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Anticarin-β shows a promising antiosteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis

Acta Pharmaceutica Sinica B 2022年第5期12卷 2268-2279页

作者： Gan Wang Min Zhang Ping Meng Chengbo Long Xiaodong Luo Xingwei Yang Yunfei Wang Zhiye Zhang James Mwangi Peter Muiruri Kamau Zhi Daic Zunfu Ke Yi Zhang Wenlin Chen Xudong Zhao Fei Ge Qiumin Lv Mingqiang Rong Dongsheng Li Yang Jin Xia Sheng Ren Lai Key Laboratory of Animal Models and Human Disease Mechanisms Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesKunming Primate Research Centerand National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyKunming 650107China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Institutes for Drug Discovery and Development Chinese Academy of SciencesShanghai 201203China Sino-African Joint Research Center Chinese Academy of ScienceWuhan 430074China Department of Pathology First Afﬁliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Orthopaedic Surgery First Afﬁliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Breast Surgery Third Afﬁliated Hospital of Kunming Medical UniversityYunnan Cancer CenterKunming 650118China Department of Breast Surgery First Afﬁliated Hospital of Kunming Medical UniversityKunming 650032China Department of Biosciences University of OsloOslo 0316Norway Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental ProtectionAnd State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 434000China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan 430071China

Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex(TRiC) contains eight paralogous subunits(CCT1-8), and assists the folding of as many as 10% of cytosolic *** is essential for the progression of some cancers, but the roles of TRiC subunits in osteosarcoma remain to be explored. Here, we show that CCT4/TRiC is significantly correlated in human osteosarcoma,and plays a critical role in osteosarcoma cell survival. We identify a compound anticarin-β that can specifically bind to and inhibit CCT4. Anticarin-β shows higher selectivity in cancer cells than in normal cells. Mechanistically, anticarin-β potently impedes CCT4-mediated STAT3 maturation. Anticarin-β displays remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of ***, our data uncover a key role of CCT4 in osteosarcoma, and propose a promising treatment strategy for osteosarcoma by disrupting CCT4 and proteostasis.

关键词： Proteostasis CCT TRiC Osteosarcoma STAT3 Anticarin-β PDX model

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Causal effect of serum 25 hydroxyvitamin D concentration on cardioembolic stroke: Evidence from two-sample Mendelian randomization

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Nutrition, Metabolism and Cardiovascular Diseases 2024年第5期34卷 1305-1313页

作者： Habibi, Danial Teymoori, Farshad Ebrahimi, Navid Fateh, Sahand Tehrani Najd-Hassan-Bonab, Leila Saeidian, Amir Hossein Soleymani Taloubaghi, Alireza Asgarian, Sara Hosseinpanah, Farhad Hakonarson, Hakon Azizi, Fereidoun Hedayati, Mehdi Daneshpour, Maryam Sadat Akbarzadeh, Mahdi Mansourian, Marjan Department of Biostatistics and Epidemiology School of Health Student Research Committee Isfahan University of Medical Sciences Isfahan Iran Nutrition and Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti Tehran Iran School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran School of Medicine Tehran University of Medical Sciences Tehran Iran Cellular and Molecular Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran Center for Applied Genomics The Children's Hospital of Philadelphia Abramson Research Building Suite 1016I 3615 Civic Center Boulevard Philadelphia 19104-4318 PA United States Data Science and AI Applications Graduate School of Engineering Science and Technology National Yunlin University of Science and Technology Douliu Taiwan Obesity Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran Department of Pediatrics University of Pennsylvania Perelman School of Medicine Philadelphia PA United States Division of Human Genetics The Children's Hospital of Philadelphia Philadelphia PA United States Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran Epidemiology and Biostatistics Department School of Health Child Growth and Development Research Center Research Institute for Primordial Prevention of Non-Communicable Disease Isfahan University of Medical Sciences Isfahan Iran Department of Nutrition School of Public Health Iran University of Medical Sciences Tehran Iran Department of Biostatistics and Epidemiology School of Health Isfahan University of Medical Sciences Isfahan Iran

