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AB0205 A NOVEL METHOD FOR PREDICTING 1-YEAR RETENTION OF ABATACEPT USING machine learning TECHNIQUES: DIRECTIONALITY AND IMPORTANCE OF PREDICTORS

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Annals of the Rheumatic Diseases 2021年 80卷 1127-1128页

作者： R. Alten C. Behar C. Boileau P. Merckaert E. Afari V. Vannier-Moreau S. Connolly A. Najm P.A. Juge A. Rai Y. Elbez K. Lozenski Schlosspark-Klinik University Department of Internal Medicine Rheumatology Berlin Germany Tulsy Co-founder Paris France Excelya N/A Boulogne-Billancourt France Data Revenue GmbH Machine Learning Engineering Department Berlin Germany Private Practice N/A Brunoy France Bristol Myers Squibb Medical Affairs France Rueil-Malmaison France Bristol Myers Squibb Global Drug Development Princeton United States of America University of Glasgow Institute of Infection Immunity and Inflammation College of Medical Veterinary and Life Sciences Glasgow United Kingdom Université de Paris AP-HP Hôpital Bichat Claude-Bernard Department of Rheumatology Paris France Bristol Myers Squibb Global Biometrics and Data Science Princeton United States of America Deepscover Biostatistics Puteaux France Bristol Myers Squibb Immunology and Fibrosis Princeton United States of America

Background: In the ACTION ( NCT02109666 ) study, multivariable Cox proportional hazards regression models showed that the predictors of 1-year retention to abatacept treatment were: patient global pain assessment, country, reason for stopping last biologic, number of prior biologic treatments, abatacept monotherapy, RF/anti-cyclic citrullinated peptide (CCP) status, previous neoplasms, psychiatric disorders and cardiac disorders. 1 machine learning techniques, using the gradient-boosting model, subsequently identified additional predictors of abatacept retention in patients with moderate-to-severe RA enrolled in ACTION; however, the analysis did not show the directionality of the predictors. 2 Objectives: To improve the clinical interpretability of the machine learning model in terms of directionality and the importance of each variable in predicting retention. Methods: Previous analyses using the gradient-boosting model to identify predictors of abatacept retention at 1 year in the ACTION study have been described. 2 This analysis used SHapley Additive exPlanations (SHAP), a mathematical framework, to show how a particular predictor value influences prediction in the context of all other predictors. Higher SHAP values indicate a higher likelihood of retention. The contribution of every variable in the model's prediction (with the exception of country variables) was computed for each data point to capture individual variable impact. This enabled interpretation for level of importance and directionality at a patient level. Results: Using data from 2350 patients enrolled in ACTION (May 2008 to December 2013), the mean retention rate at 1 year was 59.3% (n=1393). Overall variable importance is shown in Figure 1 . After removal of country variables, the top five baseline predictors of retention were: no previous corticosteroid use, ACR functional class II, ≥2 prior biologic treatments prior to abatacept initiation, abatacept monotherapy and HAQ-DI. In terms of direction

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Confidence intervals uncovered: Are we ready for real-world medical imaging AI?

