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Joint Conference of the European Medical and Biological engineering Conference, EMBEC 2017 and Nordic-Baltic Conference on Biomedical engineering and Medical Physics, NBC 2107

作者： Filos, Dimitris Triantafyllidis, A. Manolios, V. Livitckaia, K. Claes, J. Buys, R. Cornelissen, V. Kouidi, E. Maglaveras, N. Chouvarda, I. Centre for Research and Technology Hellas Institute of Applied Biosciences Thessaloniki Greece Lab of Computing Medical Informatics & Biomedical lmaging Technologies School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece Katholieke Universiteit Leuven Research Group for Cardiovascular and Respiratory Rehabilitation Belgium Laboratory of Sports Medicine Aristotle University of Thessaloniki Thermi Greece Department of Electrical Engineering and Computer Science Northwestern University EvanstonIL United States

ISBN: (纸本)9789811051210

Exercise-based rehabilitation plays a key role for patients with cardiovascular disease (CVD) in improving their well-being and reducing their symptoms. Monitoring and assessing the exercise response at an individual level is critical toward achieving better health outcomes. 15 exercise sessions performed by 5 CVD patients and 9 sessions from 3 regularly active individuals were monitored, and heart rate (HR) data were acquired. A model based on the HR dynamics during exercising at different intensities was built, and simulations were performed to assess performance in different scenarios of exercise selection. Our results show that the application of simple rules in exercise selection, which consider both the HR and the beneficial HR zones of individuals, can lead to beneficial execution of exercise programs (%time spent in beneficial HR zones: 60.6±27.5 for CVD patients). Personalized guidance during exercise has the potential to significantly contribute in the beneficial execution of exercise-based cardiac rehabilitation programs. © Springer Nature Singapore Pte Ltd. 2018.

关键词： Patient rehabilitation

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First polarisation measurement of coherently photoproduced J/ψ in ultra-peripheral Pb–Pb collisions at s_NN=5.02 TeV

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Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics 2025年 865卷

作者： Acharya, S. Adamová, D. Adler, A. Aglieri Rinella, G. Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. Ahn, S.U. Ahuja, I. Akindinov, A. Al-Turany, M. Aleksandrov, D. Alessandro, B. Alfanda, H.M. Alfaro Molina, R. Ali, B. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alocco, G. Alt, T. Altsybeev, I. Alvarado, J.R. Anaam, M.N. Andrei, C. Andronic, A. Anguelov, V. Antinori, F. Antonioli, P. Apadula, N. Aphecetche, L. Appelshäuser, H. Arata, C. Arcelli, S. Aresti, M. Arnaldi, R. Arneiro, J.G.M.C.A. Arsene, I.C. Arslandok, M. Augustinus, A. Averbeck, R. Azmi, M.D. Badalà, A. Bae, J. Baek, Y.W. Bai, X. Bailhache, R. Bailung, Y. Balbino, A. Baldisseri, A. Balis, B. Banerjee, D. Banoo, Z. Barbera, R. Barile, F. Barioglio, L. Barlou, M. Barnaföldi, G.G. Barnby, L.S. Barret, V. Barreto, L. Bartels, C. Barth, K. Bartsch, E. Bastid, N. Basu, S. Batigne, G. Battistini, D. Batyunya, B. Bauri, D. Bazo Alba, J.L. Bearden, I.G. Beattie, C. Becht, P. Behera, D. Belikov, I. Bell Hechavarria, A.D.C. Bellini, F. Bellwied, R. Belokurova, S. Belyaev, V. Bencedi, G. Beole, S. Bercuci, A. Berdnikov, Y. Berdnikova, A. Bergmann, L. Besoiu, M.G. Betev, L. Bhaduri, P.P. Bhasin, A. Bhat, M.A. Bhattacharjee, B. Bianchi, L. Bianchi, N. Bielčík, J. Bielčíková, J. Biernat, J. Bigot, A.P. Bilandzic, A. Biro, G. Biswas, S. Bize, N. Blair, J.T. Blau, D. Blidaru, M.B. Bluhme, N. Blume, C. Boca, G. Bock, F. Bodova, T. Bogdanov, A. Boi, S. Bok, J. Boldizsár, L. Bombara, M. Bond, P.M. Bonomi, G. Borel, H. Borissov, A. Borquez Carcamo, A.G. Bossi, H. Botta, E. Bouziani, Y.E.M. Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. Bruno, G.E. Buckland, M.D. Budnikov, D. Buesching, H. Bufalino, S. Buhler, P. Buthelezi, Z. Bylinkin, A. Bysiak, S.A. Cai, M. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J.M.M. Camerini, P. Canedo, F.D.M. Cantway, S.L. Carabas, M. Carballo, A.A. Carnesecchi, F. Caron, R. Carvalho, L.A.D. Castillo Castellanos, J. Catalano, F. Ceballos Sanchez, C. Chakaberia, I. Chakraborty, P. Chandra, S. Chapeland, S. Chartier, M. Chattopa A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation Yerevan Armenia AGH University of Krakow Cracow Poland Bogolyubov Institute for Theoretical Physics National Academy of Sciences of Ukraine Kiev Ukraine Bose Institute Department of Physics Centre for Astroparticle Physics and Space Science (CAPSS) Kolkata India California Polytechnic State University San Luis Obispo CA United States Central China Normal University Wuhan China Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN) Havana Cuba Centro de Investigación y de Estudios Avanzados (CINVESTAV) Mexico City and Mérida Mexico Chicago State University Chicago IL United States China Institute of Atomic Energy Beijing China Chungbuk National University Cheongju South Korea Comenius University Bratislava Faculty of Mathematics Physics and Informatics Bratislava Slovakia COMSATS University Islamabad Islamabad Pakistan Creighton University Omaha NE United States Department of Physics Aligarh Muslim University Aligarh India Department of Physics Pusan National University Pusan South Korea Department of Physics Sejong University Seoul South Korea Department of Physics University of California Berkeley CA United States Department of Physics University of Oslo Oslo Norway Department of Physics and Technology University of Bergen Bergen Norway Dipartimento di Fisica Università di Pavia Pavia Italy Dipartimento di Fisica dell'Università Sezione INFN Cagliari Italy Dipartimento di Fisica dell'Università Sezione INFN Trieste Italy Dipartimento di Fisica dell'Università Sezione INFN Turin Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Bologna Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Catania Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Padova Italy Dipartimento di Fisica ‘E.R. Caianiello’ dell'Università Gruppo Collegato INFN Salerno Italy Dipartimento DISAT del Politecnico

