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arXiv 2024年

作者： Huijben, Evi M.C. Terpstra, Maarten L. Galapon, Arthur Pai, Suraj Thummerer, Adrian Koopmans, Peter Afonso, Manya van Eijnatten, Maureen Gurney-Champion, Oliver Chen, Zeli Zhang, Yiwen Zheng, Kaiyi Li, Chuanpu Pang, Haowen Ye, Chuyang Wang, Runqi Song, Tao Fan, Fuxin Qiu, Jingna Huang, Yixing Ha, Juhyung Park, Jong Sung Alain-Beaudoin, Alexandra Bériault, Silvain Yu, Pengxin Guo, Hongbin Huang, Zhanyao Li, Gengwan Zhang, Xueru Fan, Yubo Liu, Han Xin, Bowen Nicolson, Aaron Zhong, Lujia Deng, Zhiwei Müller-Franzes, Gustav Khader, Firas Li, Xia Zhang, Ye Hémon, Cédric Boussot, Valentin Zhang, Zhihao Wang, Long Bai, Lu Wang, Shaobin Mus, Derk Kooiman, Bram Sargeant, Chelsea A.H. Henderson, Edward G.A. Kondo, Satoshi Kasai, Satoshi Karimzadeh, Reza Ibragimov, Bulat Helfer, Thomas Dafflon, Jessica Chen, Zijie Wang, Enpei Perko, Zoltan Maspero, Matteo Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands Radiotherapy Department University Medical Center Utrecht Utrecht Netherlands Computational Imaging Group for MR Diagnostics & Therapy University Medical Center Utrecht Utrecht Netherlands Department of Radiation Oncology University Medical Center Groningen University of Groningen Groningen Netherlands GROW School for Oncology Maastricht University Medical Centre Maastricht Netherlands Department of Radiation Oncology LMU University Hospital LMU Munich Munich Germany Department of Radiation Oncology Radboud University Medical Center Nijmegen Netherlands Wageningen University & Research Wageningen Plant Research Wageningen Netherlands Department of Radiology and Nuclear Medicine Amsterdam UMC Location University of Amsterdam Amsterdam Netherlands Cancer Center Amsterdam Imaging and Biomarkers Amsterdam Netherlands School of Biomedical Engineering Southern Medical University Guangzhou China School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China School of Biomedical Engineering ShanghaiTech University Shanghai China Fudan University Shanghai China Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Germany Indiana University Bloomington United States Advanced Development Engineering Elekta Ltd Montreal Canada Infervision Medical Technology Co. Ltd. Beijing China Department of Biomedical Engineering Shantou University China Independent researchers Department of Computer Science Vanderbilt University Nashville United States Australian e-Health Research Centre CSIRO HerstonQLD Australia Los AngelesCA United States University Hospital Aachen Aachen Germany Center for Proton Therapy Paul Scherrer Institut Villigen Switzerland Department of Computer Science ETH Zurich Zurich Switzerland University Rennes 1 CLCC Eugène Marquis INSERM LTSI Rennes France Subtle Medical Shanghai China MedMind Technology Co.

Radiation therapy plays a crucial role in cancer treatment, necessitating precise delivery of radiation to tumors while sparing healthy tissues over multiple days. Computed tomography (CT) is integral for treatment planning, offering electron density data crucial for accurate dose calculations. However, accurately representing patient anatomy is challenging, especially in adaptive radiotherapy, where CT is not acquired daily. Magnetic resonance imaging (MRI) provides superior soft-tissue contrast. Still, it lacks electron density information, while cone beam CT (CBCT) lacks direct electron density calibration and is mainly used for patient positioning. Adopting MRI-only or CBCT-based adaptive radiotherapy eliminates the need for CT planning but presents challenges. Synthetic CT (sCT) generation techniques aim to address these challenges by using image synthesis to bridge the gap between MRI, CBCT, and CT. The SynthRAD2023 challenge was organized to compare synthetic CT generation methods using multi-center ground truth data from 1080 patients, divided into two tasks: 1) MRI-to-CT and 2) CBCT-to-CT. The evaluation included image similarity and dose-based metrics from proton and photon plans. The challenge attracted significant participation, with 617 registrations and 22/17 valid submissions for tasks 1/2. Top-performing teams achieved high structural similarity indices (≥ 0.87/0.90) and gamma pass rates for photon (≥ 98.1%/99.0%) and proton (≥ 97.3%/97.0%) plans. However, no significant correlation was found between image similarity metrics and dose accuracy, emphasizing the need for dose evaluation when assessing the clinical applicability of sCT. SynthRAD2023 facilitated the investigation and benchmarking of sCT generation techniques, providing insights for developing MRI-only and CBCT-based adaptive radiotherapy. It showcased the growing capacity of deep learning to produce high-quality sCT, reducing reliance on conventional CT for treatment planning. © 2024, CC

