TAROGE-M is a radio antenna array atop ∼ 2.7 km-high Mt. Melbourne in Antarctica for detecting ultra-high energy (UHE, E > 1017 eV) air showers in near-horizontal directions. Besides the detection of cosmic rays a...
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The naturally occurring bile acid lithocholic acid (LCA) has been a crucial core structure for many non-sugar-containing sialyltranferase (ST) inhibitors documented in literature. With the aim of elucidating the impac...
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The naturally occurring bile acid lithocholic acid (LCA) has been a crucial core structure for many non-sugar-containing sialyltranferase (ST) inhibitors documented in literature. With the aim of elucidating the impact of the terminal carboxyl acid substituent of LCA on its ST inhibition, in this present study, we report the (bio)isosteric replacement-based design and synthesis of sulfonate and sulfate analogues of LCA. Among these compounds, the sulfate analogue SPP-002 was found to selectively inhibit N-glycan sialylation by at least an order of magnitude, indicating a substantial improvement in both potency and selectivity when compared to the unmodified parent bile acid. Molecular docking analysis supported the stronger binding of the synthetic analogue in the enzyme active site. Treatment with SPP-002 also hampered the migration, adhesion, and invasion of MDA-MB-231 cells in vitro by suppressing the expression of signaling proteins involved in the cancer metastasis-associated integrin/FAK/paxillin pathway. In totality, these findings offer not only a novel structural scaffold but also valuable insights for the future development of more potent and selective ST inhibitors with potential therapeutic effects against tumor cancer metastasis.
The increasing prevalence of multidrug-resistant Acinetobacter baumannii as an opportunistic pathogen in wound infections raises significant concerns due to its antibiotic resistance and biofilm-mediated antibiotic to...
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Angstrom-Prescott model, defined by , was applied to estimate solar L so J radiation for 11 meteorological stations in Thailand. In this research, the empirical coefficients ('a' and 'b') were calculat...
Angstrom-Prescott model, defined by , was applied to estimate solar L so J radiation for 11 meteorological stations in Thailand. In this research, the empirical coefficients ('a' and 'b') were calculated by using the least square model. Statistical values, i.e., root mean square error (RMSE) and correlation, were analyzed the model ability in estimating solar radiation by compared with the measurement. The empirical coefficients overall Thailand were interpolated by using geographic information system (GIS). This technique can be calculated for estimation of solar radiation in every region in Thailand. In the results, the statistical tests show the ability of Angstrom-Prescott model to estimate solar radiation in Thailand and the least square method is suitable for computing empirical coefficients.
The 5×5 km resolution of Non-Hydrostatic Regional Climate Model (NHRCM) developed by Meteorological Research Institute, Japan was used to evaluate the southwest monsoon season that affects to Thailand during mid-...
The 5×5 km resolution of Non-Hydrostatic Regional Climate Model (NHRCM) developed by Meteorological Research Institute, Japan was used to evaluate the southwest monsoon season that affects to Thailand during mid-May until mid-October in each years. Bulk-type cloud microphysics, Kain-Fritsch convective scheme, Mellor-Yamada-Nakanishi-Niino level 3 PBL scheme, clear-sky radiation scheme and Hirai-Ohizumi land surface scheme are used as model configuration to simulate climate data under high emission scenario-RCP 8.5. This research was conducted for 2 time periods, i.e., baseline period (1981–2000) and future period (2080–2099), to estimate the southwest monsoon season onset and offset over Thailand by using average wind vector and cumulative precipitation in consecutive 5 days (pentad). Furthermore, the rain-break phase, less precipitation ranges during the southwest monsoon season, had also been analysed.
Electrochemical deposition of Al-doped ZnO（AZO） on the ITO glass was investigated in baths containing various concentrations of aluminum nitrate. The electrochemical and chemical reactions can be deduced by means of...