The first measurement of the polarisation of coherently photoproduced J/ψ mesons in ultra-peripheral Pb–Pb collisions, using data at sNN=5.02 TeV, is presented. The J/ψ meson is measured via its dimuon decay channe...

The first measurement of the polarisation of coherently photoproduced J/ψ mesons in ultra-peripheral Pb–Pb collisions, using data at s_NN=5.02 TeV, is presented. The J/ψ meson is measured via its dimuon decay channel in the forward rapidity interval −4.0−1 ± 5% (syst) is analysed. Hadronic activity is highly suppressed since the interaction is mediated by a photon. The polar and azimuthal angle distributions of the decay muons are measured, and the polarisation parameters λ_θ, λ_φ, λ_θφ are extracted. The analysis is carried out in the helicity frame. The results are found to be consistent with a transversely polarised J/ψ. These values are compared with previous measurements by the H1 and ZEUS experiments. The polarisation parameters of coherent J/ψ photoproduction in Pb–Pb collisions are found to be consistent with the s-channel helicity conservation hypothesis. © 2025 CERN for the benefit of the ALICE Collaboration

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First study of the two-body scattering involving charm hadrons

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Physical Review D 2022年第5期106卷 052010-052010页

作者： S. Acharya D. Adamová A. Adler J. Adolfsson G. Aglieri Rinella M. Agnello N. Agrawal Z. Ahammed S. Ahmad S. U. Ahn I. Ahuja Z. Akbar A. Akindinov M. Al-Turany S. N. Alam D. Aleksandrov B. Alessandro H. M. Alfanda R. Alfaro Molina B. Ali Y. Ali A. Alici N. Alizadehvandchali A. Alkin J. Alme G. Alocco T. Alt I. Altsybeev M. N. Anaam C. Andrei D. Andreou A. Andronic V. Anguelov F. Antinori P. Antonioli C. Anuj N. Apadula L. Aphecetche H. Appelshäuser S. Arcelli R. Arnaldi I. C. Arsene M. Arslandok A. Augustinus R. Averbeck S. Aziz M. D. Azmi A. Badalà Y. W. Baek X. Bai R. Bailhache Y. Bailung R. Bala A. Balbino A. Baldisseri B. Balis D. Banerjee Z. Banoo R. Barbera L. Barioglio M. Barlou G. G. Barnaföldi L. S. Barnby V. Barret C. Bartels K. Barth E. Bartsch F. Baruffaldi N. Bastid S. Basu G. Batigne D. Battistini B. Batyunya D. Bauri J. L. Bazo Alba I. G. Bearden C. Beattie P. Becht I. Belikov A. D. C. Bell Hechavarria F. Bellini R. Bellwied S. Belokurova V. Belyaev G. Bencedi S. Beole A. Bercuci Y. Berdnikov A. Berdnikova L. Bergmann M. G. Besoiu L. Betev P. P. Bhaduri A. Bhasin I. R. Bhat M. A. Bhat B. Bhattacharjee P. Bhattacharya L. Bianchi N. Bianchi J. Bielčík J. Bielčíková J. Biernat A. Bilandzic G. Biro S. Biswas J. T. Blair D. Blau M. B. Blidaru C. Blume G. Boca F. Bock A. Bogdanov S. Boi J. Bok L. Boldizsár A. Bolozdynya M. Bombara P. M. Bond G. Bonomi H. Borel A. Borissov H. Bossi E. Botta L. Bratrud P. Braun-Munzinger M. Bregant M. Broz G. E. Bruno M. D. Buckland D. Budnikov H. Buesching S. Bufalino O. Bugnon P. Buhler Z. Buthelezi J. B. Butt A. Bylinkin S. A. Bysiak M. Cai H. Caines A. Caliva E. Calvo Villar J. M. M. Camacho R. S. Camacho P. Camerini F. D. M. Canedo M. Carabas F. Carnesecchi R. Caron J. Castillo Castellanos E. A. R. Casula F. Catalano C. Ceballos Sanchez I. Chakaberia P. Chakraborty S. Chandra S. Chapeland M. Chartier S. Chattopadhyay T. G. Chavez T. Cheng C. Cheshkov B. Cheynis V. Chibante Barroso D. D. Chinellato S. Cho P. Chochula P. Christakoglou C. H. Christensen P. Christiansen T. Università degli Studi di Foggia Foggia Italy Nuclear Physics Group STFC Daresbury Laboratory Daresbury United Kingdom Jeonbuk National University Jeonju Republic of Korea Lawrence Berkeley National Laboratory Berkeley California USA European Organization for Nuclear Research (CERN) Geneva Switzerland Dipartimento DISAT del Politecnico and Sezione INFN Turin Italy INFN Sezione di Bologna Bologna Italy Department of Physics Aligarh Muslim University Aligarh India Joint Institute for Nuclear Research (JINR) Dubna Russia Faculty of Science P.J. Šafárik University Košice Slovakia Indonesian Institute of Sciences Jakarta Indonesia NRC Kurchatov Institute IHEP Protvino Russia Politecnico di Bari and Sezione INFN Bari Italy National Nuclear Research Center Baku Azerbaijan INFN Sezione di Torino Turin Italy Central China Normal University Wuhan China Instituto de Física Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil COMSATS University Islamabad Islamabad Pakistan Dipartimento di Fisica e Astronomia dell’Università and Sezione INFN Bologna Italy Universidade Federal do ABC Santo Andre Brazil Department of Physics and Technology University of Bergen Bergen Norway INFN Sezione di Cagliari Cagliari Italy Institute of Space Science (ISS) Bucharest Romania School of Physics and Astronomy University of Birmingham Birmingham United Kingdom Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania Niels Bohr Institute University of Copenhagen Copenhagen Denmark Warsaw University of Technology Warsaw Poland Physikalisches Institut Eberhard-Karls-Universität Tübingen Tübingen Germany INFN Sezione di Padova Padova Italy Laboratoire de Physique Subatomique et de Cosmologie Université Grenoble-Alpes CNRS-IN2P3 Grenoble France St. Petersburg State University St. Petersburg Russia Department of Physics University of Oslo Oslo Norway Westfälische Wilhelms-Universität Münster Institut für Kernphysik Münster

