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Biological evaluation of sulfonate and sulfate analogues of lithocholic acid: A bioisosterism-guided approach towards the discovery of potential sialyltransferase inhibitors for antimetastatic study

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Bioorganic & medicinal chemistry letters 2024年 105卷 129760页

作者： Ser John Lynon P Perez Chia-Ling Chen Tzu-Ting Chang Wen-Shan Li Institute of Chemistry Academia Sinica Taipei 115 Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Sustainable Chemical Science and Technology Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Biomedical Translation Research Center Academia Sinica Taipei 115 Taiwan. Institute of Chemistry Academia Sinica Taipei 115 Taiwan. Biomedical Translation Research Center Academia Sinica Taipei 115 Taiwan Department of Medicinal and Applied Chemistry College of Life Science Kaohsiung Medical University Kaohsiung 807 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung 804 Taiwan Department of Chemistry College of Science Tamkang University New Taipei City 251 Taiwan. Electronic address: wenshan@gate.sinica.edu.tw.

The naturally occurring bile acid lithocholic acid (LCA) has been a crucial core structure for many non-sugar-containing sialyltranferase (ST) inhibitors documented in literature. With the aim of elucidating the impact of the terminal carboxyl acid substituent of LCA on its ST inhibition, in this present study, we report the (bio)isosteric replacement-based design and synthesis of sulfonate and sulfate analogues of LCA. Among these compounds, the sulfate analogue SPP-002 was found to selectively inhibit N-glycan sialylation by at least an order of magnitude, indicating a substantial improvement in both potency and selectivity when compared to the unmodified parent bile acid. Molecular docking analysis supported the stronger binding of the synthetic analogue in the enzyme active site. Treatment with SPP-002 also hampered the migration, adhesion, and invasion of MDA-MB-231 cells in vitro by suppressing the expression of signaling proteins involved in the cancer metastasis-associated integrin/FAK/paxillin pathway. In totality, these findings offer not only a novel structural scaffold but also valuable insights for the future development of more potent and selective ST inhibitors with potential therapeutic effects against tumor cancer metastasis.

关键词： Cancer metastasis Integrin-FAK-paxillin signaling pathway Lithocholic acid Sialyltransferase inhibitor

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Ferric chloride-driven microwave-assisted hydrothermal pretreatment for boosting macroalgal sugar recovery and solubilization

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Biomass and Bioenergy 2025年 200卷

作者： Wei-Hsin Chen Jamin Jamir Escalante Jherwin B. Ocreto Ayyadurai Saravanakumar Vahabodin Goodarz Department of Aeronautics and Astronautics National Cheng Kung University Tainan 701 Taiwan Research Center for Smart Sustainable Circular Economy Tunghai University Taichung 407 Taiwan Department of Mechanical Engineering National Chin-Yi University of Technology Taichung 411 Taiwan International Degree Program in Energy Engineering National Cheng Kung University Tainan 701 Taiwan Energy Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City 1101 Philippines Center for Research in Environment Sustainability Advocacy and Climate Change (REACH) Directorate of Research SRM Institute of Science and Technology Kattankulathur Chengalpattu District 603203 Tamil Nadu India Applied Biotechnology Research Center Baqiyatallah University of Medical Sciences P.O. Box 19945-546 Tehran Iran

