younsi, Ziri Gammie, Charles F. Gold, Roman Wong, And George N. Akiyama, Kazunori Alberdi, Antxon Alef, Walter Algaba, Juan Carlos Anantua, Richard Asada, Keiichi Azulay, Rebecca Bach, Uwe Baczko, Anne-Kathrin Ball, David Baloković, Mislav Barrett, John Bauböck, Michi Benson, Bradford A. Bintley, Dan Blackburn, Lindy Blundell, Raymond Bouman, Katherine L. Bower, Geoffrey C. Boyce, Hope Bremer, Michael Brinkerink, Christiaan D. Brissenden, Roger Britzen, Silke Broderick, Avery E. Broguiere, Dominique Bustamante, Sandra Byun, Do-Young Carlstrom, John E. Ceccobello, Chiara Chael, Andrew Chan, Chi-Kwan Chang, Dominic O. Chatterjee, Koushik Chatterjee, Shami Chen, Ming-Tang Chen, Yongjun Cheng, Xiaopeng Cho, Ilje Christian, Pierre Conroy, Nicholas S. Conway, John E. Cordes, James M. Crawford, Thomas M. Crew, Geoffrey B. Cruz-Osorio, Alejandro Cui, Yuzhu De Laurentis, Mariafelicia Deane, Roger Dempsey, Jessica Desvignes, Gregory Dhruv, Vedant Doeleman, Sheperd S. Dougal, Sean Dzib, Sergio A. Eatough, Ralph P. Emami, Razieh Falcke, Heino Farah, Joseph Fish, Vincent L. Fomalont, Ed Alyson Ford, H. Fraga-Encinas, Raquel Freeman, William T. Friberg, Per Fromm, Christian M. Fuentes, Antonio Galison, Peter García, Roberto Gentaz, Olivier Georgiev, Boris Goddi, Ciriaco Gómez-Ruiz, Arturo I. Gómez, José L. Gu, Minfeng Gurwell, Mark Hada, Kazuhiro Haggard, Daryl Haworth, Kari Hecht, Michael H. Hesper, Ronald Heumann, Dirk Ho, Luis C. Ho, Paul Honma, Mareki Huang, Chih-Wei L. Huang, Lei Hughes, David H. Ikeda, Shiro Violette Impellizzeri, C.M. Inoue, Makoto Issaoun, Sara James, David J. Jannuzi, Buell T. Janssen, Michael Jeter, Britton Jiang, Wu Jiménez-Rosales, Alejandra Johnson, Michael D. Jorstad, Svetlana Joshi, Abhishek V. Jung, Taehyun Karami, Mansour Karuppusamy, Ramesh Kawashima, Tomohisa Keating, Garrett K. Kettenis, Mark Kim, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kino, Motoki Koay, Jun Yi Kocherlakota, Prashant K CCS-2 Los Alamos National Laboratory P.O. Box 1663 Los AlamosNM87545 United States JILA Department of Astrophysical and Planetary Sciences University of Colorado BoulderCO80309 United States Department of Astrophysics IMAPP Radboud University P.O. Box 9010 Nijmegen6500 GL Netherlands Department of Physics National Taiwan Normal University No. 88 Sec.4 Tingzhou Rd. Taipei116 Taiwan Center of Astronomy and Gravitation National Taiwan Normal University No. 88 Sec. 4 Tingzhou Road Taipei116 Taiwan Institute of Astronomy and Astrophysics Academia Sinica 11F of Astronomy-Mathematics Building AS/NTU No. 1 Sec. 4 Roosevelt Rd Taipei10617 Taiwan Department of Astronomy Columbia Astrophysics Laboratory Columbia University 550 W 120th Street New YorkNY10027 United States Center for Computational Astrophysics Flatiron Institute 162 Fifth Avenue New YorkNY10010 United States Radboud University P.O. Box 9010 Nijmegen6500 GL Netherlands Mullard Space Science Laboratory University College London Holmbury St. Mary Dorking SurreyRH5 6NT United Kingdom Institut für Theoretische Physik Goethe-Universität Frankfurt Max-von-Laue-Straße 1 Frankfurt am MainD-60438 Germany Department of Physics University of Illinois 1110 West Green Street UrbanaIL61801 United States Department of Astronomy University of Illinois at Urbana-Champaign 1002 West Green Street UrbanaIL61801 United States NCSA University of Illinois 1205 W Clark St UrbanaIL61801 United States CP3-Origins University of Southern Denmark Campusvej 55 Odense MDK-5230 Denmark School of Natural Sciences Institute for Advanced Study 1 Einstein Drive PrincetonNJ08540 United States Princeton Gravity Initiative Princeton University PrincetonNJ08544 United States Massachusetts Institute of Technology Haystack Observatory 99 Millstone Road WestfordMA01886 United States National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Harvard University 20 Gar