This article presents the first measurement of the interaction between charm hadrons and nucleons. The two-particle momentum correlations of pD− and p¯D+ pairs are measured by the ALICE Collaboration in high-multiplicity pp collisions at s=13 TeV. The data are compatible with the Coulomb-only interaction hypothesis within (1.1–1.5)σ. The level of agreement slightly improves if an attractive nucleon (N)D¯ strong interaction is considered, in contrast to most model predictions which suggest an overall repulsive interaction. This measurement allows for the first time an estimation of the 68% confidence level interval for the isospin I=0 inverse scattering length of the ND¯ state f0,I=0−1∈[−0.4,0.9] fm−1, assuming negligible interaction for the isospin I=1 channel.

关键词： Hadron colliders

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Charm-quark fragmentation fractions and production cross section at midrapidity in pp collisions at the LHC

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Physical Review D 2022年第1期105卷 L011103-L011103页

作者： S. Acharya D. Adamová A. Adler J. Adolfsson G. Aglieri Rinella M. Agnello N. Agrawal Z. Ahammed S. Ahmad S. U. Ahn I. Ahuja Z. Akbar A. Akindinov M. Al-Turany S. N. Alam D. Aleksandrov B. Alessandro H. M. Alfanda R. Alfaro Molina B. Ali Y. Ali A. Alici N. Alizadehvandchali A. Alkin J. Alme T. Alt L. Altenkamper I. Altsybeev M. N. Anaam C. Andrei D. Andreou A. Andronic M. Angeletti V. Anguelov F. Antinori P. Antonioli C. Anuj N. Apadula L. Aphecetche H. Appelshäuser S. Arcelli R. Arnaldi I. C. Arsene M. Arslandok A. Augustinus R. Averbeck S. Aziz M. D. Azmi A. Badalà Y. W. Baek X. Bai R. Bailhache Y. Bailung R. Bala A. Balbino A. Baldisseri B. Balis M. Ball D. Banerjee R. Barbera L. Barioglio M. Barlou G. G. Barnaföldi L. S. Barnby V. Barret C. Bartels K. Barth E. Bartsch F. Baruffaldi N. Bastid S. Basu G. Batigne B. Batyunya D. Bauri J. L. Bazo Alba I. G. Bearden C. Beattie I. Belikov A. D. C. Bell Hechavarria F. Bellini R. Bellwied S. Belokurova V. Belyaev G. Bencedi S. Beole A. Bercuci Y. Berdnikov A. Berdnikova D. Berenyi L. Bergmann M. G. Besoiu L. Betev P. P. Bhaduri A. Bhasin M. A. Bhat B. Bhattacharjee P. Bhattacharya L. Bianchi N. Bianchi J. Bielčík J. Bielčíková J. Biernat A. Bilandzic G. Biro S. Biswas J. T. Blair D. Blau M. B. Blidaru C. Blume G. Boca F. Bock A. Bogdanov S. Boi J. Bok L. Boldizsár A. Bolozdynya M. Bombara P. M. Bond G. Bonomi H. Borel A. Borissov H. Bossi E. Botta L. Bratrud P. Braun-Munzinger M. Bregant M. Broz G. E. Bruno M. D. Buckland D. Budnikov H. Buesching S. Bufalino O. Bugnon P. Buhler Z. Buthelezi J. B. Butt S. A. Bysiak D. Caffarri M. Cai H. Caines A. Caliva E. Calvo Villar J. M. M. Camacho R. S. Camacho P. Camerini F. D. M. Canedo F. Carnesecchi R. Caron J. Castillo Castellanos E. A. R. Casula F. Catalano C. Ceballos Sanchez P. Chakraborty S. Chandra S. Chapeland M. Chartier S. Chattopadhyay A. Chauvin T. G. Chavez C. Cheshkov B. Cheynis V. Chibante Barroso D. D. Chinellato S. Cho P. Chochula P. Christakoglou C. H. Christensen P. Christiansen T. Chujo C. Cicalo L. Cifarelli Variable Energy Cyclotron Centre Homi Bhabha National Institute Kolkata India Nuclear Physics Institute of the Czech Academy of Sciences Řež u Prahy Czech Republic Johann-Wolfgang-Goethe Universität Frankfurt Institut für Informatik Fachbereich Informatik und Mathematik Frankfurt Germany Lund University Department of Physics Division of Particle Physics Lund Sweden European Organization for Nuclear Research (CERN) Geneva Switzerland Dipartimento DISAT del Politecnico and Sezione INFN Turin Italy INFN Sezione di Bologna Bologna Italy Department of Physics Aligarh Muslim University Aligarh India Korea Institute of Science and Technology Information Daejeon Republic of Korea Faculty of Science P.J. Šafárik University Košice Slovakia Indonesian Institute of Sciences Jakarta Indonesia NRC Kurchatov Institute—ITEP Moscow Russia Research Division and ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Darmstadt Germany Fudan University Shanghai China National Research Centre Kurchatov Institute Moscow Russia INFN Sezione di Torino Turin Italy Central China Normal University Wuhan China Instituto de Física Universidad Nacional Autónoma de México Mexico City Mexico COMSATS University Islamabad Islamabad Pakistan Dipartimento di Fisica e Astronomia dell’Università and Sezione INFN Bologna Italy University of Houston Houston Texas USA Department of Physics and Technology University of Bergen Bergen Norway Institut für Kernphysik Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany St. Petersburg State University St. Petersburg Russia Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania Nikhef National institute for subatomic physics Amsterdam Netherlands Westfälische Wilhelms-Universität Münster Institut für Kernphysik Münster Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany INFN Sezione di Padova Padova Italy Lawrence Berkeley National Lab