This study examines the catalytic hydrothermal solubilization of macroalgae using FeCl 3 under microwave-assisted heating to optimize total reducing sugars (TRS) yield and solubilization efficiency. A Box-Behnken design evaluates FeCl 3 concentration (0.05–0.15 M), temperature (50–150 °C), and reaction time (5–25 min) on biomass conversion. Higher FeCl 3 concentration (0.05 M–0.15 M) further enhances TRS yield to 354 mg·g −1 and solubilization to 44.11%, likely due to Fe 3+ catalyzing cellulose and hemicellulose depolymerization. Reaction time has the least effect compared to temperature and FeCl 3 concentration. The RSM shows while an increase in reaction time contributes to a higher TRS yield, its influence on solubilization remains relatively minor. RSM shows high predictability (R 2 = 0.9968 for TRS, 0.9940 for solubilization). Optimal conditions (0.15 M FeCl 3 , 98 °C, 25 min) yield 190.11 mg·g −1 TRS and 43.16% solubilization with minimal byproducts. Thermal analysis (TG-FTIR) reveals that pretreatment shifts biomass decomposition from 900 °C (raw) to 625 °C (0.15 M FeCl 3 ), indicating enhanced breakdown. SEM images show increased porosity, roughness, and fractures, improving hydrolysis. Py-GC/MS analysis identifies high-value pyrolysis products such as benzene, toluene, phenol, styrene, and naphthalene. Overall, FeCl 3 -catalyzed microwave-assisted hydrothermal pretreatment significantly enhances sugar recovery and biomass solubilization, demonstrating its potential for bioethanol production and value-added chemical synthesis.

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Combination of curcumin or chitosan with photodynamic therapy as an effective alternative therapy for overcoming wound infection associated with multidrug-resistant Acinetobacter baumannii

The Microbe

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The Microbe 2025年 7卷

作者： Manta Yonpiam Dhammika Leshan Wannigama Aye Mya Sithu Shein Tingting Liao Cameron Hurst Peter N. Monk Mohan Amarasiri Phatthranit Phattharapornjaroen Puey Ounjai Thammakorn Saethang Vishnu Nayak Badavath Sirirat Luk-in Sumanee Nilgate Ubolrat Rirerm Sukrit Srisakul Natharin Ngamwongsatit Asada Leelahavanichkul Naveen Kumar Devanga Ragupathi Talerngsak Kanjanabuch Phurin Narkban Tanittha Chatsuwan Department of Microbiology Faculty of Medicine Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand Center of Excellence in Antimicrobial Resistance and Stewardship Research Faculty of Medicine Chulalongkorn University Bangkok Thailand Dual degree Medical Science program Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan School of Medicine Faculty of Health and Medical Sciences The University of Western Australia Nedlands Western Australia Australia Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries The University of Sheffield Sheffield United Kingdom Pathogen Hunter's Research Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan Department of Infectious Diseases Faculty of Medicine Yamagata University Yamagata Japan Department of Clinical Epidemiology Faculty of Medicine Thammasat University Rangsit 10120 Thailand Department of Infection Immunity & Cardiovascular Disease University of Sheffield Medical School United Kingdom Center of Excellence in Applied Epidemiology Thammasat University Rangsit 10120 Thailand Department of Civil and Environmental Engineering Graduate School of Engineering Tohoku University Miyagi Japan Faculty of Health Science Technology Chulabhorn Royal Academy Bangkok 10210 Thailand HRH Princess Chulabhorn Disaster and Emergency Medicine Center Chulabhorn Royal Academy Bangkok 10210 Thailand Department of Biology Faculty of Science Mahidol University Bangkok Thailand Department of Computer Science Faculty of Science Kasetsart University Bangkok Thailand School of Pharmacy & Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Hyderabad 509301 India Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahi

The increasing prevalence of multidrug-resistant Acinetobacter baumannii as an opportunistic pathogen in wound infections raises significant concerns due to its antibiotic resistance and biofilm-mediated antibiotic tolerance. This underscores the urgent need to explore an alternative approach to effectively managing wound infections caused by MDR A. baumannii . In this study, combining subinhibitory concentrations of curcumin (25 µg/ml) or chitosan (156 µg/ml) with photodynamic therapy-PDT (10 J/cm 2 ) resulted in a significant reduction of planktonic viabilities and biofilm biovolume of MDR A. baumannii clinical isolates in vitro . In murine A. baumannii- associated wound infection, a combination of curcumin (25 µg/ml) or chitosan (156 µg/ml) with PDT (10 J/cm 2 ) resulted in complete bacterial eradication with wound healing at Day 15 of post-treatments with these combination therapies. Our study demonstrated that combining curcumin or chitosan with PDT at their subinhibitory concentrations represents a promising alternative strategy as localized therapy for effectively managing A. baumannii -associated wound infection.

