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Tuberculosis screening among children and adolescents in China:insights from a mathematical model

Intelligent Medicine 2023年第3期3卷 157-163页

作者： Janne Estill Yangqin Xu Shouyuan Wu Lidong Hu Nan Yang Shu Yang Yaolong Chen Guobao Li Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China Institute of Global Health University of GenevaGenevaSwitzerland School of Public Health Lanzhou UniversityLanzhouGansu 730000China Department of Rheumatology and Immunology The First Medical CenterChinese PLA General HospitalBejing 100853China College of Medical Information Engineering Chengdu University of Traditional Chinese MedicineChengduSichuan 610000China Research Unit of Evidence-Based Evaluation and Guidelines Chinese Academy of Medical Sciences(2021RU017)School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China Lanzhou University Institute of Health Data Science LanzhouGansu 730000China WHO Collaborating Centre for Guideline Implementation and Knowledge Translation LanzhouGansu 730000China Department of Lung Disease Shenzhen Third People's HospitalThe Second Affiliated HospitalSouthern University of Science and TechnologyShenzhen Guangdong 518112China

Background Tuberculosis(TB)continues to be prevalent in China also among children and adolescents in *** built a dynamic mathematical model for TB transmission in China,and applied it to compare the epidemic trends 2021–2030 under a range of screening interventions focusing on children and *** We developed a dynamic mathematical model with a flexible *** model can be applied either stochastically or deterministically,and can encompass arbitrary age structure and resistance *** the present version,we used the deterministic version excluding resistance but including age structure with six groups:0–5,6–11,12–14,15–17,18–64,and 65 years and *** parameterized the model by literature data and fitting it to case and death estimates provided by the World Health *** compared the new TB cases and TB-related deaths in each age group over the period 2021–2030 in 10 scenarios that involved intensified screening of particular age groups of children,adolescents,or young adults,or decreased or increased diagnostic accuracy of the *** Screening the entire age class of 18-year-old persons would prevent 517,000 TB cases and 14,600 TB-related deaths between years 2021 and 2030,corresponding to 6.6%and 5.5%decrease from the standard of care projection,*** screening of children aged 6–11 and,to a lesser extent,0–5 years,also reduced TB incidence and mortality,particularly among children of the respective ages but also in other age *** contrast,intensified screening of adolescents did not have a major *** with a simpler and less accurate method resulted in worsened outcomes,which could not be offset by more intensive *** accurate screening and better sensitivity to detect latent TB could prevent 2.3 million TB cases and 68,500 TB deaths in the coming 10 *** Routine screening in schools can efficiently reduce the burden of TB in *** should be intensifie

关键词： Tuberculosis China Children and adolescents Mathematical model Screening

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The Last JITAI? Exploring Large Language Models for Issuing Just-in-Time Adaptive Interventions: Fostering Physical Activity in a Conceptual Cardiac Rehabilitation Setting

arXiv

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arXiv 2024年

作者： Haag, David Kumar, Devender Gruber, Sebastian Hofer, Dominik Sareban, Mahdi Treff, Gunnar Niebauer, Josef Bull, Christopher Schmidt, Albrecht Smeddinck, Jan David Ludwig Boltzmann Institute for Digital Health and Prevention Salzburg Austria Department of Psychology Paris-Lodron-University of Salzburg Salzburg Austria Digital Health Information Systems Center for Health & Bioresources AIT Austrian Institute of Technology GmbH Graz Austria University of Southern Denmark Odense Denmark Institute of Business Informatics - Data & Knowledge Engineering Johannes Kepler University Linz Linz Austria Human Motion Analytics Salzburg Research Forschungsgesellschaft Salzburg Austria LMU Munich Munich Germany University Institute for Sports Medicine Prevention and Rehabilitation Salzburg Austria Institute of Molecular Sports and Rehabilitation Medicine Paracelsus Medical University Salzburg Austria Open Lab School of Computing Newcastle University Newcastle upon Tyne United Kingdom