arXiv

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arXiv 2024年

作者： Christodoulou, Evangelia Reinke, Annika Houhou, Rola Kalinowski, Piotr Erkan, Selen Sudre, Carole H. Burgos, Ninon Boutaj, Sofiène Loizillon, Sophie Solal, Maëlys Rieke, Nicola Cheplygina, Veronika Antonelli, Michela Mayer, Leon D. Tizabi, Minu D. Jorge Cardoso, M. Simpson, Amber Jäger, Paul F. Kopp-Schneider, Annette Varoquaux, Gaël Colliot, Olivier Maier-Hein, Lena Heidelberg Div. Intelligent Medical Systems Germany AI Health Innovation Cluster Germany NCT Heidelberg a partnership between DKFZ Heidelberg University Hospital Germany DKFZ Heidelberg Helmholtz Imaging Germany HIDSS4Health - Helmholtz Information and Data Science School for Health Germany DKFZ Heidelberg Interactive Machine Learning Group Germany MRC Unit for Lifelong Health and Ageing UCL Centre for Medical Image Computing Department of Computer Science University College London United Kingdom School of Biomedical Engineering and Imaging Science King’s College London United Kingdom Sorbonne Université Institut du Cerveau - Paris Brain Institute - ICM CNRS Inria Inserm AP-HP Hôpital de la Pitié-Salpêtrière France NVIDIA Germany Department of Computer Science IT University of Copenhagen Denmark Centre for Medical Image Computing University College London United Kingdom School of Computing Queen’s University Canada Department of Biomedical and Molecular Sciences Queen’s University Canada Division of Biostatistics DKFZ Germany Parietal project team INRIA Saclay-Île de France France Faculty of Mathematics and Computer Science Heidelberg University Germany Medical Faculty Heidelberg University Germany

Medical imaging is spearheading the AI transformation of healthcare. Performance reporting is key to determine which methods should be translated into clinical practice. Frequently, broad conclusions are simply derived from mean performance values. In this paper, we argue that this common practice is often a misleading simplification as it ignores performance variability. Our contribution is threefold. (1) Analyzing all MICCAI segmentation papers (n = 221) published in 2023, we first observe that more than 50% of papers do not assess performance variability at all. Moreover, only one (0.5%) paper reported confidence intervals (CIs) for model performance. (2) To address the reporting bottleneck, we show that the unreported standard deviation (SD) in segmentation papers can be approximated by a second-order polynomial function of the mean Dice similarity coefficient (DSC). Based on external validation data from 56 previous MICCAI challenges, we demonstrate that this approximation can accurately reconstruct the CI of a method using information provided in publications. (3) Finally, we reconstructed 95% CIs around the mean DSC of MICCAI 2023 segmentation papers. The median CI width was 0.03 which is three times larger than the median performance gap between the first and second ranked method. For more than 60% of papers, the mean performance of the second-ranked method was within the CI of the first-ranked method. We conclude that current publications typically do not provide sufficient evidence to support which models could potentially be translated into clinical practice. © 2024, CC BY.

关键词： Medical imaging

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Weisfeiler and Leman go machine learning: The Story so far

arXiv

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arXiv 2021年

作者： Morris, Christopher Lipman, Yaron Maron, Haggai Rieck, Bastian Kriege, Nils M. Grohe, Martin Fey, Matthias Borgwardt, Karsten Department of Computer Science RWTH Aachen University Aachen Germany Meta AI Research Department of Computer Science and Applied Mathematics Weizmann Institute of Science Rehovot Israel NVIDIA Research Tel Aviv Israel AIDOS Lab Institute of AI for Health Helmholtz Zentrum München and Technical University of Munich Munich Germany Faculty of Computer Science University of Vienna Vienna Austria Research Network Data Science University of Vienna Vienna Austria Kumo.AI Mountain ViewCA United States Machine Learning & Computational Biology Lab Department of Biosystems Science and Engineering ETH Zürich Basel Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland

In recent years, algorithms and neural architectures based on the Weisfeiler–Leman algorithm, a well-known heuristic for the graph isomorphism problem, have emerged as a powerful tool for machine learning with graphs and relational data. Here, we give a comprehensive overview of the algorithm’s use in a machine-learning setting, focusing on the supervised regime. We discuss the theoretical background, show how to use it for supervised graph and node representation learning, discuss recent extensions, and outline the algorithm’s connection to (permutation-)equivariant neural architectures. Moreover, we give an overview of current applications and future directions to stimulate further research. Copyright © 2021, The Authors. All rights reserved.