关键词： Acinetobacter baumannii Multidrug-resistant (MDR) Photodynamic therapy (PDT) Curcumin Chitosan Biofilm eradication Wound infection Alternative therapy

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Estimation of solar radiation using Angstrom-Prescott model and interpolation of empirical coefficients in Thailand

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Journal of Physics: Conference Series 2018年第1期1144卷

作者： K Keawsang-in S Ratjiranukool P Ratjiranukool PhD's Degree Program in Applied Physics Faculty of Science Chiang Mai University Department of Physics and Materials Faculty of Science Chiang Mai University Department of Physics Faculty of Science and Technology Chiang Mai Rajabhat University

Angstrom-Prescott model, defined by , was applied to estimate solar L so J radiation for 11 meteorological stations in Thailand. In this research, the empirical coefficients ('a' and 'b') were calculated by using the least square model. Statistical values, i.e., root mean square error (RMSE) and correlation, were analyzed the model ability in estimating solar radiation by compared with the measurement. The empirical coefficients overall Thailand were interpolated by using geographic information system (GIS). This technique can be calculated for estimation of solar radiation in every region in Thailand. In the results, the statistical tests show the ability of Angstrom-Prescott model to estimate solar radiation in Thailand and the least square method is suitable for computing empirical coefficients.

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Evaluation of Southwest Monsoon Change over Thailand by High-resolution Regional Climate Model under High RCP Emission Scenario

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Journal of Physics: Conference Series 2018年第1期1144卷

作者： Theerapat Arpornrat Sujittra Ratjiranukool Pakpoom Ratjiranukool Hidekata Sasaki Master's Degree Program in Applied Physics Department of Physics and Materials Science Faculty of Science Chiang Mai University Chiang Mai Thailand. Department of Physics and Materials Science Faculty of Science Chiang Mai University Chiang Mai Thailand. Department of Physics Faculty of Science and Technology Chiang Mai Rajabhat University Chiang Mai Thailand. Meteorological Research Institute Tsukaba Japan.

The 5×5 km resolution of Non-Hydrostatic Regional Climate Model (NHRCM) developed by Meteorological Research Institute, Japan was used to evaluate the southwest monsoon season that affects to Thailand during mid-May until mid-October in each years. Bulk-type cloud microphysics, Kain-Fritsch convective scheme, Mellor-Yamada-Nakanishi-Niino level 3 PBL scheme, clear-sky radiation scheme and Hirai-Ohizumi land surface scheme are used as model configuration to simulate climate data under high emission scenario-RCP 8.5. This research was conducted for 2 time periods, i.e., baseline period (1981–2000) and future period (2080–2099), to estimate the southwest monsoon season onset and offset over Thailand by using average wind vector and cumulative precipitation in consecutive 5 days (pentad). Furthermore, the rain-break phase, less precipitation ranges during the southwest monsoon season, had also been analysed.

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Electroplating of ZnO Influenced by the Concentration of Aluminum Nitrate in the Bath

Electroplating of ZnO Influenced by the Concentration of Alu...