We evaluated the viability of using Large Language Models (LLMs) to trigger and personalize content in Just-in-Time Adaptive Interventions (JITAIs) in digital health. As an interaction pattern representative of context-aware computing, JITAIs are being explored for their potential to support sustainable behavior change, adapting interventions to an individual’s current context and needs. Challenging traditional JITAI implementation models, which face severe scalability and flexibility limitations, we tested GPT-4 for suggesting JITAIs in the use case of heart-healthy activity in cardiac rehabilitation. Using three personas representing patients affected by CVD with varying severeness and five context sets per persona, we generated 450 JITAI decisions and messages. These were systematically evaluated against those created by 10 laypersons (LayPs) and 10 healthcare professionals (HCPs). GPT-4-generated JITAIs surpassed human-generated intervention suggestions, outperforming both LayPs and HCPs across all metrics (i.e., appropriateness, engagement, effectiveness, and professionalism). These results highlight the potential of LLMs to enhance JITAI implementations in personalized health interventions, demonstrating how generative AI could revolutionize context-aware computing. © 2024, CC BY.

关键词： Electronic health record

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Poisoning attack against estimating from pairwise comparisons

arXiv

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arXiv 2021年

作者： Ma, Ke Xu, Qianqian Zeng, Jinshan Cao, Xiaochun Huang, Qingming The School of Computer Science and Technology University of Chinese Academy of Sciences Beijing100049 China The Artificial Intelligence Research Center Peng Cheng Laboratory Shenzhen518055 China The Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China The School of Computer and Information Engineering Jiangxi Normal University Jiangxi Nanchang330022 China Institute of Information Engineering Chinese Academy of Sciences Beijing100093 China The School of Cyber Security University of Chinese Academy of Sciences Beijing100049 China The Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China The School of Computer Science and Technology University of Chinese Academy of Sciences Beijing100049 China The Key Laboratory of Big Data Mining and Knowledge Management The School of Economics and Management University of Chinese Academy of Sciences Beijing100049 China

As pairwise ranking becomes broadly employed for elections, sports competitions, recommendation, information retrieval and so on, attackers have strong motivation and incentives to manipulate or disrupt the ranking list. They could inject malicious comparisons into the training data to fool the target ranking algorithm. Such a technique is called "poisoning attack" in regression and classification tasks. In this paper, to the best of our knowledge, we initiate the first systematic investigation of data poisoning attack on the pairwise ranking algorithms, which can be generally formalized as the dynamic and static games between the ranker and the attacker, and can be modeled as certain kinds of integer programming problems mathematically. To break the computational hurdle of the underlying integer programming problems, we reformulate them into the distributionally robust optimization (DRO) problems, which are computational tractable. Based on such DRO formulations, we propose two efficient poisoning attack algorithms and establish the associated theoretical guarantees including the existence of Nash equilibrium and the generalization ability bounds. The effectiveness of the suggested poisoning attack strategies is demonstrated by a series of toy simulations and several real data experiments. These experimental results show that the proposed methods can significantly reduce the performance of the ranker in the sense that the correlation between the true ranking list and the aggregated results with toxic data can be decreased dramatically. © 2021, CC BY-NC-ND.

关键词： Toys

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CHAOS Challenge - Combined (CT-MR) healthy abdominal organ segmentation