Interpretation of resolved polarized images of black holes by the Event Horizon Telescope (EHT) requires predictions of the polarized emission observable by an Earth-based instrument for a particular model of the black hole accretion system. Such predictions are generated by general relativistic radiative transfer (GRRT) codes, which integrate the equations of polarized radiative transfer in curved spacetime. A selection of ray-tracing GRRT codes used within the EHT collaboration is evaluated for accuracy and consistency in producing a selection of test images, demonstrating that the various methods and implementations of radiative transfer calculations are highly consistent. When imaging an analytic accretion model, we find that all codes produce images similar within a pixel-wise normalized mean squared error (NMSE) of 0.012 in the worst case. When imaging a snapshot from a cell-based magnetohydrodynamic simulation, we find all test images to be similar within NMSEs of 0.02, 0.04, 0.04, and 0.12 in Stokes I, Q, U, and V respectively. We additionally find the values of several image metrics relevant to published EHT results to be in agreement to much better precision than measurement uncertainties. © 2023, CC BY.

关键词： Mean square error

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Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

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Nature genetics 2023年第3期55卷 519-520页

作者： Ceres Fernandez-Rozadilla Maria Timofeeva Zhishan Chen Philip Law Minta Thomas Stephanie Schmit Virginia Díez-Obrero Li Hsu Juan Fernandez-Tajes Claire Palles Kitty Sherwood Sarah Briggs Victoria Svinti Kevin Donnelly Susan Farrington James Blackmur Peter Vaughan-Shaw Xiao-Ou Shu Jirong Long Qiuyin Cai Xingyi Guo Yingchang Lu Peter Broderick James Studd Jeroen Huyghe Tabitha Harrison David Conti Christopher Dampier Mathew Devall Fredrick Schumacher Marilena Melas Gad Rennert Mireia Obón-Santacana Vicente Martín-Sánchez Ferran Moratalla-Navarro Jae Hwan Oh Jeongseon Kim Sun Ha Jee Keum Ji Jung Sun-Seog Kweon Min-Ho Shin Aesun Shin Yoon-Ok Ahn Dong-Hyun Kim Isao Oze Wanqing Wen Keitaro Matsuo Koichi Matsuda Chizu Tanikawa Zefang Ren Yu-Tang Gao Wei-Hua Jia John Hopper Mark Jenkins Aung Ko Win Rish Pai Jane Figueiredo Robert Haile Steven Gallinger Michael Woods Polly Newcomb David Duggan Jeremy Cheadle Richard Kaplan Timothy Maughan Rachel Kerr David Kerr Iva Kirac Jan Böhm Lukka-Pekka Mecklin Pekka Jousilahti Paul Knekt Lauri Aaltonen Harri Rissanen Eero Pukkala Johan Eriksson Tatiana Cajuso Ulrika Hänninen Johanna Kondelin Kimmo Palin Tomas Tanskanen Laura Renkonen-Sinisalo Brent Zanke Satu Männistö Demetrius Albanes Stephanie Weinstein Edward Ruiz-Narvaez Julie Palmer Daniel Buchanan Elizabeth Platz Kala Visvanathan Cornelia Ulrich Erin Siegel Stefanie Brezina Andrea Gsur Peter Campbell Jenny Chang-Claude Michael Hoffmeister Hermann Brenner Martha Slattery John Potter Konstantinos Tsilidis Matthias Schulze Marc Gunter Neil Murphy Antoni Castells Sergi Castellví-Bel Leticia Moreira Volker Arndt Anna Shcherbina Mariana Stern Bens Pardamean Timothy Bishop Graham Giles Melissa Southey Gregory Idos Kevin McDonnell Zomoroda Abu-Ful Joel Greenson Katerina Shulman Flavio Lejbkowicz Kenneth Offit Yu-Ru Su Robert Steinfelder Temitope Keku Bethany van Guelpen Thomas Hudson Heather Hampel Rachel Pearlman Sonja Berndt Richard Hayes Marie Elena Martinez Sushma Thomas Douglas Corley Paul Pharoah Susanna Larsson Yun Yen Heinz-Jo Edinburgh Cancer Research Centre Institute of Genomics and Cancer University of Edinburgh Edinburgh UK. Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain. Colon Cancer Genetics Group Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK. Danish Institute for Advanced Study Department of Public Health University of Southern Denmark Odense Denmark. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University Medical Center Nashville TN USA. Division of Genetics and Epidemiology Institute of Cancer Research London UK. Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA. Genomic Medicine Institute Cleveland Clinic Cleveland OH USA. Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA. Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain. Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain. Consortium for Biomedical Research in Epidemiology and Public Health Madrid Madrid Spain. Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain. Department of Biostatistics School of Public Health University of Washington Seattle WA USA. Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK. Department of Public Health Richard Doll Building University of Oxford Oxford UK. Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA. Department of Preventive Medicine USC Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA USA. Center for Public Health Genomics Department of Public Health Sciences University of Virginia Charlottesville VA USA. De