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2016 International Conference on Materials science and Nanotechnology

作者： Jing-Chie Lin Amrita Choudhury Yao-Tien Tsneg Kun-Cheng Peng Institute of Materials Science and Engineering “Central University” International Master Degree Program in Applied Materials Science “Central University” Department of Materials Science and Engineering Mingchi University of Technology

Electrochemical deposition of Al-doped ZnO（AZO） on the ITO glass was investigated in baths containing various concentrations of aluminum nitrate. The electrochemical and chemical reactions can be deduced by means of investigating cathodic polarization curves and time/electroplating-current curves for further characterizing structures of ZnO and AZO, and establishing growth mechanism. High-quality AZO nanorods, depositing on ITO substrate that coated with ZnO seed-layer, were utilized the electrochemical method at-1.0 V（against a reference electrode of Ag/AgC l in 3.0 M KCl） in the bath of 90 °C. After annealing at 350 °C, ZnO and AZO nanorods were analyzed by field-emission scanning electron microscope（FESEM） to explore the morphology of nanostructure. The SEM image displayed that the lower Al concentrations（20 ~ 60 μM） in the bath, the average diameter of nanorods decreased;while the Al concentrations excessed over 60 μM, the morphology of the AZO nanorods turned into partial-area nanosheets instead of the nanorods spread. The crystal structure of the AZO nanorods were identified by using grazing-incident X-ray diffraction（GIXRD）. The patterns of the Al ions in the range of 20 ~ 60 μM in the bath showed that the preferred orientations were along with the [002] direction which confirmed the result of AZO nanorods well aligned in c-axis orientation, and the characterized peak（002） slightly shifted to the right suggested that Al atoms had doped into the ZnO lattice. We also adopted the X-ray photoelectron spectroscopy to characterize the elemental and chemical compositions of the AZO nanorods. XPS spectrums confirmed that the Al atoms successfully doped. Finally, for identifying the optimal boundary condition of Al content in ZnO, the nanorods with various Al concentrations were utilized via dye-sensitized solar cells（DSSC） experiment with the standard solar Simulators（AM1.5 G） and J-V Measurement. We found that the AZO nanorods as the photoanode contained 2.84 at.% A

关键词： Al-doped ZnO electrochemical deposition Dye-Sensitized Solar Cells aluminum concentration X-ray photoelectron spectroscopy

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Recent innovations in material research

Recent innovations in material research

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作者： Cai, W.J. Chen, D. Hu, H. Huang, X.P. Khotsyanovskii, A.O. Li, X.S. Silva, F.J.G. Yao, S.H. Zheng, H.N. Department of Chemical Materials and Biomolecular Engineering University of Connecticut United States School of Engineering and Applied Science Harvard University United States Department of Mechanical Automotive and Materials Engineering University of Windsor Canada Department of Mechanical Engineering Massachusetts Institute of Technology United States Pisarenko Institute of Problems of Strength National Academy of Sciences of Ukraine Ukraine Mechanical Engineering Department ISEP School of Engineering Polytechnic of Porto Portugal Bachelor Degree Program in Technology Management Chang Jung Christian University Taiwan

The new trends and developments in the novel functional materials and material research innovations presented at the 3rd Global Conference on Materials science and Engineering (CMSE2014), which was held on 20-23 October 2014 in Shanghai, China, is discussed. R. Toyoda, M. Tawata, M. Hashimoto, and Y. Matsumura presented 'Internal stress control of transition-metal thin films', where the effects of ion bombardment parameter Pi on the internal stress of thin films were evaluated. X.G. Wang, Z.L. Chen, and X.Y. Wang presented their study 'Measurement of the interface characteristic based on ultrasonic longitudinal wave', which provided a lucrative alternative to conventional ultrasonic techniques, since it allows one to avoid the mutual superposition of reflected waves at the same thin coating interface. P. Wang and C.Y. Zhao presented their 'Study on reducing railway noise by porous concrete sound-absorbing panel', which is crucial for noise reduction near the railway lines. In the paper entitled 'Numerical study on the heat preservation of the ladle used for twin-roll strip casting', J.H. Dong, M. Chen and N. Wang developed a 3D mathematical model, in order to analyze the heat transfer and temperature drop on the ladle using the finite volume method.

关键词： Finite volume method

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The frequency analysis of Double-End Tuning Fork quartz resonators

The frequency analysis of Double-End Tuning Fork quartz reso...