arXiv

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arXiv 2020年

作者： Kavur, A. Emre Gezer, N. Sinem Barış, Mustafa Conze, Pierre-Henri Groza, Vladimir Pham, Duc Duy Chatterjee, Soumick Ernst, Philipp Özkan, Savaş Baydar, Bora Lachinov, Dmitry Han, Shuo Pauli, Josef Isensee, Fabian Perkonigg, Matthias Sathish, Rachana Rajan, Ronnie Aslan, Sinem Sheet, Debdoot Dovletov, Gurbandurdy Speck, Oliver Nürnberger, Andreas Maier-Hein, Klaus H. Akar, Gözde Bozdagı Ünal, Gözde Dicle, Oguz Selver, M. Alper Graduate School of Natural and Applied Sciences Dokuz Eylul University Izmir Turkey Department of Radiology Faculty Of Medicine Dokuz Eylul University Izmir Turkey Dept. of Ophthalmology and Optometry Medical Uni. of Vienna Austria Intelligent Systems Faculty of Engineering University of Duisburg-Essen Germany Division of Medical Image Computing German Cancer Research Center Heidelberg Germany CIR Lab Dept of Biomedical Imaging and Image-guided Therapy Medical Uni. of Vienna Austria IMT Atlantique LaTIM UMR 1101 Brest France Department of Electrical and Electronics Engineering Middle East Technical University Ankara Turkey Department of Electrical Engineering Indian Institute of Technology Kharagpur India School of Medical Science and Technology Indian Institute of Technology Kharagpur India Ca’ Foscari University of Venice ECLT DAIS Venice Italy Ege University International Computer Institute Izmir Turkey Johns Hopkins University Baltimore United States Data and Knowledge Engineering Group Otto von Guericke University Magdeburg Germany Magnetic Resonance Otto von Guericke University Magdeburg Germany Median Technologies Valbonne France Department of Computer Engineering Istanbul Technical University Istanbul Turkey Department of Electrical and Electronics Engineering Dokuz Eylul University Izmir Turkey

—Segmentation of abdominal organs has been a comprehensive, yet unresolved, research field for many years. In the last decade, intensive developments in deep learning (DL) have introduced new state-of-the-art segmentation systems. Despite outperforming the overall accuracy of existing systems, the effects of DL model properties and parameters on the performance is hard to interpret. This makes comparative analysis a necessary tool to achieve explainable studies and systems. Moreover, the performance of DL for emerging learning approaches such as cross-modality and multi-modal tasks have been rarely discussed. In order to expand the knowledge in these topics, CHAOS – Combined (CT-MR) Healthy Abdominal Organ Segmentation challenge has been organized in the IEEE International Symposium on Biomedical Imaging (ISBI), 2019, in Venice, Italy. Despite a large number of the previous abdomen related challenges, the majority of which are focused on tumor/lesion detection and/or classification with a single modality, CHAOS providesboth abdominal CT and MR data from healthy subjects. Five different and complementary tasks have been designed to analyze the capabilities of the current approaches from multiple perspectives. The results are investigated thoroughly, compared with manual annotations and interactive methods. The outcomes are reported in detail to reflect the latest advancements in the field. CHAOS challenge and data will be available online to provide a continuous benchmark resource for segmentation. Copyright © 2020, The Authors. All rights reserved.

关键词： Medical imaging

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Correction to: Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel's pore: a modeling study

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Journal of biological physics 2022年第4期48卷 477-478页

作者： Markos N Xenakis Dimos Kapetis Yang Yang Jordi Heijman Stephen G Waxman Giuseppe Lauria Catharina G Faber Hubert J Smeets Patrick J Lindsey Ronald L Westra Department of Toxicogenomics Section Clinical Genomics Maastricht University PO Box 616 6200 MD Maastricht The Netherlands. mrksxenakis@***. Research School for Mental Health and Neuroscience (MHeNS) Maastricht University PO Box 616 6200 MD Maastricht The Netherlands. mrksxenakis@***. Neuroalgology Unit Fondazione IRCCS Istituto Neurologico "Carlo Besta" Via Celoria 11 20133 Milan Italy. Department of Medicinal Chemistry and Molecular Pharmacology Purdue University College of Pharmacy IN 47907 West Lafayette USA. Purdue Institute for Integrative Neuroscience IN 47907 West Lafayette USA. Department of Cardiology CARIM School for Cardiovascular Diseases Maastricht University PO Box 616 6200 MD Maastricht The Netherlands. Department of Neurology and Center for Neuroscience and Regeneration Research Yale University School of Medicine New Haven CT 06510 USA. Rehabilitation Research Center Veterans Affairs Connecticut Healthcare System West Haven CT 06516 USA. Department of Biomedical and Clinical Sciences "Luigi Sacco" University of Milan Via G.B. Grassi 74 20157 Milan Italy. Department of Neurology Maastricht University Medical Center PO Box 5800 6202 AZ Maastricht The Netherlands. Department of Toxicogenomics Section Clinical Genomics Maastricht University PO Box 616 6200 MD Maastricht The Netherlands. Research School for Mental Health and Neuroscience (MHeNS) Maastricht University PO Box 616 6200 MD Maastricht The Netherlands. Research School for Oncology and Developmental Biology (GROW) Maastricht University PO Box 616 6200 MD Maastricht The Netherlands. Department of Data Science and Knowledge Engineering Maastricht University PO Box 616 6200 MD Maastricht The Netherlands.