关键词： Radiotherapy

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167-PFlops deep learning for electron microscopy: From learning physics to atomic manipulation

167-PFlops deep learning for electron microscopy: From learn...

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2018 International Conference for High Performance Computing, Networking, Storage, and Analysis, SC 2018

作者： Patton, Robert M. Travis Johnston, J. Young, Steven R. Schuman, Catherine D. March, Don D. Potok, Thomas E. Rose, Derek C. Lim, Seung-Hwan Karnowski, Thomas P. Ziatdinov, Maxim A. Kalinin, Sergei V. Oak Ridge National Laboratory Oak RidgeTN37831-6085 United States Computational Data Analytics Group United States Geographic Information Science and Technology Group United States Imaging Signals and Machine Learning Group United States Institute for Functional Imaging of Materials United States Center for Nanophase Materials Sciences United States

ISBN: (纸本)9781538683842

An artificial intelligence system called MENNDL, which used 25,200 NVIDIA Volta GPUs on Oak Ridge National Laboratory's Summit machine, automatically designed an optimal deep learning network in order to extract structural information from raw atomic-resolution microscopy data. In a few hours, MENNDL creates and evaluates millions of networks using a scalable, parallel, asynchronous genetic algorithm augmented with a support vector machine to automatically find a superior deep learning network topology and hyper-parameter set than a human expert can find in months. For the application of electron microscopy, the system furthers the goal of improving our understanding of the electron-beam-matter interactions and real-time image-based feedback, which enables a huge step beyond human capacity towards nanofabricating materials automatically. MENNDL has been scaled to the 4,200 available nodes of Summit achieving a measured 152.5 PFlops, with an estimated sustained performance of 167 PFlops when the entire machine is available. © 2018 IEEE.

关键词： Genetic algorithms

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Constructing Impactful machine learning Research for Astronomy: Best Practices for Researchers and Reviewers

arXiv

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arXiv 2023年

作者： Huppenkothen, Daniela Ntampaka, Michelle Ho, Matthew Fouesneau, Morgan Nord, Brian Peek, J.E.G. Walmsley, Mike Wu, John F. Avestruz, C. Buck, Tobias Brescia, Massimo Finkbeiner, Douglas P. Goulding, Andy D. Kacprzak, T. Melchior, Peter Pasquato, Mario Ramachandra, Nesar Ting, Yuan-Sen van de Ven, Glenn Villar, Soledad Villar, V.A. Zinger, Elad SRON Netherlands Institute for Space Research Niels Bohrweg 4 Leiden2333CA Netherlands Anton Pannekoek Institute for Astronomy University of Amsterdam Science Park 904 Amsterdam1098 XH Netherlands Space Telescope Science Institute BaltimoreMD21218 United States Department of Physics & Astronomy Johns Hopkins University BaltimoreMD21218 United States UMR 7095 98 bis bd Arago ParisF-75014 France Königstuhl 17 HeidelbergD-69117 Germany Fermi National Accelerator Laboratory P. O. Box 500 BataviaIL60510 United States Kavli Institute for Cosmological Physics University of Chicago ChicagoIL60637 United States Department of Astronomy and Astrophysics University of Chicago ChicagoIL60637 United States Jodrell Bank Centre for Astrophysics Department of Physics & Astronomy University of Manchester ManchesterM13 9PL United Kingdom Dunlap Institute for Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada Leinweber Center for Theoretical Physics University of Michigan Ann ArborMI48109 United States Department of Physics University of Michigan Ann ArborMI48109 United States Universität Heidelberg Interdisziplinäres Zentrum für Wissenschaftliches Rechnen Im Neuenheimer Feld 205 Heidelberg69120 Germany Universität Heidelberg Zentrum für Astronomie Institut für Theoretische Astrophysik Albert-Ueberle-Straße 2 Heidelberg69120 Germany Department of Physics "E. Pancini " University Federico II of Napoli Via Cinthia 21 NapoliI-80126 Italy INAF Astronomical Observatory of Capodimonte Salita Moiariello 16 NapoliI-80131 Italy Department of Physics Harvard University 17 Oxford St. CambridgeMA02138 United States Harvard-Smithsonian Center for Astrophysics 60 Garden St. CambridgeMA02138 United States Department of Astrophysical Sciences Princeton University PrincetonNJ08544 United States Swiss Data Science Center Paul Scherrer Institute Villigen5303 Switzerland Center for Statistics & Machine Learn