Recent pT-integrated cross-section measurements of the ground-state charm mesons and baryons, D0, D+, Ds+, Λc+, and Ξc0, are used to evaluate the charm fragmentation fractions and production cross section per unit of rapidity at midrapidity (|y|<0.5), in pp collisions at s=5.02 TeV at the LHC. The latter is dσcc¯/dy||y|<0.5=1165±44(stat)−101+134(syst) μb. These measurements were obtained for the first time in hadronic collisions at the LHC, including the charm baryon states, recently measured by ALICE at midrapidity. The charm fragmentation fractions differ significantly from the values measured in e+e− and ep collisions, providing evidence of the dependence of the parton-to-hadron fragmentation fractions on the collision system, indicating that the assumption of their universality is not supported by the measured cross sections. An increase of a factor of about 3.3 for the fragmentation fraction for the Λc+ with a significance of 5σ between the values obtained in pp collisions and those obtained in e+e− (ep) collisions is reported. The fragmentation fraction for the Ξc0 was obtained for the first time in any collision system. The measured fragmentation fractions were used to update the cc¯ cross sections per unit of rapidity at |y|<0.5 at s=2.76 and 7 TeV, which are about 40% higher than the previously published results. The data were compared with perturbative-QCD calculations and lie at the upper edge of the theoretical bands.

关键词： Hadron-hadron interactions

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Measurement of the inclusive WZ production cross section in pp collisions at = 13.6 TeV

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Journal of High Energy Physics 2025年第4期2025卷 1-48页

作者： Hayrapetyan, A. Tumasyan, A. Adam, W. Andrejkovic, J. W. Benato, L. Bergauer, T. Chatterjee, S. Damanakis, K. Dragicevic, M. Hussain, P. S. Jeitler, M. Krammer, N. Li, A. Liko, D. Mikulec, I. Schieck, J. Schöfbeck, R. Schwarz, D. Sonawane, M. Waltenberger, W. Wulz, C.-E. Janssen, T. Van Laer, T. Van Mechelen, P. Breugelmans, N. D’Hondt, J. Dansana, S. De Moor, A. Delcourt, M. Heyen, F. Lowette, S. Makarenko, I. Müller, D. Tavernier, S. Tytgat, M. Van Onsem, G. P. Van Putte, S. Vannerom, D. Bilin, B. Clerbaux, B. Das, A. K. De Bruyn, I. De Lentdecker, G. Evard, H. Favart, L. Gianneios, P. Jaramillo, J. Khalilzadeh, A. Khan, F. A. Lee, K. Malara, A. Shahzad, M. A. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. De Coen, M. Dobur, D. Gokbulut, G. Hong, Y. Knolle, J. Lambrecht, L. Marckx, D. Amarilo, K. Mota Skovpen, K. Van Den Bossche, N. van der Linden, J. Wezenbeek, L. Benecke, A. Bethani, A. Bruno, G. Caputo, C. De Favereau De Jeneret, J. Delaere, C. Donertas, I. S. Giammanco, A. Guzel, A. O. Jain, Sa. Lemaitre, V. Lidrych, J. Mastrapasqua, P. Tran, T. T. Turkcapar, S. Alves, G. A. Coelho, E. Correia Silva, G. Hensel, C. Menezes De Oliveira, T. Mora Herrera, C. Rebello Teles, P. Soeiro, M. Tonelli Manganote, E. J. Vilela Pereira, A. Aldá Júnior, W. L. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Gomes De Souza, R. Laux Kuhn, T. Macedo, M. Martins, J. Mundim, L. Nogima, H. Pinheiro, J. P. Santoro, A. Sznajder, A. Thiel, M. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Maietto Silverio, I. Mercadante, P. G. Novaes, S. F. Orzari, B. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Shumka, E. Keshri, S. Laroze, D. Thakur, S. Cheng, T. Javaid, T. Yuan, L. Hu, Z. Liang, Z. Liu, J. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. Jiang, C. H. Kapoor, A. Liao, H. Yerevan Physics Institute Yerevan Armenia Yerevan State University Yerevan Armenia Institut für Hochenergiephysik Vienna Austria TU Wien Vienna Austria Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Ghent University Ghent Belgium Université Libre de Bruxelles Bruxelles Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil FACAMP - Faculdades de Campinas Sao Paulo Brazil Universidade Estadual de Campinas Campinas Brazil Federal University of Rio Grande do Sul Porto Alegre Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China University of Chinese Academy of Sciences Beijing China Center of Advanced Science and Technology Beijing China Spallation Neutron Source Guangdong China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Guangdong Provincial Key Laboratory of Nuclear Science and Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal University Guangzhou China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Nanjing Normal University Nanjing China Henan Normal University Xinxiang China University of Shanghai for Science and Technology Shanghai China The University of Iowa Iowa City Iowa USA Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de

