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Natural polyphenols as novel interventions for aging and age-related diseases: Exploring efficacy, mechanisms of action and implications for future research

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Chinese Herbal Medicines 2025年第2期17卷 279-291页

作者： Wenze Wu Yan Mi Qingqi Meng Ning Li Wei Li Pu Wang Yue Hou Liaoning Key Laboratory of Bioresource Research and Development National Frontiers Science Center for Industrial Intelligence and Systems OptimizationKey Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationCollege of Life and Health SciencesNortheastern University Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City School of Traditional Chinese Materia MedicaShenyang Pharmaceutical University Faculty of Pharmaceutical Sciences Toho University College of Pharmacy Shenzhen Technology University

Natural polyphenols are a group of components widely found in traditional Chinese medicines and have been demonstrated to delay or prevent the development of aging and age-related diseases in recent years. As far as we know, the studies of natural polyphenols in aging and aging-related diseases have never been extensively reviewed. In the present paper, we reviewed recent advances of natural polyphenols in aging and common age-related diseases and the current technological methods to improve the bioavailability of natural polyphenols. The results showed that natural polyphenols have the potential to prevent or treat aging and common age-related diseases through multiple ***, structural modifications, and matrix processing could provide strong technical support for the development of natural polyphenols to prevent or treat aging and age-related diseases. In conclusion, natural polyphenols have important potential in the prevention and treatment of aging and age-related diseases.

关键词： aging cancer cardiovascular disease natural polyphenols neurodegenerative diseases

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Oracle-guided Dynamic User Preference Modeling for Sequential Recommendation 25

Oracle-guided Dynamic User Preference Modeling for Sequentia...

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18th ACM International Conference on Web Search and data Mining, WSDM 2025

作者： Xia, Jiafeng Li, Dongsheng Gu, Hansu Lu, Tun Zhang, Peng Shang, Li Gu, Ning Fudan University Shanghai China Microsoft Research Asia Shanghai China Amazon Seattle United States School of Computer Science Shanghai Key Laboratory of Data Science Fudan University Shanghai China Fudan Institute on Aging MOE Laboratory for National Development and Intelligent Governance Shanghai Institute of Intelligent Electronics & Systems Fudan University Shanghai China

ISBN: (纸本)9798400713293

Sequential recommendation methods can capture dynamic user preferences from user historical interactions to achieve better performance. However, most existing methods only use past information extracted from user historical interactions to train the models, leading to the deviations of user preference modeling. Besides past information, future information is also available during training, which contains the "oracle" user preferences in the future and will be beneficial to model dynamic user preferences. Therefore, we propose an oracle-guided dynamic user preference modeling method for sequential recommendation (Oracle4Rec), which leverages future information to guide model training on past information, aiming to learn "forward-looking" models. Specifically, Oracle4Rec first extracts past and future information through two separate encoders, then learns a forward-looking model through an oracle-guiding module which minimizes the discrepancy between past and future information. We also tailor a two-phase model training strategy to make the guiding more effective. Extensive experiments demonstrate that Oracle4Rec is superior to state-of-the-art sequential methods. Further experiments show that Oracle4Rec can be leveraged as a generic module in other sequential recommendation methods to improve their performance with a considerable margin. © 2025 Copyright held by the owner/author(s).

关键词： dynamic user preference modeling

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A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy

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Chinese Journal of Natural Medicines 2025年第2期23卷 214-224页

作者： Qingqi Meng Yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang Yan Wang Yueyang Liu Guoliang Chen Yue Hou Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNational Frontiers Science Center for Industrial Intelligence and Systems OptimizationKey Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110167China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China Shenyang Key Laboratory of Vascular Biology Science and Research CenterDepartment of PharmacologyShenyang Medical CollegeShenyang 110034China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China

Ischemic stroke(IS)is a prevalent neurological disorder often resulting in significant disability or ***,extracted from Polygonum cuspidatum *** Zucc.(commonly known as Japanese knotweed),has been recognized for its potent neuroprotective ***,the neuroprotective efficacy of its derivative,(E)-4-(3,5-dimethoxystyryl)quinoline(RV02),against ischemic stroke remains inadequately *** study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in *** research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic *** findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species(ROS)through mitophagy ***,Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in *** results suggest that RV02 shows promise as a neuroprotective agent,with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.