Background and aims: The putative association between serum 25-hydroxyvitamin D concentration [25(OH)D] and the risk of cardioembolic stroke (CES) has been examined in observational studies, which indicate controversial findings. We performed Mendelian randomization (MR) analysis to determine the causal relationship of serum 25(OH)D with the risk of CES. Methods and results: The summary statistics dataset on the genetic variants related to 25(OH)D was used from the published GWAS of European descent participants in the UK Biobank, including 417,580 subjects, yielding 143 independent loci in 112 1-Mb regions. GWAS summary data of CES was obtained from GIGASTROKE Consortium, which included European individuals (10,804 cases, 1,234,808 controls). Our results unveiled a causal relationship between 25(OH)D and CES using IVW [OR = 0.82, 95% CI: 0.67–0.98, p = 0.037]. Horizontal pleiotropy was not seen [MR-Egger intercept = 0.001;p = 0.792], suggesting an absence of horizontal pleiotropy. Cochrane's Q [Q = 78.71, p-value = 0.924], Rucker's Q [Q = 78.64, p-value = 0.913], and I² = 0.0% (95% CI: 0.0%, 24.6%) statistic suggested no heterogeneity. This result remained consistent using different MR methods and sensitivity analyses, including Maximum likelihood [OR = 0.82, 95%CI: 0.67–0.98, p-value = 0.036], Constrained maximum likelihood [OR = 0.76, 95%CI: 0.64–0.90, p-value = 0.002], Debiased inverse-variance weighted [OR = 0.82, 95%CI: 0.68–0.99, p-value = 0.002], MR-PRESSO [OR = 0.82, 95%CI 0.77–0.87, p-value = 0.022], RAPS [OR = 0.82, 95%CI 0.67–0.98, p-value = 0.038], MR-Lasso [OR = 0.82, 95%CI 0.68–0.99, p-value = 0.037]. Conclusion: Our MR analysis provides suggestive evidence that increased 25(OH)D levels may play a protective role in the development of cardioembolic stroke. Determining the role of 25(OH)D in stroke subtypes has important clinical and public health implications. © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atheros

关键词： Cardioembolic stroke Genome-wide association study Mendelian randomization Serum 25(OH)D concentration

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Profiling of Essential Oil Constituents in Ocimum Species

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Proceedings of the National Academy of Sciences India Section B - Biological Sciences 2020年第3期90卷 577-583页

作者： Maurya, Shiwani Sangwan, Neelam Singh Department of Metabolic and Structural Biology CSIR-Central Institute of Medicinal and Aromatic Plants Lucknow 226015 India Academy of Scientific and Innovative Research (AcSIR) CSIR-Human Resource Development Centre Campus Sector 19 Kamla Nehru Nagar Ghaziabad 201002 Uttar Pradesh India Department of Biochemistry and Molecular Biology School of Interdisciplinary and Applied Life Science Central University of Haryana Mahendergarh 123031 Haryana India

Ocimum species are herbaceous plants with great medicinal importance. Various tissues of the plants are being used in folk remedies for a variety of purposes. The pharmacologically active natural products present in essential oils in the Ocimum species belong to two major classes of natural compounds, viz. phenylpropanoids and terpenoids. In the present study, the essential oils from the inflorescence, leaf, and stem tissues of four major Ocimum species were hydro-distilled and analyzed. Gas chromatography–mass spectrometry profiling to unravel the phytomolecules and compositional quantification showed the occurrence of distinct tissue-based variability of phytomolecules. Phenylpropanoids such as eugenol and methyl chavicol were specifically found in the tissues of O. sanctum, O. gratissimum, and O. basilicum, respectively, whereas O. kilimandscharicum was distinct in possessing a terpenoid phytomolecule camphor predominantly in its tissues. The study also analyzed the uniqueness of the distribution of phytochemical constituents of essential oil in Ocimum species in tissue- and species-specific manner. Leaves were the major site of accumulation of essential oil, whereas inflorescence and stem also contained essential oil constituents albeit in low quantities. © 2019, The National Academy of Sciences, India.

关键词： Camphor Essential oil Ocimum species Phenylpropanoids Terpenoids

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ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices

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Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2025年第4期10卷 425-436页