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Correction: Association of low-frequency and rare coding variants with information processing speed

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Translational psychiatry 2022年第1期12卷 88页

作者： Jan Bressler Gail Davies Albert V Smith Yasaman Saba Joshua C Bis Xueqiu Jian Caroline Hayward Lisa Yanek Jennifer A Smith Saira S Mirza Ruiqi Wang Hieab H H Adams Diane Becker Eric Boerwinkle Archie Campbell Simon R Cox Gudny Eiriksdottir Chloe Fawns-Ritchie Rebecca F Gottesman Megan L Grove Xiuqing Guo Edith Hofer Sharon L R Kardia Maria J Knol Marisa Koini Oscar L Lopez Riccardo E Marioni Paul Nyquist Alison Pattie Ozren Polasek David J Porteous Igor Rudan Claudia L Satizabal Helena Schmidt Reinhold Schmidt Stephen Sidney Jeannette Simino Blair H Smith Stephen T Turner Sven J van der Lee Erin B Ware Rachel A Whitmer Kristine Yaffe Qiong Yang Wei Zhao Vilmundur Gudnason Lenore J Launer Annette L Fitzpatrick Bruce M Psaty Myriam Fornage M Arfan Ikram Cornelia M van Duijn Sudha Seshadri Thomas H Mosley Ian J Deary Human Genetics Center School of Public Health University of Texas Health Science Center at Houston Houston TX USA. jan.bressler@uth.tmc.edu. Lothian Birth Cohorts University of Edinburgh Edinburgh UK. Department of Psychology University of Edinburgh Edinburgh UK. Icelandic Heart Association Kopavogur Iceland. Gottfried Schatz Research Center for Cell Signaling Metabolism and Aging Medical University of Graz Graz Austria. Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle WA USA. Brown Foundation Institute of Molecular Medicine University of Texas Health Science Center at Houston Houston TX USA. Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK. Generation Scotland Centre for Genomic and Experimental Medicine Institute of Genetics and Cancer University of Edinburgh Edinburgh UK. Department of General Internal Medicine Johns Hopkins University School of Medicine Baltimore MD USA. Department of Epidemiology School of Public Health University of Michigan Ann Arbor MI USA. Survey Research Center Institute for Social Research University of Michigan Ann Arbor MI USA. Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands. Department of Neurology Sunnybrook Health Sciences Centre Toronto ON Canada. Department of Medicine University of Toronto Toronto ON Canada. Department of Biostatistics Boston University School of Public Health Boston MA USA. Framingham Heart Study Framingham MA USA. Department of Neurology and Alzheimer Center Amsterdam Neuroscience Vrieje Universiteit Medical Center Amsterdam The Netherlands. Human Genetics Center School of Public Health University of Texas Health Science Center at Houston Houston TX USA. Human Genome Sequencing Center Baylor College of Medicine Houston TX USA. Centre for Genomic and Experimental Medicine Institute of Genetics and Cancer University of Edinburgh Ed

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Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk

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European journal of human genetics : EJHG 2022年第5期30卷 630-631页