关键词： (E)-4-(3 5-dimethoxystyryl)quinoline Resveratrol Ischemic stroke Mitophagy Parkin

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Quality of Service-aware 6G-Enabled NB-IoT for Health Monitoring in Long Distance High-Speed Trains

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IEEE Transactions on Consumer Electronics 2025年

作者： Roy, Bipasha Guha Roy, Deepsubhra Guha Dutta, Piyali Khan, Surbhi Bhatia Asiri, Fatima Ayadi, Manel Institute of Engineering and Management Kolkata India Institute of Engineering and Management Kolkata India University of Salford Chitkara University Institute of Engineering and Technology Chitkara University Department of Data Science United Kingdom University Centre for Research and Development Chandigarh University India Centre for Research Impact and Outcome Punjab Rajpura140401 India King Khalid University College of computer science Informatics and computer systems department Saudi Arabia Princess Nourah bint Abdulrahman University College of Computer and Information Sciences Department of Information Systems Riyadh11671 Saudi Arabia

Internet of Things connectivity in home health monitoring is a high-in-demand application area. The electronics industry and procedural researchers seek high-end, secured, on-time, cost-effective ways to build reliable quality of service (QoS) proved autonomous systems using existing wireless techniques. Also, the continuous availability of a traffic-free gateway, particularly in isolated places, is necessary for large-scale data gathering and real-time data update processes to function the sensor nodes in an Internet of Things (IoT) network. Improved Narrowband IoT (NB-IoT) is one of the most desirable networks offered by 6th generation (6G) connectivity in IoT-associated remote-monitoring proceedings. In this article, we propose a QoS-aware narrow bandwidth allocation-based prototype model for healthcare monitoring in long-distance high-speed trains during the patient transfer from home to the healthcare center or vice versa. This article demonstrates a possible enhancement in social aspects of cognitive IoT applications with large data systems in industrial informatics. © 1975-2011 IEEE.

关键词： Frequency allocation

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Frequency-aware Graph Signal Processing for Collaborative Filtering 25

Frequency-aware Graph Signal Processing for Collaborative Fi...

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Companion Proceedings of the ACM on Web Conference 2025

作者： Jiafeng Xia Dongsheng Li Hansu Gu Tun Lu Peng Zhang Li Shang Ning Gu Fudan University Shanghai China and School of Computer Science and Shanghai Key Laboratory of Data Science Fudan University Shanghai China Microsoft Research Asia Shanghai China *** Seattle USA Fudan University Shanghai China Fudan Institute on Aging MOE Laboratory for National Development and Intelligent Governance and Shanghai Institute of Intelligent Electronics & Systems Fudan University Shanghai China and School of Computer Science and Shanghai Key Laboratory of Data Science Fudan University Shanghai China

ISBN: (纸本)9798400713316

Graph Signal Processing (GSP) based recommendation algorithms have recently attracted lots of attention for high efficiency. However, these methods failed to utilize user/item unique characteristics, as well as user and item high-order neighborhood information when modeling user preference, leading to sub-optimal performance. To this end, we propose a frequency-aware graph signal processing method (FaGSP) for collaborative filtering (CF). Firstly, we design a Cascaded Filter Module to capture both unique and common user/item characteristics to more accurately model user preference. Then, we devise a Parallel Filter Module to fully utilize high-order neighborhood information of users/items for more accurate user preference modeling. Finally, we combine these modules via a linear model to further improve recommendation accuracy. Extensive experiments demonstrate the superiority of our method from prediction accuracy and training efficiency.