machine learning has rapidly become a tool of choice for the astronomical community. It is being applied across a wide range of wavelengths and problems, from the classification of transients to neural network emulators of cosmological simulations, and is shifting paradigms about how we generate and report scientific results. At the same time, this class of method comes with its own set of best practices, challenges, and drawbacks, which, at present, are often reported on incompletely in the astrophysical literature. With this paper, we aim to provide a primer to the astronomical community, including authors, reviewers, and editors, on how to implement machine learning models and report their results in a way that ensures the accuracy of the results, reproducibility of the findings, and usefulness of the method. Copyright © 2023, The Authors. All rights reserved.

关键词： machine learning

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People flow prediction technology for crowd navigation

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NTT Technical Review 2018年第8期16卷 47-52页

作者： Sato, Daisuke Shiohara, Hisako Miyamoto, Masaru Ueda, Naonori Proactive Navigation Project NTT Service Evolution Laboratories Japan Service Innovation Laboratory NTT Service Evolution Laboratories Japan Ueda Research Laboratory Japan Machine Learning and Data Science Center NTT Communication Science Laboratories Japan

We are investigating the use of incomplete observation data in order to predict the large-scale flow of people for major events such as the Olympic Games and to derive guidance measures in advance to prevent the occurrence of congestion. In this article, we introduce a spatio-temporal variable online prediction algorithm for forecasting congestion risk, and we explain our research and development efforts to utilize the algorithm. © 2018 Nippon Telegraph and Telephone Corp. All rights reserved.

关键词： Risk assessment

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SimBIG: Field-level Simulation-Based Inference of Galaxy Clustering

arXiv

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arXiv 2023年

作者： Lemos, Pablo Parker, Liam Hahn, ChangHoon Ho, Shirley Eickenberg, Michael Hou, Jiamin Massara, Elena Modi, Chirag Dizgah, Azadeh Moradinezhad Blancard, Bruno Régaldo-Saint Spergel, David Department of Physics Université de Montréal 1375 Avenue Thérèse-Lavoie-Roux MontréalQCH2V 0B3 Canada Mila - Quebec Artificial Intelligence Institute 6666 Rue Saint-Urbain MontréalQCH2S 3H1 Canada Ciela - Montreal Institute for Astrophysical Data Analysis and Machine Learning Montréal Canada Center for Computational Astrophysics Flatiron Institute 162 5th Avenue New YorkNY10010 United States Department of Physics Princeton University PrincetonNJ08544 United States Center for Cosmology and Particle Physics Department of Physics New York University New YorkNY10003 United States Department of Physics Carnegie Mellon University PittsburghPA15213 United States Center for Computational Mathematics Flatiron Institute 162 5th Avenue New YorkNY10010 United States Department of Astronomy University of Florida 211 Bryant Space Science Center GainesvilleFL32611 United States Max-Planck-Institut für Extraterrestrische Physik Postfach 1312 Giessenbachstrasse 1 Garching bei München85748 Germany Waterloo Centre for Astrophysics University of Waterloo 200 University Ave W WaterlooONN2L 3G1 Canada Department of Physics and Astronomy University of Waterloo 200 University Ave W WaterlooONN2L 3G1 Canada Département de Physique Théorique Université de Genève 24 quai Ernest Ansermet Genève 41211 Switzerland

