检索结果-内蒙古大学图书馆

Single-cell transcriptomics and epigenomics point to CD58-CD2 interaction in controlling primary melanoma growth and immunity

引用

Cancer Communications 2025年第4期45卷 465-470页

作者： Antonia Stubenvoll Maria Schmidt Johanna Moeller Max Alexander Lingner Chango Carolyn Schultz Olga Antoniadou Henry Loeffler-Wirth Stephan Bernhart Florian Groβe Beatrice Thier Annette Paschen Ulf Anderegg Jan CSimon Mirjana Ziemer Clara TSchoeder Hans Binder Manfred Kunz Department of Dermatology Venereology and AllergologyUniversity of Leipzig Medical CenterLeipzigGermany Interdisciplinary Center for Bioinformatics University of LeipzigLeipzigGermany Institute for Drug Discovery University of Leipzig Medical CenterLeipzigGermany Bioinformatics Group Department of Computer ScienceUniversity of LeipzigLeipzigGermany Department of Diagnostics Fraunhofer Institute of Cell Therapy and Immunology(IZI)LeipzigGermany Center for Scalable Data Analytics and Artificial Intelligence(ScaDS.AI)Dresden/Leipzig LeipzigGermany Department of Dermatology University Hospital EssenUniversity Duisburg-Essen and German Cancer Consortium(DKTK)Partner Site Essen/DüsseldorfEssenGermany

Immunotherapy is currently one of the most promising treatment options for malignant melanoma[1].To uncover new immunological targets for future treatment approaches,single-cell transcriptomic and epigenomic analyses ... 详细信息

关键词： malignant melanoma single cell transcriptomics melanocytic nevus immunity immunotherapy primary melanoma epigenomic analyses epigenomics cd cd interaction

来源：评论

学校读者我要写书评

暂无评论

NFT Appraisal Using Machine Learning 23

NFT Appraisal Using Machine Learning

引用

5th Asia Pacific Information Technology Conference, APIT 2023

作者： Dawod, Ahmed Dawod Mohammed Munkhdalai, Lkhagvadorj Park, Kwang Ho Ryu, Keun Ho Pham, Van Huy Database and Bioinformatics Laboratory College of Electrical and Computer Engineering Chungbuk National University Cheongju28644 Korea Republic of Data Science Laboratory Faculty of Information Technology Ton Duc Thang University Ho Chi Minh City700000 Viet Nam

ISBN: (纸本)9781450399500

Non-Fungible Tokens (NFTs) are digital assets based on a blockchain and those are characterized as unique cryptographic tokens and non-interchangeable. To date, research into the NFT marketplace has been relatively limited. As it is an emerging platform with many unique elements, The NFT market has been impacted due to recent fluctuations in crypto-asset markets more broadly. This current bear market cycle has shed light on concerns around the value of NFTs, profit-based motivation, and environmental sustainability. However, periods of volatility and cyclicality are to be expected with any nascent technology as it develops a product-market fit. consequently, the appraisal of real-price for NFT collections is essential for individual financial security and investment making. In this study, we evaluate the machine learning algorithms to appraise their real-price based on NFT item's characteristics, market event information, and their rarity score data acquired by retrieved from the biggest marketplace OpenSea. Furthermore, the procedures were applied to meet the objectives of this study we built prediction models based on various machine-learning algorithms ranging from Random Forest, XGBoost, SVM, Lasso, ElasticNet, Ridge, Linear Polynomial Regression, TabNet, CatBoost, and LightGBM models. From the results, LightGBM regression model outperformed the other by RMSE around 0.905. The best R2 is only found in this model, which has a value of 0.917. © 2023 ACM.

关键词： Blockchain

来源：评论

学校读者我要写书评

暂无评论

Literature study of stunting supplementation in Indonesian utilizing text mining approach 7

Literature study of stunting supplementation in Indonesian u...

引用

7th International Conference on Computer Science and Computational Intelligence, CSCI 2022

作者： Sudigyo, Digdo Hidayat, Alam Ahmad Nirwantono, Rudi Rahutomo, Reza Trinugroho, Joko Pebrianto Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program Bina Nusantara University Jakarta11480 Indonesia

Numerous research on stunting supplementation interventions in Indonesia have been published. The information can be extracted through data mining, especially from academic research databases. In this paper, we presented a text mining-based literature review strategy to create a pipeline that researchers can use to accelerate the development of stunting supplementation intervention research in Indonesia. Utilizing various NLP (Natural Language Processing) techniques, data were crawled, processed, and visualized using Python. The crawling dataset used a module from the Pubmed API (Application Programming Interface) to collect literature papers. The NLTK (Natural Language Toolkit) module and itertools were used to process text data. The n-grams model was applied to process tokens into bigrams and trigrams. Text information was visualized using Matplotlib and Word cloud packages. There is an increasing number of publication in stunting supplementation intervention according to our result, which was observed from 2015 to 2021. West Java was the province where most of the stunting research has been conducted, as determined by research abstracts. Top occurrences obtained from the bigram and trigrams models calculation produced different terms. The word pairings that occurred the most frequently in the bigram and trigram model analyses were "child-aged" and "iron-folic-acid," respectively. The findings of this study are expected to help researchers to obtain the latest research topics related to stunting supplementation interventions in Indonesia. © 2022 Elsevier B.V.. All rights reserved.

