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Scientific discovery in the age of artificial intelligence

NATURE 2023年第7978期621卷 E33-E33页

作者： Wang, Hanchen Fu, Tianfan Du, Yuanqi Gao, Wenhao Huang, Kexin Liu, Ziming Chandak, Payal Liu, Shengchao Van Katwyk, Peter Deac, Andreea Anandkumar, Anima Bergen, Karianne Gomes, Carla P. Ho, Shirley Kohli, Pushmeet Lasenby, Joan Leskovec, Jure Liu, Tie-Yan Manrai, Arjun Marks, Debora Ramsundar, Bharath Song, Le Sun, Jimeng Tang, Jian Velickovic, Petar Welling, Max Zhang, Linfeng Coley, Connor W. Bengio, Yoshua Zitnik, Marinka Department of Engineering University of Cambridge Cambridge UK Department of Computing and Mathematical Sciences California Institute of Technology Pasadena CA USA NVIDIA Santa Clara CA USA Department of Computational Science and Engineering Georgia Institute of Technology Atlanta GA USA Department of Computer Science Cornell University Ithaca NY USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Department of Computer Science Stanford University Stanford CA USA Department of Physics Massachusetts Institute of Technology Cambridge MA USA Harvard-MIT Program in Health Sciences and Technology Cambridge MA USA Mila – Quebec AI Institute Montreal Quebec Canada Université de Montréal Montreal Quebec Canada HEC Montréal Montreal Quebec Canada CIFAR AI Chair Toronto Ontario Canada Department of Earth Environmental and Planetary Sciences Brown University Providence RI USA Data Science Institute Brown University Providence RI USA Center for Computational Astrophysics Flatiron Institute New York NY USA Department of Astrophysical Sciences Princeton University Princeton NJ USA Department of Physics Carnegie Mellon University Pittsburgh PA USA Department of Physics and Center for Data Science New York University New York NY USA Google DeepMind London UK Department of Computer Science and Technology University of Cambridge Cambridge UK Microsoft Research Beijing China Department of Biomedical Informatics Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Harvard Data Science Initiative Cambridge MA USA Kempner Institute for the Study of Natural and Artificial Intelligence Harvard University Cambridge MA USA Department of Systems Biology Harvard Medical School Boston MA USA Deep Forest Sciences Palo Alto CA USA BioMap Beijing China Mo

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The effect of organic acid hydrolysis on the properties of nanocellulose from edamame husk (Glycine max (L.) merill)

Case Studies in Chemical and Environmental Engineering

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Case Studies in Chemical and Environmental Engineering 2025年 11卷

作者： Wahyudi, Muhammad Sapto Holilah Bahruji, Hasliza Prasetyoko, Didik Asranudin Pratama, Agus Wedi Indriani, Dina Wahyu Suryanegara, Lisman Faradilla, RH Fitri Mahardika, Melbi Wardani, Ratih Kusuma Piluharto, Bambang Knight, Victor Feizal Norrrahim, Mohd Nor Faiz Research Center for Biomass and Bioproducts National Research and Innovation Agency of Indonesia (BRIN) Cibinong Indonesia Research Collaboration Center for Nanocellulose BRIN-Andalas University Padang Indonesia Study Program of Chemistry Faculty of Science and Technology UIN Sunan Kalijaga Yogyakarta Indonesia Centre of Advanced Material and Energy Sciences Universiti Brunei Darussalam Jl. Tungku Link BE 1410 Brunei Darussalam Department of Chemistry Faculty of Science and Data Analytics Institut Teknologi Sepuluh Nopember Surabaya Indonesia Research Center for Applied Microbiology National Research and Innovation Agency (BRIN) Cibinong Indonesia Department of Biosystem Engineering Faculty of Agricultural Technology Universitas Brawijaya Jalan Veteran Malang Indonesia Department of Food Science and Technology Faculty of Agriculture Universitas Halu Oleo Kendari Indonesia Academy Pharmacy of Surabaya Ketintang Gayungan Surabaya 60231 Indonesia Department of Chemistry Faculty of Mathematics and Natural Sciences University of Jember Jember Indonesia Research Center for Chemical Defence Defence Research Institute Universiti Pertahanan Nasional Malaysia Kem Sungai Besi Kuala Lumpur 57000 Malaysia