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Electrochemical deposition of Al-doped ZnO（AZO） on the ITO glass was investigated in baths containing various concentrations of aluminum nitrate. The electrochemical and chemical reactions can be deduced by means of investigating cathodic polarization curves and time/electroplating-current curves for further characterizing structures of ZnO and AZO, and establishing growth mechanism. High-quality AZO nanorods, depositing on ITO substrate that coated with ZnO seed-layer, were utilized the electrochemical method at-1.0 V（against a reference electrode of Ag/AgC l in 3.0 M KCl） in the bath of 90 °C. After annealing at 350 °C, ZnO and AZO nanorods were analyzed by field-emission scanning electron microscope（FESEM） to explore the morphology of nanostructure. The SEM image displayed that the lower Al concentrations（20 ~ 60 μM） in the bath, the average diameter of nanorods decreased;while the Al concentrations excessed over 60 μM, the morphology of the AZO nanorods turned into partial-area nanosheets instead of the nanorods spread. The crystal structure of the AZO nanorods were identified by using grazing-incident X-ray diffraction（GIXRD）. The patterns of the Al ions in the range of 20 ~ 60 μM in the bath showed that the preferred orientations were along with the [002] direction which confirmed the result of AZO nanorods well aligned in c-axis orientation, and the characterized peak（002） slightly shifted to the right suggested that Al atoms had doped into the ZnO lattice. We also adopted the X-ray photoelectron spectroscopy to characterize the elemental and chemical compositions of the AZO nanorods. XPS spectrums confirmed that the Al atoms successfully doped. Finally, for identifying the optimal boundary condition of Al content in ZnO, the nanorods with various Al concentrations were utilized via dye-sensitized solar cells（DSSC） experiment with the standard solar Simulators（AM1.5 G） and J-V Measurement. We found that the AZO nanorods as the photoanode contained 2.84 at.% A
The new trends and developments in the novel functional materials and material research innovations presented at the 3rd Global Conference on Materials science and Engineering (CMSE2014), which was held on 20-23 Octob...
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The new trends and developments in the novel functional materials and material research innovations presented at the 3rd Global Conference on Materials science and Engineering (CMSE2014), which was held on 20-23 October 2014 in Shanghai, China, is discussed. R. Toyoda, M. Tawata, M. Hashimoto, and Y. Matsumura presented 'Internal stress control of transition-metal thin films', where the effects of ion bombardment parameter Pi on the internal stress of thin films were evaluated. X.G. Wang, Z.L. Chen, and X.Y. Wang presented their study 'Measurement of the interface characteristic based on ultrasonic longitudinal wave', which provided a lucrative alternative to conventional ultrasonic techniques, since it allows one to avoid the mutual superposition of reflected waves at the same thin coating interface. P. Wang and C.Y. Zhao presented their 'Study on reducing railway noise by porous concrete sound-absorbing panel', which is crucial for noise reduction near the railway lines. In the paper entitled 'Numerical study on the heat preservation of the ladle used for twin-roll strip casting', J.H. Dong, M. Chen and N. Wang developed a 3D mathematical model, in order to analyze the heat transfer and temperature drop on the ladle using the finite volume method.
The objective of our research was to use the new model to analyze the frequency of Double-Ended Tuning Fork (DETF) quartz resonators by Hamilton's principle with piezoelectric constitutive law. The DETF can be vie...
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ISBN:
(纸本)9781622764655
The objective of our research was to use the new model to analyze the frequency of Double-Ended Tuning Fork (DETF) quartz resonators by Hamilton's principle with piezoelectric constitutive law. The DETF can be viewed to be composed of two parallel slender beams and two proof mass at the ends of these tuning fork beams. The purpose of the proof mass is used to modulate the frequencies and mode shape of tuning fork beams. There are two types of in-plane vibration modes, that is, in-phase and anti-phase modes. The stress and moment at the clamped ends for the antiphase mode is less than those of in-phase one. So we focus on the bending anti-phase mode and investigate the layout of the electrodes so as to excite this desired mode. We use Hamihon's principle for piezoelectric elastic body to derive the equations of motion. We take it into account that quartz are anisotropic in stiffness, dielectric constants, and piezoelectric coefficients. The slender tuning fork beam can be modeled as Euler beams. There are no existing models that can be used to describe the deformation of the proof mass. We propose the new beam model that can approximately model the rotation, of the cross-section of the proof mass, caused by the tuning fork beams. We also find the proper form of electric potential for the quartz. Based on the general form of exact solutions of vibration for the proof mass and tuning fork beams and the interface and boundary conditions the characteristic equation for frequencies can be derived. The analytical solution agrees well with experimental ones.
