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Effusol ameliorates ischemic stroke by targeting NLRP3 protein to regulate NLRP3 inflammasome-mediated pyroptosis

Phytomedicine 2025年 136卷 156253页

作者： Xu, Libin Li, Siyu Qi, Jiaxin Mi, Yan Zhang, Ying Yang, Yuxin Wang, Yingjie Zhou, Di Li, Ning Hou, Yue Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health Sciences National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart Industry Ministry of Education Northeastern University Shenyang China School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City Shenyang Pharmaceutical University Shenyang 110016 China

Background: The significance of pyroptosis as an inflammatory mode of death in ischemic stroke (IS) has attracted much attention in recent years. Effusol is a dihydrophenanthrene component extracted from Juncus effusus L. Previous studies have found that Juncus effusus L. has a good inhibitory effect against microglia activation. However, it is not clear whether effusol inhibits microglia over-activation and attenuates its mediated microglia pyroptosis in the treatment of IS. Purpose: The aim is to examine how effusol influences the initiation and activation stages of pyroptosis, as well as the NLRP3 inflammasome, resulting from microglial over-activation triggered post-IS. Methods: This study investigated the impact of effusol on neurological severity and edema to assess its neuroprotective effects in IS. Mechanistically, immunofluorescence and western blotting were applied to explore the initiation and activation of the NLRP3 inflammasome. Finally, we employed the NLRP3 specific inhibitor, molecular docking, drug affinity responsive target stability (DARTS), and cellular thermal shift assay (CETSA) to further explore the underlying targets of effusol. Results: Effusol mitigated IS-induced damage and downregulated the expression of inflammatory factors at the mRNA level, the protein levels of toll-like receptor 4 (TLR4), nuclear transcription factor NF-κB p65, and key components of the NLRP3 inflammasome. Effusol also mitigated mitochondrial damage by increasing ATP levels and decreasing mitochondrial membrane potential. Importantly, effusol targets NLRP3 protein to inhibit pyroptosis, thereby suppressing the hyperactivation of NLRP3 inflammasome. Conclusions: Effusol may be protective against IS by targeting NLRP3 proteins to inhibit NLRP3 inflammasome activation-mediated pyroptosis. This finding provides a theoretical basis and a prospective drug candidate for the treatment of effusol in IS. © 2024 Elsevier GmbH

关键词： Effusol Ischemic stroke Microglia NLRP3 inflammasome Pyroptosis

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Digital Twin-Enabled Real-Time Optimization System for Traffic and Power Grid Management in 6G-Driven Smart Cities

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IEEE Internet of Things Journal 2025年

作者： Prathiba, Sahaya Beni Krishnamoorthy, Sri Ram Kannan, Karuna Soundari Selvaraj, Arikumar K. Ranganayakulu, Dhanalakshmi Fang, Kai Gadekallu, Thippa Reddy Vellore Institute of Technology Centre for Cyber Physical Systems School of Computer Science and Engineering Chennai600127 India Vellore Institute of Technology School of Electronics Engineering Chennai600127 India College of Engineering and Technology Department of Data Science and Business Systems Kattankulathur603 203 India Zhejiang A and F University College of Mathematics and Computer Science Hangzhou311300 China Zhejiang A and F University Division of Research and Development Lovely Professional University College of Mathematics and Computer Science Hangzhou Phagwara311300 India Chitkara University Center of Research Impact and Outcome Punjab Rajpura140401 India

The advent of 6G-enabled Internet of Everything(IoE) technologies is set to revolutionize urban infrastructures by providing fast, consistent, and low-delay capabilities for communication. 6G connectivity will integrate traffic and power grids for adaptive urban management. However, current traffic networks and power grids face critical challenges such as fragmented data processing, delayed responses, and outdated resource management leading to inefficiencies like traffic congestion and power outages. In 6G-enabled smart grid cities, system complexity and interdependence demand dynamic, real-time solutions, further exacerbating inefficiencies. To address these issues, this study introduces Digital Twin-enabled Real-time Optimization System (DT-ROS), a dynamic framework designed to optimize urban traffic and power grid systems. DT-ROS integrates a dual-tier Digital Twin (DT) and an advanced scheduling framework based on Priority Age of Information Deep Q Scheduler (PAoI-QS). The dual-tier framework builds an elementary and Integrated Digital Twin (IDT) with Auto-Regressive Integrated Moving Average (ARIMA)-based forecasting for accurate real-time traffic and energy demand predictions. The advanced scheduling framework minimizes the Age of Information (AoI), ensuring decision-making relies on the most current and relevant data. By continuously monitoring and processing real-time data, DT-ROS creates virtual models to simulate system behavior and dynamically allocate resources. Simulation results demonstrate the effectiveness of DT-ROS, achieving a 30% reduction in traffic congestion and a 25% improvement in power grid stability compared to existing methods. To create effective, robust, and sustainable urban systems for future smart cities, DT-ROS addresses traffic and electricity problems. © 2014 IEEE.