关键词： data mining

来源：评论

学校读者我要写书评

暂无评论

CCAC: Contrastive Learning with Channel Attention and Contour Loss for Brain Image Registration

CCAC: Contrastive Learning with Channel Attention and Contou...

引用

2023 IEEE International Conference on bioinformatics and Biomedicine, BIBM 2023

作者： Zhang, Ying Shi, Dantong Wang, Jiaqi Xiang, Jinhai Zhang, Wen Huazhong Agricultural University College of Informatics Wuhan China Agricultural Bioinformatics Key Laboratory of Hubei Province Hubei Engineering Technology Research Center of Agricultural Big Data Key Laboratory of Smart Farming for Agricultural Animals Ministry of Agriculture Wuhan China

ISBN: (纸本)9798350337488

In medical image analysis, image registration plays a key role in establishing the deformation field between image pairs. A good deformation model is essential for high-quality estimates. However, most existing approaches still face great challenges in extracting better image features and generating detailed information on deformation fields. In this paper, we present a brain image registration model based on contrastive learning with channel attention and contour loss (CCAC). To integrate lower-level features more effectively, we propose a channel attention-based skip connection to obtain weight information of features at different encoder layers. To enhance the feature consistency of semantics in different stages, we then introduce multi-stage contrastive learning to capture semantics at different stages. Moreover, in order to reduce the influence caused by the disparities of inter-image gray value in registered images, contour feature loss is employed. Both qualitative and quantitative experiments on the popular LPBA40 dataset demonstrate that our method can achieve much better performance than the baseline methods. © 2023 IEEE.

关键词： Brain MR image Channel attention Contour features Medical image registration Multistage contrastive learning

来源：评论

学校读者我要写书评

暂无评论

A review: data pre-processing techniques used for diabetes prediction 9th

A review: Data pre-processing techniques used for diabetes p...

引用

9th International Conference on Computer Science and Computational Intelligence, ICCSCI 2024

作者： Isnan, Mahmud Elwirehardja, Gregorius Natanael Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Cmputer Science Department BINUS Graduate Program Computer Science Program Bina Nusantara University Jakarta11480 Indonesia

When processing datasets in diabetes classification, common problems included a large number of missing values, outliers, and dataset imbalance. To deal with those issues, this study analyzed 18 studies on diabetes classification with machine learning algorithms over the past 5 years. This revealed the important role of data pre-processing in creating effective classification models, as it was found that by using different data pre-processing techniques, the same model can provide different performance. The study identified K-Nearest Neighbor (KNN) and support vector machine (SVM) as superior methods for filling in missing values, achieving an accuracy of 98.49% and 94.89%, respectively. These approaches outperformed traditional methods such as median or mean replacement. However, the challenge of imbalanced data sets remains in all studies reviewed. The common evaluation metrics used to evaluate the created models in previous studies included accuracy, precision, specificity, sensitivity/recall, and F1 Score. Overall, this review showed that the role of data pre-processing is no less important than algorithm selection to improve the performance of machine learning models in diabetes classification. © 2024 The Authors.

关键词： Adversarial machine learning

来源：评论

学校读者我要写书评

暂无评论

Network Biology of KEGG Enriched Viral Comorbidities in Psoriasis Subjects 3

Network Biology of KEGG Enriched Viral Comorbidities in Psor...

引用

3rd IEEE International Virtual Conference on Innovations in Power and Advanced Computing Technologies, i-PACT 2021

作者： Subhashini, D. Anand, Daniel Alex Sathyabama Institute of Science and Technology Department of Bioinformatics Centre for Molecular Data Science and Systems Biology Chennai India

ISBN: (纸本)9781665426916

Network biology is now becoming one of the emerging streams to understand the pathophysiology of diseases as they generate bio molecular networks as undirected graphs, which are manageable to conveniently view. In our demonstration, we performed the initial enrichment of DEGs obtained from psoriasis subjects in DAVID. From which, two KEGG pathways in addition to eight GO terms were collected. Moreover, the genes were uploaded in NetworkAnalyst and protein to protein interaction network was studied for 16 sub networks. The KEGG annotation of the first, big sub network was enriched in pathways associated with measles and influenza A, for which the hubs were spotlighted. The other 15 sub networks were explored in KEGG and found to be linked with the synthesis and metabolism of various bio molecules. © 2021 IEEE.

关键词： Proteins

来源：评论

学校读者我要写书评

暂无评论

Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial

arXiv

引用

arXiv 2025年

作者： Wu, Wei Deng, Zizhen Zhang, Chi Liao, Can Wang, Jinzhuo Department of Big Data and Biomedical AI College of Future Technology Peking University Beijing100871 China Institute of Bioinformatics University of Georgia AthensGA United States

Addressing the unavoidable bias inherent in supervised aging clocks, we introduce Sundial, a novel framework that models molecular dynamics through a diffusion field, capturing both the population-level aging process and the individual-level relative aging order. Sundial enables unbiased estimation of biological age and the forecast of aging roadmap. Faster-aging individuals from Sundial exhibit a higher disease risk compared to those identified from supervised aging clocks. This framework opens new avenues for exploring key topics, including age- and sex-specific aging dynamics and faster yet healthy aging paths. © 2025, CC BY.