作者： Ganesan, Saampras Barrios, Fernando A. Batta, Ishaan Bauer, Clemens C.C. Braver, Todd S. Brewer, Judson A. Brown, Kirk Warren Cahn, Rael Cain, Joshua A. Calhoun, Vince D. Cao, Lei Chetelat, Gaël Ching, Christopher R.K. Creswell, J. David Dagnino, Paulina Clara Davanger, Svend Davidson, Richard J. Deco, Gustavo Dutcher, Janine M. Escrichs, Anira Eyler, Lisa T. Fani, Negar Farb, Norman A.S. Fialoke, Suruchi Fresco, David M. Garg, Rahul Garland, Eric L. Goldin, Philippe Hafeman, Danella M. Jahanshad, Neda Kang, Yoona Khalsa, Sahib S. Kirlic, Namik Lazar, Sara W. Lutz, Antoine McDermott, Timothy J. Pagnoni, Giuseppe Piguet, Camille Prakash, Ruchika S. Rahrig, Hadley Reggente, Nicco Saccaro, Luigi F. Sacchet, Matthew D. Siegle, Greg J. Tang, Yi-Yuan Thomopoulos, Sophia I. Thompson, Paul M. Torske, Alyssa Treves, Isaac N. Tripathi, Vaibhav Tsuchiyagaito, Aki Turner, Matthew D. Vago, David R. Valk, Sofie Zeidan, Fadel Zalesky, Andrew Turner, Jessica A. King, Anthony P. Department of Biomedical Engineering The University of Melbourne Carlton VIC Australia Contemplative Studies Centre Melbourne School of Psychological Sciences The University of Melbourne Melbourne VIC Australia Systems Lab of Neuroscience Neuropsychiatry and Neuroengineering The University of Melbourne Parkville VIC Australia Universidad Nacional Autónoma de México Instituto de Neurobiolgía México Querétaro Mexico Center for Translational Research in Neuroimaging and Data Science: Georgia State University Georgia Institute of Technology and Emory University Atlanta GA United States Department of Psychology Northeastern University Boston Massachusetts Brain and Cognitive Science McGovern Institute for Brain Research Massachusetts Institute of Technology Cambridge Massachusetts Department of Psychological and Brain Sciences Washington University St. Louis Missouri Department of Behavioral and Social Sciences Brown University School of Public Health Providence Rhode Island Department of Psychology Carnegie Mellon University Pittsburgh PA United States University of Southern California Department of Psychiatry & Behavioral Sciences Los Angeles California University of Southern California Center for Mindfulness Science Los Angeles California Institute for Advanced Consciousness Studies Santa Monica California Department of Psychiatry and Behavioral Health The Ohio State University College of Medicine Columbus OH United States Normandie University Université de Caen Normandie INSERM U1237 Neuropresage Team Cyceron Caen France Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine of the University of Southern California Los Angeles California Desert-Pacific Mental Illness Research Education and Clinical Center VA San Diego Healthcare System San Diego California Computational Neuroscience Group Center for Brain and Cognition Department of Information and Communication Technologies Universitat Pompeu Fa

Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past decade, neuroimaging has been used to examine the neuroscientific basis of meditation practices, effects, states, and outcomes for clinical and nonclinical populations. However, the generalizability and replicability of current neuroscientific models of meditation have not yet been established, because they are largely based on small datasets entrenched with heterogeneity along several domains of meditation (e.g., practice types, meditation experience, clinical disorder targeted), experimental design, and neuroimaging methods (e.g., preprocessing, analysis, task-based, resting-state, structural magnetic resonance imaging). These limitations have precluded a nuanced and rigorous neuroscientific phenotyping of meditation practices and their potential benefits. Here, we present ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)–Meditation, the first worldwide collaborative consortium for neuroscientific investigations of meditation practices. ENIGMA-Meditation will enable systematic meta- and mega-analyses of globally distributed neuroimaging datasets of meditation using shared, standardized neuroimaging methods and tools to improve statistical power and generalizability. Through this powerful collaborative framework, existing neuroscientific accounts of meditation practices can be extended to generate novel and rigorous neuroscientific insights that account for multidomain heterogeneity. ENIGMA-Meditation will inform neuroscientific mechanisms that underlie therapeutic action of meditation practices on psychological and cognitive attributes, thereby advancing the f

关键词： Consortium ENIGMA Magnetic resonance imaging (MRI) Meditation Mindfulness Neuroimaging

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Using instant messaging for collaboration: A study of the relationships among organizational trust, justice, and spirituality 11th

Using instant messaging for collaboration: A study of the re...