We present the first simulation-based inference (SBI) of cosmological parameters from field-level analysis of galaxy clustering. Standard galaxy clustering analyses rely on analyzing summary statistics, such as the power spectrum, P, with analytic models based on perturbation theory. Consequently, they do not fully exploit the non-linear and non-Gaussian features of the galaxy distribution. To address these limitations, we use the SimBIG forward modelling framework to perform SBI using normalizing flows. We apply SimBIG to a subset of the BOSS CMASS galaxy sample using a convolutional neural network with stochastic weight averaging to perform massive data compression of the galaxy field. We infer constraints on (Equation presented) and (Equation presented). While our constraints on Ωm are in-line with standard P analyses, those on σ8 are 2.65× tighter. Our analysis also provides constraints on the Hubble constant H0 = 64.5 ± 3.8 km/s/Mpc from galaxy clustering alone. This higher constraining power comes from additional non-Gaussian cosmological information, inaccessible with P. We demonstrate the robustness of our analysis by showcasing our ability to infer unbiased cosmological constraints from a series of test simulations that are constructed using different forward models than the one used in our training dataset. This work not only presents competitive cosmological constraints but also introduces novel methods for leveraging additional cosmological information in upcoming galaxy surveys like DESI, PFS, and Euclid. © 2023, CC0.

关键词： Galaxies

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Time series featurization via topological data analysis

arXiv

引用

arXiv 2018年

作者： Kim, Kwangho Kim, Jisu Rinaldo, Alessandro Department of Statistics & Data Science Machine Learning Department} Carnegie Mellon University PittsburghPA15213 United States Inria Saclay – Île-de-France Palaiseau France Department of Statistics & Data Science Carnegie Mellon University Pittsburgh United States

We develop a novel algorithm for feature extraction in time series data by leveraging tools from topological data analysis. Our algorithm provides a simple, efficient way to successfully harness topological features of the attractor of the underlying dynamical system for an observed time series. The proposed methodology relies on the persistent landscapes and silhouette of the Rips complex obtained after a de-noising step based on principal components applied to a time-delayed embedding of a noisy, discrete time series sample. We analyze the stability properties of the proposed approach and show that the resulting TDA-based features are robust to sampling noise. Experiments on synthetic and real-world data demonstrate the effectiveness of our approach. We expect our method to provide new insights on feature extraction from granular, noisy time series data. Copyright © 2018, The Authors. All rights reserved.

关键词： Time series

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Hybrid physical-deep learning model for astronomical inverse problems

arXiv

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arXiv 2019年

作者： Lanusse, François Melchior, Peter Moolekamp, Fred Berkeley Center for Cosmological Physics Berkeley Institute for Data Science University of California Berkeley BerkeleyCA94709 United States Department of Astrophysical Sciences Center for Statistics and Machine Learning Princeton University PrincetonNJ08544 United States LSST Project Management Office TucsonAZ United States Department of Astrophysical Sciences Princeton University PrincetonNJ08544 United States

We present a Bayesian machine learning architecture that combines a physically motivated parametrization and an analytic error model for the likelihood with a deep generative model providing a powerful data-driven prior for complex signals. This combination yields an interpretable and differentiable generative model, allows the incorporation of prior knowledge, and can be utilized for observations with different data quality without having to retrain the deep network. We demonstrate our approach with an example of astronomical source separation in current imaging data, yielding a physical and interpretable model of astronomical scenes. Copyright © 2019, The Authors. All rights reserved.

