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26th International Conference on Miniaturized systems for Chemistry and Life Sciences, microTAS 2022

作者： He, Xinyu Xu, Junyan Wang, Xiaoli Xu, Yi Key Disciplines Lab of Novel Micro-Nano Devices and System Technology Chongqing University China School of Chemistry and Chemical Engineering Chongqing University China School of Optoelectronic Engineering Chongqing University China

ISBN: (纸本)9781733419048

For the enrichment of vascular endothelial growth factor 165 (VEGF165) in blood, a novel microfluidic chip integrated blood centrifugation unit and PEG8000-KH2PO4 aqueous two-phase system (P-K-ATPS) enrichment unit was proposed. The blood was pretreated on the chip, including centrifugation, reagent mixing, transport and concentration, and enrichment of VEGF165 in P-K-ATPS on paper, which took a total of 12 min. Finally, the enrichment effect was characterized by the fluorescence method. The results showed that the enrichment of VEGF165 in whole blood could complete on the chip simply, quickly, efficiently, and automatically. © 2022 microTAS 2022 - 26th International Conference on Miniaturized systems for Chemistry and Life Sciences. All rights reserved.

关键词： microfluidic chips

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Magnetic ''mechanical hand'': 3D manipulation of droplets using a superhydrophobic electromagnet needle 21

Magnetic ''mechanical hand'': 3D manipulation of droplets us...

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21st International Conference on Miniaturized systems for Chemistry and Life Sciences, microTAS 2017

作者： Yang, Chao Li, Gang Key Laboratory of Optoelectronic Technology and System Ministry of Education Defense Key Disciplines Lab of Novel Micro-nano Devices and System Technology Chongqing University China

ISBN: (纸本)9780692941836

We present a novel magnetic droplet manipulation platform that exploits a superhydrophobic electromagnet needle (EMN) to perform complex liquid manipulations on an open surface. By switching or adjusting the power supply of EMN, the platform can simply and flexibly perform a full range droplet manipulations, including droplet transport, fusion, mixing, magnetic beads (MBs) extraction, and droplet dispensing. The EMN-based droplet manipulation is facile, cost-effective, and programmable, which will significantly enhance the functionality of magnetic droplet platforms and thus broaden their applicability to numerous fields of life science. © 17CBMS-0001.

关键词： Needles

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Rapid prototyping of concave microwells for spheroid culture by combining micromilling and caramel replica moulding 24

Rapid prototyping of concave microwells for spheroid culture...

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24th International Conference on Miniaturized systems for Chemistry and Life Sciences, microTAS 2020

作者： Dong, Zhiyuan Sun, Bangyong Li, Gang Key Laboratory of Optoelectronic Technology and Systems Ministry of Education Defense Key Disciplines Lab of Novel Micro-Nano Devices and System Technology Chongqing University Chongqing400044 China

ISBN: (纸本)9781733419017

A novel method based on the combination of micromilling and caramel replica molding is demonstrated to fabricate concave microwell arrays for high throughput cell spheroid culture. Instead of using microfabrication technique, this method simply utilizes micromilling, double replica and thermal reflow to create concave structures for generating multicellular aggregates. © 2020 CBMS-0001

关键词： Milling (machining)

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A novel paper-based electrowetting device using cellulose paper and paraffin wax 26

A novel paper-based electrowetting device using cellulose pa...

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26th International Conference on Miniaturized systems for Chemistry and Life Sciences, microTAS 2022

作者： Li, He Yan, Zhibin Jin, Mingliang Zhou, Guofu Shui, Lingling Guangdong Provincial Key Laboratory of Optical Information Materials and Technology Institute of Electronic Paper Displays South China Academy of Advanced Optoelectronics South China Normal University Guangzhou510006 China Defense Key Disciplines Lab of Novel Micro-nano Devices and System Technology Chongqing University Chongqing400044 China School of Information and Optoelectronic Science and Engineering South China Normal University Guangzhou510006 China Guangdong Shunde Innovative Design Institute Guangdong Foshan528318 China

ISBN: (纸本)9781733419048

Paper-based microfluidic devices based on continuous-flow (μPAD) and electrowetting on dielectric (EWOD), have attracted increasing attention due to their low cost and excellent liquid handling capability. Here, we report a novel paper-based EWOD devices fabricated with the cellulose paper as substrate and paraffin wax as dielectric layer, which have been widely used in μPAD. Two methods are proposed to fabricate paraffin wax layer, including melting and spray-coating. Under DC electric field, the spray-coating-based devices show larger contact angle changes but with smaller hysteresis than the melting-based one. Our study opens up a new way for fabrication of the hybrid paper-based microfluidic device in the future. © 2022 microTAS 2022 - 26th International Conference on Miniaturized systems for Chemistry and Life Sciences. All rights reserved.