关键词： machine learning

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Depth selection for deep ReLU nets in feature extraction and generalization

arXiv

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arXiv 2020年

作者： Han, Zhi Yu, Siquan Lin, Shao-Bo Zhou, Ding-Xuan State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Shenyang China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang China School of Information Science and Engineering Northeastern University Shenyang China Center of Intelligent Decision-Making and Machine Learning School of Management Xi'an Jiaotong University Xi'an China School of Data Science Department of Mathematics City University of Hong Kong Hong Kong

Deep learning is recognized to be capable of discovering deep features for representation learning and pattern recognition without requiring elegant feature engineering techniques by taking advantage of human ingenuity and prior knowledge. Thus it has triggered enormous research activities in machine learning and pattern recognition. One of the most important challenge of deep learning is to figure out relations between a feature and the depth of deep neural networks (deep nets for short) to reflect the necessity of depth. Our purpose is to quantify this feature-depth correspondence in feature extraction and generalization. We present the adaptivity of features to depths and vice-verse via showing a depth-parameter trade-off in extracting both single feature and composite features. Based on these results, we prove that implementing the classical empirical risk minimization on deep nets can achieve the optimal generalization performance for numerous learning tasks. Our theoretical results are verified by a series of numerical experiments including toy simulations and a real application of earthquake seismic intensity prediction. Copyright © 2020, The Authors. All rights reserved.

关键词： Feature extraction

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A multi-objective deep reinforcement learning algorithm for spatio-temporal latency optimization in mobile IoT-enabled edge computing networks

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Simulation Modelling Practice and Theory 2025年 143卷

作者： Parisa Khoshvaght Amir Haider Amir Masoud Rahmani Farhad Soleimanian Gharehchopogh Ferzat Anka Jan Lansky Mehdi Hosseinzadeh Institute of Research and Development Duy Tan University Da Nang Vietnam School of Engineering & Technology Duy Tan University Da Nang Vietnam Centre for Research Impact & Outcome Chitkara University Institute of Engineering and Technology Chitkara University Rajpura 140401 Punjab India Department of AI and Robotics Sejong University Seoul 05006 Republic of Korea Future Technology Research Center National Yunlin University of Science and Technology Yunlin Taiwan Department of Computer Engineering Ur. C. Islamic Azad University Urmia Iran Data Science Application and Research Center (VEBIM) Fatih Sultan Mehmet Vakif University Istanbul Türkiye Department of Computer Science and Mathematics Faculty of Economic Studies University of Finance and Administration Prague Czech Republic Pattern Recognition and Machine Learning Laboratory School of Computing Gachon University Seongnam Republic of Korea

The rapid increase in Mobile Internet of Things (IoT) devices requires novel computational frameworks. These frameworks must meet strict latency and energy efficiency requirements in Edge and Mobile Edge Computing (MEC) systems. Spatio-temporal dynamics, which include the position of edge servers and the timing of task schedules, pose a complex optimization problem. These challenges are further exacerbated by the heterogeneity of IoT workloads and the constraints imposed by device mobility. The balance between computational overhead and communication challenges is also a problem. To solve these issues, advanced methods are needed for resource management and dynamic task scheduling in mobile IoT and edge computing environments. In this paper, we propose a Deep Reinforcement learning (DRL) multi-objective algorithm, called a Double Deep Q-learning (DDQN) framework enhanced with Spatio-temporal mobility prediction, latency-aware task offloading, and energy-constrained IoT device trajectory optimization for federated edge computing networks. DDQN was chosen for its optimize stability and reduced overestimation in Q-values. The framework employs a reward-driven optimization model that dynamically prioritizes latency-sensitive tasks, minimizes task migration overhead, and balances energy efficiency across devices and edge servers. It integrates dynamic resource allocation algorithms to address random task arrival patterns and real-time computational demands. Simulations demonstrate up to a 35 % reduction in end-to-end latency, a 28 % improvement in energy efficiency, and a 20 % decrease in the deadline-miss ratio compared to benchmark algorithms.

