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6th Asia Conference on Cognitive Engineering and Intelligent Interaction, CEII 2023

作者： Toapanta Toapanta, Segundo Moises Gomez Diaz, Eriannys Zharayth Quintana, Yngrid Melo Cesar Gancino Vargas, Julio Research Department Sangolquí Ecuador Education Department Sangolquí Ecuador Systems and Data Management Department Sangolquí Ecuador Software Development Department Sangolquí Ecuador

ISBN: (纸本)9798350306965

Attacks on information security in the cloud have been manifested for many years, due to the types of services it offers, including data storage;Cloud attacks, security protocols, and benchmark algorithms were analyzed to identify security gaps that are vulnerable to different attacks. The main objective is to propose a Conceptual Model to protect the cloud against attacks. Qualitative, descriptive and deductive reasoning was used to analyze the information from the reference articles. It resulted in a Conceptual Model to protect the cloud against attacks, a Cloud Security Prototype and an Algorithm using flowchart techniques to protect the cloud from attacks. It was concluded that the conceptual model to protect the cloud from attacks proposed allows users to have an identity, authorization, authentication and audit (IAAA) so that the information has confidentiality, integrity and availability (CIA) in a distributed environment in the cloud. © 2023 IEEE.

关键词： Network security

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Hierarchical Graph Signal Processing for Collaborative Filtering 24

Hierarchical Graph Signal Processing for Collaborative Filte...

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33rd ACM Web Conference, WWW 2024

作者： Xia, Jiafeng Li, Dongsheng Gu, Hansu Lu, Tun Zhang, Peng Shang, Li Gu, Ning Fudan University Shanghai China Microsoft Research Asia Shanghai China Seattle United States School of Computer Science and Shanghai Key Laboratory of Data Science Fudan University China Fudan Institute on Aging MOE Laboratory for National Development and Intelligent Governance Shanghai Institute of Intelligent Electronics and Systems Fudan University China

ISBN: (纸本)9798400701719

Graph Signal Processing (GSP) has proven to be a highly effective and efficient tool for predicting user future interactions in recommender systems. However, current GSP methods recognize user interaction patterns based on the interactions of all users, so that the recognized interaction patterns are not fully user-matched and easily impacted by other users with different interaction behaviors, resulting in sub-optimal recommendation performance. To this end, we propose a hierarchical graph signal processing method (HiGSP) for collaborative filtering, which consists of two key modules: 1) the cluster-wise filter module that recognizes user unique interaction patterns merely from interactions of users with similar preferences, making the recognized patterns able to reflect user preference without being influenced by other users with different interaction behaviors, and 2) the globally-aware filter module that serves as a complementary to the cluster-wise filter module to recognize user general interaction patterns more effectively from all user interactions. By linearly combining these two modules, HiGSP can recognize user-matched interaction patterns, so as to model user preference and predict user future interactions more accurately. Extensive experiments on six real-world datasets demonstrate the superiority of HiGSP compared to other GCN-based and GSP-based recommendation methods in terms of efficacy and efficiency. © 2024 ACM.

关键词： Collaborative filtering

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Epilepsy Detection Grand Challenge 48

Epilepsy Detection Grand Challenge

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48th IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP 2023

作者： Chatzichristos, Christos Bhagubai, Miguel Van Paesschen, Wim De Vos, Maarten Un. Hospital Leuven Lab. for Epilepsy Research KU Leuven & Department of Neurology Belgium Signal Processing and Data Analytics KU Leuven STADIUS Center for Dynamical Systems Department of Electrical Engineering Leuven Belgium KU Leuven Department Development and Regeneration Leuven Belgium

ISBN: (纸本)9781728163277

In this paper, we describe the epilepsy detection grand challenge, in association with ICASSP 2023. The challenge was centered on seizure detection using wearable behind-the-ear EEG. Two separate tasks were set for the participants: 1) obtain the best overall performance in seizure detection;2) systematically engineer the data in a data-centric task to optimize a given AI model for seizure detection. © 2023 IEEE.

关键词： Neurology

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Geoinformational Approach to Assessing the Accessibility for Urban Areas

Geoinformational Approach to Assessing the Accessibility for...