The increasing demand for sustainable materials has highlighted nanocellulose as a promising candidate due to its exceptional mechanical strength, thermal stability, and superior barrier properties. These attributes enable its application in diverse fields, including packaging, biomedical devices, and nanocomposites. This study investigates the valorization of edamame bean husks, a byproduct of the globally consumed legume snack, as a sustainable feedstock for nanocellulose production. Cellulose was extracted from the husks via delignification and bleaching, followed by a green and facile acid hydrolysis method employing organic acids (maleic acid, lactic acid, citric acid, and formic acid) to produce nanocellulose. The resulting nanocellulose exhibited a fibrillar morphology with particle sizes ranging from 7.59 to 17.51 nm, depending on the acid used. X-ray diffraction analysis revealed a crystallinity index ranging from 63.49 % to 67.24 %. Notably, acid hydrolysis significantly enhanced the thermal stability of the nanocellulose compared to both the raw husk and isolated cellulose. These findings demonstrate the potential of edamame agricultural waste as a valuable resource for sustainable and eco-friendly nanocellulose production, contributing to a circular bioeconomy. © 2025 The Authors

关键词： Characterization Edamame husk waste Green synthesis Nanocellulose Organic acids

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Evaluation of lahar flood hazard management policy using participatory planning in Putih watershed, Magelang regency, central java, Indonesia

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IOP Conference Series: Earth and Environmental science 2021年第1期683卷

作者： A L Permatasari I A Suherningtyas P P K Wiguna Geography Study Program Faculty of Science and Technology Universitas Amikom Yogyakarta Center for Spatial Data Infrastructure Development Universitas Udayana Bali

The occurrence of Lahar floods after Merapi Volcano eruption in 2010 still continue to be a concern for the government and the community. Kali Putih is one of the rivers that originates in Merapi Volcano and is one of the Lahar flood hazard area. Non-structural mitigation efforts have been carried out by the government. Until now, there are still community activities in the forbidden hazard area. Regulations regarding to spatial planning regulation in the hazard area need to be evaluated. The aim of the study is to evaluate the Lahar flood hazard mitigation based on participatory mapping and Focus Group Discussions (FGD). The research area is Jumoyo Village, which is the highest Lahar hazard flood area. The results indicate that there are still residential areas and community activities in the Lahar flood hazard area. The community does not want to lose their livelihood or relocation of their homes. The community expect that the government is able to revive the economic activities of the community through the establishment of new economic centres without relocation of their homes. The community also expect that the government able to creating new employment.

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A model for Optimizing the health and economic impacts of Covid-19 under social distancing measures;A study for the number of passengers and their seating arrangements in Aircrafts

arXiv

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arXiv 2020年

作者： Ghorbani, Elaheh Molavian, Hamid Barez, Fred Department of Aviation and Technology Study San Jose State University San JoseCA95192 United States Magic Distance San JoseCA95126 United States Data Science Immersive Program Galvanize Inc. San FranciscoCA94105 United States

Covid-19 has had a disastrous economic impact on countries and industries as countries have gone through the lockdown process to reduce the health impact of Covid-19. As countries have begun the reopening phases, businesses have been allowed to have on-site customers but with reduced number of people on their sites to follow the social distancing measures. This has resulted in a big burden on the economic side of these businesses as their number of customers have decreased substantially. In this study we propose a model to minimize the economic impact of Covid-19 for businesses and organizations that have implemented social distancing measures as well as health impact of Covid-19 for their customers and employees. We introduce quantity Spread in which minimizing Spread gives the optimum number and arrangement of people on a given site with a social distancing measure. We apply our model to a real-world case and optimize the number of passengers and their arrangements under a social distancing measure for two different popular aircraft seat layouts using Annealing Monte Carlo technique. We obtain the optimum numbers and optimal arrangements of passengers considering both family groups and individual passengers for the social distancing measure. The obtained optimal arrangements of passengers show complex patterns with groups and individual passengers are mixed in complex and non-trivial ways. This demonstrates the necessity of using our model or its variants to find these optimal arrangements. Moreover, we show that any other arrangements of passengers with the same number of passengers is a suboptimal arrangement with higher health risks as a result of lower distance between passengers. Our model could be implemented to other social setups such as sports events, theaters, medical centers, etc. Copyright © 2020, The Authors. All rights reserved.