关键词： Double deep Q-learning Latency and energy efficiency Mobile edge computing Spatio-temporal optimization

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UCPM: Uncertainty-Guided Cross-Modal Retrieval with Partially Mismatched Pairs

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IEEE transactions on image processing : a publication of the IEEE Signal Processing Society 2025年 PP卷 PP页

作者： Quanxing Zha Xin Liu Yiu-Ming Cheung Shu-Juan Peng Xing Xu Nannan Wang Huaqiao University Department of Computer Science Xiamen 361021 China Key Laboratory of Pattern Recognition and Computer Vision Xiamen 361021 China Huaqiao University Fujian Key Laboratory of Big Data Intelligence and Security Xiamen 361021 China Hong Kong Baptist University Department of Computer Science Hong Kong Huaqiao University Department of Artificial Intelligence Xiamen 361021 China Fujian Province University Key Laboratory of Computer Vision and Machine Learning (Huaqiao University) Xiamen 361021 China University of Electronic Science and Technology of China Center for Future Multimedia School of Computer Science and Engineering Chengdu 610051 China Xidian University State Key Laboratory of Integrated Services Networks Xi’an 710071 China

The manual annotation of perfectly aligned labels for cross-modal retrieval (CMR) is incredibly labor-intensive. As an alternative, the collection of co-occurring data pairs from the Internet is a remarkably cost-effective way, but which, inevitably induces the Partially Mismatched Pairs (PMPs) and therefore significantly degrades the retrieval performance without particular treatment. Previous efforts often utilize the pair-wise similarity to filter out the mismatched pairs, and such operation is highly sensitive to mismatched or ambiguous data and thus leads to sub-optimal performance. To alleviate these concerns, we propose an efficient approach, termed UCPM, i.e., Uncertainty-guided Cross-modal retrieval with Partially Mismatched pairs, which can significantly reduce the adverse impact of mismatched data pairs. Specifically, a novel Uncertainty Guided Division (UGD) strategy is sophisticatedly designed to divide the corrupted training data into confident matched (clean), easily-identifiable mismatched (noisy) and hardly-determined hard subsets, and the derived uncertainty can simultaneously guide the informative pair learning while reducing the negative impact of potential mismatched pairs. Meanwhile, an effective Uncertainty Self-Correction (USC) mechanism is concurrently presented to accurately identify and rectify the fluctuated uncertainty during the training process, which further improves the stability and reliability of the estimated uncertainty. Besides, a Trusted Margin Loss (TML) is newly designed to enhance the discriminability between those hard pairs, by dynamically adjusting their soft margins to amplify the positive contributions of matched pairs while suppressing the negative impacts of mismatched pairs. Extensive experiments on three widely-used benchmark datasets, verify the effectiveness and reliability of UCPM compared with the existing SOTA approaches, and significantly improve the robustness in both synthetic and real-world PMPs. The code i

关键词： Cross-modal retrieval partially mismatched pairs trusted margin loss uncertainty guided division uncertainty self-correction

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Feature extraction for hyperspectral imagery: The evolution from shallow to deep

arXiv

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arXiv 2020年

作者： Rasti, Behnood Hong, Danfeng Hang, Renlong Ghamisi, Pedram Kang, Xudong Chanussot, Jocelyn Benediktsson, Jon Atli Machine Learning Group Exploration Division Helmholtz Institute Freiberg for Resource Technology Helmholtz-Zentrum Dresden-Rossendorf Freiberg09599 Germany Univ. Grenoble Alpes CNRS Grenoble INP GIPSAlab Grenoble38000 France Jiangsu Key Laboratory of Big Data Analysis Technology School of Automation Nanjing University of Information Science and Technology Nanjing210044 China Machine Learning Group Exploration Division Helmholtz Institute Freiberg for Resource Technology Helmholtz-Zentrum Dresden-Rossendorf Freiberg09599 Germany College of Electrical and Information Engineering Hunan University Changsha410082 China Key Laboratory of Visual Perception and Artificial Intelligence of Hunan Province Changsha410082 China Univ. Grenoble Alpes Inria CNRS Grenoble INP LJK GrenobleF-38000 France Faculty of Electrical and Computer Engineering University of Iceland Reykjavik101 Iceland Faculty of Electrical and Computer Engineering University of Iceland Reykjavik107 Iceland