关键词： collaborative filtering

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HYBRID VECTOR QUANTIZATION METHODS FOR IMAGE AND VIDEO COMPRESSION

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PATTERN RECOGNITION LETTERS 1994年第3期15卷 243-251页

作者： MAA, CYM Electronic Data Systems Detroit Research and Development 901 Tower Drive Troy MI 48098 USA

In this paper the output of vector quantization of a digital image is regarded as a two-dimensional map, that is, another gray-level image, and a hybrid method is proposed to further (losslessly) compress this map. A ... 详细信息

关键词： VECTOR QUANTIZATION IMAGE COMPRESSION VECTOR COMPRESSION CONTEXT MODELING

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Anisotropic exchange spin model to investigate the Curie temperature dispersion of L10-FePt magnetic nanoparticles

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Journal of Applied Physics 2025年第18期137卷

作者： Ochiai, Kohei Tsuyama, Tomoyuki Shimizu, Sumera Zhang, Lei Watanabe, Jin Kudo, Fumito Zhu, Jian-Gang Okuno, Yoshishige Resonac Corporation Research Center for Computational Science and Informatics 8 Ebisu-cho Kanagawa-ku Kanagawa Yokohama221-8517 Japan Resonac Hard Disk Corporation Research & Development Center 5-1 Yawatakaigan-dori Chiba Ichihara290-0067 Japan Data Storage Systems Center Carnegie Mellon University PittsburghPA15213 United States Electrical and Computer Engineering Department Carnegie Mellon University PittsburghPA15213 United States Materials Science and Engineering Department Carnegie Mellon University PittsburghPA15213 United States

We developed an anisotropic exchange spin model that accounts for magnetic anisotropy and evaluated the Curie temperature ( T c ) dispersion due to finite-size effects in L1 0 -FePt nanoparticles. In heat-assisted magnetic recording (HAMR) media, a next-generation magnetic recording technology, high-density recording is achieved by locally heating L1 0 -FePt nanoparticles near their T c and rapidly cooling them. However, variations in T c caused by differences in particle size and shape can compromise recording stability and areal density capacity, making the control of T c dispersion critical. In this study, we constructed atomistic Landau-Lifshitz-Gilbert models to explicitly incorporate the spin exchange anisotropy of L 1 0 -FePt, based on parameters determined by first-principles calculations. Using this model, we evaluated the impact of particle size on T c dispersion. As a result, (1) the T c dispersion critical to the performance of HAMR can be reproduced, whereas it was previously underestimated by isotropic models and (2) approximately 70 % of the experimentally observed T c dispersion can be attributed to particle-size effects. This research highlights the role of exchange anisotropy in amplifying finite-size effects and underscores the importance of size control in HAMR media. © 2025 Author(s).

关键词： Magnetic nanoparticles

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COMPUTER-GRAPHICS IN AIRPORT MANAGEMENT

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COMPUTERS & GRAPHICS 1985年第4期9卷 423-433页

作者： ALEM, WK DESHMUKH, SS International Airports Projects Data Systems Research & Development P.O. Box 6326 Jeddah 21442 Kingdom of Saudi Arabia

Computer graphics technology has been in use for over a decade. This technology has matured to a point where large applications involving databases can now be undertaken. This article describes the use of graphics technology in management of airport utilities, facilities and land. The systems described took over 60 manyears of development effort. This is considered as one of the largest and most complex undertakings in the application of computer graphics technology. As far as can be determined, no other airport in the world has a system of this size, complexity and sophistication. The events that led to a decision to develop the system are summarized. The system and how it is currently used at the airports within the Kingdom of Saudi Arabia are described.

关键词： COMPUTER GRAPHICS

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miR-200 family: Gatekeepers of fibrinolytic regulation in lung pathologies during acute lung injury

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Archives of Biochemistry and Biophysics 2025年 768卷 110398页

作者： Jeena, T.M. Rakshitha, C. Muneesa, Fathimath M Varughese, Aleena Akarsha Raju, Rajesh Krishnan, Deepak Mugaranja, Kirana Bhandary, Yashodhar P. Cell Biology & Molecular Genetics Division Yenepoya Research Centre Yenepoya Deemed to be University Karnataka Mangalore India Specialized Research Unit Yenepoya Medical College & Hospital Yenepoya Deemed to be University Karnataka Mangalore India IQRAA Centre for Research and Development (ICRD) IQRAA International Hospital & Research Centre Kerala Calicut India The University of Texas Health Science Centre United States Centre for Integrative Omics Data Science (CIODS) Yenepoya Deemed to be University Karnataka Mangalore India Centre for Systems Biology and Molecular Medicine Yenepoya Deemed to be University Karnataka Mangalore India