关键词： Wetting

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A Superhydrophobic Perforated microwell Plate for Facile and Robust Spheroid Cultures in Sitting-Drop Format

A Superhydrophobic Perforated Microwell Plate for Facile and...

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IEEE International Conference on micro Electro Mechanical systems

作者： Bangyong Sun Qiang Zhao Gang Li Defense Key Disciplines Lab of Novel Micro-Nano Devices and System Technology Key Laboratory of Optoelectronic Technology and Systems Ministry of Education Chongqing University Chongqing China

ISBN: (数字)9781665419123

ISBN: (纸本)9781665430241

This paper presents a sitting-drop (SD) strategy for the facile, robust and long-term cell spheroid cultures. Unlike the conventional hanging-drop (HD) method, the SD strategy employs a superhydrophobic perforated microwell plate (SHPMP) for spatially confining arrays of cell suspension droplets to culture 3D spheroids. Benefitting from the combination of upward positioning of cell suspension droplets and non-wettability of microwell surface, the SAHPMP-based SD platform not only maintains the simplicity and high oxygen availability of the HD method but also provides high mechanical stability and easiness of exchanging medium, thus enabling a robust long-term spheroid culture in a high-throughput manner.

关键词： micromechanical devices Suspensions (mechanical systems) Three-dimensional displays Tools Surface tension Stability analysis Gravity

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Integrated microfluidic SERS chip for the capture and detection of pathogenic bacteria in the air 24

Integrated microfluidic SERS chip for the capture and detect...

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24th International Conference on Miniaturized systems for Chemistry and Life Sciences, microTAS 2020

作者： Su, Xi Ren, Rui Li, Shifang Chen, Li Xu, Yi Key Disciplines Lab of Novel Micro-nano Devices and System Technology Chongqing University China School of Chemistry and Chemical Engineering Chongqing University China School of Optoelectronic Engineering Chongqing University China

ISBN: (纸本)9781733419017

Based on the adhesion between chitosan gel and pathogenic bacteria, and the Raman enhancement effect of silver nanoparticles (Ag NPs), a microfluidic SERS chip integrated with the both micro-nano structures was proposed to realize bacterial sampling and detection. Aiming at the detection of pathogenic bacteria in simulated aerosol, an integrated process of acquisition, isolation and in-situ rapid identification was realized. Through simulation calculation and experiment, the pathogen capture function of the chip was verified, and it was shown that the chip could effectively distinguish S. aureus ATCC 6538 and E. Coli JM109 by their SERS spectra. © 2020 CBMS-0001

关键词： Escherichia coli

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Two-dimensional materials for future information technology: status and prospects

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Science China(Information Sciences) 2024年第6期67卷 1-147页

作者： Hao QIU Zhihao YU Tiange ZHAO Qi ZHANG Mingsheng XU Peifeng LI Taotao LI Wenzhong BAO Yang CHAI Shula CHEN Yiqi CHEN Hui-Ming CHENG Daoxin DAI Zengfeng DI Zhuo DONG Xidong DUAN Yuhan FENG Yu FU Jingshu GUO Pengwen GUO Yue HAO Jun HE Xiao HE Jingyi HU Weida HU Zehua HU Xinyue HUANG Ziyang HUANG Ali IMRAN Ziqiang KONG Jia LI Qian LI Weisheng LI Lei LIAO Bilu LIU Can LIU Chunsen LIU Guanyu LIU Kaihui LIU Liwei LIU Sheng LIU Yuan LIU Donglin LU Likuan MA Feng MIAO Zhenhua NI Jing NING Anlian PAN Tian-Ling REN Haowen SHU Litao SUN Yue SUN Quanyang TAO Zi-Ao TIAN Dong WANG Hao WANG Haomin WANG Jialong WANG Junyong WANG Wenhui WANG Xingjun WANG Yeliang WANG Yuwei WANG Zhenyu WANG Yao WE... Department of Applied Physics The Hong Kong Polytechnic University Key Laboratory for Micro-Nano Physics and Technology of Hunan Province College of Materials Science and EngineeringHunan University College of Integrated Circuits Zhejiang University Shenzhen Geim Graphene Center Shenzhen Key Laboratory of Layered Materials for Value-Added ApplicationsTsinghua-Berkeley Shenzhen Institute & Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua University State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZijingang CampusZhejiang University National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics (SINANO)Chinese Academy of Sciences College of Chemistry and Chemical Engineering Hunan University Key Laboratory of Quantum State Construction and Manipulation (Ministry of Education) Department of PhysicsRenmin University of China School of Integrated Circuits Beijing National Research Center for Information Science and Technology (BNRist)Tsinghua University School of Electronic Science and Engineering Nanjing University The State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology Shaanxi Joint Key Laboratory of GrapheneSchool of MicroelectronicsXidian University Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan University School of Integrated Circuits Huazhong University of Science and Technology Center for Nanochemistry (CNC) Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking University State Key Laboratory for Artificial Microstruct