The final version of the paper can be found in IEEE Geoscience and Remote Sensing Magazine. Hyperspectral images provide detailed spectral information through hundreds of (narrow) spectral channels (also known as dimensionality or bands) with continuous spectral information that can accurately classify diverse materials of interest. The increased dimensionality of such data makes it possible to significantly improve data information content but provides a challenge to the conventional techniques (the so-called curse of dimensionality) for accurate analysis of hyperspectral images. Feature extraction, as a vibrant field of research in the hyperspectral community, evolved through decades of research to address this issue and extract informative features suitable for data representation and classification. The advances in feature extraction have been inspired by two fields of research, including the popularization of image and signal processing as well as machine (deep) learning, leading to two types of feature extraction approaches named shallow and deep techniques. This article outlines the advances in feature extraction approaches for hyperspectral imagery by providing a technical overview of the state-of-the-art techniques, providing useful entry points for researchers at different levels, including students, researchers, and senior researchers, willing to explore novel investigations on this challenging topic. In more detail, this paper provides a bird's eye view over shallow (both supervised and unsupervised) and deep feature extraction approaches specifically dedicated to the topic of hyperspectral feature extraction and its application on hyperspectral image classification. Additionally, this paper compares 15 advanced techniques with an emphasis on their methodological foundations in terms of classification accuracies. Furthermore, to push this vibrant field of research forward an impressive amount of codes and libraries is shared at: https://***/Behnoo

关键词： Feature extraction

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Uplink-downlink duality between multiple-access and broadcast channels with compressing relays

arXiv

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arXiv 2020年

作者： Liu, Liang Liu, Ya-Feng Patil, Pratik Yu, Wei the Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hong Kong the State Key Laboratory of Scientific and Engineering Computing Institute of Computational Mathematics and Scientific/Engineering Computing Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing100190 China The Edward S. Rogers Sr. Department of Electrical and Computer Engineering the University of Toronto the Department of Statistics and Data Science and the Machine Learning Department Carnegie Mellon University PittsburghPA15213 United States The Edward S. Rogers Sr. Department of Electrical and Computer Engineering University of Toronto 10 King’s College Road TorontoONM5S3G4 Canada

—Uplink-downlink duality refers to the fact that under a sum-power constraint, the capacity regions of a Gaussian multiple-access channel and a Gaussian broadcast channel with Hermitian transposed channel matrices are identical. This paper generalizes this result to a cooperative cellular network, in which remote access-points are deployed as relays in serving the users under the coordination of a central processor (CP). In this model, the users and the relays are connected over noisy wireless links, while the relays and the CP are connected over noiseless but rate-limited fronthaul links. Based on a Lagrangian technique, this paper establishes a duality relationship between such a multiple-access relay channel and broadcast relay channel, under the assumption that the relays use compression-based strategies. Specifically, we show that under the same total transmit power constraint and individual fronthaul rate constraints, the achievable rate regions of the Gaussian multiple-access and broadcast relay channels are identical, when either independent compression or Wyner-Ziv and multivariate compression strategies are used. The key observations are that if the beamforming vectors at the relays are fixed, the sum-power minimization problems under the achievable rate and fronthaul constraints in both the uplink and the downlink can be transformed into either a linear programming or a semidefinite programming problem depending on the compression technique, and that the uplink and downlink problems are Lagrangian duals of each other. Moreover, the dual variables corresponding to the downlink rate constraints become the uplink powers;the dual variables corresponding to the downlink fronthaul constraints become the uplink quantization noises. This duality relationship enables an efficient algorithm for optimizing the downlink transmission and relaying strategies based on the uplink. Copyright © 2020, The Authors. All rights reserved.