关键词： Coronavirus

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Should workers be physically active after work?Associations of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels-An individual participant data meta-analysis

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Journal of Sport and Health science 2025年第1期14卷 49-60页

作者： Bart Cillekens Pieter Coenen Maaike A.Huysmans Andreas Holtermann Richard P.Troiano Paul Jarle Mork Steinar Krokstad Els Clays Dirk De Bacquer Mette Aadahl Line Lund Kårhus Anette Sjøl Lars Bo Andersen Jussi Kauhanen Ari Voutilainen Richard Pulsford Emmanuel Stamatakis Uri Goldbourt Annette Peters Barbara Thorand Annika Rosengren Lena Björck Kyle Sprow Kristin Franzon Miguel Rodriguez-Barranco Leila Luján-Barroso Lars Alfredsson Martin Bahls Till Ittermann Miriam Wanner Matthias Bopp Jacob Louis Marott Peter Schnohr Børge G.Nordestgaarda Knut Eirik Dalene Ulf Ekelund Johan Clausen Magnus T.Jensen Christina Bjørk Petersen Niklas Krause Jos Twisk Willem van Mechelen Allard J.van der Beek Department of Public and Occupational Health Amsterdam Public Health Research InstituteVrije Universiteit AmsterdamAmsterdam UMCAmsterdam 1081 HVthe Netherlands National Research Centre for the Working Environment Copenhagen 2100Denmark Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark U.S.Public Health Service ArlingtonVA 22201USA Department of Public Health and Nursing Norwegian University of Science and TechnologyTrondheim 8905Norway Levanger Hospital Nord-Trøndelag Hospital TrustLevanger 7601Norway Department of Public Health and Primary Care Ghent UniversityGhent 9000Belgium Center for Clinical Research and Prevention Bispebjerg and Frederiksberg HospitalFrederiksberg 2000Denmark The Capital Region of Denmark Copenhagen 1172Denmark Western Norway University of Applied Sciences Faculty of EducationArts and SportsSogndal 5414Norway Institute of Public Health and Clinical Nutrition University of Eastern FinlandKuopio 1627Finland Faculty of Health and Life Sciences University of ExeterExeter EX12LUUK Mackenzie Wearables Research Hub Charles Perkins CentreThe University of SydneyNSW 2050Australia School of Health Sciences Faculty of Medicine and HealthThe University of SydneyNSW 2050Australia Sackler Medical faculty in Tel Aviv University Tel Aviv 6997801Israel Institute of Epidemiology Helmholtz Zentrum MünchenGerman Research Center for Environmental HealthNeuherberg 85764Germany German Centre for Cardiovascular Research(DZHK e.V.) partner site Munich Heart AllianceMunich 80636Germany Institute for Medical Information Processing Biometryand Epidemiology(IBE)Pettenkofer School of Public HealthFaculty of MedicineLudwig-Maximilians-UniversitätMunich 80636Germany Institute of Medicine Department of Molecular and Clinical MedicineSahlgrenska AcademyUniversity of GothenburgGothenburg 40530Sweden Region Västra Götaland Sahlgrenska University HospitalDepartment of Medicine Geriatrics and Emergency Medicine/ÖstraGothenb

Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity *** study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity *** This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished *** criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and *** males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)*** males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically *** females,most effects were similar but more imprecise,especially in the higher occupational physical activity *** Higher levels of leisure-time physical activity were generally associated with lower mortality ***,results for workers with moderate and high

关键词： Mortality Individual participant data Physical activity paradox Job demands

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Search for Majorana Neutrinos with the Complete KamLAND-Zen dataset