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11th International Conference on Wireless Internet , WiCON 2018

作者： Neng-Tang, Huang Hui-Lin, Lee Department of Technology Application and Human Resource Development National Normal University 162 Sec.1 Heping E. Rd Taipei Taiwan

ISBN: (纸本)9783030061579

Enterprises must use human resource management to create the difference in the fierce competition of today’s business environment. Employees are an enterprise’s most important assets, and it is important for administrators to grasp the psychology of their staff. Modern technology provided by mobile instant messaging (IM) has created a communication revolution, creating a culture of "texting rather than talking" through the use of smart phone mobile applications, such as WhatsApp, Line, and WeChat. Therefore, it is important for researchers to consider the influence of IM on work relationships and communication. This study explores the relationships between organizational trust, organizational justice, and organizational spirituality in the context of IM communication. Structural equation modeling was used to analyze questionnaire data, showing that organizational spirituality predicted organizational trust and organizational justice. The findings suggested that organizations should utilize the benefits of IM, create an organizational justice strategy, offer better human resource management, and create an environment in which employees’ organizational spirituality can be enhanced. © 2019, ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.

关键词： human resource management

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Institutional networking capability as a catalyst for sustainable supply chains in the manufacturing sector of Ghana: The role of green human resource management strategy and green dynamic capability

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Journal of Environmental Management 2025年 387卷 125865页

作者： Mensah, Philip Opoku Yong, Jing Yi Dura, Codruța Cornelia Mensah, Henry Kofi University of Strathclyde Department of Work Employment and Organisation Scotland United Kingdom School of Management and Marketing Faculty of Business and Law Taylor's University Malaysia University of Petroşani Department of Economics Romania University of Oradea Doctoral School of Economic Sciences Romania Kwame Nkrumah University of Science and Technology Department of Human Resource and Organisational Development Ghana

This study explores the influence of Green human resource Management Strategy (GHRMS) on supply chain environmental sustainability in manufacturing SMEs, emphasising the mediating role of green dynamic capability and the moderating effect of institutional networking capability. Quantitative data was gathered from 263 owners and managers in Ghana's manufacturing sector. The Covariant-Based Structural Equation Modelling (CB-SEM) approach within Amos (v.23) was employed to test the proposed hypotheses. The findings revealed that GHRMS significantly enhances supply chain environmental sustainability by fostering eco-conscious HR practices. Green dynamic capability partially mediates this relationship, enabling firms to develop and adapt sustainable competencies. Additionally, institutional networking capability strengthens the indirect effect of GHRMS on supply chain sustainability, demonstrating the crucial role of external networks in achieving environmental goals. These findings underscore the importance of both internal organisational capabilities and external collaborations in driving sustainable supply chain practices in emerging economies. This study provides strategic insights for firms aiming to integrate GHRMS into their environmental sustainability initiatives, fostering a greener and more resilient supply chain ecosystem. © 2025 Elsevier Ltd

关键词： resource allocation

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A new capnellene skeleton from the octocoral Capnella imbricata (Quoy & Gaimard, 1833)

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Journal of Molecular Structure 2023年 1271卷

作者： Wu, I-Ting Fan, Yu-Chen Lin, Guan-Zhou Wang, Yi-Lin Hwang, Tsong-Long Lai, Kuei-Hung Chung, Hsu-Ming Department of Applied Chemistry National Pingtung University Pingtung900391 Taiwan Graduate Institute of Biomedical Sciences Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan33305 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan33305 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan333 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei11031 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei11031 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Chemical investigations on the ethyl acetate extract of the octocoral Capnella imbricata collected from the waters of Taiwan, which led to the isolation of three capnellenes (1–3), including one new metabolite, 9(12)-capnellene-8β,10α,15-triol (1), along with two known metabolites, 9(12)-capnellene-5α,8β,10α-triol (2), and 9(12)-capnellene-8β,10α-diol (3). The structures of the isolated metabolites were elucidated through extensive spectroscopic analyses, while the relative stereochemistry of 3 was confirmed by a single-crystal X-ray diffraction analysis for the first time in this study. Compounds 1–3 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. © 2022 Elsevier B.V.