The inclusive WZ production cross section is measured in proton-proton collisions at a centre-of-mass energy of 13.6 TeV, using data collected during 2022 with the CMS detector, corresponding to an integrated luminosity of 34.7 fb−1. The measurement uses multileptonic final states and a simultaneous likelihood fit to the number of events in four different lepton flavour categories: eee, eeμ, μμe, and μμμ. The selection is optimized to minimize the number of background events, and relies on an efficient prompt lepton discrimination strategy. The WZ production cross section is measured in a phase space defined within a 30 GeV window around the Z boson mass, as σtotal (pp → WZ) = 55.2 ± 1.2 (stat) ± 1.2 (syst) ± 0.8 (lumi) ± 0.3 (theo) pb. In addition, the cross section is measured in a fiducial phase space closer to the detector-level requirements. All the measurements presented in this paper are in agreement with standard model predictions.

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Measurements of inclusive and differential cross sections for top quark production in association with a Z boson in proton-proton collisions at = 13 TeV

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Journal of High Energy Physics 2025年第2期2025卷 1-53页

作者： Hayrapetyan, A. Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. Chatterjee, S. Damanakis, K. Dragicevic, M. Hussain, P. S. Jeitler, M. Krammer, N. Li, A. Liko, D. Mikulec, I. Schieck, J. Schöfbeck, R. Schwarz, D. Sonawane, M. Waltenberger, W. Wulz, C.-E. Janssen, T. Van Laer, T. Van Mechelen, P. Breugelmans, N. D’Hondt, J. Dansana, S. De Moor, A. Delcourt, M. Heyen, F. Lowette, S. Makarenko, I. Müller, D. Tavernier, S. Tytgat, M. Van Onsem, G. P. Van Putte, S. Vannerom, D. Bilin, B. Clerbaux, B. Das, A. K. De Lentdecker, G. Evard, H. Favart, L. Gianneios, P. Jaramillo, J. Khalilzadeh, A. Khan, F. A. Lee, K. Mahdavikhorrami, M. Malara, A. Paredes, S. Shahzad, M. A. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. De Coen, M. Dobur, D. Gokbulut, G. Hong, Y. Knolle, J. Lambrecht, L. Marckx, D. Mota Amarilo, K. Skovpen, K. Van Den Bossche, N. van der Linden, J. Wezenbeek, L. Benecke, A. Bethani, A. Bruno, G. Caputo, C. De Favereau De Jeneret, J. Delaere, C. Donertas, I. S. Giammanco, A. Guzel, A. O. Jain, Sa. Lemaitre, V. Lidrych, J. Mastrapasqua, P. Tran, T. T. Wertz, S. Alves, G. A. Alves Gallo Pereira, M. Coelho, E. Correia Silva, G. Hensel, C. Menezes De Oliveira, T. Mora Herrera, C. Moraes, A. Rebello Teles, P. Soeiro, M. Vilela Pereira, A. Aldá Júnior, W. L. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Gomes De Souza, R. Laux Kuhn, T. Macedo, M. Martins, J. Mundim, L. Nogima, H. Pinheiro, J. P. Santoro, A. Sznajder, A. Thiel, M. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Maietto Silverio, I. Mercadante, P. G. Novaes, S. F. Orzari, B. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Shumka, E. Keshri, S. Laroze, D. Thakur, S. Cheng, T. Javaid, T. Yuan, L. Hu, Z. Liang, Z. Liu, J. Yi, K. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. Jiang, C. H. Yerevan Physics Institute Yerevan Armenia Yerevan State University Yerevan Armenia Institut für Hochenergiephysik Vienna Austria TU Wien Vienna Austria Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Ghent University Ghent Belgium Université Libre de Bruxelles Bruxelles Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual de Campinas Campinas Brazil Federal University of Rio Grande do Sul Porto Alegre Brazil UFMS Nova Andradina Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Nanjing Normal University Nanjing China The University of Iowa Iowa City U.S.A. Institute of High Energy Physics Beijing China University of Chinese Academy of Sciences Beijing China China Center of Advanced Science and Technology Beijing China China Spallation Neutron Source Guangdong China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Guangdong Provincial Key Laboratory of Nuclear Science and Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal University Guangzhou China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Henan Normal University Xinxiang China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) — Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engine

Measurements are presented of inclusive and differential cross sections for Z boson associated production of top quark pairs ( $$ \textrm{t}\overline{\textrm{t}}\textrm{Z} $$ ) and single top quarks (tZq or tWZ). The data were recorded in proton-proton collisions at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb−1. Events with three or more leptons, electrons or muons, are selected and a multiclass deep neural network is used to separate three event categories, the $$ \textrm{t}\overline{\textrm{t}}\textrm{Z} $$ and tWZ processes, the tZq process, and the backgrounds. A profile likelihood approach is used to unfold the differential cross sections, to account for systematic uncertainties, and to determine the correlations between the two signal categories in one global fit. The inclusive cross sections for a dilepton invariant mass between 70 and 110 GeV are measured to be 1.14 ± 0.07 pb for the sum of $$ \textrm{t}\overline{\textrm{t}}\textrm{Z} $$ and tWZ, and 0.81 ± 0.10 pb for tZq, in good agreement with theoretical predictions.