关键词： Linear programming

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The state-of-the-art in Cardiac MRI Reconstruction: Results of the CMRxRecon Challenge in MICCAI 2023

arXiv

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arXiv 2024年

作者： Lyu, Jun Qin, Chen Wang, Shuo Wang, Fanwen Li, Yan Wang, Zi Guo, Kunyuan Ouyang, Cheng Tänzer, Michael Liu, Meng Sun, Longyu Sun, Mengting Li, Qin Shi, Zhang Hua, Sha Li, Hao Chen, Zhensen Zhang, Zhenlin Xin, Bingyu Metaxas, Dimitris N. Yiasemis, George Teuwen, Jonas Zhang, Liping Chen, Weitian Pang, Yanwei Liu, Xiaohan Razumov, Artem Dylov, Dmitry V. Dou, Quan Yan, Kang Xue, Yuyang Du, Yuning Dietlmeier, Julia Garcia-Cabrera, Carles Hemidi, Ziad Al-Haj Vogt, Nora Xu, Ziqiang Zhang, Yajing Chu, Ying-Hua Chen, Weibo Bai, Wenjia Zhuang, Xiahai Qin, Jing Wu, Lianmin Yang, Guang Qu, Xiaobo Wang, He Wang, Chengyan Psychiatry Neuroimaging Laboratory Brigham and Women’s Hospital Harvard Medical School 399 Revolution Drive BostonMA02215 United States Department of Electrical and Electronic Engineering & I-X Imperial College London United Kingdom Digital Medical Research Center School of Basic Medical Sciences Fudan University Shanghai China Department of Bioengineering & I-X Imperial College London LondonW12 7SL United Kingdom Cardiovascular Magnetic Resonance Unit Royal Brompton Hospital Guy’s and St Thomas’ NHS Foundation Trust LondonSW3 6NP United Kingdom Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance National Institute for Data Science in Health and Medicine Institute of Artificial Intelligence Xiamen University Xiamen361102 China Department of Computing Department of Brain Sciences Imperial College London LondonSW7 2AZ United Kingdom Human Phenome Institute Fudan University 825 Zhangheng Road Pudong New District Shanghai201203 China Department of Radiology Zhongshan Hospital Fudan University Shanghai China Department of Cardiovascular Medicine Ruijin Hospital Lu Wan Branch Shanghai Jiao Tong University School of Medicine Shanghai China Institute of Science and Technology for Brain-Inspired Intelligence Fudan University Shanghai200433 China Department of Computer Science Rutgers University PiscatawayNJ08854 United States AI for Oncology Netherlands Cancer Institute Plesmanlaan 121 Amsterdam1066 CX Netherlands Department of Imaging and Interventional Radiology The Chinese University of Hong Kong Hong Kong TJK-BIIT Lab School of Electrical and Information Engineering Tianjin University Tianjin300072 China Skolkovo Institute Of Science And Technology Center for Artificial Intelligence Technology 30/1 Bolshoy blvd. Moscow121205 Russia Department of Biomedical Engineering University of Virginia

Cardiac magnetic resonance imaging (MRI) provides detailed and quantitative evaluation of the heart’s structure, function, and tissue characteristics with high-resolution spatial-temporal imaging. However, its slow imaging speed and motion artifacts are notable limitations. Undersampling reconstruction, especially data-driven algorithms, has emerged as a promising solution to accelerate scans and enhance imaging performance using highly under-sampled data. Nevertheless, the scarcity of publicly available cardiac k-space datasets and evaluation platform hinder the development of data-driven reconstruction algorithms. To address this issue, we organized the Cardiac MRI Reconstruction Challenge (CMRxRecon) in 2023, in collaboration with the 26th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI). CMRxRecon presented an extensive k-space dataset comprising cine and mapping raw data, accompanied by detailed annotations of cardiac anatomical structures. With overwhelming participation, the challenge attracted more than 285 teams and over 600 participants. Among them, 22 teams successfully submitted Docker containers for the testing phase, with 7 teams submitted for both cine and mapping tasks. All teams use deep learning based approaches, indicating that deep learning has predominately become a promising solution for the problem. The first-place winner of both tasks utilizes the E2E-VarNet architecture as backbones. In contrast, U-Net is still the most popular backbone for both multi-coil and single-coil reconstructions. This paper provides a comprehensive overview of the challenge design, presents a summary of the submitted results, reviews the employed methods, and offers an in-depth discussion that aims to inspire future advancements in cardiac MRI reconstruction models. The summary emphasizes the effective strategies observed in Cardiac MRI reconstruction, including backbone architecture, loss function, pre-processing techn