arXiv

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arXiv 2024年

作者： Abe, S. Araki, T. Chiba, K. Eda, T. Eizuka, M. Funahashi, Y. Furuto, A. Gando, A. Gando, Y. Goto, S. Hachiya, T. Hata, K. Ichimura, K. Ieki, S. Ikeda, H. Inoue, K. Ishidoshiro, K. Kamei, Y. Kawada, N. Kishimoto, Y. Koga, M. Marthe, A. Matsumoto, Y. Mitsui, T. Miyake, Haruhiko Morita, D. Nakamura, K. Nakamura, R. Nakamura, R. Nakane, J. Ono, T. Ozaki, H. Saito, K. Sakai, T. Shimizu, I. Shirai, J. Shiraishi, K. Suzuki, A. Tachibana, K. Tamae, K. Watanabe, H. Watanabe, K. Yoshida, S. Umehara, S. Fushimi, K. Kotera, K. Urano, Y. Berger, B.E. Fujikawa, B.K. Learned, J.G. Maricic, J. Fu, Z. Ghosh, S. Smolsky, J. Winslow, L.A. Efremenko, Y. Karwowski, H.J. Markoff, D.M. Tornow, W. Dell'Oro, S. Donnell, T.O. Detwiler, J.A. Enomoto, S. Decowski, M.P. Weerman, K.M. Grant, C. Penek, O. Song, H. Li, A. Axani, S.N. Garcia, M. Sarfraz, M. Research Center for Neutrino Science Tohoku University Sendai980-8578 Japan Department of Human Science Obihiro University of Agriculture and Veterinary Medicine Hokkaido Obihiro080-8555 Japan The University of Tokyo Institutes for Advanced Study The University of Tokyo Chiba Kashiwa277-8583 Japan Graduate Program on Physics for the Universe Tohoku University Sendai980-8578 Japan Graduate School of Science Osaka University Toyonaka Osaka560-0043 Japan Research Center for Nuclear Physics Osaka University Osaka Ibaraki567-0047 Japan Department of Physics Tokushima University Tokushima770-8506 Japan Graduate School of Integrated Arts and Sciences Tokushima University Tokushima770-8502 Japan Nuclear Science Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Department of Physics and Astronomy University of Hawaii at Manoa HonoluluHI96822 United States Massachusetts Institute of Technology CambridgeMA02139 United States Department of Physics and Astronomy University of Tennessee KnoxvilleTN37996 United States Triangle Universities Nuclear Laboratory DurhamNC27708 United States Physics Departments Duke University DurhamNC27708 United States North Carolina Central University DurhamNC27707 United States The University of North Carolina at Chapel Hill Chapel HillNC27599 United States Center for Neutrino Physics Virginia Polytechnic Institute State University BlacksburgVA24061 United States Center for Experimental Nuclear Physics and Astrophysics University of Washington SeattleWA98195 United States Nikhef The University of Amsterdam Science Park Amsterdam Netherlands Boston University BostonMA02215 United States Halıcıoglu Data Science Institute Department of Physics University of California San Diego La Jolla CA92093 United States Department of Physics and Astronomy University of Delaware NewarkDE19716 United States

We present a search for neutrinoless double-beta (0νββ) decay of 136Xe using the full KamLAND-Zen 800 dataset with 745 kg of enriched xenon, corresponding to an exposure of 2.097 ton yr of 136Xe. This updated search benefits from a more than twofold increase in exposure, recovery of photo-sensor gain, and reduced background from muon-induced spallation of xenon. Combining with the search in the previous KamLAND-Zen phase, we obtain a lower limit for the 0νββ decay half-life of T1/20ν > 3.8 × 1026 yr at 90% C.L., a factor of 1.7 improvement over the previous limit. The corresponding upper limits on the effective Majorana neutrino mass are in the range 28–122 meV using phenomenological nuclear matrix element calculations. © 2024, CC BY.

关键词： Xenon

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INTRODUCTION

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Bulletin of the American Meteorological Society 2024年第8期105卷 S1-S11页

作者： Boyer, T. Blunden, J. Dunn, R.J.H. NOAA/NESDIS National Centers for Environmental Information Silver Spring Maryland NOAA/NESDIS National Centers for Environmental Information Asheville North Carolina Met Office Hadley Centre Exeter United Kingdom European Centre for Medium-Range Weather Forecasts Reading United Kingdom University of Maryland College Park Maryland Scripps Institution of Oceanography University of California San Diego La Jolla California NOAA/NWS National Centers for Environmental Prediction Climate Prediction Center College Park Maryland Brandenburg University of Technology (BTU) Cottbus-Senftenberg Germany Servicio Meteorológico Nacional Buenos Aires Argentina NOAA/OAR Physical Sciences Laboratory Boulder Colorado European Centre for Medium-Range Weather Forecasts Bonn Germany Center for Geophysical Research and School of Physics University of Costa Rica San José Costa Rica Department of Meteorology and National Centre for Earth Observation University of Reading Reading United Kingdom Centro Nacional de Monitoramento e Alertas de Desastres Naturais CEMADEN São Paulo Brazil Université Grenoble Alpes Institut des Géosciences de l’Environnement IRD CNRS Grenoble INP Grenoble France Hampton University Hampton Virginia Seychelles Meteorological Authority Mahe Seychelles Section for Glaciers Ice and Snow Norwegian Water Resources and Energy Directorate Oslo Norway National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Agriculture Osaka Metropolitan University Sakai Japan Science Faculty Universidad Nacional de Colombia Bogotá Colombia University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder Colorado Servicio Nacional de Meteorología e Hidrología del Perú Lima Perú Centro de Investigaciones sobre Desertificación – Spanish National Research Council (CSIC-UV-GVA) Valencia Spain Hydro-Climate Extremes Lab (H-CEL) Ghent University Ghent Belgium Department o