Acute lung injury (ALI) is a severe condition characterized by acute inflammation and respiratory distress, often leading to significant morbidity and mortality. The complex pathophysiology of ALI involves alterations in various molecular and cellular processes, including those regulated by the miR-200 family. This study aims to investigate the regulatory function of miR-200 family members on the fibrinolytic system using three different agents: Bleomycin, IL-17A, and TGF-β, in both in vitro (A549 cells) and in vivo (C57BL/6 mice) models. The role of miR-200a and miR-200b in modulating the fibrinolytic system was assessed through mRNA and protein expression analyses. The results show that in both in vitro and in vivo models, treatment with miR-200a and miR-200b mimics greatly reduced the abnormalities caused by the three drugs. Treatments were given during the inflammatory phase of ALI at two different time points for the in vivo studies: 3 and 7 days. This was evidenced by increased uPA and uPAR mRNA levels and decreased PAI-1 mRNA and protein expression. The inverse regulatory roles of miR-200 family members, particularly miR-200a and miR-200b, suggest potential therapeutic targets in ALI. Furthermore, our study highlights how IL-17A and TGF-β modulate the fibrinolytic system and EMT pathway by influencing the expression of the miR-200 family in ALI. It elucidates the regulatory function of the miR-200 family in restoring the fibrinolytic system and the EMT pathway during lung injury, underscoring the significant therapeutic potential of miR-200 in treating ALI. © 2025 Elsevier Inc.

关键词： Acute lung injury (ALI) Bleomycin Fibrinolytic system IL-17A and TGF- β miR-200 family

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Anisotropic Exchange Spin Model to Investigate the Curie Temperature Dispersion of Finite-Size L10-FePt Magnetic Nanoparticles

arXiv

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arXiv 2025年

作者： Ochiai, Kohei Tsuyama, Tomoyuki Shimizu, Sumera Zhang, Lei Watanabe, Jin Kudo, Fumito Zhu, Jian-Gang Okuno, Yoshishige Resonac Corporation Research Center for Computational Science and Informatics 8 Ebisu-cho Kanagawa-ku Kanagawa. Yokohama221-8517 Japan Resonac Hard Disk Corporation Research & Development Center 5-1 Yawatakaigan-dori Chiba Ichihara290-0067 Japan Data Storage Systems Center Carnegie Mellon University PittsburghPA15213 United States Electrical and Computer Engineering Department Carnegie Mellon University PittsburghPA15213 United States Materials Science and Engineering Department Carnegie Mellon University PittsburghPA15213 United States

We developed an anisotropic spin model that accounts for magnetic anisotropy and evaluated the Curie temperature (Tc) dispersion due to finite size effects in L10-FePt nanoparticles. In heat-assisted magnetic recording (HAMR) media, a next-generation magnetic recording technology, high-density recording is achieved by locally heating L10-FePt nanoparticles near their Tc and rapidly cooling them. However, variations in Tc caused by differences in particle size and shape can compromise recording stability and areal density capacity, making the control of Tc dispersion critical. In this study, we constructed atomistic LLG models to explicitly incorporate the spin exchange anisotropy of L10-FePt, based on parameters determined by first-principles calculations. Using this model, we evaluated the impact of particle size on Tc dispersion. As a result, (1) the Tc dispersion critical to the performance of HAMR can be reproduced, whereas it was previously underestimated by isotropic models and (2) approximately 70% of the experimentally observed Tc dispersion can be attributed to particle size effects. This research highlights the role of exchange anisotropy in amplifying finite-size effects and underscores the importance of size control in HAMR media. Copyright © 2025, The Authors. All rights reserved.

关键词： Curie temperature

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