作者： Eileen O Dareng Jonathan P Tyrer Daniel R Barnes Michelle R Jones Xin Yang Katja K H Aben Muriel A Adank Simona Agata Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Gerasimos Aravantinos Banu K Arun Annelie Augustinsson Judith Balmaña Elisa V Bandera Rosa B Barkardottir Daniel Barrowdale Matthias W Beckmann Alicia Beeghly-Fadiel Javier Benitez Marina Bermisheva Marcus Q Bernardini Line Bjorge Amanda Black Natalia V Bogdanova Bernardo Bonanni Ake Borg James D Brenton Agnieszka Budzilowska Ralf Butzow Saundra S Buys Hui Cai Maria A Caligo Ian Campbell Rikki Cannioto Hayley Cassingham Jenny Chang-Claude Stephen J Chanock Kexin Chen Yoke-Eng Chiew Wendy K Chung Kathleen B M Claes Sarah Colonna Linda S Cook Fergus J Couch Mary B Daly Fanny Dao Eleanor Davies Miguel de la Hoya Robin de Putter Joe Dennis Allison DePersia Peter Devilee Orland Diez Yuan Chun Ding Jennifer A Doherty Susan M Domchek Thilo Dörk Andreas du Bois Matthias Dürst Diana M Eccles Heather A Eliassen Christoph Engel Gareth D Evans Peter A Fasching James M Flanagan Renée T Fortner Eva Machackova Eitan Friedman Patricia A Ganz Judy Garber Francesca Gensini Graham G Giles Gord Glendon Andrew K Godwin Marc T Goodman Mark H Greene Jacek Gronwald Eric Hahnen Christopher A Haiman Niclas Håkansson Ute Hamann Thomas V O Hansen Holly R Harris Mikael Hartman Florian Heitz Michelle A T Hildebrandt Estrid Høgdall Claus K Høgdall John L Hopper Ruea-Yea Huang Chad Huff Peter J Hulick David G Huntsman Evgeny N Imyanitov Claudine Isaacs Anna Jakubowska Paul A James Ramunas Janavicius Allan Jensen Oskar Th Johannsson Esther M John Michael E Jones Daehee Kang Beth Y Karlan Anthony Karnezis Linda E Kelemen Elza Khusnutdinova Lambertus A Kiemeney Byoung-Gie Kim Susanne K Kjaer Ian Komenaka Jolanta Kupryjanczyk Allison W Kurian Ava Kwong Diether Lambrechts Melissa C Larson Conxi Lazaro Nhu D Le Goska Leslie Jenny Lester Fabienne Lesueur Douglas A Levine Lian Li Jingmei Li Jennifer T Loud Karen H Lu Jan Lubiński Phuong L Mai Siranoush Manoukian Jeffrey R Marks Ra University of Cambridge Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care Cambridge UK. University of Cambridge Centre for Cancer Genetic Epidemiology Department of Oncology Cambridge UK. Center for Bioinformatics and Functional Genomics Cedars-Sinai Medical Center Los Angeles CA USA. Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen The Netherlands. Netherlands Comprehensive Cancer Organisation Utrecht The Netherlands. The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital Family Cancer Clinic Amsterdam The Netherlands. Veneto Institute of Oncology IOV-IRCCS Immunology and Molecular Oncology Unit Padua Italy. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Fred A. Litwin Center for Cancer Genetics Toronto ON Canada. University of Toronto Department of Molecular Genetics Toronto ON Canada. University of California Irvine Department of Epidemiology Genetic Epidemiology Research Institute Irvine CA USA. N.N. Alexandrov Research Institute of Oncology and Medical Radiology Minsk Belarus. 'Agii Anargiri' Cancer Hospital Athens Greece. University of Texas MD Anderson Cancer Center Department of Breast Medical Oncology Houston TX USA. Lund University Department of Cancer Epidemiology Clinical Sciences Lund Sweden. Vall d'Hebron Institute of Oncology Hereditary cancer Genetics Group Barcelona Spain. University Hospital of Vall d'Hebron Department of Medical Oncology Barcelona Spain. Rutgers Cancer Institute of New Jersey Cancer Prevention and Control Program New Brunswick NJ USA. Landspitali University Hospital Department of Pathology Reykjavik Iceland. University of Iceland BMC (Biomedical Centre) Faculty of Medicine Reykjavik Iceland. University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg Department of Gynecology and Obstetrics Comprehensive Cancer Center ER-EMN Erlangen Germany. Vanderbilt University School of Medicine Division of Epide

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