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Measurement of the and tH production rates in the H → decay channel using proton-proton collision data at = 13 TeV

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Journal of High Energy Physics 2025年第2期2025卷 1-75页

作者： Hayrapetyan, A. Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. Chatterjee, S. Damanakis, K. Dragicevic, M. Hussain, P. S. Jeitler, M. Krammer, N. Li, A. Liko, D. Mikulec, I. Schieck, J. Schöfbeck, R. Schwarz, D. Sonawane, M. Templ, S. Waltenberger, W. Wulz, C.-E. Darwish, M. R. Janssen, T. Van Mechelen, P. Breugelmans, N. D’Hondt, J. Dansana, S. De Moor, A. Delcourt, M. Heyen, F. Lowette, S. Makarenko, I. Müller, D. Tavernier, S. Tytgat, M. Van Onsem, G. P. Van Putte, S. Vannerom, D. Bilin, B. Clerbaux, B. Das, A. K. De Lentdecker, G. Evard, H. Favart, L. Gianneios, P. Jaramillo, J. Khalilzadeh, A. Khan, F. A. Lee, K. Mahdavikhorrami, M. Malara, A. Paredes, S. Shahzad, M. A. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. De Coen, M. Dobur, D. Gokbulut, G. Hong, Y. Knolle, J. Lambrecht, L. Marckx, D. Mota Amarilo, K. Samalan, A. Skovpen, K. Van Den Bossche, N. van der Linden, J. Wezenbeek, L. Benecke, A. Bethani, A. Bruno, G. Caputo, C. De Favereau De Jeneret, J. Delaere, C. Donertas, I. S. Giammanco, A. Guzel, A. O. Jain, Sa. Lemaitre, V. Lidrych, J. Mastrapasqua, P. Tran, T. T. Wertz, S. Alves, G. A. Alves Gallo Pereira, M. Coelho, E. Correia Silva, G. Hensel, C. Menezes De Oliveira, T. Moraes, A. Rebello Teles, P. Soeiro, M. Vilela Pereira, A. Aldá Júnior, W. L. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Gomes De Souza, R. Macedo, M. Martins, J. Mora Herrera, C. Mundim, L. Nogima, H. Pinheiro, J. P. Santoro, A. Sznajder, A. Thiel, M. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Maietto Silverio, I. Mercadante, P. G. Novaes, S. F. Orzari, B. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Shumka, E. Keshri, S. Thakur, S. Cheng, T. Javaid, T. Yuan, L. Hu, Z. Liang, Z. Liu, J. Yi, K. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. Jiang, C. H. Yerevan Physics Institute Yerevan Armenia Yerevan State University Yerevan Armenia Institut für Hochenergiephysik Vienna Austria TU Wien Vienna Austria Universiteit Antwerpen Antwerpen Belgium Institute of Basic and Applied Sciences Faculty of Engineering Arab Academy for Science Technology and Maritime Transport Alexandria Egypt Vrije Universiteit Brussel Brussel Belgium Ghent University Ghent Belgium Université Libre de Bruxelles Bruxelles Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual de Campinas Campinas Brazil Federal University of Rio Grande do Sul Porto Alegre Brazil UFMS Nova Andradina Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Nanjing Normal University Nanjing China The University of Iowa Iowa City U.S.A. Institute of High Energy Physics Beijing China University of Chinese Academy of Sciences Beijing China China Center of Advanced Science and Technology Beijing China China Spallation Neutron Source Guangdong China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Guangdong Provincial Key Laboratory of Nuclear Science and Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal University Guangzhou China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Henan Normal University Xinxiang China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) — Fudan University Shanghai China Zhejiang University Hangzhou

An analysis of the production of a Higgs boson (H) in association with a top quark-antiquark pair ( $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ ) or a single top quark (tH) is presented. The Higgs boson decay into a bottom quark-antiquark pair (H → $$ \textrm{b}\overline{\textrm{b}} $$ ) is targeted, and three different final states of the top quark decays are considered, defined by the number of leptons (electrons or muons) in the event. The analysis utilises proton-proton collision data collected at the CERN LHC with the CMS experiment at $$ \sqrt{s} $$ = 13 TeV in 2016–2018, which correspond to an integrated luminosity of 138 fb−1. The observed $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ production rate relative to the standard model expectation is 0.33 ± 0.26 = 0.33 ± 0.17(stat) ± 0.21(syst). Additionally, the $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ production rate is determined in intervals of Higgs boson transverse momentum. An upper limit at 95% confidence level is set on the tH production rate of 14.6 times the standard model prediction, with an expectation of $$ {19.3}_{-6.0}^{+9.2} $$ . Finally, constraints are derived on the strength and structure of the coupling between the Higgs boson and the top quark from simultaneous extraction of the $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ and tH production rates, and the results are combined with those obtained in other Higgs boson decay channels.

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Measurement of the inclusive cross section in final states with at least one lepton and additional jets with 302 pb−1 of pp collisions at = 5.02 TeV

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Journal of High Energy Physics 2025年第4期2025卷 1-44页