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2022 International Siberian Conference on Control and Communications, SIBCON 2022

作者： Kurlov, Aleksey V. Materuhin, Andrey V. Dresvyanin, Andrey V. Gvozdev, Oleg G. Moscow State University of Geodesy and Cartography Scientific and Research Laboratory of Urban Technology and Spatial Development Moscow Russia Moscow State University of Geodesy and Cartography Department of Data Acquisition Systems Moscow Russia Moscow State University of Geodesy and Cartography Monitoring Systems Laboratory Moscow Russia

ISBN: (纸本)9781665476287

An important part of the accessibility of the urban environment is the connectivity of transport network, especially regarding to its usage via personal transport. There are many methods of quantitative analysis of this aspect. A significant part of them is based on the isochronal analysis. The article assumes that on the local scale the one of the key factors indicating a transport network connectivity is the asymmetry between forward and backward routes between pairs of points. A method of such analysis, the computational experiment, and the following statistical analysis procedure for checking this hypothesis. Performing this procedure allows us to confirm the hypothesis with statistical significance p=*** experiment presented in the article demonstrates the need to take into account the path asymmetry factor for calculating and evaluating transport accessibility. The given method can be used in optimizing public transport routes, designing traffic flows, and planning the development of the territory in urban agglomerations. © 2022 IEEE.

关键词： Transportation routes

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Network pharmacology and single-cell transcriptomic analysis with molecular docking to elucidate the potential compounds and targets of Polygonum cuspidatum *** *** hepatocellular carcinoma

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iLIVER 2024年第3期3卷 41-51页

作者： Wenze Wu Yuzhu Shi Yongzi Wu Rui Zhang Xinyan Wu Weidi Zhao Zhiyuan Chen Gang Ye Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNational Frontiers Science Center for Industrial Intelligence and Systems OptimizationKey Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110169China College of Veterinary Medicine Sichuan Agricultural UniversityChengdu 625014China School of Physical Education Shanxi UniversityTaiyuan 030006China

Background and aims:Polygonum cuspidatum *** Zucc.(***)and its active components have been clinically proven to have anti-hepatocellular carcinoma ***,the potential targets of *** for these effects have not yet been ***:We used network pharmacology and single-cell transcriptomic analysis with molecular docking to elucidate the active components and targets of *** for hepatocellular ***:CDK1,ESR1,HSP90A11,and MAPK1 were shown to be the key targets of *** for hepatocellular *** was found to be likely correlated with the improved abnormal expression of CDK1 and ESR1 and the poor prognosis of HSP90AA1 and ***1 was identified as the most potential antihepatocellular carcinoma target of *** the active components of ***,physcion diglucoside was found to have the most potential to treat hepatocellular carcinoma by targeting ***:Our study provides novel insights into the anti-hepatocellular carcinoma pharmacological effects of ***,which could serve as a scientific basis for its development as a medicinal resource and the targeting of CDK1 for hepatocellular carcinoma treatment.

关键词： Hepatocellular carcinoma Network pharmacology Molecular dynamics simulation Molecular docking Polygonum cuspidatum Single-cell transcriptomic analysis

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The statistical observation localized equivalent-weights particle filter in a simple nonlinear model

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Acta Oceanologica Sinica 2022年第2期41卷 80-90页

作者： Yuxin Zhao Shuo Yang Renfeng Jia Di Zhou Xiong Deng Chang Liu Xinrong Wu College of Intelligent Systems Science and Engineering Harbin Engineering UniversityHarbin 150001China Harbin Marine Boiler&Turbine Research Institute Harbin 150078China China Ship Development and Design Center Wuhan 430064China Key Laboratory of Marine Environmental Information Technology National Marine Data and Information ServiceState Oceanic AdministrationTianjin 300171China

This paper presents an improved approach based on the equivalent-weights particle filter(EWPF)that uses the proposal density to effectively improve the traditional particle *** proposed approach uses historical data to calculate statistical observations instead of the future observations used in the EWPF’s proposal density and draws on the localization scheme used in the localized PF(LPF)to construct the localized *** new approach is called the statistical observation localized EWPF(LEWPF-Sobs);it uses statistical observations that are better adapted to the requirements of real-time assimilation and the localization function is used to calculate weights to reduce the effect of missing observations on the *** approach not only retains the advantages of the EWPF,but also improves the assimilation quality when using sparse *** experiments performed with the Lorenz 96 model show that the statistical observation EWPF is better than the EWPF and EAKF when the model uses standard distribution *** of the statistical observation localized EWPF and LPF reveal the advantages of the new method,with fewer particles giving better *** particular,the new improved filter performs better than the traditional algorithms when the observation network contains densely spaced measurements associated with model state nonlinearities.