In 2023, La Niña conditions that generally prevailed in the eastern Pacific Ocean from mid-2020 into early 2023 gave way to a strong El Niño by October. Atmospheric concentrations of Earth’s major greenhouse gases—carbon dioxide, methane, and nitrous oxide—all increased to record-high levels. The annual global average carbon dioxide concentration in the atmosphere rose to 419.3±0.1 ppm, which is 50% greater than the pre-industrial level. The growth from 2022 to 2023 was 2.8 ppm, the fourth highest in the record since the 1960s. The combined short-term effects of El Niño and the long-term effects of increasing levels of heat-trapping gases in the atmosphere contributed to new records for many essential climate variables reported here. The annual global temperature across land and oceans was the highest in records dating as far back as 1850, with the last seven months (June–December) having each been record warm. Over land, the globally averaged temperature was also record high. Dozens of countries reported record or near-record warmth for the year, including China and continental Europe as a whole (warmest on record), India and Russia (second warmest), and Canada (third warmest). Intense and widespread heatwaves were reported around the world. In Vietnam, an all-time national maximum temperature record of 44.2°C was observed at Tuong Duong on 7 May, surpassing the previous record of 43.4°C at Huong Khe on 20 April 2019. In Brazil, the air temperature reached 44.8°C in Araçuaí in Minas Gerais on 20 November, potentially a new national record and 12.8°C above normal. The effect of rising temperatures was apparent in the cryosphere, where snow cover extent by June 2023 was the smallest in the 56-year record for North America and seventh smallest for the Northern Hemisphere overall. Heatwaves contributed to the greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Due to rapid volume loss beginning in 2021, St. A

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Sustainable improvement of food SMEs through halal certification: A meta-analysis

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AIP Conference Proceedings 2024年第1期2957卷

作者： Rizal Bahara Muhammad N. Aidi Khaswar Syamsu Euis Sunarti Anuraga Jayanegara Natural Resources and Environmental Management Science Study Program Graduate School IPB University Jl Pajajaran No 1 Kampus IPB Baranangsiang Bogor West Java 1614 Indonesia Statistics and Data Science Department Mathematics and Natural Science Faculty IPB University Jl. Lingkar Kampus IPB Dramaga Bogor West Java 16680 Indonesia Halal Science Center LPPM IPB. Gedung Pascasarjana Gedung Kimia IPB University Jl Pajajaran No 1 Kampus IPB Baranangsiang Bogor West Java 1644 Indonesia Department of Family and Consumer Sciences Faculty of Human Ecology IPB University Jl. Lingkar Kampus IPB Dramaga Bogor West Java 16610 Indonesia Department of Nutrition and Feed Technology Faculty of Animal Science IPB University Jl. Lingkar Kampus IPB Dramaga Bogor West Java 16680 Indonesia

Small and medium enterprises (SMEs) are one of the important economic drivers in Indonesia, including during the Covid-19 pandemic. Indonesia as the country with the largest Muslim population requires halal certificates for all food products sold in Indonesia. Obstacles to the implementation and certification of halal in the food SME sector are still encountered due to, among others, the cost of certification, knowledge from human resources, ease of access and information. The purpose of this study was to evaluate the role of halal certification on financial performance in Food SMEs by employing the meta-analysis method. A number of six articles out of 55 articles were selected and integrated into a database. The data were analyzed based on the Hedges’ d (standardized mean difference/SMD) effect size values and confidence interval (CI) values by using the Open MEE software. The results showed that halal-certified food SMEs significantly increased sales (SMD: 3.182; 95% CI:1.228 to 5.136; p<0.001) as compared to those of food SMEs that were not halal-certified. In the location in the Indonesia subgroup, halal certification at Food SMEs in Bogor city had a higher sale (SMD: 12.105; 95% CI: 10.289 to 13.922; p<0.001) compared to other cities. The conclusion of this study is that halal certification enhances sales and thus contributes to the sustainability of food SMEs.