Aboard current ships, such as the DDG 51, engineering control and damage control activities are manpower intensive. It is anticipated that, for future combatants, the workload demand arising from operation of systems ...
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Aboard current ships, such as the DDG 51, engineering control and damage control activities are manpower intensive. It is anticipated that, for future combatants, the workload demand arising from operation of systems under conditions of normal steaming and during casualty response will need to be markedly reduced via automated monitoring, autonomous control, and other technology initiatives. Current DDG 51 class ships can be considered as a manpower baseline and under Condition III typical engineering control involves seven to eight watchstanders at manned stations in the Central Control Station, the engine rooms and other machinery spaces. In contrast to this manning level, initiatives such as DD 21 and the integrated engineering plant (IEP) envision a partnership between the operator and the automation system, with more and more of the operator's functions being shifted to the automation system as manning levels decrease. This paper describes some human systems integration studies of workload demand reduction and, consequently, manning reduction that can be achieved due to application of several advanced technology concepts. Advanced system concept studies in relation to workload demand are described and reviewed including. Piecemeal applications of diverse automation and remote control technology concepts to selected high driver tasks in current DDG 51 activities. Development of the reduced ship's crew by virtual presence system that will provide automated monitoring and display to operators of machinery health, compartment conditions, and personnel health. The IEP envisions the machinery control system as a provider of resources that are used by various consumers around the ship. Resource needs and consumer priorities are at all times dependent upon the ship's current mission and the availability of equipment pawnbrokers.
作者：
Benson, JCaplan, IJacobs, RJohn Benson:received his BS degree in Mechanical Engineering and MS degree in Environmental Engineering from the University of Maryland. He is a registered Professional Engineer in the State of Maryland. He Joined the Naval Sufrace Warfare Center
Carderock Division Environmental Quality Department in 1990 as a project engineer and is now managing the non-oily wastewater (graywater and blackwater) project area. Mr. Ivan Caplan:graduated from Drexel University (Philadelphia
Pennsylvania) with a BS in Metallurgical Engineering and was awarded a MS degree from the Johns Hopkins University (Baltimore Maryland) in Mechanics and Materials Science. Mr. Caplan has spent most of his career at the Carderock Division Naval Surface Warfare Center (NSWC) and is currently the Head of the Wastewater Management Branch in the Carderock Division's Environmental Quality Department. Previously Mr. Caplan managed the US Navy's Applied Research Program in Ship & Submarine Materials Technology. In addition Mr. Caplan was manager of the US Navy's Titanium Technology Program Office and during his government career held several external Program Manager positions on at the Naval Sea Systems Command and another at the Air Force Office of Scientific Research. Rachel Jacobs:received BS degrees in Chemical Engineering and Marine Biology from the University of Maryland
College Park. After working for the Naval Research Laboratory in Washington DC and the Center for Marine Biotechnology in Baltimore MD she joined the staff of the Naval Surface Warfare Center's Environmental Quality Department in 1997. Since thta time Ms. Jacobs has worked in the non-oily wastewater treatment area and her principal responsibility has been to technically supervise the evaluation operation and modification graywater treatment.
In anticipation of more stringent environmental regulations, the increasing costs of waste disposal, and the need for naval combatants to operate unimpeded in littoral waters, the U.S. Navy has identified the need to ...
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In anticipation of more stringent environmental regulations, the increasing costs of waste disposal, and the need for naval combatants to operate unimpeded in littoral waters, the U.S. Navy has identified the need to develop technologies which are appropriate for the control and treatment of blackwater and graywater. This paper will describe the status of development efforts by the Carderock Division, Naval Surface Warfare Center (CDNSWC) and its supporting contractors, under sponsorship of Naval Sea Systems Command (NAVSEA) and the Office of Naval Research. The challenge was to develop treatment systems that meet Navy shipboard requirements for affordability, compactness, low manning/maintenance, high reliability and safety, and EM, noise, vibration and shock. Membrane ultrafiltration based systems, incorporating aerobic biological pre-treatment and ultraviolet light post treatment disinfection, have ken developed to meet these requirements. Both external and in-tank membrane systems will be described in terms of performance, system operation and space and weight advantages.
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