Over the past 70 years, the semiconductor industry has undergone transformative changes,largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensional(2D) materials like transition metal dichalcogenides(TMDs) and graphene are pivotal in overcoming the limitations of silicon-based technologies, offering innovative approaches in transistor design and functionality, enabling atomic-thin channel transistors and monolithic 3D integration. We review the important progress in the application of 2D materials in future information technology, focusing in particular on microelectronics and optoelectronics. We comprehensively summarize the key advancements across material production, characterization metrology, electronic devices, optoelectronic devices, and heterogeneous integration on silicon. A strategic roadmap and key challenges for the transition of 2D materials from basic research to industrial development are outlined. To facilitate such a transition, key technologies and tools dedicated to 2D materials must be developed to meet industrial standards, and the employment of AI in material growth, characterizations, and circuit design will be essential. It is time for academia to actively engage with industry to drive the next 10 years of 2D material research.

关键词： two-dimensional (2D) materials information technology production technology standardization of characterization microelectronic devices optoelectronic devices multi-functional integration

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Study of microfluidic Chip Integrated with Thermosensitive Flexible Sheet and its Application for the Detection Bacteria on the Surface of Objects

SSRN

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SSRN 2023年

作者： Su, Xi Ren, Rui Ge, Chuang Wang, Li Chen, Li Xu, Yi College of Advanced Materials Engineering Jiaxing Nanhu University Jiaxing314001 China Key Disciplines Lab of Novel Micro-Nano Devices and System Technology Key Laboratory of Optoelectronic Technology and Systems Ministry of Education Chongqing University Chongqing Shapingba400044 China School of Chemistry and Chemical Engineering Chongqing University Chongqing Shapingba400044 China School of Optoelectronic Engineering Chongqing University Chongqing Shapingba400044 China Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital Chongqing400030 China

A microfluidic chip integrated with thermosensitive flexible sheet was proposed to efficiently detect bacteria on the surface of objects, which has the functions of sampling, transfer, concentration and detection of bacteria. It could potentially be used to address the problems of the complex and separate operations between sampling and detection, low transfer efficiency and low detection efficiency. The microchip was composed of a flexible sheet with poly (N-isopropylacrylamide) (PNIPAAm) gel micropillar array and a PDMS cover sheet containing a canopy-shaped microchannel. The thermosensitive PNIPAAm gel micropillar array with high specific surface area and unique properties of adhesion-release to bacteria was adopted for the efficient sampling and release the bacteria. The released bacteria were transferred and labeled in the canopy-shaped microchannel, and then the labeled bacteria were concentrated and detected in-situ on the microchip. Under the optimized experimental conditions, the sampling and the elution efficiency of S. aureus on stainless steel sheet could be up to 75.6% and 88.4%, respectively. The detection limit of S. aureus was 5.15×103 CFU/cm2, and the whole process took no more than 45 min. The established detection method with the designed microchip has potential applications in the efficient detection of bacteria on the surface of objects. © 2023, The Authors. All rights reserved.