关键词： Metabolites

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Production of functionalized clay-CNC based biopolymeric nanocomposite from agro-waste biomass for bulky industrial wastewater treatment via continuous column adsorption study with mathematical modeling: A critical review

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Journal of Cleaner Production 2025年 518卷

作者： Md. Mahmudur Rahman Songita Rani Adhikary M Mohinur Rahman Rabby Md. Mahafujul Hassan Salah Knani Syed Hasibul Akhfer Md. Khalid Al Zuhanee BCSIR Rajshahi Laboratory Bangladesh Council of Scientific and Industrial Research (BCSIR) Rajshahi 6206 Bangladesh Department of Applied Chemistry & Chemical Engineering Islamic University Kushtia 7003 Bangladesh Department of Chemical Engineering Rajshahi University of Engineering and Technology (RUET) Rajshahi 6204 Bangladesh Center for Scientific Research and Entrepreneurship Northern Border University Arar 73213 Saudi Arabia Human Resource Development (HRD) Gazipur Digital University Kaliakair Gazipur 1750 Bangladesh

Due to extensive industrialization, fluctuating technologies, and an overgrowing population a colossal amount of hazardous effluent is generated every moment and discharged directly into the environment. This crude wastewater can contaminate the environment and food cycle; causing serious damage not only to the ecosystem but also to public health. Therefore, it is critical to treat this wastewater by improving an ecological and economical technology before discharging/reusing. However, researchers are exasperating to improve an efficient and effective technology for the refinement of the bulky industrial wastewater. Here, some state-of-the-art production techniques of the FC-CNC bionanosorbents have been proposed for the effective purification of bulky effluent via a continuous adsorption system. This technology is superior to other methods due to its lower cost, higher efficiency, innovative and beneficial nature, and high selectivity. Instead, the precursors (cellulose and clay) are more available, nontoxic, ecofriendly, biodegradable, thermally and mechanically stable, and have shown high surface area, porous structure, possessed substantial active binding sites that could have been busting their adsorption performances. Still there are several complications concerning the effective processing/modification of the main precursors, production techniques, mechanism, and mode of application while purifying the crude wastewater. Henceforth, this review paper would be devoted by concentrating the modification process, advance production methods, synergistic mechanism to support the mono and/or multilayer physisorption, chemisorption, diffusion/deep penetration, and mode of application addressing the bulky wastewater treatment. By discovering the gaps and suggesting impending instructions, this study aims to expand the fabrication, categorization, and application of the FC-CNC bionanoadsorbents.

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A Novel Sterol from the Formosan Soft Coral Lobophytum Durum

SSRN

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SSRN 2023年

作者： Hung, Chia-Ling Huang, Li-Chieh Shih, Kun-Yauh Lai, Kuei-Hung Peng, Bo-Rong Hwang, Tsong-Long Li, Chia-Ying Chung, Hsu-Ming Department of Applied Chemistry National Pingtung University Pingtung900391 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei11031 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei11031 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei11031 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan333323 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan333324 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan333423 Taiwan

Chromatographic investigation on the ethyl acetate extract of the soft coral Lobophytum durum collected from the waters of Guishan Island in northeast Taiwan resulted in the isolation of three sterols 1–3, including one novel sterol, 3β-hydroxy-25-methylene-5-cholesten-7-one (1), and two previously reported sterols, 7-oxogorgosterol (2), and (24S)-ergostane-3β,5α,6β,25-tetraol 25-monoacetate (3). The structures of sterols 1–3 were determined by extensive spectroscopic data analysis and by comparison with those previously reported in the literature. Additionally, the absolute configuration of sterol 3 was identified by a single-crystal X-ray diffraction analysis for the first time in this study. The anti-inflammatory activities of sterols 1–3 were evaluated by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. © 2023, The Authors. All rights reserved.

关键词： Spectroscopic analysis

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Engineering-Oriented curriculum to high school gifted students: A case of paper mechanism

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AIP Conference Proceedings 2023年第1期2685卷

作者： Yung-Chiau Tsao Jiun-De Tsao NTNU Department of Technology Application and Human Resource Development 162 He-Ping East Road Sec1 Taipei 10610 Taiwan R.O.C. Department of Early Childhood Development and Education Chaoyang University of Technology 168 Jifong E. Rd. Wufong Township Taichung County 41349 Taiwan R.O.C.

The STEAM interdisciplinary integrated-thematic curriculum with engineering design is the main concept of the 12-year basic education curricula of technology. This research is based on the engineering design orientation as a teaching strategy, developing project for paper mechanism, and implementing Living technology courses for gifted high school students in Taiwan to test the teaching effectiveness. In the project, students need to integrate the theory, using engineering design process methods, performing work prediction and evaluation, prototyping experiments and trial work, and finally optimizing the work and improving the design. The results of the present study facilitate us get deeper understanding of the practical implementation and engineering thinking skills of gifted students. Suggestions based on the results were generated to improve the future Living technology curriculum. The findings in this study serve as a reference for the future design, development, and implementation of STEAM curricula.

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