关键词： Smart power grids

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Mode switching control design with initial value compensation and its application to head positioning control on magnetic disk drives

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IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS 1996年第1期43卷 65-73页

作者： Yamaguchi, T Shishida, K Tohyama, S Hirai, H Disk Storage Development Department Advanced Technology Research & Development Division Data Storage & Retrieval Systems Division Hitachi and Limited Kanagawa Japan Mechanical Engineering Reasearch Laboratory Hitachi and Limited Ibaraki Japan

To meet an increasing demand for high performance and large-capacity in magnetic hard disk drives, both a fast response and a precise positioning are strongly required for the head positioning control. A mode switching control (MSG) system, which includes a track seeking controller, a track following one, and a switching function, is widely used to meet this requirement. The issue for MSC is to confirm a design method of servo mode switching. This paper proposes the initial value compensation method (IVC). The IVC inputs certain initial values in the controller state variables at mode switching in order to improve the transient response after switching. There are two approaches to determine the values: 1) minimizing a linear-quadratic function of the plant state variables, and 2) cancelling the unfavorable poles of the transfer function between initial values and head position by relocating zeros. Some experimental results are shown to be effective.

关键词： Control design Control systems Magnetic heads Magnetic variables control Hard disks Design methodology Servomechanisms Transient response Transfer functions Poles and zeros

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A MATHEMATICAL-MODEL OF ATTRITION data

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NAVAL research LOGISTICS 1995年第4期42卷 585-607页

作者： HARTLEY, DS Center for Modeling Simulation and Gaming Martin Marietta Energy Systems Inc. Data Systems Research and Development Program Applied Technology Organization 1099 CommercePark Oak Ridge Tennessee

The Lanchester square and linear laws do not provide good models of combat attrition as evidenced in historical data. A particular homogeneous, mixed, linear-logarithmic law, however, does provide a good approximation...

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Some of the issues in the implementation of artificial intelligence in engineering design

Some of the issues in the implementation of artificial intel...

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International Congress and Exposition

作者： Oza, R.D. Research and Development Electronic Data Systems Corp. Warren MI United States

The Designer Model, a model based on the design methodology of a human designer, is examined to identify in detail the role of the systems Design View Point (SDVP) in the solution of a design problem. The SDVP reflects complexity of a multidomain design problem due to coupling of domains, and introduces iteration or the element of search in solving the design problem. It is, thus, possible to use an appropriate performance index to direct the search techniques which are available in Artificial Intelligence in implementing the design solution. © Copyright 1986 Society of Automotive Engineers, Inc.

关键词： Iterative methods

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development of updated maintenance energy requirements of cattle using calorimeter data of growing cattle and suckler cows

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Livestock Science 2025年 296卷

作者： Chen, Xianjiang Reynolds, Christopher K. Crompton, Les A. Lively, Francis Gordon, Alan Yan, Tianhai Sustainable Livestock Systems Branch Agri-Food and Biosciences Institute Co Down BT26 6DR Hillsborough United Kingdom Statistics and Data Service Branch Agri-Food and Biosciences Institute Belfast BT9 5PX United Kingdom Centre for Dairy Research School of Agriculture Policy and Development University of Reading Reading RG6 6AR United Kingdom

An accurate prediction of maintenance energy requirement is essential for rationing growing cattle and suckler cows for improved production efficiency and reduced environmental footprint. There is evidence that the current UK energy feeding system (Agricultural and Food research Council,1993) underpredicts maintenance energy requirement for growth of modern cattle. The objective of the present study was to develop updated maintenance energy requirements for growing cattle. data used were collated from calorimeter chamber studies (each with digestibility measurements) undertaken at the Agri-Food Biosciences Institute (n = 249) and the University of Reading (n = 48) between 1993 and 2015. The dataset comprises data from 176 growing dairy and beef steers, 88 growing Holstein-Friesian heifers and 34 dry mature suckler cows. Cattle were offered diets containing either forage only (n = 81) or a mixture of forage and concentrates (n = 211) at various feeding levels. Energy intake and outputs were measured using indirect open-circuit respiration calorimeter chambers and digestibility trials. Linear and multiple linear regressions between retained energy (RE) and ME intake (MEI) were used to determine the net energy (NE_m) and metabolisable energy (ME_m) requirements for maintenance of body tissue energy without loss or gain. data were analysed using a linear mixed model (restricted maximum likelihood estimation method), with animal gender, live weight, forage type and dietary forage proportion fitted as additional fixed effects while research centre, experiment and chamber number as random effects. The NE_m derived from the linear relationship between RE and MEI was 0.42 MJ/kg^0.75 of live weight (equivalent to 0.40 MJ/kg^0.75 of calculated empty body weight). The ME_m values were determined to be 0.53 and 0.55 MJ/kg^0.75 of live weight (equivalent to 0.50 and 0.52 MJ/kg^0.75 of calculated empty

关键词： Calorimeter data Growing cattle Maintenance energy requirement Net energy Regression