关键词： data assimilation particle filter equivalent weights particle filter localization methods

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A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy

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Chinese Journal of Natural Medicines 2025年第2期23卷 214-224页

作者： Qingqi Meng Yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang Yan Wang Yueyang Liu Guoliang Chen Yue Hou Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNational Frontiers Science Center for Industrial Intelligence and Systems OptimizationKey Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110167China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China Shenyang Key Laboratory of Vascular Biology Science and Research CenterDepartment of PharmacologyShenyang Medical CollegeShenyang 110034China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China

Ischemic stroke(IS)is a prevalent neurological disorder often resulting in significant disability or ***,extracted from Polygonum cuspidatum *** Zucc.(commonly known as Japanese knotweed),has been recognized for its potent neuroprotective ***,the neuroprotective efficacy of its derivative,(E)-4-(3,5-dimethoxystyryl)quinoline(RV02),against ischemic stroke remains inadequately *** study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in *** research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic *** findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species(ROS)through mitophagy ***,Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in *** results suggest that RV02 shows promise as a neuroprotective agent,with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.

关键词： (E)-4-(3 5-dimethoxystyryl)quinoline Resveratrol Ischemic stroke Mitophagy Parkin

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Modeling and Simulation for the Spread of Covid-19 in an Indian City: A Case Study 22

Modeling and Simulation for the Spread of Covid-19 in an Ind...

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Proceedings of the Winter Simulation Conference

作者： Aditya A. Paranjape Souvik Barat Anwesha Basu Rohan Salvi Supratim Ghosh Vinay Kulkarni Software Systems & Services TCS Research Tata Research Development and Design Centre Pune INDIA School of Information Sciences University of Illinois at Urbana-Champaign Champaign IL USA Decision & Data Sciences TCS Research Tata Research Development and Design Centre Pune INDIA

We present a case study on modeling and predicting the course of Covid-19 in the Indian city of Pune. The results presented in this paper are concerned primarily with the wave of infections triggered by the Delta variant during the period between February and June 2021. Our work demonstrates the necessity for bringing together compartmental stock-and-flow and agent-based models and the limitations of each approach when used individually. Some of the work presented here was carried out in the process of advising the local city administration and reflects the challenges associated with employing these models in a real-world environment with its uncertainties and time pressures. Our experience, described in the paper, also highlights the risks associated with forecasting the course of an epidemic with evolving variants.

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Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase

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Chinese Journal of Natural Medicines 2024年第6期22卷 486-500页

作者： YANG Yanqiu CHE Yue FANG Mingxia YAO Xiaohu ZHOU Di WANG Feng CHEN Gang LIANG Dong LI Ning HOU Yue Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNorth-eastern UniversityShenyang 110000China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110000China School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110000China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541000China

Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic ***,the effects and mechanism of reynosin on neuroinflammation remain *** current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein ***,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand *** analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 ***,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the ***,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in *** collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.

关键词： Microglia NLRP3 inflammasome Reactive oxygen species NADPH oxidase Neuron Reynosin

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Natural polyphenols as novel interventions for aging and age-related diseases:Exploring efficacy,mechanisms of action and implications for future research

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Chinese Herbal Medicines 2025年第2期17卷 279-291页

作者： Wenze Wu Yan Mi Qingqi Meng Ning Li Wei Li Pu Wang Yue Hou Liaoning Key Laboratory of Bioresource Research and Development National Frontiers Science Center for Industrial Intelligence and Systems OptimizationKey Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationCollege of Life and Health SciencesNortheastern UniversityShenyang 110169China Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 117004China Faculty of Pharmaceutical Sciences Toho UniversityMiyamaFunabashiChiba 274-8510Japan College of Pharmacy Shenzhen Technology UniversityShenzhen 518118China

Natural polyphenols are a group of components widely found in traditional Chinese medicines and have been demonstrated to delay or prevent the development of aging and age-related diseases in recent *** far as we know,the studies of natural polyphenols in aging and aging-related diseases have never been extensively *** the present paper,we reviewed recent advances of natural polyphenols in aging and common age-related diseases and the current technological methods to improve the bioavailability of natural *** results showed that natural polyphenols have the potential to prevent or treat aging and common age-related diseases through multiple ***,structural modifications,and matrix processing could provide strong technical support for the development of natural polyphenols to prevent or treat aging and age-related *** conclusion,natural polyphenols have important potential in the prevention and treatment of aging and age-related diseases.

关键词： aging cancer cardiovascular disease natural polyphenols neurodegenerative diseases

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