作者： Hayrapetyan, A. Tumasyan, A. Adam, W. Andrejkovic, J. W. Bergauer, T. Chatterjee, S. Damanakis, K. Dragicevic, M. Hussain, P. S. Jeitler, M. Krammer, N. Li, A. Liko, D. Mikulec, I. Schieck, J. Schöfbeck, R. Schwarz, D. Sonawane, M. Waltenberger, W. Wulz, C.-E. Janssen, T. Van Laer, T. Van Mechelen, P. Breugelmans, N. D’Hondt, J. Dansana, S. De Moor, A. Delcourt, M. Heyen, F. Lowette, S. Makarenko, I. Müller, D. Tavernier, S. Tytgat, M. Van Onsem, G. P. Van Putte, S. Vannerom, D. Bilin, B. Clerbaux, B. Das, A. K. De Lentdecker, G. Evard, H. Favart, L. Gianneios, P. Jaramillo, J. Khalilzadeh, A. Khan, F. A. Lee, K. Mahdavikhorrami, M. Malara, A. Paredes, S. Shahzad, M. A. Thomas, L. Vanden Bemden, M. Vander Velde, C. Vanlaer, P. De Coen, M. Dobur, D. Gokbulut, G. Hong, Y. Knolle, J. Lambrecht, L. Marckx, D. Mota Amarilo, K. Skovpen, K. Van Den Bossche, N. van der Linden, J. Wezenbeek, L. Benecke, A. Bethani, A. Bruno, G. Caputo, C. De Favereau De Jeneret, J. Delaere, C. Donertas, I. S. Giammanco, A. Guzel, A. O. Jain, Sa. Lemaitre, V. Lidrych, J. Mastrapasqua, P. Tran, T. T. Wertz, S. Alves, G. A. Alves Gallo Pereira, M. Coelho, E. Correia Silva, G. Hensel, C. Menezes De Oliveira, T. Mora Herrera, C. Moraes, A. Rebello Teles, P. Soeiro, M. Vilela Pereira, A. Aldá Júnior, W. L. Barroso Ferreira Filho, M. Brandao Malbouisson, H. Carvalho, W. Chinellato, J. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. Fonseca De Souza, S. Gomes De Souza, R. Laux Kuhn, T. Macedo, M. Martins, J. Mundim, L. Nogima, H. Pinheiro, J. P. Santoro, A. Sznajder, A. Thiel, M. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Maietto Silverio, I. Mercadante, P. G. Novaes, S. F. Orzari, B. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Petrov, A. Shumka, E. Keshri, S. Laroze, D. Thakur, S. Cheng, T. Javaid, T. Yuan, L. Hu, Z. Liang, Z. Liu, J. Chen, G. M. Chen, H. S. Chen, M. Iemmi, F. Jiang, C. H. Kapoor Yerevan Physics Institute Yerevan Armenia Yerevan State University Yerevan Armenia Institut für Hochenergiephysik Vienna Austria TU Wien Vienna Austria Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Ghent University Ghent Belgium Université Libre de Bruxelles Bruxelles Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual de Campinas Campinas Brazil Federal University of Rio Grande do Sul Porto Alegre Brazil UFMS Nova Andradina Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China University of Chinese Academy of Sciences Beijing China China Center of Advanced Science and Technology Beijing China China Spallation Neutron Source Guangdong China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Guangdong Provincial Key Laboratory of Nuclear Science and Guangdong-Hong Kong Joint Laboratory of Quantum Matter South China Normal University Guangzhou China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Nanjing Normal University Nanjing China Henan Normal University Xinxiang China The University of Iowa Iowa City USA Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineeri

A measurement of the top quark pair ( $$ \textrm{t}\overline{\textrm{t}} $$ ) production cross section in proton-proton collisions at a centre-of-mass energy of 5.02 TeV is presented. The data were collected at the LHC in autumn 2017, in dedicated runs with low-energy and low-intensity conditions with respect to the default configuration, and correspond to an integrated luminosity of 302 pb−1. The measurement is performed using events with one electron or muon, and multiple jets, at least one of them being identified as originating from a b quark (b tagged). Events are classified based on the number of all reconstructed jets and of b-tagged jets. Multivariate analysis techniques are used to enhance the separation between the signal and backgrounds. The measured cross section is $$ 62.5\pm 1.6{\left(\textrm{stat}\right)}_{-2.5}^{+2.6}\left(\textrm{syst}\right)\pm 1.2\left(\textrm{lumi}\right) $$ pb. A combination with the result in the dilepton channel based on the same data set yields a value of 62.3 ± 1.5 (stat) ± 2.4 (syst) ± 1.2 (lumi) pb, to be compared with the standard model prediction of $$ {69.5}_{-3.7}^{+3.5} $$ pb at next-to-next-to-leading order in perturbative quantum chromodynamics.

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids

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Nature 2023年第7965期618卷 E19-E20页

作者： Sarah E Graham Shoa L Clarke Kuan-Han H Wu Stavroula Kanoni Greg J M Zajac Shweta Ramdas Ida Surakka Ioanna Ntalla Sailaja Vedantam Thomas W Winkler Adam E Locke Eirini Marouli Mi Yeong Hwang Sohee Han Akira Narita Ananyo Choudhury Amy R Bentley Kenneth Ekoru Anurag Verma Bhavi Trivedi Hilary C Martin Karen A Hunt Qin Hui Derek Klarin Xiang Zhu Gudmar Thorleifsson Anna Helgadottir Daniel F Gudbjartsson Hilma Holm Isleifur Olafsson Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M Brumpton Humaira Rasheed Sanni E Ruotsalainen Aki S Havulinna Yogasudha Veturi QiPing Feng Elisabeth A Rosenthal Todd Lingren Jennifer Allen Pacheco Sarah A Pendergrass Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E Miller Archie Campbell Kuang Lin Iona Y Millwood George Hindy Asif Rasheed Jessica D Faul Wei Zhao David R Weir Constance Turman Hongyan Huang Mariaelisa Graff Anubha Mahajan Michael R Brown Weihua Zhang Ketian Yu Ellen M Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian'an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood Yingji Ji Zishan Gao Simon Haworth Ruth E Mitchell Jin Fang Chai Mette Aadahl Jie Yao Ani Manichaikul Helen R Warren Julia Ramirez Jette Bork-Jensen Line L Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Carlo Sidore Edoardo Fiorillo Aaron F McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T Møllehave Betina H Thuesen Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E Galesloot Jonathan P Bradfield E Warwick Daw Joseph M Zmuda Jonathan S Mitchell Christian Fuchsberger Henry Christensen Jennifer A Brody Mary F Feitosa Mary K Wojczynski Michael Preuss Massimo Mangino Paraskevi Christofidou Niek Verweij Jan W Benjamins Jorgen Engmann Rachel L Kember Roderick C Slieker Ken Sin Lo Nuno R Zilhao Phuong Le Marcus E Kleber Graciela E Delgado Shaofeng Huo Dai Department of Internal Medicine Division of Cardiology University of Michigan Ann Arbor MI USA. VA Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Department of Biostatistics and Center for Statistics Genetics University of Michigan Ann Arbor MI USA. Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK. Endocrinology Boston Children's Hospital Boston MA USA. Medical and Population Genetics Broad Institute Cambridge MA USA. Department of Genetic Epidemiology University of Regensburg Regensburg Germany. McDonnell Genome Institute and Department of Medicine Washington University St Louis MO USA. Department of Precision Medicine Division of Genome Science National Institute of Health Cheongju-si South Korea. Tohoku Medical Megabank Organization Tohoku University Sendai Japan. Sydney Brenner Institute for Molecular Bioscience Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa. Center for Research on Genomics and Global Health National Human Genome Research Institute National Institutes of Health Bethesda MD USA. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Wellcome Sanger Institute Hinxton UK. Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA. Atlanta VA Health Care System Decatur GA USA. Malcolm Randall VA Medical Center Gainesville FL USA. Division of Vascular Sur