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SeizeIT2: Wearable dataset Of Patients With Focal Epilepsy

arXiv

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arXiv 2025年

作者： Bhagubai, Miguel Chatzichristos, Christos Swinnen, Lauren Macea, Jaiver Zhang, Jingwei Lagae, Lieven Jansen, Katrien Schulze-Bonhage, Andreas Sales, Francisco Mahler, Benno Weber, Yvonne Van Paesschen, Wim De Vos, Maarten STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven3001 Belgium Laboratory for Epilepsy Research UZ Leuven Leuven3000 Belgium Department of Development and Regeneration KU Leuven Leuven3000 Belgium Department of Pediatric Neurology UZ Leuven Leuven3000 Belgium Epilepsy Center University Medical Center Freiburg University Freiburg79106 Germany Epilepsy Reference Center Coimbra University Hospital Coimbra3004-504 Portugal Department of Neurology Karolinska University Hospital Stockholm171 77 Sweden Department of Epileptology and Neurology RWTH University of Aachen Aachen52074 Germany

The increasing technological advancements towards miniaturized physiological measuring devices have enabled continuous monitoring of epileptic patients outside of specialized environments. The large amounts of data that can be recorded with such devices holds significant potential for developing automated seizure detection frameworks. In this work, we present SeizeIT2, the first open dataset of wearable data recorded in patients with focal epilepsy. The dataset comprises more than 11,000 hours of multimodal data, including behind-the-ear electroencephalography, electrocardiography, electromyography and movement (accelerometer and gyroscope) data. The dataset contains 886 focal seizures recorded from 125 patients across five different European Epileptic Monitoring Centers. We present a suggestive training/validation split to propel the development of AI methodologies for seizure detection, as well as two benchmark approaches and evaluation metrics. The dataset can be accessed on OpenNeuro and is stored in Brain Imaging data Structure (BIDS) format. © 2025, CC BY-NC-ND.

关键词： Electroencephalography

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Web-based collaborative information integration for scientific research

Web-based collaborative information integration for scientif...

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23rd International Conference on data Engineering, ICDE 2007

作者： Wang, Fusheng Liu, Peiya Rabsch, Cornelius Kling, Patrick Pearson, John Integrated Data Systems Department Siemens Corporate Research Department of Mathematics and Computer Science University of Mannheim Business Development Department Siemens Corporate Research

ISBN: (纸本)1424408032

Scientific research becomes increasingly reliant on collaborative effort among multiple institutions and interdisciplinary consortia, through sharing scientific experiments and data and collaboration on analysis of data and results. Besides information sharing, there is a growing need to create a framework to enable collaborative, crossdisciplinary research, which can facilitate a research community into a default mode of collaboration, including: i) enabling scientific researchers to dynamically interact with others, collaboratively author, annotate, review, comment on others' data, and discuss their research;ii) providing a dynamic collaboration environment by harnessing collective contributions from a group of researchers;and iii) facilitating broader participation of people into research projects. While traditional data management and integration systems put much focus on passively integrating existing data, the collaboration among data providers and users is quite limited. In this paper, we present a Web-based collaborative platform to dynamically integrate information for scientific research. Besides data integration, the system provides essential collaboration capabilities to boost user participation and collaboration. The system will not only enable users as active information contributors to bring significant new values to the data, but also provide an environment for scientific researchers to do collaborative research in a large research community. © 2007 IEEE.

关键词： Computer supported cooperative work

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Integration of UML with simulink into embedded software engineering

Integration of UML with simulink into embedded software engi...

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ICROS-SICE International Joint Conference 2009, ICCAS-SICE 2009

作者： Farkas, Tibor Meiseki, Emi Neumann, Carsten Okano, Kunihisa Hinnerichs, Andreas Kamiya, Shingo Fraunhofer FOKUS Working Group Embedded Systems Engineering Berlin Germany NTT DATA Corporation Research and Development Headquarters Tokyo Japan

ISBN: (纸本)9784907764333

Today, control algorithms of electronic in-vehicle functions are implemented on various networked control units with different software architectures and designs. Special effort is needed when integrating those artifacts and software components from different sources to overcome the limits of efficient integration of model-based design into the embedded development. This paper focuses on the advantages of model-based development by mixing object-oriented and signal-oriented modeling concepts together and referencing (generated) legacy software components to get an overall software design. Therefore, we present an integration methodology of UML and Simulink modeling concepts to a traditional automotive software engineering process. Furthermore we describe the model-based engineering of a car-door control system as an example. © 2009 SICE.

关键词： Software design

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An object-oriented environment for multiple AI paradigms

An object-oriented environment for multiple AI paradigms

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International Conference on Tools for Artificial Intelligence (ICTAI)

作者： M.H. Ibrahim S.W. Woyak Electronic Data Systems Corporation Research and Development

Consideration is given to EDS/OWL, an object-oriented environment which provides a uniform framework for integrating programming paradigms. The authors describe how EDS/OWL integrates access-oriented, rule-based and logic programming in an object-oriented environment. The integration extends the underlying language yet continues to use the existing constructs as well as the parser, interpreter and tools. Moreover, the object-oriented framework supports further novel extensions frequently required by specific artificial-intelligence (AI) applications.< >

关键词： Artificial intelligence OWL Logic programming Object oriented programming Application software data systems research and development Knowledge representation Programming environments Software engineering

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