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The 230 GHz Variability of Numerical Models of Sagittarius A* I. Parameter Surveys on Varying Ion-electron Temperature Ratios Under Strongly Magnetized Conditions

arXiv

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arXiv 2023年

作者： Chan, Ho-Sang Chan, Chi-Kwan Prather, Ben S. Wong, George N. Gammie, Charles Department of Physics Institute of Theoretical Physics The Chinese University of Hong Kong N.T. Shatin Hong Kong JILA University of Colorado National Institute of Standards and Technology 440 UCB BoulderCO80309-0440 United States Department of Astrophysical and Planetary Sciences University of Colorado 391 UCB BoulderCO80309 United States Steward Observatory Department of Astronomy University of Arizona 933 N. Cherry Avenue TucsonAZ85721 United States Data Science Institute University of Arizona 1230 N. Cherry Avenue TucsonAZ85721 United States Program in Applied Mathematics University of Arizona 617 North Santa Rita TucsonAZ85721 United States Los Alamos National Lab Los AlamosNM87545 United States School of Natural Sciences Institute for Advanced Study 1 Einstein Drive PrincetonNJ08540 United States Princeton Gravity Initiative Princeton University PrincetonNJ08544 United States Department of Physics University of Illinois at Urbana-Champaign 1110 West Green Street UrbanaIL61801 United States Department of Astronomy University of Illinois at Urbana-Champaign 1002 West Green Street UrbanaIL61801 United States NCSA University of Illinois at Urbana-Champaign 1205 W. Clark St. UrbanaIL61801 United States Illinois Center for the Advanced Study of the Universe University of Illinois at Urbana-Champaign 1110 West Green St. UrbanaIL61801 United States

The 230 GHz lightcurves of Sagittarius A* (Sgr A*) predicted by general relativistic magnetohydrodynamics (GRMHD) and ray-tracing (GRRT) models in Event Horizon Telescope Collaboration et al. (2022) have higher variability M∆T compared to observations. In this series of papers, we explore the origin of such large brightness variability. In this first paper, we performed large GRRT parameter surveys that span from the optically thin to the optically thick regimes, covering the ion-electron temperature ratio under strongly magnetized conditions, RLow, from 1 to 60. We find that increasing RLow can lead to either an increase or a reduction in M∆T depending on other model parameters, making it consistent with the observed variability of Sgr A* in some cases. Our analysis of GRRT image snapshots finds that the major contribution to the large M∆T for the RLow = 1 models comes from the photon rings. However, secondary contributions from the accretion flow are also visible depending on the spin parameter. Our work demonstrates the importance of the electron temperature used for modelling radiatively inefficient accretion flows and places new constraints on the ion-electron temperature ratio. A more in-depth analysis for understanding the dependencies of M∆T on RLow will be performed in subsequent papers. © 2023, CC BY.

关键词： Black holes

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BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2023年第6期20卷 824-835页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species that is representative of the data obtained in many neuroscience laboratories interested in neuron tracing. Here, we report generated gold standard manual annotations for a subset of the available imaging datasets and quantified tracing quality for 35 automatic tracing algorithms. The goal of generating such a hand-curated diverse dataset is to advance the development of tracing algorithms and enable generalizable benchmarking. Together with image quality features, we pooled the data in an interactive web application that enables users and developers to perform principal component analysis, t-distributed stochastic neighbor embedding, correlation and clustering, visualization of imaging and tracing data, and benchmarking of automatic tracing algorithms in user-defined data subsets. The image quality metrics explain most of the variance in the data, followed by neuromorphological features related to neuron size. We observed that diverse algorithms can provide complementary information to obtain accurate results and developed a method to iteratively combine methods and generate consensus reconstructions. The consensus trees obtained provide estimates of the neuron structure ground truth that typically outperform single algorithms in noisy datasets. However, specific algorithms may outperform the consensus tree strategy in specific imaging conditions. Finally, to aid users in predicting the most accurate automatic tracing results without manual annotations for comparison, we used support vector machine regression to predict reconstruction quality given an image volume and a set of automatic tracings.

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