关键词： Source separation

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Algorithmic Regularization in learning Deep Homogeneous Models: Layers are Automatically Balanced

arXiv

引用

arXiv 2018年

作者： Du, Simon S. Hu, Wei Lee, Jason D. Machine Learning Department School of Computer Science Carnegie Mellon University Computer Science Department Princeton University. Department of Data Sciences and Operations Marshall School of Business University of Southern California.

We study the implicit regularization imposed by gradient descent for learning multi-layer homogeneous functions including feed-forward fully connected and convolutional deep neural networks with linear, ReLU or Leaky ReLU activation. We rigorously prove that gradient flow (i.e. gradient descent with infinitesimal step size) effectively enforces the differences between squared norms across different layers to remain invariant without any explicit regularization. This result implies that if the weights are initially small, gradient flow automatically balances the magnitudes of all layers. Using a discretization argument, we analyze gradient descent with positive step size for the non-convex low-rank asymmetric matrix factorization problem without any regularization. Inspired by our findings for gradient flow, we prove that gradient descent with step sizes ηt = O (t -(1/2 +δ)) (0 Copyright © 2018, The Authors. All rights reserved.

关键词： Gradient methods

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Distribution-Free Prediction Sets for Two-Layer Hierarchical Models

arXiv

引用

arXiv 2018年

作者： Dunn, Robin Wasserman, Larry Ramdas, Aaditya Novartis Pharmaceuticals Corporation Advanced Methodology and Data Science East HanoverNJ United States Department of Statistics & Data Science Carnegie Mellon University PittsburghPA United States Machine Learning Department Carnegie Mellon University PittsburghPA United States

We consider the problem of constructing distribution-free prediction sets for data from two-layer hierarchical distributions. For iid data, prediction sets can be constructed using the method of conformal prediction. The validity of conformal prediction hinges on the exchangeability of the data, which does not hold when groups of observations come from distinct distributions, such as multiple observations on each patient in a medical database. We extend conformal methods to a hierarchical setting. We develop CDF pooling, single subsampling, and repeated subsampling approaches to construct prediction sets in unsupervised and supervised settings. We compare these approaches in terms of coverage and average set size. If asymptotic coverage is acceptable, we recommend CDF pooling for its balance between empirical coverage and average set size. If we desire coverage guarantees, then we recommend the repeated subsampling approach. Supplementary materials are available online. Copyright © 2018, The Authors. All rights reserved.

关键词： Forecasting

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FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare

arXiv

引用

arXiv 2023年

作者： Lekadir, Karim Feragen, Aasa Fofanah, Abdul Joseph Frangi, Alejandro F. Buyx, Alena Emelie, Anais Lara, Andrea Porras, Antonio R. Chan, An-Wen Navarro, Arcadi Glocker, Ben Botwe, Benard O. Khanal, Bishesh Beger, Brigit Wu, Carol C. Cintas, Celia Langlotz, Curtis P. Rueckert, Daniel Mzurikwao, Deogratias Fotiadis, Dimitrios I. Zhussupov, Doszhan Ferrante, Enzo Meijering, Erik Weicken, Eva González, Fabio A. Asselbergs, Folkert W. Prior, Fred Krestin, Gabriel P. Collins, Gary S. Tegenaw, Geletaw S. Kaissis, Georgios Misuraca, Gianluca Tsakou, Gianna Dwivedi, Girish Kondylakis, Haridimos Jayakody, Harsha Woodruf, Henry C. Mayer, Horst Joachim Aerts, Hugo JWL Walsh, Ian Chouvarda, Ioanna Buvat, Irène Tributsch, Isabell Rekik, Islem Duncan, James Kalpathy-Cramer, Jayashree Zahir, Jihad Park, Jinah Mongan, John Gichoya, Judy W. Schnabel, Julia A. Kushibar, Kaisar Riklund, Katrine Mori, Kensaku Marias, Kostas Amugongo, Lameck M. Fromont, Lauren A. Maier-Hein, Lena Alberich, Leonor Cerdá Rittner, Leticia Phiri, Lighton Marrakchi-Kacem, Linda Donoso-Bach, Lluís Martí-Bonmatí, Luis Cardoso, M. Jorge Bobowicz, Maciej Shabani, Mahsa Tsiknakis, Manolis Zuluaga, Maria A. Bielikova, Maria Fritzsche, Marie-Christine Camacho, Marina Linguraru, Marius George Wenzel, Markus De Bruijne, Marleen Tolsgaard, Martin G. Ghassemi, Marzyeh Ashrafuzzaman, Md Goisauf, Melanie Yaqub, Mohammad Abadía, Mónica Cano Mahmoud, Mukhtar M.E. Elattar, Mustafa Rieke, Nicola Papanikolaou, Nikolaos Lazrak, Noussair Díaz, Oliver Salvado, Olivier Pujol, Oriol Sall, Ousmane Guevara, Pamela Gordebeke, Peter Lambin, Philippe Brown, Pieta Abolmaesumi, Purang Dou, Qi Lu, Qinghua Osuala, Richard Nakasi, Rose Zhou, S. Kevin Napel, Sandy Colantonio, Sara Albarqouni, Shadi Joshi, Smriti Carter, Stacy Klein, Stefan Petersen, Steffen E. Aussó, Susanna Awate, Suyash Raviv, Tammy Riklin Cook, Tessa Mutsvangwa, Tinashe E.M. Rogers, Wendy A. Niessen, Wiro J. Puig-Bosch, Xènia Zeng, Yi Mohammed, Yunusa G. Aquino, Yves Saint James Salahuddin, Zohaib Starmans, Martijn P.A. Department de Matemàtiques i Informàtica Universitat de Barcelona Barcelona Spain Barcelona Spain DTU Compute Technical University of Denmark Kgs Lyngby Denmark Department of Mathematics and Computer Science Faculty of Science and Technology Milton Margai Technical University Freetown Sierra Leone Center for Computational Imaging & Simulation Technologies in Biomedicine Schools of Computing and Medicine University of Leeds Leeds United Kingdom Cardiovascular Science and Electronic Engineering Departments KU Leuven Leuven Belgium Institute of History and Ethics in Medicine Technical University of Munich Munich Germany Faculty of Engineering of Systems Informatics and Sciences of Computing Galileo University Guatemala City Guatemala Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus AuroraCO United States Department of Medicine Women’s College Research Institute University of Toronto Toronto Canada Universitat Pompeu Fabra BarcelonaBeta Brain Research Center Barcelona Spain Department of Computing Imperial College London London United Kingdom School of Biomedical & Allied Health Sciences University of Ghana Accra Ghana Department of Midwifery & Radiography School of Health & Psychological Sciences City University of London United Kingdom Kathmandu Nepal European Heart Network Brussels Belgium Department of Thoracic Imaging University of Texas MD Anderson Cancer Center Houston United States IBM Research Africa Nairobi Kenya Departments of Radiology Medicine and Biomedical Data Science Stanford University School of Medicine Stanford United States Institute for AI and Informatics in Medicine Klinikum rechts der Isar Technical University Munich Munich Germany Department of Computing Imperial College London London United Kingdom Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania United Republic of Ioannina Greece Almaty AI Lab Almaty Kazakhstan

Background: Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. In recent years, concerns have been raised about the clinical, technical, ethical and legal risks associated with healthcare AI. To increase adoption in the real world, it is essential that AI technologies are trusted and accepted by patients, clinicians, health organisations and authorities. This paper describes the FUTURE-AI framework as the first international consensus guideline for trustworthy AI in healthcare. Methods: The FUTURE-AI consortium was founded in 2021 and now comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two-year period, the consortium established guiding principles and best practices for trustworthy and deployable AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. Findings: The FUTURE-AI framework was established based on six guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 30 best practices were defined, addressing technical, clinical, socio-ethical and legal dimensions of trustworthy AI. The recommendations cover the entire lifecycle of healthcare AI, from design, development and validation to regulation, deployment, and monitoring. Interpretation: FUTURE-AI is a structured, risk-informed framework which provides guidance for constructing healthcare AI tools that will be trusted, deployed and adopted in real-world clinical practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of healthcare AI. Copyright © 2023, The Authors. All rights

关键词： Clinical research

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