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Author Correction:data augmentation in microscopic images for material data mining

引用

npj Computational Materials 2020年第1期6卷 476-476页

作者： Boyuan Ma Xiaoyan Wei Chuni Liu Xiaojuan Ban Haiyou Huang Hao Wang Weihua Xue Stephen Wu Mingfei Gao Qing Shen Michele Mukeshimana Adnan Omer Abuassba Haokai Shen Yanjing Su Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Beijing China School of Computer and Communication Engineering University of Science and Technology Beijing Beijing China Beijing Key Laboratory of Knowledge Engineering for Materials Science Beijing China Institute for Advanced Materials and Technology University of Science and Technology Beijing Beijing China School of Materials Science and Engineering University of Science and Technology Beijing Beijing China School of Materials Science and Technology Liaoning Technical University Liaoning China The Institute of Statistical Mathematics Research Organization of Information and Systems Tachikawa Tokyo Japan National Intellectual Property Administration Beijing China Faculty of Engineering Sciences University of Burundi Bujumbura Burundi Faculty of Engineering and Technology Palestine Technical University – Kadoorie Tulkarem Palestine College of Information Science and Engineering China University of Petroleum Beijing China Key Lab of Petroleum Data Mining China University of Petroleum Beijing China

The original version of this article omitted the following from the Acknowledgements:“This work was supported by Beijing Top Discipline for Artificial Intelligent Science and engineering,University of Science and Tec... 详细信息

关键词： HTML knowledge mining

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Target localization intervention and prognosis evaluation for an individual with mild cognitive impairment

Brain‐X

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Brain‐X 2023年第3期1卷

作者： Weiping Wang Haiyan Zhao Chang He Yuanbo Cui Zhen Wang Alexander Hramov Ping Luan Xiong Luo Jipeng Ouyang Kurths Jürgen School of Computer and Communication Engineering University of Science and Technology Beijing Beijing China Shunde Graduate School University of Science and Technology Beijing Foshan Guangdong China Beijing Key Laboratory of Knowledge Engineering for Materials Science Beijing China Contribution: Writing - review & editing Department of Neurology Peking University Third Hospital Beijing China Contribution: Resources Zhen Wang The Center for Optical Imagery Analysis and Learning and School of Mechanical Engineering Northwestern Polytechnical University Xi'an Shaanxi 710072 China. Contribution: Writing - original draft The 6th Research Institute of China Electronics Corporation Beijing China The Center for Optical Imagery Analysis and Learning and School of Mechanical Engineering Northwestern Polytechnical University Xi'an Shaanxi China Chang He School of Computer and Communication Engineering University of Science and Technology Beijing Beijing 100083 China. Contribution: Investigation Center for Technologies in Robotics and Mechatronics Components Innopolis University Innopolis Russia Saratov State Medical University Saratov Russia Contribution: Data curation Guangdong Second Provincial General Hospital & Health Science Center Shenzhen Guangdong China Department of Neurology Shunde Hospital Southern Medical University Foshan Guangdong China Institute of Physics Humboldt-University Berlin Germany Potsdam Institute for Climate Impact Research Potsdam Germany

Currently, no specific treatments are available for Alzheimer's disease (AD). Mild cognitive impairment (MCI), the preclinical stage of AD, has a high possibility of reversing symptoms through neural regulation. A state dynamics model for single brain regions was developed to simulate blood oxygen level-dependent signals in a patient with early mild cognitive impairment. Subsequently, the analysis of functional connections was used to comprehensively consider multiple complex network centralities to locate the intervention targets, and a multiple brain region collaborative control scheme was designed. Finally, the reliability and effectiveness of the intervention were verified at the brain region and subnetwork levels. This technique provides a basis for future clinical diagnosis and treatment of AD and MCI.