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Genome-wide association study of long COVID

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Nature Genetics 2025年 1-16页

作者： Vilma Lammi Tomoko Nakanishi Samuel E. Jones Juha Karjalainen Martin Broberg Hele H. Haapaniemi Matti Pirinen Mari E. K. Niemi Mattia Cordioli Mark J. Daly Andrea Ganna Hanna M. Ollila J. Brent Richards Yukinori Okada Shea J. Andrews Beatriz Cortés Rafael de Cid Susana Iraola-Guzmán Natalia Blay Xavier Farré Heath E. O’Brien Thompson Hannah Patrick J. Short Ana Ochoa-Guzman Michelle Duran-Gomez Brian E. Fulton-Howard Masahiro Kanai Axel Schmidt Daniella Balla Julia Heggemann Sonja Schultz Pari Behzad Markus M. Nöthen Abigail Miller Kerstin U. Ludwig Ruth E. Mitchell George Davey Smith Nicholas J. Timpson Abdou Mousas Evangelos Evangelou Evangelia Ntzani Konstantinos K. Tsilidis Massimo Mangino Alicia Huerta-Chagoya Nasa Sinnott-Armstrong Elizabeth T. Cirulli Francisco Tanudjaja Efren Sandoval Nicole L. Washington Simon White Alexandre Bolze Kelly M. Schiabor Barrett Marc Vaudel Alex S. F. Kwong Amit K. Maiti Minttu M. Marttila Daniel C. Posner Alexis A. Rodriguez Chiara Batini Beatriz Guillen-Guio Olivia C. Leavy Anna L. Guyatt Catherine John Louise V. Wain Francesca Minnai Anna R. Dearman Benedict Hignell Meena Kumari C. A. Robert Warmerdam Lude H. Franke Celia B. Sequeros Søren Brunak David Westergaard Karina Banasik Thomas W. Winkler Iris M. Heid Daniel M. Jordan Ryan C. Thompson Alexander W. Charney Laura G. Sloofman Nicole W. Simons Noam D. Beckmann Raimonds Rešcenko Vita Rovite Peculis Raitis Monta Briviba Janis Klovinš Laura Ansone Lorenzo Miano Flora Peyvandi Francesco Malvestiti Nicola Montano Alessandra Bandera Francesco Bruno Arturo Blasi Jacqueline M. Lane Jakob M. Cherry Ryan K. Chung Laura Carvajal-Silva Kevin Aguilar-Valdés Leslie C. Cerpa Tamara V. Arévalo Eduardo Lamoza Alicia Colombo Ricardo A. Verdugo Erika Frangione Xu Xinyi Jennifer Taher Jordan Lerner-Ellis Lindsay Guare Shefali S. Verma Ekaterina Vergasova Michil Trofimov Layal Shaheen Nikolay Plotnikov Anna Kim Dmitrii Kharitonov Alexei Kamelin Alexander Rakitko Eirini Marouli Pasquale Striano Ummu Afeera Zainulabid Ashutosh Kumar Hajar Fa Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland Department of Human Genetics McGill University Montreal Quebec Canada Centre for Clinical Epidemiology Department of Medicine Lady Davis Institute Jewish General Hospital McGill University Montreal Quebec Canada Kyoto-McGill International Collaborative Program in Genomic Medicine Graduate School of Medicine Kyoto University Kyoto Japan Department of Genome Informatics Graduate School of Medicine the University of Tokyo Tokyo Japan Research Fellow Japan Society for the Promotion of Science Tokyo Japan Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA USA Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA USA Department of Mathematics and Statistics University of Helsinki Helsinki Finland Department of Public Health University of Helsinki Helsinki Finland Broad Institute Cambridge MA USA Analytical and Translational Genetics Unit Massachusetts General Hospital Harvard Medical School Boston MA USA Center for Genomic Medicine Massachusetts General Hospital Boston MA USA Anesthesia Critical Care and Pain Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Twin Research King’s College London London UK 5 Prime Sciences Inc Montreal Quebec Canada Department of Epidemiology Biostatistics and Occupational Health McGill University Montreal Quebec Canada Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan Laboratory for Systems Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Laboratory of Statistical Immunology Immunology Frontier Research Center (WPI-IFReC) Osaka University Suita Japan Departmen

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association ofFOXP4with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID.

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