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19th International Congress on Sound and Vibration 2012, ICSV 2012

作者： Huang, Bo-Shiun Chien, Wen-Tien Chang Chang, Chia-Ou Chou, Chan-Shin Shieh, Fa-Hwa Institute of Applied Mechanics National Taiwan University 106 Taipei Taiwan Degree Program of Information Technology Fooyin University 831 Ta-Liao Kaohsiung Taiwan Chung-Shan Institute of Science and Technology 325 Longtan Taoyuan County Taiwan

ISBN: (纸本)9781622764655

The objective of our research was to use the new model to analyze the frequency of Double-Ended Tuning Fork (DETF) quartz resonators by Hamilton's principle with piezoelectric constitutive law. The DETF can be viewed to be composed of two parallel slender beams and two proof mass at the ends of these tuning fork beams. The purpose of the proof mass is used to modulate the frequencies and mode shape of tuning fork beams. There are two types of in-plane vibration modes, that is, in-phase and anti-phase modes. The stress and moment at the clamped ends for the antiphase mode is less than those of in-phase one. So we focus on the bending anti-phase mode and investigate the layout of the electrodes so as to excite this desired mode. We use Hamihon's principle for piezoelectric elastic body to derive the equations of motion. We take it into account that quartz are anisotropic in stiffness, dielectric constants, and piezoelectric coefficients. The slender tuning fork beam can be modeled as Euler beams. There are no existing models that can be used to describe the deformation of the proof mass. We propose the new beam model that can approximately model the rotation, of the cross-section of the proof mass, caused by the tuning fork beams. We also find the proper form of electric potential for the quartz. Based on the general form of exact solutions of vibration for the proof mass and tuning fork beams and the interface and boundary conditions the characteristic equation for frequencies can be derived. The analytical solution agrees well with experimental ones.

关键词： Quartz

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Human systems integration and advanced technology in engineering department workload and manpower reduction

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NAVAL ENGINEERS JOURNAL 2003年第1期115卷 57-65页

作者： Lively, KA Seman, AJ Kirkpatrick, M KENNETH A. LIVELY graduated from the University of Colorado with a BS in applied mathematics and an MS in mathematics in 1976 and from the Massachusetts Institute of Technology with an MS in electrical engineering and the degree ocean engineer in naval architecture and marine engineering in 1984. He retired from the U.S. Navy in 1989 after 23 years of service. Assignments included electrical officer on the USS Constellation (CV 64) project engineer for the DDG 51 machinery control system (NAVSEA) and DDG 51 Technical Director (NAVSEA). He was vice president of the PDI Division of Bird-Johnson Company from July 1989 to November 1998 where he managed various gas turbine and machinery controls related development projects. He joined Anteon Corporation's Systems Engineering Group as senior controls engineer in December 1998 where he provided technical support to the integrated power systems program (NAVSEA PMS 510) and managed the Office of Naval Research Afloat Laboratory. DR. MARK KIRKPATRICK is currently an independent consultant in human factors and work-load/manning analysis and modeling. He holds a Ph.D. degree in experimental psychology from The Ohio State University and has 34 years of experience in applied human factors. From 1982 through 2000 Dr. Kirkpatrick served as the senior vice president of Carlow International. Prior to joining Carlow in 1982 Dr. Kirkpatrick served as a member of the technical staff at North American Rockwell's Missiles Division and as a project director and vice president for Essex Corporation. His areas of expertise include workload simulation task analysis operator-in-the-loop simulation human performance experimentation statistical analysis and human factors T&E. He has directed and/or participated in human factors projects for the U.S. Navy U.S. Army NASA Department of Transportation the U.S. Nuclear Regulatory Commission and private industry. ANTHONY J. SEMAN III is the technical manager for the reduced ship's crew by virtual presence (RSVP) advanced technology d