关键词： microfluidic chips

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In-Situ Monitoring of Quorum Sensing Signaling Molecules in Bacterial Biofilms by a SERS Chip with Array micro-Chambers

SSRN

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SSRN 2023年

作者： Liu, Lulu Ma, Wenrui Tan, Haolan Ge, Chuang Zhang, Bei Wang, Chunyan Zhang, Yang Xu, Yi Key Disciplines Lab of Novel Micro-Nano Devices and System Technology Key Laboratory of Optoelectronic Technology and Systems Ministry of Education Chongqing University Shapingba Chongqing400044 China College of Chemistry and Chemical Engineering Chongqing University of Science and Technology Chongqing401331 China School of Chemistry and Chemical Engineering Chongqing University Shapingba Chongqing400044 China School of Optoelectronic Engineering Chongqing University Shapingba Chongqing400044 China Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital Chongqing400030 China College of Pharmacy and Bioengineering Chongqing University of Technology Chongqing400054 China

The monitoring of signaling molecules related quorum sensing (QS) in bacterial biofilms was crucial for the better understanding how QS influenced the biofilm formation. In this paper, a SERS microfluidic chip integrated with array micro-chambers and nano-silver substrate was fabricated for the monitoring of QS signaling molecules in Pseudomonas aeruginosa biofilms. The self-assembled nano-silver substrate showed good homogeneity and stability with the enhancement factor up to 1.84×108, which guaranteed the detection sensitivity of signaling molecules. The dynamic change of pyocyanine, as an important signal molecule, was monitored during the growth of Pseudomonas aeruginosa biofilms by comparing the peak intensity at 1350 cm-1. By using the same chip, the inhibitory effects of different drugs including conventional antibiotics (ceftazidime), as well as natural antibacterial components (curcumin and tannic acid) were also investigated. The order of inhibition effect on pseudomonas aeruginosa biofilms growth was in turns ceftazidime > curcumin > tannic acid. The secretion period of pyocyanin was also affected by drugs treatment. Furthermore, pyocyanine secreted by Pseudomonas aeruginosa were confirmed by mass spectrometry (MS) and the concentration relationship obtained by MS/MS was consistent with the SERS detection. The proposed method based on the SERS chip for monitoring QS in bacterial biofilms had advantages of in-situ detection, flexibility and efficiency. © 2023, The Authors. All rights reserved.

关键词： Mass spectrometry

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Porous Au/Aao: A Simple and Feasible Sers Substrate for Dynamic Monitoring and Mechanism Analysis of DNA Oxidation

SSRN

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SSRN 2022年

作者： Xiang, Songtao Wang, Xiaoli Pang, Yiquan Ge, Chuang Xu, Yi Chen, Li Li, Shunbo Wang, Li Key Disciplines Lab of Novel Micro-Nano Devices and System Technology Key Laboratory of Optoelectronic Technology and Systems Ministry of Education Chongqing University Shapingba Chongqing 400044 China School of Chemistry and Chemical Engineering Chongqing University Shapingba Chongqing 400044 China School of Optoelectronic Engineering Chongqing University Shapingba Chongqing 400044 China International R & D Center of Micro-nano Systems and New Materials Technology Chongqing University Shapingba Chongqing 400044 China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital Shapingba Chongqing 400030 China

Herein, a simple approach was proposed to acquire an orderly and controllable periodic structure. Firstly, the optimal parameters of porous anodic aluminum oxide (AAO) were screened out by FDTD solutions. Combined with magnetron sputtering of gold nano-film, the Au/AAO SERS substrate was thus fabricated. The enhancement factor (EF) was calculated to be 4.87×106, and SERS spectra with good reproducibility were also acquired. The oxidization process of plasmid DNA was thus monitored under the conditions of low detection power and short integration time. Fenton 's reagent was used as oxidizing reagent, and Na2SO4 was applied for the internal standard in SERS analysis. The changes of I657/I998, I723/I998, I1587/I998, I1648/I998 were studied over time. DNA oxidation product 8-OHdG was also detected in this process. Then the relationship between the relative peak intensity ratios and the base structure change in DNA was established. The conclusions of SERS spectral analysis were verified by agarose gel electrophoresis, DNA oxidative damage gel detection and colorimetric detection of 8-OHdG. The mechanism analysis of DNA oxidation process was thus studied. The simple and feasible detection strategy we proposed could extend the application of SERS technology in the process monitoring of photosensitive or other unstable biological samples. © 2022, The Authors. All rights reserved.

关键词： Aluminum oxide

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