关键词： adaptive pinning control Alzheimer's disease BOLD signals computational modeling Sub_network

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NaCdSb: An Orthorhombic Zintl Phase with Exceptional Intrinsic Thermoelectric Performance

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Angewandte Chemie 2022年第3期135卷

作者： Kai Guo Yuting Zhang Song Yuan Qinghang Tang Chen Lin Pengfei Luo Jiong Yang Shusheng Pan Li-Dong Zhao Guofeng Cheng Jiye Zhang Jun Luo School of Physics and Materials Science Guangzhou University Guangzhou 510006 China Research Center for Advanced Information Materials (CAIM) Huangpu Research & Graduate School of Guangzhou University Sino-Singapore Guangzhou Knowledge City Huangpu District Guangzhou 510555 China Contribution: Conceptualization (lead) Formal analysis (equal) Writing - original draft (lead) School of Materials Science and Engineering Shanghai University 99 Shangda Road Shanghai 200444 China Contribution: Data curation (equal) Investigation (equal) Validation (lead) Contribution: Data curation (lead) Formal analysis (equal) Materials Genome Institute Shanghai University 99 Shangda Road Shanghai 200444 China Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education and School of Physics and Technology Wuhan University Wuhan 430072 China Contribution: Investigation (equal) Contribution: Investigation (equal) Methodology (supporting) Contribution: Investigation (equal) Writing - review & editing (supporting) School of Materials Science and Engineering Beihang University Beijing 100191 China Contribution: Methodology (equal) Writing - review & editing (equal) Analysis & Testing Center for Inorganic Materials Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China Contribution: Formal analysis (equal) Investigation (supporting) Contribution: Data curation (equal) Writing - review & editing (supporting) Contribution: Supervision (lead) Writing - review & editing (equal)

Many Zintl phases are promising thermoelectric materials owning to their features like narrow band gaps, multiband behaviors, ideal charge transport tunnels, and loosely bound cations. Herein we show a new Zintl phase NaCdSb with exceptional intrinsic thermoelectric performance. Pristine NaCdSb exhibits semiconductor behaviors with an experimental hole concentration of 2.9×10 18 cm −3 and a calculated band gap of 0.5 eV. As the temperature increases, the hole concentration rises gradually and approaches its optimal one, leading to a high power factor of 11.56 μW cm −1 K −2 at 673 K. The ultralow thermal conductivity is derived from the small phonon group velocity and short phonon lifetime, ascribed to the structural anharmonicity of Cd−Sb bonds. As a consequence, a maximum zT of 1.3 at 673 K has been achieved without any doping optimization or structural modification, demonstrating that NaCdSb is a remarkable thermoelectric compound with great potential for performance improvement.

关键词： Electron-Crystal NaCdSb Phonon-Glass Thermoelectric Properties Zintl Phase

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Publisher Correction: Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020

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Eye (London, England) 2024年第11期38卷 2229-2231页