Aboard current ships, such as the DDG 51, engineering control and damage control activities are manpower intensive. It is anticipated that, for future combatants, the workload demand arising from operation of systems under conditions of normal steaming and during casualty response will need to be markedly reduced via automated monitoring, autonomous control, and other technology initiatives. Current DDG 51 class ships can be considered as a manpower baseline and under Condition III typical engineering control involves seven to eight watchstanders at manned stations in the Central Control Station, the engine rooms and other machinery spaces. In contrast to this manning level, initiatives such as DD 21 and the integrated engineering plant (IEP) envision a partnership between the operator and the automation system, with more and more of the operator's functions being shifted to the automation system as manning levels decrease. This paper describes some human systems integration studies of workload demand reduction and, consequently, manning reduction that can be achieved due to application of several advanced technology concepts. Advanced system concept studies in relation to workload demand are described and reviewed including. Piecemeal applications of diverse automation and remote control technology concepts to selected high driver tasks in current DDG 51 activities. Development of the reduced ship's crew by virtual presence system that will provide automated monitoring and display to operators of machinery health, compartment conditions, and personnel health. The IEP envisions the machinery control system as a provider of resources that are used by various consumers around the ship. Resource needs and consumer priorities are at all times dependent upon the ship's current mission and the availability of equipment pawnbrokers.

关键词： Naval warfare

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Blackwater and Graywater on US navy ships: Technical challenges and solutions

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NAVAL ENGINEERS JOURNAL 1999年第3期111卷 293-306页

作者： Benson, J Caplan, I Jacobs, R John Benson:received his BS degree in Mechanical Engineering and MS degree in Environmental Engineering from the University of Maryland. He is a registered Professional Engineer in the State of Maryland. He Joined the Naval Sufrace Warfare Center Carderock Division Environmental Quality Department in 1990 as a project engineer and is now managing the non-oily wastewater (graywater and blackwater) project area. Mr. Ivan Caplan:graduated from Drexel University (Philadelphia Pennsylvania) with a BS in Metallurgical Engineering and was awarded a MS degree from the Johns Hopkins University (Baltimore Maryland) in Mechanics and Materials Science. Mr. Caplan has spent most of his career at the Carderock Division Naval Surface Warfare Center (NSWC) and is currently the Head of the Wastewater Management Branch in the Carderock Division's Environmental Quality Department. Previously Mr. Caplan managed the US Navy's Applied Research Program in Ship & Submarine Materials Technology. In addition Mr. Caplan was manager of the US Navy's Titanium Technology Program Office and during his government career held several external Program Manager positions on at the Naval Sea Systems Command and another at the Air Force Office of Scientific Research. Rachel Jacobs:received BS degrees in Chemical Engineering and Marine Biology from the University of Maryland College Park. After working for the Naval Research Laboratory in Washington DC and the Center for Marine Biotechnology in Baltimore MD she joined the staff of the Naval Surface Warfare Center's Environmental Quality Department in 1997. Since thta time Ms. Jacobs has worked in the non-oily wastewater treatment area and her principal responsibility has been to technically supervise the evaluation operation and modification graywater treatment.

In anticipation of more stringent environmental regulations, the increasing costs of waste disposal, and the need for naval combatants to operate unimpeded in littoral waters, the U.S. Navy has identified the need to develop technologies which are appropriate for the control and treatment of blackwater and graywater. This paper will describe the status of development efforts by the Carderock Division, Naval Surface Warfare Center (CDNSWC) and its supporting contractors, under sponsorship of Naval Sea Systems Command (NAVSEA) and the Office of Naval Research. The challenge was to develop treatment systems that meet Navy shipboard requirements for affordability, compactness, low manning/maintenance, high reliability and safety, and EM, noise, vibration and shock. Membrane ultrafiltration based systems, incorporating aerobic biological pre-treatment and ultraviolet light post treatment disinfection, have ken developed to meet these requirements. Both external and in-tank membrane systems will be described in terms of performance, system operation and space and weight advantages.

关键词： Naval vessels

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