关键词： Mapping

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Lessons Learned from Assessing Trustworthy AI in Practice

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Digital Society 2023年第3期2卷 1-25页

作者： Vetter, Dennis Amann, Julia Bruneault, Frédérick Coffee, Megan Düdder, Boris Gallucci, Alessio Gilbert, Thomas Krendl Hagendorff, Thilo van Halem, Irmhild Hickman, Eleanore Hildt, Elisabeth Holm, Sune Kararigas, Georgios Kringen, Pedro Madai, Vince I. Wiinblad Mathez, Emilie Tithi, Jesmin Jahan Westerlund, Magnus Wurth, Renee Zicari, Roberto V. Computational Vision and Artificial Intelligence Lab Goethe University Frankfurt Frankfurt Am Main Germany Z-Inspection® Initiative Venice Italy Health Ethics and Policy Lab ETH Zurich Zurich Switzerland Strategy and Innovation Careum Foundation Zurich Switzerland Philosophie Departement Collège André-Laurendeau Montréal Canada École Des Médias Université du Québec À Montréal Montréal Canada Department of Medicine Division of Infectious Diseases and Immunology New York University Grossman School of Medicine New York City USA Department of Computer Science University of Copenhagen Copenhagen Denmark Digital Life Initiative Cornell Tech New York City USA Cluster of Excellence “Machine Learning: New Perspectives for Science” University of Tuebingen Tuebingen Germany School of Law University of Bristol Bristol UK Center for the Study of Ethics in the Professions Illinois Institute of Technology Chicago USA Department of Business Management and Analytics Arcada University of Applied Sciences Helsinki Finland Department of Food & Resource Economics University of Copenhagen Copenhagen Denmark Department of Physiology Faculty of Medicine University of Iceland Reykjavik Iceland QUEST Centre for Responsible Research Berlin Institute of Health Charité Universitätsmedizin Berlin Berlin Germany Faculty of Computing Engineering and the Built Environment School of Computing and Digital Technology Birmingham City University Birmingham UK Parallel Computing Labs Intel Santa Clara USA School of Economics Innovation and Technology Kristiania University College Oslo Norway Data Science Graduate School Seoul National University Seoul South Korea

Building artificial intelligence (AI) systems that adhere to ethical standards is a complex problem. Even though a multitude of guidelines for the design and development of such trustworthy AI systems exist, these guidelines focus on high-level and abstract requirements for AI systems, and it is often very difficult to assess if a specific system fulfills these requirements. The Z-Inspection® process provides a holistic and dynamic framework to evaluate the trustworthiness of specific AI systems at different stages of the AI lifecycle, including intended use, design, and development. It focuses, in particular, on the discussion and identification of ethical issues and tensions through the analysis of socio-technical scenarios and a requirement-based framework for ethical and trustworthy AI. This article is a methodological reflection on the Z-Inspection® process. We illustrate how high-level guidelines for ethical and trustworthy AI can be applied in practice and provide insights for both AI researchers and AI practitioners. We share the lessons learned from conducting a series of independent assessments to evaluate the trustworthiness of real-world AI systems, as well as key recommendations and practical suggestions on how to ensure a rigorous trustworthiness assessment throughout the lifecycle of an AI system. The results presented in this article are based on our assessments of AI systems in the healthcare sector and environmental monitoring, where we used the framework for trustworthy AI proposed in the Ethics Guidelines for Trustworthy AI by the European Commission’s High-Level Expert Group on AI. However, the assessment process and the lessons learned can be adapted to other domains and include additional frameworks.

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