作者： Konrad Pesudovs Hugh R. Taylor Tabassom Sedighi Rupert R. A. Bourne Shahina Pardhan Van Charles Lansingh John H. Kempen Ian Tapply Arthur G. Fernandes Maria Vittoria Cicinelli Alessandro Arrigo Nicolas Leveziel Serge Resnikoff Seth Flaxman Mukkharram M. Bikbov Tasanee Braithwaite Alain Bron Ching-Yu Cheng Monte A. Del Monte Joshua R. Ehrlich Leon B. Ellwein David Friedman João M. Furtado Gus Gazzard Ronnie George M. Elizabeth Hartnett Jost B. Jonas Rim Kahloun Moncef Khairallah Rohit C. Khanna Janet Leasher Julie-Anne Little Vinay Nangia Michal Nowak Tunde Peto Pradeep Ramulu Fotis Topouzis Mitiadis Tsilimbaris Ya Xing Wang Ningli Wang Paul Svitil Briant Theo Vos Katrin Burkart Kaleb Coberly Xiaochen Dai Stephen S. Lim Tomislav Mestrovic Ali H. Mokdad Christopher J. L. Murray Jaimie D. Steinmetz Awoke Misganaw Yohannes Habtegiorgis Abate Mohammad Abdollahi Mozhan Abdollahi Ayele Mamo Abebe Olumide Abiodun Richard Gyan Aboagye Woldu Aberhe Abrha Hasan Abualruz Hiwa Abubaker Ali Eman Abu-Gharbieh Salahdein Aburuz Tadele Girum Girum Adal Mesafint Molla Adane Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Muhammad Sohail Afzal Muhammad Umair Shahin Aghamiri Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Ali Ahmadi Siamak Sabour Ayman Ahmed Haroon Ahmed Ahmad Samir Alfaar Abid Ali Syed Shujait Shujait Ali Awais Altaf Hubert Amu Emmanuel Manu Sofia Androudi Rodrigo Anguita Abhishek Anil Rimple Jeet Kaur Muhammad Aaqib Shamim Saeid Anvari Anayochukwu Edward Anyasodor Francis Appiah Jalal Arabloo Haleh Ayatollahi Mosab Arafat Damelash Areda Reza Arefnezhad Brhane Berhe Aregawi Akeza Awealom Asgedom Tahira Ashraf Seyyed Shamsadin Athari Bantalem Tilaye Tilaye Atinafu Birhan Tsegaw Taye Maha Moh’d Wahbi Atout Alok Atreya Ahmed Y. Azzam Hassan Babamohamadi Sara Bagherieh Yogesh Bahurupi Atif Amin Baig Shumaila Nargus Biswajit Banik Mainak Bardhan Saurav Basu Kavita Batra Nebiyou Simegnew Bayileyegn Fatemeh Bazvand Addisu Shunu Beyene Awoke Masrie Asrat Derese Devidas S. Bhagat Akshaya Srikanth Bhagavathula Pankaj Bh Medicine & Health University of New South Wales Sydney NSW Australia School of Optometry and Vision Science University of New South Wales Sydney NSW Australia School of Population and Global Health University of Melbourne Carlton VIC Australia Vision and Eye Research Institute Anglia Ruskin University Cambridge UK HelpMeSee Instituto Mexicano de Oftalmologia Santiago de Querétaro Mexico University of Miami Gables FL USA University of Utah Salt Lake City UT USA Chief Medical Office HelpMeSee New York NY USA Mexican Institute of Ophthalmology Queretaro Mexico Department of Ophthalmology Massachusetts Eye and Ear/Shepens Eye Research Institute/Harvard Medical School Boston MA USA Eye Unit MyungSung Christian Medical Center (MCM) Comprehensive Specialized Hospital and MyungSun Medical College Addis Ababa Ethiopia Department of Ophthalmology Addis Ababa University Addis Ababa Ethiopia Sight for Souls Bellevue WA USA Department of Ophthalmology Harvard University Boston MA USA Eye Unit MyungSung Medical College Addis Ababa Ethiopia Addenbrooke’s Hospital Cambridge UK Department of Ophthalmology Cambridge University Hospitals Cambridge UK Federal University of Sao Paolo Sao Paolo SP Brazil University of Calgary Calgary AB Canada Department of Ophthalmology and Visual Sciences Federal University of São Paulo Sao Paulo Brazil School of Medicine Vita-Salute San Raffaele University Milan Italy Department of Ophthalmology IRCCS San Raffaele Scientific Institute Milan Italy Department of Ophthalmology San Raffaele Scientific Institute Milano Italy IRCCS San Raffaele Scientific Institute Vita-Salute University Milan Italy Scientific Institute San Raffaele Hospital Vita-Salute University Milan Italy University of Poitiers Poitiers France CHU de Poitiers Poitiers France Ophthalmology Department CHU de Poitiers (Poitiers University Hospital) Poitiers France Unité 1084 National Institute of Health and Medical Research (INSERM) Poitiers France

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