关键词： Molecular dynamics

来源：评论

学校读者我要写书评

暂无评论

How Long short-term memory artificial neural network, synthetic data, and fine-tuning improve the classification of raw EEG data 6

How Long short-term memory artificial neural network, synthe...

引用

6th Scientific School "Dynamics of Complex Networks and their Applications", DCNA 2022

作者： Nasybullin, Albert Maksimenko, Vladimir Kurkin, Semen Innopolis University Laboratory of Data Analysis and Bioinformatics Center for Artificial Intelligence Innopolis Russia Innopolis University Neuroscience and Cognitive Technology Laboratory Center for Technologies in Robotics and Mechatronics Components Innopolis Russia

ISBN: (数字)9781665461740

ISBN: (纸本)9781665461740

In this paper, we discuss a Machine Learning pipeline for the classification of EEG data. We propose a combination of synthetic data generation, long short-term memory artificial neural network (LSTM), and fine-tuning to solve classification problems for experiments with implicit visual stimuli, such as the Necker cube with different levels of ambiguity. The developed approach increased the quality of the classification model of raw EEG data. © 2022 IEEE.

关键词： Classification (of information)

来源：评论

学校读者我要写书评

暂无评论

Single-cell technologies: current and near future

引用

Science China(Life Sciences) 2025年第1期68卷 1-4页

作者： Chenfei Wang Qi Liu Xiaohui Fan Tieliu Shi KeyLaboratory of Spine and Spinal CordInjury Repairand Regeneration Ministry of EducationOrthopedics DepartmentTongji HospitalBioinformatics DepartmentSchoolofLifeSciencesandTechnologyTongji UniversityShanghai 200082China Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Research Institute of Intelligent Computing Zhejiang LabHangzhou 311121China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of Advanced Theory and Application in Statistics and Data Science(MOE) School of StatisticsEast China Normal UniversityShanghai 200062China

Single-cell technologies enable the indepth exploration of multiple biological hierarchies at the scale of individual cells,which have deepened our knowledge of cellular diversity,tissue organization,and overall organism function(Sun et al.,2024).In 2009,single-cell RNA sequencing(scRNA-seq)was first developed as a powerful tool to dissect gene expression and uncover transcriptional *** the rapid advancement of technology,single-cell approaches have expanded to encompass other omics,such as genomics,epigenomics,proteomics,and ***,multimodal technologies including spatially resolved transcriptomics and clustered regularly interspaced short palindromic repeats(CRISPR)screening at the single-cell level further advanced our ability to comprehensively understand cellular ***-cell methods provide deeper insights into disease mechanisms across various conditions,including cancer,developmental disorders,and aging-associated *** this issue,we focus on topics related to single-cell methods,covering the following four aspects:(i)single-cell multi-omic sequencing technology;(ii)single-cell spatial technology;(iii)singlecell CRISPR screening technology;(iv)applications of single-cell technology.

关键词： expanded enable insight

来源：评论

学校读者我要写书评

暂无评论

Utilizing Semi-supervised Method in Predicting BRCA1 Pathogenicity Variants 8

Utilizing Semi-supervised Method in Predicting BRCA1 Pathoge...

引用

8th International Conference on Computer Science and Computational Intelligence, ICCSCI 2023

作者： Hidayat, Alam Ahmad Trinugroho, Joko Pebrianto Nirwantono, Rudi Sudigyo, Digdo Pardamean, Bens Department of Mathematics School of Computer Science Bina Nusantara University 11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program Bina Nusantara University Jakarta11480 Indonesia

Quantifying the effect of mutations in the BRCA1 gene is useful for understanding their clinical consequences on breast cancer. Machine learning models can be applied to predict the landscape of protein variant effects that might not be always accessible by experiments. In this work, we propose a simple semi-supervised learning method using a Gaussian mixture model to predict ~90% of the unlabeled missense variants of the BRCA1 gene collected from the ClinVar database. High-quality embeddings are used as a feature of the protein sequences, extracted using the latest pre-trained transformer-based language protein model. A statistical test show that the protein embeddings are effective and robust for predicting pathogenicity. Further, the lower representations of the features are then fed into the semi-supervised model. The prediction performance of the model only for the labeled testing data achieves an AUC score and an accuracy of 79.27% and 71.58%, respectively. Using our defined pathogenic probability score, we find that ~94% of variants in our unlabeled dataset are well-separated into either benign or pathogenic classes according to that scoring. Our scores obtain a moderate Spearman rank correlation with the results of established unsupervised variant effect models. Finally, our approach can potentially be developed for more accurate and biologically reliable predictions of the variant effects. © 2023 The Authors. Published by Elsevier B.V.

关键词： embeddings language model mutation effect protein sequence semi-supervised learning

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：